Detailed information for compound 1632785

Basic information

Technical information
  • TDR Targets ID: 1632785
  • Name: 9-(4-bromophenyl)purine-2,6-diamine
  • MW: 305.133 | Formula: C11H9BrN6
  • H donors: 2 H acceptors: 3 LogP: 1.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)n1cnc2c1nc(N)nc2N
  • InChi: 1S/C11H9BrN6/c12-6-1-3-7(4-2-6)18-5-15-8-9(13)16-11(14)17-10(8)18/h1-5H,(H4,13,14,16,17)
  • InChiKey: SYYKVMSYLQEHIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-amino-9-(4-bromophenyl)purin-6-yl]amine
  • NCI60_002480
  • NSC210442

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0351 0.0587 0.0587
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0587 0.0532
Giardia lamblia Hypothetical protein 0.0351 0.0587 0.0532
Loa Loa (eye worm) hypothetical protein 0.0351 0.0587 0.0587
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1824 0.3312 0.3273
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0351 0.0587 0.0587
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.544 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0587 0.0641
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0351 0.0587 0.0532
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0107 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.4645 0.8529 0.8529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0795 0.1409 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.4327 0.7941 0.7941
Echinococcus granulosus serine protein kinase ATM 0.1029 0.1841 0.1841
Trichomonas vaginalis PIKK family atypical protein kinase 0.2938 0.5371 0.5371
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0351 0.0587 0.0587
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0678 0.1192 0.114
Loa Loa (eye worm) hypothetical protein 0.1109 0.1989 0.1989
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0587 0.0587
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0165 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.3218 0.5891 0.5891
Trichomonas vaginalis PIKK family atypical protein kinase 0.146 0.2638 0.2638
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0064 0.0057 0.0057
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0107 0.0137 0.0137
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0587 0.0587
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1029 0.1841 0.1793
Echinococcus multilocularis nervana 2 0.0064 0.0057 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.1824 0.3312 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.1824 0.3312 0.3312
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0137 0.0079
Schistosoma mansoni fkbp-rapamycin associated protein 0.1029 0.1841 0.1841
Brugia malayi Protein kinase domain containing protein 0.0104 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0351 0.0587 0.0587
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0587 0.0587
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0112 0.0146 0.0146
Echinococcus granulosus serine/threonine protein kinase 0.0071 0.007 0.007
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0107 0.0137 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.1146 0.2059 0.2059
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.007 0.007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0463
Trichomonas vaginalis AGC family protein kinase 0.004 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0795 0.1409 0.1409
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.1841 0.1841
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0107 0.0137 0.1482
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.544 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1029 0.1841 0.1841
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.1824 0.3312 0.3312
Echinococcus multilocularis Zinc finger, PHD finger 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.2938 0.5371 0.5371
Toxoplasma gondii FATC domain-containing protein 0.1029 0.1841 0.2358
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.544 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0587 0.0587
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0107 0.0137 0.0079
Leishmania major phosphatidylinositol kinase related protein, putative 0.0351 0.0587 0.0457
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0351 0.0587 0.0587
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0107 0.0137 0.0137
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0109 0.0109
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0351 0.0587 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0587 0.0587
Plasmodium vivax hypothetical protein, conserved 0.0351 0.0587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0678 0.1192 0.1192
Trichomonas vaginalis PIKK family atypical protein kinase 0.3251 0.595 0.595
Schistosoma mansoni hypothetical protein 0.0795 0.1409 0.1409
Mycobacterium tuberculosis Conserved hypothetical protein 0.0351 0.0587 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3218 0.5891 0.5891
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0137 0.0079
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0351 0.0587 0.0463
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0587 0.0587
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0137 0.0006
Echinococcus multilocularis 0.0351 0.0587 0.0587
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0351 0.0587 0.0587
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.2933 0.5363 0.5363
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0351 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0351 0.0587 0.0587
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0351 0.0587 1
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0463
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.544 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.544 1 1
Loa Loa (eye worm) FKBP5 protein 0.0107 0.0137 0.0137
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0351 0.0587 0.0532
Trypanosoma cruzi target of rapamycin kinase 3 0.4332 0.795 0.7937
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0107 0.0137 0.0079
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1029 0.1841 0.1793
Loa Loa (eye worm) hypothetical protein 0.0093 0.0109 0.0109
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0098 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0351 0.0587 0.0587
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0587 0.0587
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1824 0.3312 0.3312
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1029 0.1841 0.1841
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.544 1 1
Leishmania major hypothetical protein, unknown function 0.0351 0.0587 0.0457
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.2933 0.5363 0.5363
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.3251 0.595 0.595
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0137 0.0137
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0137 0.0079
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4332 0.795 0.7921
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1029 0.1841 0.1841
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0587 0.0463
Loa Loa (eye worm) hypothetical protein 0.0678 0.1192 0.1192
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.0587 0.0587
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.007 0.007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.544 1 1
Echinococcus granulosus nervana 2 0.0064 0.0057 0.0057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.226 0.4117 0.4039
Leishmania major phosphatidylinositol kinase, putative 0.0351 0.0587 0.0457
Entamoeba histolytica protein kinase, putative 0.0098 0.0119 0.0119
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0587 0.0641
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1824 0.3312 0.322
Leishmania major phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0457
Trichomonas vaginalis immunophilin, putative 0.0107 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0678 0.1192 0.1192
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.544 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0107 0.0137 0.0137
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1824 0.3312 0.3273
Echinococcus multilocularis fk506 binding protein 0.0107 0.0137 0.0137
Echinococcus granulosus nervana 2 0.0064 0.0057 0.0057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0587 0.0641
Schistosoma mansoni voltage-gated potassium channel 0.0123 0.0165 0.0165
Onchocerca volvulus 0.0351 0.0587 0.5
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0351 0.0587 0.0587
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0107 0.0137 0.0137
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0351 0.0587 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0064 0.0057 0.0057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.544 1 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0064 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0351 0.0587 0.0587
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1824 0.3312 0.3224
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0351 0.0587 0.0532
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.1841 0.1841
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.4327 0.7941 0.7941
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2573 0.4697 0.4626
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0587 0.0587
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Entamoeba histolytica protein kinase, putative 0.0104 0.0131 0.0131
Entamoeba histolytica protein kinase 2, putative 0.0065 0.0058 0.0058
Echinococcus multilocularis nervana 2 0.0064 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0351 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1029 0.1841 0.1841
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1824 0.3312 0.3224
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0071 0.007 0.0012
Onchocerca volvulus 0.0351 0.0587 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2938 0.5371 0.5371
Echinococcus multilocularis serine protein kinase ATM 0.1029 0.1841 0.1841
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0351 0.0587 0.0587
Leishmania major phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0457
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0351 0.0587 0.0587
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.544 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0351 0.0587 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.3532 0.647 0.647
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0112 0.0146 0.0146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Schistosoma mansoni immunophilin 0.0107 0.0137 0.0137
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.007 0.007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1824 0.3312 0.3312
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0351 0.0587 0.0587
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0587 0.0641
Loa Loa (eye worm) AGC/AKT protein kinase 0.0104 0.0131 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.544 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0132 0.0132
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1824 0.3312 0.3312
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0351 0.0587 0.0587
Trypanosoma cruzi Protein kinase B 0.0071 0.007 0.0012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.544 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1824 0.3312 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.3251 0.595 0.595
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0112 0.0146 0.0146
Giardia lamblia GTOR 0.544 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0587 0.0587
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0587 0.0587
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.544 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0351 0.0587 0.0587
Trichomonas vaginalis fk506-binding protein, putative 0.0107 0.0137 0.0137
Echinococcus multilocularis rac serine:threonine kinase 0.0071 0.007 0.007
Schistosoma mansoni immunophilin 0.0107 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.1824 0.3312 0.3312
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0587 0.0587
Brugia malayi p70 ribosomal S6 kinase beta 0.0098 0.0119 0.0119
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0587 0.0587
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0065 0.0058 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1824 0.3312 0.3312
Trichomonas vaginalis PIKK family atypical protein kinase 0.4327 0.7941 0.7941
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0351 0.0587 0.0587
Leishmania major phosphatidylinositol 3-kinase, putative 0.1824 0.3312 0.322
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0587 0.0587
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0351 0.0587 0.0587
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0137 0.0137
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0587 0.0587
Leishmania major hypothetical protein, conserved 0.0351 0.0587 0.0457
Entamoeba histolytica protein kinase rad3, putative 0.1029 0.1841 0.1841
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0587 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.4327 0.7941 0.7941
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1029 0.1841 0.1733
Schistosoma mansoni immunophilin 0.0093 0.0109 0.0109
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0351 0.0587 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4332 0.795 0.7922
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0351 0.0587 0.0587
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0112 0.0146 0.0146
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0065 0.0058 0.0058
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0137 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.544 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0795 0.1409 0.1409
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0351 0.0587 1
Loa Loa (eye worm) hypothetical protein 0.1146 0.2059 0.2059
Echinococcus granulosus Glutaredoxin protein 5 0.0064 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1029 0.1841 0.1841
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0532
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0587 0.0457
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0351 0.0587 0.0532
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0795 0.1409 0.1409
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0107 0.0137 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0587 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.3649 0.6687 0.6687
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0587
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0351 0.0587 0.0532
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0587 0.0587
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0351 0.0587 0.0587
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.4046 0.7422 0.7422
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0351 0.0587 0.0532
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0107 0.0137 0.0137
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1146 0.2059 0.2656
Loa Loa (eye worm) phosphatidylinositol 3 0.544 1 1
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0098 0.0118 0.0118
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.0587 0.0587
Entamoeba histolytica hypothetical protein 0.0351 0.0587 0.0587
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0107 0.0137 0.0137
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0587 0.0587
Mycobacterium leprae conserved hypothetical protein 0.0351 0.0587 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0351 0.0587 0.0587
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0131 0.0131
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0351 0.0587 0.0587
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0107 0.0137 0.5
Brugia malayi FAT domain containing protein 0.0795 0.1409 0.1409
Loa Loa (eye worm) hypothetical protein 0.1029 0.1841 0.1841
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0107 0.0137 0.0137
Echinococcus granulosus serine threonine protein kinase nrc 0.0065 0.0058 0.0058
Plasmodium vivax hypothetical protein 0.0351 0.0587 1
Entamoeba histolytica protein kinase, putative 0.0104 0.0131 0.0131
Toxoplasma gondii target of rapamycin (TOR), putative 0.4046 0.7422 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1029 0.1841 0.1841
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0587 0.0587
Giardia lamblia Phosphatidylinositol 4-kinase 0.0351 0.0587 0.0532
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1029 0.1841 0.1841
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0105 0.0132 0.0132
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0351 0.0587 0.0587
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0107 0.0137 0.1482
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0587 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.2933 0.5363 0.5363
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0351 0.0587 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2938 0.5371 0.5371
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0351 0.0587 0.0532
Trichomonas vaginalis PIKK family atypical protein kinase 0.4327 0.7941 0.7941
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0137 0.0079
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0351 0.0587 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1824 0.3312 0.3312
Entamoeba histolytica hypothetical protein 0.1029 0.1841 0.1841

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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