TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 287.4 | Formula: C17H25N3O
H donors: 3 H acceptors: 2 LogP: 3.94 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H]1C[C@](C)(CNc2n[nH]c3c2cccc3)CC(C1)(C)C
InChi: 1S/C17H25N3O/c1-16(2)8-12(21)9-17(3,10-16)11-18-15-13-6-4-5-7-14(13)19-20-15/h4-7,12,21H,8-11H2,1-3H3,(H2,18,19,20)/t12-,17-/m0/s1
InChiKey: JEHHKSYKGOOOHI-SJCJKPOMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.6029	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1271	0.2056	0.2676
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0107	0.0113	0.5
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0389	0.0584	0.0577
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0389	0.0584	0.0667
Schistosoma mansoni	immunophilin	0.0107	0.0113	0.0106
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0389	0.0584	0.0577
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0096	0.0095	0.0088
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0389	0.0584	0.0545
Entamoeba histolytica	protein kinase, putative	0.0102	0.0106	0.0065
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0389	0.0584	0.0577
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4484	0.7421	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0389	0.0584	0.0577
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0389	0.0584	0.0545
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0389	0.0584	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Schistosoma mansoni	immunophilin	0.0092	0.0088	0.0081
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0389	0.0584	0.0577
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4044	0.6686	0.6686
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.014	0.0168	0.0168
Brugia malayi	FAT domain containing protein	0.0882	0.1406	0.14
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0389	0.0584	0.0577
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.6029	1	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0107	0.0113	0.0007
Leishmania major	hypothetical protein, unknown function	0.0389	0.0584	0.0476
Giardia lamblia	Hypothetical protein	0.0389	0.0584	0.0545
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0545
Schistosoma mansoni	fkbp-rapamycin associated protein	0.114	0.1838	0.1833
Loa Loa (eye worm)	hypothetical protein	0.1271	0.2056	0.205
Echinococcus multilocularis	nervana 2	0.0063	0.004	0.0033
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0389	0.0584	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0882	0.1406	0.14
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0545
Loa Loa (eye worm)	hypothetical protein	0.013	0.0152	0.0145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3256	0.5369	0.5369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4796	0.794	0.794
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0389	0.0584	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3251	0.5361	0.5361
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0389	0.0584	1
Entamoeba histolytica	protein kinase rad3, putative	0.114	0.1838	0.1804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.331	0.331
Entamoeba histolytica	hypothetical protein	0.0389	0.0584	0.0545
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0389	0.0584	0.0584
Trichomonas vaginalis	PIKK family atypical protein kinase	0.114	0.1838	0.1838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Loa Loa (eye worm)	phosphatidylinositol 3	0.0389	0.0584	0.0577
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0107	0.0113	0.0072
Loa Loa (eye worm)	phosphatidylinositol 3	0.0389	0.0584	0.0577
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0107	0.0113	0.0106
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.114	0.1838	0.1833
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0063	0.004	0.0033
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0107	0.0113	0.0106
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Plasmodium vivax	hypothetical protein	0.0389	0.0584	1
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0389	0.0584	0.0577
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.114	0.1838	0.1804
Schistosoma mansoni	hypothetical protein	0.0882	0.1406	0.14
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0107	0.0113	0.0072
Entamoeba histolytica	hypothetical protein	0.0389	0.0584	0.0545
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.6029	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.6029	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0052	0.0011
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2022	0.331	0.3234
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0389	0.0584	0.0584
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0107	0.0113	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.331	0.331
Echinococcus granulosus	serine/threonine protein kinase	0.007	0.0052	0.0045
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.015	0.0185	0.0178
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0107	0.0113	0.1321
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3914	0.6469	0.6469
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0389	0.0584	0.0667
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0389	0.0584	0.0584
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3256	0.5369	0.5369
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.007	0.0052	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.331	0.331
Trichomonas vaginalis	PIKK family atypical protein kinase	0.114	0.1838	0.1838
Entamoeba histolytica	hypothetical protein	0.0389	0.0584	0.0545
Echinococcus granulosus	nervana 2	0.0063	0.004	0.0033
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0584
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0389	0.0584	0.0577
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0389	0.0584	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.6029	1	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0476
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0389	0.0584	0.0577
Loa Loa (eye worm)	hypothetical protein	0.114	0.1838	0.1833
Loa Loa (eye worm)	FKBP5 protein	0.0107	0.0113	0.0106
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0389	0.0584	0.0584
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2851	0.4695	0.4638
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4796	0.794	0.794
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0064	0.0041	0.0034
Trypanosoma cruzi	target of rapamycin kinase 3	0.4801	0.7949	0.794
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0389	0.0584	0.0577
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0092	0.0088	0.0081
Echinococcus granulosus	serine threonine protein kinase nrc	0.0064	0.0041	0.0034
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.015	0.0185	0.0178
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0389	0.0584	0.0584
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0389	0.0584	0.0545
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0107	0.0113	0.0106
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0052	0.0045
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.114	0.1838	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4796	0.794	0.794
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0389	0.0584	0.0545
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.114	0.1838	0.1751
Leishmania major	hypothetical protein, conserved	0.0389	0.0584	0.0476
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0064	0.0041	0.0034
Loa Loa (eye worm)	phosphatidylinositol 3	0.2022	0.331	0.3305
Brugia malayi	Protein kinase domain containing protein	0.0102	0.0106	0.0099
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0545
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0389	0.0584	0.0584
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2022	0.331	0.3305
Schistosoma mansoni	immunophilin	0.0107	0.0113	0.0106
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2022	0.331	0.3239
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4796	0.794	0.794
Loa Loa (eye worm)	phosphatidylinositol 3	0.0389	0.0584	0.0577
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0389	0.0584	0.0584
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.6029	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.015	0.0185	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3603	0.5949	0.5949
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2022	0.331	0.3305
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0052	0.0045
Trichomonas vaginalis	fk506-binding protein, putative	0.0107	0.0113	0.0113
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.6029	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Mycobacterium leprae	conserved hypothetical protein	0.0389	0.0584	0.5
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4801	0.7949	0.7927
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0107	0.0113	0.0113
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0107	0.0113	0.0007
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0389	0.0584	0.0483
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0751	0.1189	0.1189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.114	0.1838	0.1838
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0389	0.0584	0.0577
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0476
Giardia lamblia	GTOR	0.6029	1	1
Toxoplasma gondii	FATC domain-containing protein	0.114	0.1838	0.238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.331	0.331
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0584
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3603	0.5949	0.5949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3251	0.5361	0.5361
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0088	0.0081
Entamoeba histolytica	protein kinase, putative	0.0096	0.0095	0.0054
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.114	0.1838	0.1804
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0107	0.0113	0.0072
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4801	0.7949	0.7925
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0389	0.0584	0.0545
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.6029	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0483
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0389	0.0584	0.0577
Plasmodium vivax	hypothetical protein, conserved	0.0389	0.0584	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0389	0.0584	0.0584
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0107	0.0113	0.0106
Loa Loa (eye worm)	phosphatidylinositol 3	0.6029	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0389	0.0584	0.0584
Echinococcus multilocularis	nervana 2	0.0063	0.004	0.0033
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.6029	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0389	0.0584	0.0545
Entamoeba histolytica	hypothetical protein	0.114	0.1838	0.1804
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0389	0.0584	0.0577
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2022	0.331	0.331
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0389	0.0584	0.0667
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0063	0.004	0.0033
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.014	0.0168	0.0168
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0107	0.0113	0.0072
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Schistosoma mansoni	voltage-gated potassium channel	0.0164	0.0208	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0584	0.0577
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0107	0.0113	0.1321
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0389	0.0584	0.0545
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2022	0.331	0.3305
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0107	0.0113	0.0106
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.6029	1	1
Onchocerca volvulus		0.0389	0.0584	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0751	0.1189	0.1189
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6029	1	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.0063	0.004	0.0033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0052	0.0011
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0389	0.0584	0.0584
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2022	0.331	0.3239
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0389	0.0584	0.0667
Brugia malayi	p70 ribosomal S6 kinase beta	0.0096	0.0095	0.0088
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2504	0.4115	0.4052
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0389	0.0584	0.0476
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0389	0.0584	0.0577
Echinococcus granulosus	Glutaredoxin protein 5	0.0063	0.004	0.0033
Echinococcus multilocularis	serine protein kinase ATM	0.114	0.1838	0.1833
Schistosoma mansoni	voltage-gated potassium channel	0.0164	0.0208	0.0201
Onchocerca volvulus		0.0389	0.0584	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.1229	0.1986	0.198
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0751	0.1189	0.1183
Echinococcus granulosus	nervana 2	0.0063	0.004	0.0033
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0107	0.0113	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1618	0.2635	0.2635
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3567	0.5889	0.5889
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0882	0.1406	0.14
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4796	0.794	0.794
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0389	0.0584	0.0577
Echinococcus multilocularis	Zinc finger, PHD finger	0.0389	0.0584	0.0577
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3256	0.5369	0.5369
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.114	0.1838	0.1833
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0389	0.0584	0.0545
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0389	0.0584	0.0577
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5148	0.8528	0.8528
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0545
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0107	0.0113	0.0113
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0389	0.0584	0.0577
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0389	0.0584	0.0667
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6029	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0389	0.0584	0.0577
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2022	0.331	0.3234
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0584
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0389	0.0584	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3603	0.5949	0.5949
Trichomonas vaginalis	conserved hypothetical protein	0.0882	0.1406	0.1406
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0751	0.1189	0.1152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3251	0.5361	0.5361
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0389	0.0584	0.0577
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0389	0.0584	0.0577
Echinococcus multilocularis		0.0389	0.0584	0.0577
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0107	0.0113	0.0072
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0584
Echinococcus multilocularis	fk506 binding protein	0.0107	0.0113	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3567	0.5889	0.5889
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0389	0.0584	0.0483
Trichomonas vaginalis	immunophilin, putative	0.0107	0.0113	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4484	0.7421	0.7421
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0389	0.0584	0.0545
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.6029	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.114	0.1838	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3256	0.5369	0.5369
Entamoeba histolytica	hypothetical protein	0.0389	0.0584	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0389	0.0584	0.0577
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0102	0.0106	0.0099
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0389	0.0584	0.0545
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0092	0.0088	0.0081
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0107	0.0113	0.0072
Leishmania major	phosphatidylinositol kinase, putative	0.0389	0.0584	0.0476
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0389	0.0584	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0882	0.1406	0.14
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0389	0.0584	0.0483
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0389	0.0584	0.0545
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2022	0.331	0.3282
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.114	0.1838	0.1804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6029	1	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0107	0.0113	0.0072
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.114	0.1838	0.1833
Entamoeba histolytica	protein kinase, putative	0.0102	0.0106	0.0065
Echinococcus granulosus	serine protein kinase ATM	0.114	0.1838	0.1833
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0107	0.0113	0.0072
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2022	0.331	0.3305
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2022	0.331	0.3282
Echinococcus multilocularis	rac serine:threonine kinase	0.007	0.0052	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.1271	0.2056	0.2056
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0106	0.0106
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0107	0.0113	0.0106
Trypanosoma cruzi	Protein kinase B	0.007	0.0052	0.0011
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0389	0.0584	0.0577
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.015	0.0185	0.0178
Schistosoma mansoni	hypothetical protein	0.0389	0.0584	0.0577

Activities

Activity type	Activity value	Assay description	Source	Reference
CL (ADMET)	= 45.2 ml/min.kg	Clearance in mouse liver microsomes at 1 uM	ChEMBL.	24900355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2011756

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1632773