Detailed information for compound 1632755

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 843.582 | Formula: C29H51I2N9O4
  • H donors: 9 H acceptors: 4 LogP: 0.83 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCC(=O)N[C@H](C(=O)NCCCNCCCCNCCCNC(=O)[C@H](CCCN=C(N)N)N)Cc1cc(I)c(c(c1)I)O
  • InChi: 1S/C29H51I2N9O4/c1-2-8-25(41)40-24(19-20-17-21(30)26(42)22(31)18-20)28(44)38-16-7-13-36-11-4-3-10-35-12-6-15-37-27(43)23(32)9-5-14-39-29(33)34/h17-18,23-24,35-36,42H,2-16,19,32H2,1H3,(H,37,43)(H,38,44)(H,40,41)(H4,33,34,39)/t23-,24-/m0/s1
  • InChiKey: OAAQEYQIFYXRKL-ZEQRLZLVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0515 0.0577 0.0541
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0515 0.0577 0.0553
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0126 0.0099
Trypanosoma cruzi Protein kinase B 0.0097 0.0038 0.0011
Schistosoma mansoni immunophilin 0.0142 0.0097 0.0059
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0699 0.0815 0.079
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0573 0.0652 0.0561
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0763 0.0897 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.5384 0.534
Echinococcus multilocularis serine protein kinase ATM 0.1498 0.1844 0.1823
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7828 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0515 0.0577 0.0553
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.0126 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.4648 0.5902 0.5863
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0165 0.0126 0.1724
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0515 0.0577 0.0671
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0573 0.0652 0.0561
Trichomonas vaginalis immunophilin, putative 0.0165 0.0126 0.0031
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.066 0.0765 0.074
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0867 0.103 0.0996
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0515 0.0577 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.5376 0.5331
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0534 0.0602 0.0577
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0983 0.1181 0.1157
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1154 0.1401 0.1378
Trichomonas vaginalis PIKK family atypical protein kinase 0.4679 0.5942 0.5903
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0699 0.0815 0.0726
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0515 0.0577 0.0553
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0228 0.0207 0.0182
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0594 0.0678 0.0653
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0165 0.0126 0.0101
Loa Loa (eye worm) FKBP5 protein 0.0165 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.2064 0.1987
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0088 0.0027 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 0.3331 0.3267
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2701 0.3394 0.3338
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0165 0.0126 0.0088
Echinococcus granulosus serine protein kinase ATM 0.1498 0.1844 0.1823
Loa Loa (eye worm) hypothetical protein 0.0142 0.0097 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.1844 0.1765
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0126 0.0101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7828 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1498 0.1844 0.1775
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2701 0.3394 0.3377
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0515 0.0577 0.0671
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.9571
Brugia malayi FAT domain containing protein 0.1154 0.1401 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.4648 0.5902 0.5863
Trichomonas vaginalis PIKK family atypical protein kinase 0.2102 0.2622 0.2551
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0165 0.0126 0.0042
Loa Loa (eye worm) hypothetical protein 0.0983 0.1181 0.1181
Loa Loa (eye worm) phosphatidylinositol 3 0.0828 0.098 0.098
Loa Loa (eye worm) hypothetical protein 0.1587 0.1958 0.1958
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0097 0.0071
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.064 0.0738 0.0649
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0234 0.0197
Entamoeba histolytica protein kinase rad3, putative 0.1498 0.1844 0.1822
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0554 0.0627 0.0602
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0534 0.0602 0.0577
Loa Loa (eye worm) phosphatidylinositol 3 0.2663 0.3345 0.3345
Echinococcus multilocularis Zinc finger, PHD finger 0.0534 0.0602 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.7828 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0534 0.0602 0.0565
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0534 0.0602 0.0576
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0126 0.0031
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0515 0.0577 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.6674 0.8513 0.8499
Echinococcus multilocularis 0.0515 0.0577 0.0553
Loa Loa (eye worm) phosphatidylinositol 3 0.0515 0.0577 0.0577
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0699 0.0815 0.0726
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1498 0.1844 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.5384 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0867 0.103 0.1007
Entamoeba histolytica hypothetical protein 0.0515 0.0577 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.1154 0.1401 0.1318
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0534 0.0602 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.6235 0.7947 0.7927
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0699 0.0815 0.079
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0234 0.0197
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.0551
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0126 0.0099
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0188 0.0093
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0534 0.0602 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 0.3331 0.3267
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.9571
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0515 0.0577 0.0551
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0515 0.0577 0.9571
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1498 0.1844 0.1813
Loa Loa (eye worm) phosphatidylinositol 3 0.0515 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.7828 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0867 0.103 0.1007
Onchocerca volvulus 0.0515 0.0577 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3262 0.4117 0.406
Entamoeba histolytica protein kinase, putative 0.0132 0.0084 0.0057
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0534 0.0602 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 0.3331 0.3267
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0573 0.0652 0.0561
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0602 0.0576
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7828 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.1181 0.1096
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0534 0.0602 0.0704
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7828 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2652 0.3331 0.3267
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0126 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0515 0.0577 0.0486
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0126 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.5376 0.5331
Trichomonas vaginalis PIKK family atypical protein kinase 0.4679 0.5942 0.5903
Loa Loa (eye worm) phosphatidylinositol kinase 0.0515 0.0577 0.0577
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2701 0.3394 0.3369
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0602 0.0511
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1498 0.1844 0.1765
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0534 0.0602 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7828 1 1
Loa Loa (eye worm) hypothetical protein 0.0515 0.0577 0.0577
Entamoeba histolytica hypothetical protein 0.1498 0.1844 0.1822
Leishmania major hypothetical protein, unknown function 0.0515 0.0577 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0983 0.1181 0.1096
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0165 0.0126 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0165 0.0126 0.0099
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6241 0.7955 0.7929
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7828 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0184 0.0151 0.0125
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0632 0.0728 0.0704
Mycobacterium tuberculosis Conserved hypothetical protein 0.0515 0.0577 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0573 0.0652 0.0616
Entamoeba histolytica protein kinase, putative 0.0141 0.0096 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0515 0.0577 0.9571
Loa Loa (eye worm) phosphatidylinositol 3 0.7828 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Entamoeba histolytica hypothetical protein 0.0515 0.0577 0.0551
Leishmania major phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.0457
Trypanosoma cruzi target of rapamycin kinase 3 0.6241 0.7955 0.795
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0165 0.0126 0.5
Toxoplasma gondii FATC domain-containing protein 0.1498 0.1844 0.2396
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0038 0.0011
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0097 0.0038 0.0011
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0515 0.0577 0.9571
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1498 0.1844 0.1775
Schistosoma mansoni hypothetical protein 0.0515 0.0577 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.6235 0.7947 0.7927
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1498 0.1844 0.1822
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0515 0.0577 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0027 0.0000083023
Entamoeba histolytica hypothetical protein 0.066 0.0765 0.074
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0126 0.0099
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0534 0.0602 0.0511
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0515 0.0577 0.0551
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0228 0.0207 0.0182
Echinococcus multilocularis rac serine:threonine kinase 0.0097 0.0038 0.0013
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0534 0.0602 0.0577
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6241 0.7955 0.7935
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0632 0.0728 0.0704
Giardia lamblia Phosphatidylinositol 4-kinase 0.0515 0.0577 0.0551
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7828 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0126 0.0031
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0088 0.0027 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2701 0.3394 0.3376
Trichomonas vaginalis PIKK family atypical protein kinase 0.4679 0.5942 0.5903
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0228 0.0207 0.0207
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0573 0.0652 0.0626
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7828 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0573 0.0652 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.6235 0.7947 0.7927
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0515 0.0577 0.0486
Leishmania major phosphatidylinositol 3-kinase, putative 0.2652 0.3331 0.3246
Leishmania major hypothetical protein, conserved 0.0603 0.0691 0.0572
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0165 0.0126 0.0042
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2701 0.3394 0.3376
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0132 0.0084 0.0084
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0534 0.0602 0.0704
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2701 0.3394 0.3377
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0515 0.0577 0.0553
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0534 0.0602 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5081 0.646 0.6426
Schistosoma mansoni immunophilin 0.0165 0.0126 0.0088
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0534 0.0602 0.0576
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0228 0.0207 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.0515 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 0.3331 0.3267
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0126 0.1724
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0573 0.0652 0.0561
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2663 0.3345 0.328
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7828 1 1
Entamoeba histolytica protein kinase, putative 0.0141 0.0096 0.0069
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7828 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.6235 0.7947 0.7927
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3695 0.4675 0.4623
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0534 0.0602 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0632 0.0728 0.065
Loa Loa (eye worm) AGC/AKT protein kinase 0.0141 0.0096 0.0096
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0126 0.0101
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1498 0.1844 0.1823
Mycobacterium leprae conserved hypothetical protein 0.0515 0.0577 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.0486
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0573 0.0652 0.0572
Loa Loa (eye worm) phosphatidylinositol 3 0.0515 0.0577 0.0577
Giardia lamblia GTOR 0.7828 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0534 0.0602 0.0482
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0515 0.0577 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.1844 0.1765
Echinococcus granulosus serine threonine protein kinase nrc 0.0088 0.0027 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2663 0.3345 0.3259
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.5384 0.534
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0573 0.0652 0.0626
Schistosoma mansoni fkbp-rapamycin associated protein 0.1498 0.1844 0.1813
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0165 0.0126 0.0099
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0601 0.0688 0.0663
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0129 0.0045
Loa Loa (eye worm) hypothetical protein 0.0632 0.0728 0.0728
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1498 0.1844 0.1822
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0602 0.0482
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0763 0.0897 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.2663 0.3345 0.328
Loa Loa (eye worm) hypothetical protein 0.1498 0.1844 0.1844
Plasmodium vivax hypothetical protein 0.0515 0.0577 0.9571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4239 0.5376 0.5331
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.5384 0.534
Trichomonas vaginalis PIKK family atypical protein kinase 0.6235 0.7947 0.7927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0515 0.0577 0.0497
Loa Loa (eye worm) hypothetical protein 0.0198 0.0169 0.0169
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0515 0.0577 0.0671
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.064 0.0738 0.0649
Echinococcus multilocularis fk506 binding protein 0.0165 0.0126 0.0101
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1154 0.1401 0.1378
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1509 0.1858 0.1835
Onchocerca volvulus 0.0515 0.0577 0.5
Brugia malayi Protein kinase domain containing protein 0.0141 0.0096 0.0011
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0515 0.0577 0.0486
Schistosoma mansoni immunophilin 0.0165 0.0126 0.0088
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0126 0.0031
Giardia lamblia Hypothetical protein 0.0515 0.0577 0.0551
Entamoeba histolytica PH domain containing protein kinase, putative 0.0097 0.0038 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Toxoplasma gondii target of rapamycin (TOR), putative 0.5833 0.7429 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0515 0.0577 0.0541
Leishmania major phosphatidylinositol kinase, putative 0.0515 0.0577 0.0457
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0602 0.0576
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0534 0.0602 0.0511
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0515 0.0577 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0097 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0515 0.0577 0.0497
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0699 0.0815 0.0737
Echinococcus granulosus serine/threonine protein kinase 0.0097 0.0038 0.0013
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0165 0.0126 0.0126
Entamoeba histolytica hypothetical protein 0.0515 0.0577 0.0551
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0699 0.0815 0.079
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.0126 0.0099
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1669 0.2064 0.2695
Trichomonas vaginalis PIKK family atypical protein kinase 0.7828 1 1
Loa Loa (eye worm) hypothetical protein 0.1154 0.1401 0.1401
Leishmania major phosphatidylinositol kinase related protein, putative 0.0515 0.0577 0.0457
Loa Loa (eye worm) hypothetical protein 0.1669 0.2064 0.2064
Trichomonas vaginalis PIKK family atypical protein kinase 0.1509 0.1858 0.1779
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0515 0.0577 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0515 0.0577 0.0486
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0699 0.0815 0.0726
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0126 0.0099
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7828 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0515 0.0577 0.0551
Schistosoma mansoni hypothetical protein 0.1154 0.1401 0.1367
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0188 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.5833 0.7429 0.7404
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0515 0.0577 0.9571
Trichomonas vaginalis PIKK family atypical protein kinase 0.5251 0.668 0.6648

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.