Detailed information for compound 1632756

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.492 | Formula: C23H26N6O2
  • H donors: 1 H acceptors: 5 LogP: 4.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(nc1C)O[C@@H]1C(C)(C)[C@H](C1(C)C)NC(=O)c1c(C)nc2n1ccnc2
  • InChi: 1S/C23H26N6O2/c1-13-15(11-24)7-8-17(27-13)31-21-22(3,4)20(23(21,5)6)28-19(30)18-14(2)26-16-12-25-9-10-29(16)18/h7-10,12,20-21H,1-6H3,(H,28,30)/t20-,21-
  • InChiKey: PGUGBMXBBJNXJE-MEMLXQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0579 0.0658 0.0658
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7872 1 1
Echinococcus granulosus voltage gated potassium channel 0.0066 0.0001 0.0001
Leishmania major phosphatidylinositol 3-kinase, putative 0.0538 0.0606 0.048
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3281 0.4119 0.4089
Loa Loa (eye worm) phosphatidylinositol 3 0.0518 0.058 0.0579
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0538 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.2669 0.3334 0.33
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0099 0.0042 0.0042
Echinococcus multilocularis fk506 binding protein 0.0168 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.058 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0989 0.1183 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.7872 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2669 0.3334 0.33
Schistosoma mansoni immunophilin 0.0168 0.0132 0.0131
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0538 0.0606 0.0606
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0189 0.0139
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0538 0.0606 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0168 0.0132 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0713 0.0829 0.0829
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0235 0.0235
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0518 0.058 0.058
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7872 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0518 0.058 0.058
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.089 0.1056 0.1056
Leishmania major phosphatidylinositol 3-kinase, putative 0.2669 0.3334 0.3245
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0518 0.058 0.0579
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0518 0.058 0.9573
Leishmania major phosphatidylinositol kinase related protein, putative 0.0518 0.058 0.0454
Loa Loa (eye worm) hypothetical protein 0.1508 0.1847 0.1847
Loa Loa (eye worm) AGC/AKT protein kinase 0.0105 0.0051 0.005
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.058
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0642 0.0739 0.0739
Onchocerca volvulus 0.0518 0.058 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0579 0.0658 0.0658
Loa Loa (eye worm) phosphatidylinositol 3 0.7872 1 1
Giardia lamblia GTOR 0.7872 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0195 0.0165 0.0165
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6277 0.7956 0.7929
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0132 0.0132
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.9573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1508 0.1847 0.1847
Trypanosoma cruzi hypothetical protein, conserved 0.0093 0.0035 0.0035
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0518 0.058 0.058
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0538 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0518 0.058 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.7872 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.272 0.34 0.34
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0538 0.0606 0.0605
Toxoplasma gondii FATC domain-containing protein 0.1508 0.1847 0.2443
Mycobacterium tuberculosis Conserved hypothetical protein 0.0518 0.058 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4705 0.5943 0.5922
Trichomonas vaginalis PIKK family atypical protein kinase 0.4264 0.5378 0.5355
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0168 0.0132 0.2172
Schistosoma mansoni immunophilin 0.0168 0.0132 0.0131
Trypanosoma cruzi target of rapamycin kinase 3 0.6277 0.7956 0.7956
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1508 0.1847 0.1806
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0518 0.058 0.0728
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0989 0.1183 0.1183
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.272 0.34 0.34
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0132 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.2669 0.3334 0.33
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1508 0.1847 0.1847
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0071 0.0007 0.0006
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0168 0.0132 0.2172
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0132 0.0081
Echinococcus multilocularis 0.0518 0.058 0.058
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0228 0.0209 0.0209
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0601 0.0686 0.0686
Schistosoma mansoni serine/threonine-protein kinase 0.0072 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.1679 0.2067 0.2027
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0518 0.058 0.058
Brugia malayi FAT domain containing protein 0.1161 0.1403 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.7872 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1508 0.1847 0.1847
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0132 0.0081
Schistosoma mansoni hypothetical protein 0.0518 0.058 0.0579
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.272 0.34 0.34
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1508 0.1847 0.1847
Echinococcus granulosus serine protein kinase ATM 0.1508 0.1847 0.1847
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0781 0.0916 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5386 0.5363
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7872 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0168 0.0132 0.0131
Entamoeba histolytica hypothetical protein 0.0518 0.058 0.058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0518 0.058 0.0728
Loa Loa (eye worm) hypothetical protein 0.0145 0.0102 0.0101
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0713 0.0829 0.0782
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0579 0.0658 0.0611
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0168 0.0132 0.5
Giardia lamblia Phosphatidylinositol 4-kinase 0.0518 0.058 0.058
Schistosoma mansoni serine/threonine-protein kinase 0.0072 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.4705 0.5943 0.5922
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1161 0.1403 0.1403
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0538 0.0606 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0989 0.1183 0.1139
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0713 0.0829 0.0829
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0579 0.0658 0.0611
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0132 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0518 0.058 0.9573
Trichomonas vaginalis PIKK family atypical protein kinase 0.4675 0.5904 0.5883
Leishmania major phosphatidylinositol kinase, putative 0.0518 0.058 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.4264 0.5378 0.5355
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0168 0.0132 0.0131
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.089 0.1056 0.1056
Entamoeba histolytica hypothetical protein 0.0672 0.0777 0.0777
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0518 0.058 0.0532
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0713 0.0829 0.0782
Loa Loa (eye worm) phosphatidylinositol 3 0.0518 0.058 0.0579
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7872 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0538 0.0606 0.0558
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0538 0.0606 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.268 0.3348 0.3315
Trichomonas vaginalis PIKK family atypical protein kinase 0.6711 0.8513 0.8505
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0538 0.0606 0.0606
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0538 0.0606 0.0606
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0132 0.0132
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0518 0.058 0.0728
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0518 0.058 0.058
Schistosoma mansoni hypothetical protein 0.1161 0.1403 0.1402
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0538 0.0606 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.627 0.7948 0.7938
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1508 0.1847 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.089 0.1056 0.1055
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5386 0.5363
Loa Loa (eye worm) phosphatidylinositol 3 0.0849 0.1003 0.1002
Loa Loa (eye worm) hypothetical protein 0.1596 0.196 0.1959
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0989 0.1183 0.1183
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0235 0.0235
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.065 0.0749 0.0702
Trichomonas vaginalis PIKK family atypical protein kinase 0.2114 0.2624 0.2586
Trichomonas vaginalis PIKK family atypical protein kinase 0.4675 0.5904 0.5883
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0132 0.0132
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0559 0.0632 0.0632
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1508 0.1847 0.1847
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0518 0.058 0.058
Entamoeba histolytica protein kinase, putative 0.0105 0.0051 0.0051
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0168 0.0132 0.0132
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.065 0.0749 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.1161 0.1403 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.1519 0.1861 0.182
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0132 0.0081
Loa Loa (eye worm) FKBP5 protein 0.0168 0.0132 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0518 0.058 0.0579
Entamoeba histolytica hypothetical protein 0.1508 0.1847 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0781 0.0916 0.0916
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0538 0.0606 0.0606
Echinococcus multilocularis serine protein kinase ATM 0.1508 0.1847 0.1847
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0177 0.0142 0.0142
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0642 0.0739 0.0739
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0168 0.0132 0.0132
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0609 0.0696 0.0696
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0518 0.058 0.9573
Trichomonas vaginalis PIKK family atypical protein kinase 0.4264 0.5378 0.5355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0518 0.058 0.0579
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0518 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5386 0.5363
Trichomonas vaginalis PIKK family atypical protein kinase 0.627 0.7948 0.7938
Loa Loa (eye worm) hypothetical protein 0.0198 0.017 0.0169
Loa Loa (eye worm) phosphatidylinositol 3 0.268 0.3348 0.3348
Entamoeba histolytica protein kinase rad3, putative 0.1508 0.1847 0.1847
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0168 0.0132 0.0131
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7872 1 1
Loa Loa (eye worm) hypothetical protein 0.1679 0.2067 0.2066
Loa Loa (eye worm) hypothetical protein 0.1161 0.1403 0.1402
Plasmodium vivax hypothetical protein 0.0518 0.058 0.9573
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0518 0.058 0.0579
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0713 0.0829 0.0782
Loa Loa (eye worm) phosphatidylinositol kinase 0.0518 0.058 0.0579
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1519 0.1861 0.1861
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1161 0.1403 0.1403
Giardia lamblia Hypothetical protein 0.0518 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Trichomonas vaginalis PIKK family atypical protein kinase 0.5281 0.6681 0.6664
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0189 0.0139
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0518 0.058 0.058
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.9573
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0538 0.0606 0.0605
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0538 0.0606 0.0558
Toxoplasma gondii target of rapamycin (TOR), putative 0.5866 0.743 1
Loa Loa (eye worm) hypothetical protein 0.0518 0.058 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.0532
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0008 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0518 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.5866 0.743 0.7417
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0132 0.0132
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7872 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1679 0.2067 0.274
Entamoeba histolytica protein kinase, putative 0.0099 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0518 0.058 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0713 0.0829 0.0828
Schistosoma mansoni immunophilin 0.0145 0.0102 0.0101
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0713 0.0829 0.0829
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0168 0.0132 0.0132
Leishmania major phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.0454
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0228 0.0209 0.0208
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.272 0.34 0.34
Trichomonas vaginalis PIKK family atypical protein kinase 0.4705 0.5943 0.5922
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0579 0.0658 0.0611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0579 0.0658 0.0657
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7872 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0642 0.0739 0.0738
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0072 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0518 0.058 0.0532
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7872 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0168 0.0132 0.0132
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0132 0.0132
Leishmania major hypothetical protein, conserved 0.0611 0.0699 0.0575
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.272 0.34 0.34
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0538 0.0606 0.0605
Brugia malayi p70 ribosomal S6 kinase beta 0.0099 0.0042 0.0042
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.272 0.34 0.34
Trichomonas vaginalis PIKK family atypical protein kinase 0.2669 0.3334 0.33
Trichomonas vaginalis PIKK family atypical protein kinase 0.627 0.7948 0.7938
Onchocerca volvulus 0.0518 0.058 0.5
Echinococcus granulosus serine/threonine protein kinase 0.0072 0.0008 0.0008
Leishmania major hypothetical protein, unknown function 0.0518 0.058 0.0454
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0538 0.0606 0.0558
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0672 0.0777 0.0777
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0168 0.0132 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.1508 0.1847 0.1806
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0518 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1508 0.1847 0.1806
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0518 0.058 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.627 0.7948 0.7938
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0538 0.0606 0.0605
Echinococcus multilocularis rac serine:threonine kinase 0.0072 0.0008 0.0008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6277 0.7956 0.7946
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0518 0.058 0.0579
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0228 0.0209 0.0208
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3716 0.4676 0.4648
Echinococcus multilocularis Zinc finger, PHD finger 0.0538 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.627 0.7948 0.7938
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0168 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0642 0.0739 0.0738
Brugia malayi Protein kinase domain containing protein 0.0105 0.0051 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0066 0.0001 0.0001
Trypanosoma cruzi Protein kinase B 0.0072 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.268 0.3348 0.3315
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0518 0.058 0.0579
Schistosoma mansoni fkbp-rapamycin associated protein 0.1508 0.1847 0.1847
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0579 0.0658 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5386 0.5363
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0518 0.058 0.9573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1508 0.1847 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0518 0.058 0.0532
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0579 0.0658 0.0657
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7872 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0518 0.058 0.0579
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0538 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5109 0.6461 0.6443
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0538 0.0606 0.0763
Mycobacterium leprae conserved hypothetical protein 0.0518 0.058 0.5
Trichomonas vaginalis fk506-binding protein, putative 0.0168 0.0132 0.0081
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0228 0.0209 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.2669 0.3334 0.33
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0066 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0538 0.0606 0.0558
Entamoeba histolytica hypothetical protein 0.0518 0.058 0.058
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7872 1 1
Entamoeba histolytica protein kinase, putative 0.0105 0.0051 0.0051
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0579 0.0658 0.0658
Leishmania major phosphatidylinositol 3-related kinase, putative 0.268 0.3348 0.326
Trichomonas vaginalis immunophilin, putative 0.0168 0.0132 0.0081
Echinococcus multilocularis voltage gated potassium channel 0.0066 0.0001 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7872 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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