Detailed information for compound 1632758

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 424.883 | Formula: C21H21ClN6O2
  • H donors: 1 H acceptors: 5 LogP: 4.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1Cl)O[C@@H]1C(C)(C)[C@H](C1(C)C)NC(=O)c1nn2c(n1)nccc2
  • InChi: 1S/C21H21ClN6O2/c1-20(2)17(26-16(29)15-25-19-24-8-5-9-28(19)27-15)21(3,4)18(20)30-13-7-6-12(11-23)14(22)10-13/h5-10,17-18H,1-4H3,(H,26,29)/t17-,18-
  • InChiKey: LYSQJNILRGZLMX-IYARVYRRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.5374 0.5327
Loa Loa (eye worm) phosphatidylinositol kinase 0.0472 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.4282 0.5939 0.5898
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0491 0.0598 0.0502
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2478 0.3398 0.3371
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1373 0.184 0.1757
Loa Loa (eye worm) hypothetical protein 0.0472 0.0571 0.0571
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7164 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0491 0.0598 1
Entamoeba histolytica hypothetical protein 0.1373 0.184 0.1817
Trichomonas vaginalis conserved hypothetical protein 0.0901 0.1175 0.1085
Leishmania major hypothetical protein, unknown function 0.0472 0.0571 0.044
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5712 0.7955 0.7926
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0164 0.0137 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0164 0.0137 0.011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7164 1 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0141 0.0052
Loa Loa (eye worm) phosphatidylinositol 3 0.7164 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0589 0.0736 0.0711
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.053 0.0652 0.0615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0472 0.0571 0.5
Entamoeba histolytica protein kinase, putative 0.0138 0.0101 0.0074
Plasmodium vivax hypothetical protein, conserved 0.0472 0.0571 0.9529
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0472 0.0571 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Toxoplasma gondii FATC domain-containing protein 0.1373 0.184 0.2386
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.004 0.0012
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0095 0.004 0.0012
Leishmania major phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.044
Trypanosoma cruzi target of rapamycin kinase 3 0.5712 0.7955 0.7949
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0164 0.0137 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0656 0.083 0.0804
Schistosoma mansoni voltage-gated potassium channel 0.0208 0.0199 0.016
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.0545
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0164 0.0137 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0178 0.0157 0.0056
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0491 0.0598 0.0513
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0472 0.0571 0.0545
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1373 0.184 0.1808
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0472 0.0571 0.9529
Trichomonas vaginalis PIKK family atypical protein kinase 0.2429 0.3329 0.3261
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.9529
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0822 0.1065 0.1041
Loa Loa (eye worm) phosphatidylinositol 3 0.0472 0.0571 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.7164 1 1
Entamoeba histolytica protein kinase, putative 0.013 0.0089 0.0062
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0491 0.0598 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2429 0.3329 0.3261
Onchocerca volvulus 0.0472 0.0571 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2986 0.4114 0.4054
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0491 0.0598 0.0572
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7164 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.053 0.0652 0.0557
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0491 0.0598 0.0693
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7164 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2429 0.3329 0.3261
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0164 0.0137 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.1175 0.1085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0472 0.0571 0.0475
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0164 0.0137 0.011
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0164 0.0137 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.4255 0.5901 0.5859
Trichomonas vaginalis PIKK family atypical protein kinase 0.1924 0.2616 0.2541
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0596 0.0746 0.0652
Schistosoma mansoni voltage-gated potassium channel 0.0208 0.0199 0.016
Loa Loa (eye worm) hypothetical protein 0.0901 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.1452 0.1951 0.1951
Loa Loa (eye worm) phosphatidylinositol 3 0.0784 0.101 0.101
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0141 0.0105 0.0079
Entamoeba histolytica protein kinase rad3, putative 0.1373 0.184 0.1817
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0511 0.0625 0.0599
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0491 0.0598 0.0572
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0491 0.0598 0.056
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0164 0.0137 0.0037
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0472 0.0571 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.6107 0.8511 0.8496
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0491 0.0598 0.0573
Loa Loa (eye worm) phosphatidylinositol 3 0.244 0.3344 0.3344
Echinococcus multilocularis Zinc finger, PHD finger 0.0491 0.0598 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.7164 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0472 0.0571 0.0571
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0656 0.083 0.0736
Echinococcus multilocularis 0.0472 0.0571 0.0546
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0822 0.1065 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.3887 0.5383 0.5336
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1373 0.184 0.1819
Entamoeba histolytica hypothetical protein 0.0472 0.0571 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.5706 0.7946 0.7925
Trichomonas vaginalis conserved hypothetical protein 0.1057 0.1395 0.1307
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0491 0.0598 0.0502
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0164 0.0137 0.011
Entamoeba histolytica hypothetical protein 0.0472 0.0571 0.0545
Trypanosoma cruzi Protein kinase B 0.0095 0.004 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0656 0.083 0.0804
Schistosoma mansoni immunophilin 0.0141 0.0105 0.0066
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.053 0.0652 0.0557
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0472 0.0571 0.0533
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7164 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Trichomonas vaginalis fk506-binding protein, putative 0.0164 0.0137 0.0037
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0472 0.0571 0.0546
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0719 0.092 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.3887 0.5383 0.5336
Echinococcus multilocularis serine protein kinase ATM 0.1373 0.184 0.1819
Trichomonas vaginalis immunophilin, putative 0.0164 0.0137 0.0037
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0822 0.1065 0.1029
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0617 0.0775 0.075
Giardia lamblia Hypothetical protein 0.0472 0.0571 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.5374 0.5327
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0164 0.0137 0.1921
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0571 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.4255 0.5901 0.5859
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.053 0.0652 0.0557
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0656 0.083 0.0736
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0901 0.1175 0.1151
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0491 0.0598 0.0573
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1057 0.1395 0.1372
Trichomonas vaginalis PIKK family atypical protein kinase 0.4282 0.5939 0.5898
Trichomonas vaginalis conserved hypothetical protein 0.1529 0.206 0.1979
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0086 0.0028 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0472 0.0571 0.0546
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.055 0.0681 0.0655
Echinococcus granulosus potassium voltage gated channel subfamily H 0.019 0.0174 0.0149
Loa Loa (eye worm) FKBP5 protein 0.0164 0.0137 0.0137
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0164 0.0137 0.0111
Echinococcus granulosus serine protein kinase ATM 0.1373 0.184 0.1819
Loa Loa (eye worm) hypothetical protein 0.0141 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.2429 0.3329 0.3261
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2478 0.3398 0.3338
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0164 0.0137 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1373 0.184 0.1767
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2478 0.3398 0.338
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0571 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.1373 0.184 0.1757
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0164 0.0137 0.0111
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7164 1 1
Brugia malayi FAT domain containing protein 0.1057 0.1395 0.1318
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.9529
Toxoplasma gondii target of rapamycin (TOR), putative 0.5339 0.7428 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0472 0.0571 0.0533
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0472 0.0571 0.0545
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.004 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0472 0.0571 0.0546
Leishmania major phosphatidylinositol kinase, putative 0.0472 0.0571 0.044
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0491 0.0598 0.0502
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0491 0.0598 0.0572
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0164 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0472 0.0571 0.0545
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0656 0.083 0.0804
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0141 0.0105 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0656 0.083 0.0747
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0472 0.0571 0.0486
Echinococcus granulosus serine/threonine protein kinase 0.0095 0.004 0.0013
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1529 0.206 0.2686
Trichomonas vaginalis PIKK family atypical protein kinase 0.7164 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0164 0.0137 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.1383 0.1855 0.1772
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0472 0.0571 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0472 0.0571 0.0475
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0656 0.083 0.0736
Loa Loa (eye worm) hypothetical protein 0.1057 0.1395 0.1395
Leishmania major phosphatidylinositol kinase related protein, putative 0.0472 0.0571 0.044
Loa Loa (eye worm) hypothetical protein 0.1529 0.206 0.206
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7164 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0164 0.0137 0.011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0472 0.0571 0.0545
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0184 0.0165 0.0138
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0472 0.0571 0.9529
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.4806 0.6677 0.6643
Schistosoma mansoni hypothetical protein 0.1057 0.1395 0.1361
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0164 0.0137 0.011
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0558 0.0692 0.0666
Loa Loa (eye worm) hypothetical protein 0.0165 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0589 0.0736 0.0736
Schistosoma mansoni fkbp-rapamycin associated protein 0.1373 0.184 0.1808
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0491 0.0598 0.0467
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0719 0.092 0.0896
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1373 0.184 0.1817
Trichomonas vaginalis PIKK family atypical protein kinase 0.5339 0.7428 0.7402
Trichomonas vaginalis PIKK family atypical protein kinase 0.244 0.3344 0.3276
Loa Loa (eye worm) hypothetical protein 0.1373 0.184 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.3887 0.5383 0.5336
Trichomonas vaginalis PIKK family atypical protein kinase 0.5706 0.7946 0.7925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0472 0.0571 0.0486
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0178 0.0157 0.0056
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0571 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.3881 0.5374 0.5327
Plasmodium vivax hypothetical protein 0.0472 0.0571 0.9529
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1057 0.1395 0.1372
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1383 0.1855 0.1832
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0596 0.0746 0.0652
Echinococcus multilocularis fk506 binding protein 0.0164 0.0137 0.0111
Brugia malayi Protein kinase domain containing protein 0.0138 0.0101 0.0012
Onchocerca volvulus 0.0472 0.0571 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0472 0.0571 0.0475
Schistosoma mansoni immunophilin 0.0164 0.0137 0.0098
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0164 0.0137 0.0037
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0472 0.0571 0.0546
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0491 0.0598 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2429 0.3329 0.3261
Trichomonas vaginalis PIKK family atypical protein kinase 0.465 0.6457 0.6421
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0491 0.0598 0.0572
Schistosoma mansoni immunophilin 0.0164 0.0137 0.0098
Loa Loa (eye worm) phosphatidylinositol 3 0.0472 0.0571 0.0571
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.019 0.0174 0.0174
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7164 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0164 0.0137 0.1921
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.244 0.3344 0.3276
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.053 0.0652 0.0557
Entamoeba histolytica protein kinase, putative 0.0138 0.0101 0.0074
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7164 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0589 0.0736 0.0653
Loa Loa (eye worm) AGC/AKT protein kinase 0.0138 0.0101 0.0101
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0164 0.0137 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.5706 0.7946 0.7925
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0491 0.0598 0.0598
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3381 0.467 0.4616
Giardia lamblia GTOR 0.7164 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0472 0.0571 0.0571
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.053 0.0652 0.0568
Leishmania major phosphatidylinositol 3-kinase, putative 0.0491 0.0598 0.0467
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1373 0.184 0.1819
Mycobacterium leprae conserved hypothetical protein 0.0472 0.0571 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.3887 0.5383 0.5336
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.053 0.0652 0.0626
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0472 0.0571 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.1373 0.184 0.1757
Echinococcus granulosus serine threonine protein kinase nrc 0.0086 0.0028 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.244 0.3344 0.3251
Schistosoma mansoni hypothetical protein 0.0472 0.0571 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.5706 0.7946 0.7925
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1373 0.184 0.1817
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0472 0.0571 0.9529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1373 0.184 0.1767
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0164 0.0137 0.011
Entamoeba histolytica hypothetical protein 0.0617 0.0775 0.075
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0491 0.0598 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0472 0.0571 0.0486
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.003 0.0002
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0472 0.0571 0.0545
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.019 0.0174 0.0149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5712 0.7955 0.7934
Echinococcus multilocularis rac serine:threonine kinase 0.0095 0.004 0.0013
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0491 0.0598 0.0573
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7164 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0472 0.0571 0.0545
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0164 0.0137 0.0037
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0086 0.0028 0.0001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0589 0.0736 0.0711
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.053 0.0652 0.0626
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7164 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.053 0.0652 0.0626
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2478 0.3398 0.3379
Trichomonas vaginalis PIKK family atypical protein kinase 0.4282 0.5939 0.5898
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.019 0.0174 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.5706 0.7946 0.7925
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0472 0.0571 0.0475
Leishmania major phosphatidylinositol 3-kinase, putative 0.2429 0.3329 0.3236
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2478 0.3398 0.338
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2478 0.3398 0.3379
Leishmania major hypothetical protein, conserved 0.056 0.0695 0.0565
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0164 0.0137 0.0049
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0491 0.0598 0.0693
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.013 0.0089 0.0089

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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