Detailed information for compound 1632757

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 423.895 | Formula: C22H22ClN5O2
  • H donors: 1 H acceptors: 4 LogP: 5.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1Cl)O[C@@H]1C(C)(C)[C@H](C1(C)C)NC(=O)c1cn2c(n1)nccc2
  • InChi: 1S/C22H22ClN5O2/c1-21(2)18(27-17(29)16-12-28-9-5-8-25-20(28)26-16)22(3,4)19(21)30-14-7-6-13(11-24)15(23)10-14/h5-10,12,18-19H,1-4H3,(H,27,29)/t18-,19-
  • InChiKey: ULAOFLXSBQYVSF-WGSAOQKQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0165 0.0129 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.613 0.7955 0.795
Leishmania major phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.0453
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0095 0.0037 0.0011
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0037 0.0011
Toxoplasma gondii FATC domain-containing protein 0.1472 0.1843 0.2396
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Entamoeba histolytica hypothetical protein 0.0506 0.0576 0.0551
Entamoeba histolytica protein kinase, putative 0.0139 0.0095 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0506 0.0576 0.9562
Mycobacterium tuberculosis Conserved hypothetical protein 0.0506 0.0576 0.5
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0564 0.0652 0.0617
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0624 0.073 0.0707
Loa Loa (eye worm) phosphatidylinositol 3 0.7688 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0185 0.0154 0.0129
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7688 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0165 0.0129 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0165 0.0129 0.0103
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.613 0.7955 0.7928
Leishmania major hypothetical protein, unknown function 0.0506 0.0576 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0966 0.118 0.1095
Entamoeba histolytica hypothetical protein 0.1472 0.1843 0.1822
Loa Loa (eye worm) hypothetical protein 0.0506 0.0576 0.0576
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0525 0.0601 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7688 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1472 0.1843 0.1765
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0525 0.0601 0.0511
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2654 0.3395 0.337
Trichomonas vaginalis PIKK family atypical protein kinase 0.4595 0.5941 0.5902
Loa Loa (eye worm) phosphatidylinositol kinase 0.0506 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.4164 0.5376 0.5331
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0129 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.0576 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0966 0.118 0.1095
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2605 0.3331 0.3267
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0129 0.0034
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7688 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0525 0.0601 0.0704
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0564 0.0652 0.0562
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7688 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0525 0.0601 0.0576
Onchocerca volvulus 0.0506 0.0576 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3204 0.4116 0.406
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3331 0.3267
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0525 0.0601 0.0566
Entamoeba histolytica protein kinase, putative 0.0131 0.0083 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.7688 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0506 0.0576 0.0576
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0858 0.1038 0.1016
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.9562
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3331 0.3267
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1472 0.1843 0.1813
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0506 0.0576 0.9562
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0506 0.0576 0.0551
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0525 0.0601 0.0522
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0191 0.0097
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0129 0.0103
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.0551
Schistosoma mansoni voltage-gated potassium channel 0.0248 0.0238 0.0201
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0691 0.0818 0.0794
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0525 0.0601 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.1134 0.1399 0.1317
Trichomonas vaginalis PIKK family atypical protein kinase 0.6124 0.7947 0.7927
Entamoeba histolytica hypothetical protein 0.0506 0.0576 0.0551
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1472 0.1843 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.417 0.5384 0.534
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0858 0.1038 0.1016
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Echinococcus multilocularis 0.0506 0.0576 0.0552
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0691 0.0818 0.073
Loa Loa (eye worm) phosphatidylinositol 3 0.0506 0.0576 0.0576
Echinococcus multilocularis Zinc finger, PHD finger 0.0525 0.0601 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.7688 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.2616 0.3344 0.3344
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0525 0.0601 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.6555 0.8513 0.8498
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0506 0.0576 0.0486
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0129 0.0034
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0525 0.0601 0.0576
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0525 0.0601 0.0566
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0545 0.0627 0.0602
Entamoeba histolytica protein kinase rad3, putative 0.1472 0.1843 0.1822
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0099 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0819 0.0987 0.0987
Loa Loa (eye worm) hypothetical protein 0.1558 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0966 0.118 0.118
Schistosoma mansoni voltage-gated potassium channel 0.0248 0.0238 0.0201
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0631 0.074 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.2064 0.2621 0.255
Trichomonas vaginalis PIKK family atypical protein kinase 0.4565 0.5902 0.5863
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0165 0.0129 0.0046
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.9562
Brugia malayi FAT domain containing protein 0.1134 0.1399 0.1327
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7688 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0129 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.1472 0.1843 0.1765
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0506 0.0576 0.067
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2654 0.3395 0.3378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1472 0.1843 0.1775
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0165 0.0129 0.0092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2654 0.3395 0.3339
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3331 0.3267
Loa Loa (eye worm) hypothetical protein 0.0142 0.0099 0.0099
Echinococcus granulosus serine protein kinase ATM 0.1472 0.1843 0.1823
Loa Loa (eye worm) FKBP5 protein 0.0165 0.0129 0.0129
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0165 0.0129 0.0104
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0228 0.0211 0.0186
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.0679 0.0655
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0506 0.0576 0.0552
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0087 0.0026 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1639 0.2063 0.1987
Trichomonas vaginalis PIKK family atypical protein kinase 0.4595 0.5941 0.5902
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1134 0.1399 0.1378
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0966 0.118 0.1157
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0525 0.0601 0.0578
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0691 0.0818 0.073
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0564 0.0652 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.4565 0.5902 0.5863
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0506 0.0576 0.067
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0165 0.0129 0.1786
Trichomonas vaginalis PIKK family atypical protein kinase 0.4164 0.5376 0.5331
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0506 0.0576 0.0551
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0858 0.1038 0.1005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0652 0.0767 0.0743
Trichomonas vaginalis immunophilin, putative 0.0165 0.0129 0.0034
Echinococcus multilocularis serine protein kinase ATM 0.1472 0.1843 0.1823
Trichomonas vaginalis PIKK family atypical protein kinase 0.417 0.5384 0.534
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0755 0.0902 0.088
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.0129 0.0034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0506 0.0576 0.0552
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7688 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0506 0.0576 0.054
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0564 0.0652 0.0562
Schistosoma mansoni immunophilin 0.0142 0.0099 0.0062
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0691 0.0818 0.0794
Trypanosoma cruzi Protein kinase B 0.0095 0.0037 0.0011
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0129 0.0103
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0506 0.0576 0.0552
Schistosoma mansoni hypothetical protein 0.1134 0.1399 0.1367
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0506 0.0576 0.9562
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.5157 0.6679 0.6647
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0191 0.0097
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0506 0.0576 0.0551
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0129 0.0103
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7688 1 1
Loa Loa (eye worm) hypothetical protein 0.1639 0.2063 0.2063
Leishmania major phosphatidylinositol kinase related protein, putative 0.0506 0.0576 0.0453
Loa Loa (eye worm) hypothetical protein 0.1134 0.1399 0.1399
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0691 0.0818 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.0576 0.0486
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0506 0.0576 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.1482 0.1857 0.1779
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.0129 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.7688 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1639 0.2063 0.2695
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.0576 0.0496
Echinococcus granulosus serine/threonine protein kinase 0.0095 0.0037 0.0013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0691 0.0818 0.0741
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0099 0.0074
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0691 0.0818 0.0794
Entamoeba histolytica hypothetical protein 0.0506 0.0576 0.0551
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0165 0.0129 0.0129
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0525 0.0601 0.0576
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0525 0.0601 0.0511
Leishmania major phosphatidylinositol kinase, putative 0.0506 0.0576 0.0453
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0506 0.0576 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0037 0.0011
Giardia lamblia Hypothetical protein 0.0506 0.0576 0.0551
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0506 0.0576 0.054
Toxoplasma gondii target of rapamycin (TOR), putative 0.5729 0.7429 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0129 0.0034
Schistosoma mansoni immunophilin 0.0165 0.0129 0.0092
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0506 0.0576 0.0486
Onchocerca volvulus 0.0506 0.0576 0.5
Brugia malayi Protein kinase domain containing protein 0.0139 0.0095 0.0011
Echinococcus multilocularis fk506 binding protein 0.0165 0.0129 0.0104
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0631 0.074 0.0651
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1482 0.1857 0.1836
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1134 0.1399 0.1378
Plasmodium vivax hypothetical protein 0.0506 0.0576 0.9562
Trichomonas vaginalis PIKK family atypical protein kinase 0.4164 0.5376 0.5331
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0506 0.0576 0.067
Loa Loa (eye worm) hypothetical protein 0.0197 0.0171 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.6124 0.7947 0.7927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.0576 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.417 0.5384 0.534
Loa Loa (eye worm) hypothetical protein 0.1472 0.1843 0.1843
Trichomonas vaginalis PIKK family atypical protein kinase 0.2616 0.3344 0.3281
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1472 0.1843 0.1822
Trichomonas vaginalis PIKK family atypical protein kinase 0.5729 0.7429 0.7404
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0755 0.0902 0.088
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0525 0.0601 0.0478
Schistosoma mansoni fkbp-rapamycin associated protein 0.1472 0.1843 0.1813
Loa Loa (eye worm) hypothetical protein 0.0624 0.073 0.073
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0168 0.0132 0.0049
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0592 0.0689 0.0665
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0165 0.0129 0.0103
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2616 0.3344 0.3258
Echinococcus granulosus serine threonine protein kinase nrc 0.0087 0.0026 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1472 0.1843 0.1765
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.0551
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0564 0.0652 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.417 0.5384 0.534
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0506 0.0576 0.0486
Mycobacterium leprae conserved hypothetical protein 0.0506 0.0576 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1472 0.1843 0.1823
Leishmania major phosphatidylinositol 3-kinase, putative 0.0525 0.0601 0.0478
Giardia lamblia GTOR 0.7688 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0564 0.0652 0.0573
Loa Loa (eye worm) phosphatidylinositol 3 0.0506 0.0576 0.0576
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0525 0.0601 0.0601
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3629 0.4674 0.4623
Trichomonas vaginalis PIKK family atypical protein kinase 0.6124 0.7947 0.7927
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0129 0.0104
Loa Loa (eye worm) AGC/AKT protein kinase 0.0139 0.0095 0.0095
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0624 0.073 0.0652
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7688 1 1
Entamoeba histolytica protein kinase, putative 0.0139 0.0095 0.0069
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2616 0.3344 0.3281
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0564 0.0652 0.0562
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0129 0.1786
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7688 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0525 0.0601 0.0576
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0228 0.0211 0.0128
Schistosoma mansoni immunophilin 0.0165 0.0129 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0506 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.499 0.6459 0.6426
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3331 0.3267
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0525 0.0601 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0506 0.0576 0.0552
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0131 0.0083 0.0083
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0525 0.0601 0.0704
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0165 0.0129 0.0046
Leishmania major hypothetical protein, conserved 0.0594 0.0691 0.057
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2654 0.3395 0.3378
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2654 0.3395 0.3378
Leishmania major phosphatidylinositol 3-kinase, putative 0.2605 0.3331 0.3244
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0506 0.0576 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.6124 0.7947 0.7927
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0228 0.0211 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.4595 0.5941 0.5902
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2654 0.3395 0.3378
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.0652 0.0628
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0564 0.0652 0.0628
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7688 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0624 0.073 0.0707
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0087 0.0026 0.0001
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0129 0.0034
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7688 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0506 0.0576 0.0551
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0525 0.0601 0.0578
Echinococcus multilocularis rac serine:threonine kinase 0.0095 0.0037 0.0013
Trypanosoma brucei target of rapamycin kinase 3, putative 0.613 0.7955 0.7936
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0228 0.0211 0.0186
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0506 0.0576 0.0551
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0028 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.0576 0.0496
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0525 0.0601 0.0511
Entamoeba histolytica hypothetical protein 0.0652 0.0767 0.0743
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0129 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1472 0.1843 0.1775
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0506 0.0576 0.9562
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1472 0.1843 0.1822
Trichomonas vaginalis PIKK family atypical protein kinase 0.6124 0.7947 0.7927
Schistosoma mansoni hypothetical protein 0.0506 0.0576 0.054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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