Detailed information for compound 1632786

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 566.743 | Formula: C30H30N8S2++
  • H donors: 0 H acceptors: 0 LogP: 7.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[n+]1c(cn2c1scc2)c1ccc(cc1)/C=N/N1CCN(CC1)/N=C\c1ccc(cc1)c1cn2c([n+]1C)scc2
  • InChi: 1S/C30H30N8S2/c1-33-27(21-35-15-17-39-29(33)35)25-7-3-23(4-8-25)19-31-37-11-13-38(14-12-37)32-20-24-5-9-26(10-6-24)28-22-36-16-18-40-30(36)34(28)2/h3-10,15-22H,11-14H2,1-2H3/q+2/b31-19-,32-20+
  • InChiKey: ARQGOPWWOWLLRE-QXLZFTBOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0475 0.0589 0.0538
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0918 0.1193 0.1185
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0475 0.0589 0.058
Loa Loa (eye worm) hypothetical protein 0.15 0.199 0.199
Echinococcus multilocularis fk506 binding protein 0.0117 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0133 0.0121 0.0121
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0082 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.4356 0.5891 0.5888
Trichomonas vaginalis PIKK family atypical protein kinase 0.1975 0.2639 0.2632
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0475 0.0589 0.058
Toxoplasma gondii FATC domain-containing protein 0.1393 0.1842 0.2369
Echinococcus multilocularis nervana 2 0.0082 0.0052 0.0052
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0475 0.0589 0.0538
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0475 0.0589 0.0589
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0475 0.0589 0.0589
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0475 0.0589 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0589 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.6286 0.8529 0.8528
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.2469 0.3313 0.3307
Trichomonas vaginalis PIKK family atypical protein kinase 0.7363 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0475 0.0589 0.058
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.5856 0.7942 0.794
Loa Loa (eye worm) hypothetical protein 0.1077 0.1411 0.1411
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.3976 0.5372 0.5368
Mycobacterium leprae conserved hypothetical protein 0.0475 0.0589 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.1393 0.1842 0.1835
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7363 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0475 0.0589 0.0589
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0117 0.0099 0.0046
Giardia lamblia Hypothetical protein 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.3976 0.5372 0.5368
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1393 0.1842 0.1842
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0475 0.0589 0.0589
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0117 0.0099 0.0046
Schistosoma mansoni serine/threonine-protein kinase 0.0091 0.0064 0.0064
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0117 0.0099 0.0099
Giardia lamblia Phosphatidylinositol 4-kinase 0.0475 0.0589 0.0538
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0589 0.0589
Leishmania major phosphatidylinositol kinase related protein, putative 0.0475 0.0589 0.0494
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0475 0.0589 0.0538
Plasmodium vivax hypothetical protein, conserved 0.0475 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0918 0.1193 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.4399 0.5951 0.5947
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1077 0.1411 0.1411
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0125 0.011 0.011
Echinococcus multilocularis Zinc finger, PHD finger 0.0475 0.0589 0.0589
Entamoeba histolytica hypothetical protein 0.0475 0.0589 0.0538
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.397 0.5364 0.5359
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0475 0.0589 0.0494
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.4356 0.5891 0.5888
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0589 0.0589
Entamoeba histolytica protein kinase rad3, putative 0.1393 0.1842 0.1799
Schistosoma mansoni immunophilin 0.0117 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.2469 0.3313 0.3307
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2469 0.3313 0.3246
Brugia malayi p70 ribosomal S6 kinase beta 0.0125 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.1552 0.206 0.206
Trypanosoma cruzi Protein kinase B 0.0091 0.0064 0.0011
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0475 0.0589 0.0589
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0153 0.0148 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.0589 0.058
Echinococcus granulosus serine/threonine protein kinase 0.0091 0.0064 0.0064
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0117 0.0099 0.0099
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0117 0.0099 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.1077 0.1411 0.1403
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0475 0.0589 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1393 0.1842 0.1799
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.0538
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2469 0.3313 0.3278
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1393 0.1842 0.1842
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0117 0.0099 0.0046
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7363 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0475 0.0589 0.0589
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2469 0.3313 0.3278
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1393 0.1842 0.1761
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7363 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0475 0.0589 0.0494
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0475 0.0589 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.397 0.5364 0.5359
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0475 0.0589 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4399 0.5951 0.5947
Trypanosoma cruzi target of rapamycin kinase 3 0.5862 0.795 0.7939
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0117 0.0099 0.5
Echinococcus granulosus serine protein kinase ATM 0.1393 0.1842 0.1842
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0475 0.0589 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0918 0.1193 0.1185
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7363 1 1
Onchocerca volvulus 0.0475 0.0589 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0475 0.0589 0.058
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0475 0.0589 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0117 0.0099 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.0494
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7363 1 1
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1393 0.1842 0.1799
Schistosoma mansoni immunophilin 0.0101 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0101 0.0077 0.0077
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0475 0.0589 0.0538
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5862 0.795 0.7929
Loa Loa (eye worm) AGC/AKT protein kinase 0.0133 0.0122 0.0122
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Toxoplasma gondii target of rapamycin (TOR), putative 0.5476 0.7422 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0135 0.0125
Echinococcus granulosus nervana 2 0.0082 0.0052 0.0052
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0589 0.0654
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0475 0.0589 0.0538
Schistosoma mansoni voltage-gated potassium channel 0.0167 0.0167 0.0167
Leishmania major phosphatidylinositol kinase, putative 0.0475 0.0589 0.0494
Trypanosoma brucei rac serine-threonine kinase, putative 0.0133 0.0122 0.0023
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0082 0.0052 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0475 0.0589 0.058
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.7363 1 1
Entamoeba histolytica hypothetical protein 0.0475 0.0589 0.0538
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0475 0.0589 0.0538
Echinococcus multilocularis serine protein kinase ATM 0.1393 0.1842 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.2469 0.3313 0.3307
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0475 0.0589 0.0538
Entamoeba histolytica PH domain containing protein kinase, putative 0.0091 0.0064 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7363 1 1
Echinococcus granulosus Glutaredoxin protein 5 0.0082 0.0052 0.0052
Loa Loa (eye worm) phosphatidylinositol kinase 0.0475 0.0589 0.0589
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0117 0.0099 0.0046
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0589 0.0654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2469 0.3313 0.3313
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0475 0.0589 0.0494
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3058 0.4118 0.4059
Leishmania major hypothetical protein, unknown function 0.0475 0.0589 0.0494
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0099 0.009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0475 0.0589 0.058
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7363 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2469 0.3313 0.3313
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0117 0.0099 0.0099
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0918 0.1193 0.1146
Echinococcus granulosus serine threonine protein kinase nrc 0.0083 0.0053 0.0053
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2469 0.3313 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.478 0.647 0.6467
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0153 0.0148 0.0148
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Schistosoma mansoni immunophilin 0.0117 0.0099 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0475 0.0589 0.0589
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0589 0.0654
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0117 0.0099 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7363 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0091 0.0064 0.0064
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7363 1 1
Trichomonas vaginalis immunophilin, putative 0.0117 0.0099 0.009
Leishmania major phosphatidylinositol 3-kinase, putative 0.2469 0.3313 0.3246
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0589 0.0589
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0475 0.0589 0.0589
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0117 0.0099 0.0861
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0117 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.5856 0.7942 0.794
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3482 0.4697 0.4644
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0589 0.0589
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0083 0.0053 0.0053
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0475 0.0589 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.3976 0.5372 0.5368
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.1393 0.1842 0.1835
Echinococcus multilocularis rac serine:threonine kinase 0.0091 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.2469 0.3313 0.3307
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.7363 1 1
Plasmodium vivax hypothetical protein 0.0475 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.0475 0.0589 0.0589
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1393 0.1842 0.1842
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0475 0.0589 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0494
Entamoeba histolytica hypothetical protein 0.0475 0.0589 0.0538
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0475 0.0589 0.058
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0475 0.0589 0.0589
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0091 0.0064 0.0011
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.5856 0.7942 0.794
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1393 0.1842 0.1799
Leishmania major hypothetical protein, conserved 0.0475 0.0589 0.0494
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1393 0.1842 0.1842
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5862 0.795 0.7929
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0101 0.0077 0.0077
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0475 0.0589 0.0538
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0153 0.0148 0.0148
Echinococcus multilocularis nervana 2 0.0082 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.0589 0.058
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7363 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0475 0.0589 0.058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2469 0.3313 0.3246
Trichomonas vaginalis PIKK family atypical protein kinase 0.4399 0.5951 0.5947
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0153 0.0148 0.0148
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0589 0.0654
Loa Loa (eye worm) phosphatidylinositol 3 0.7363 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0117 0.0099 0.0046
Entamoeba histolytica PH domain containing protein kinase, putative 0.0091 0.0064 0.0011
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0475 0.0589 0.0589
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2469 0.3313 0.3246
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0083 0.0053 0.0053
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0117 0.0099 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0589 0.0589
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2469 0.3313 0.3313
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0117 0.0099 0.0099
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.5856 0.7942 0.794
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.2469 0.3313 0.3307
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Schistosoma mansoni hypothetical protein 0.0475 0.0589 0.0589
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0475 0.0589 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.0538
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0101 0.0077 0.0077
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0589 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Trichomonas vaginalis conserved hypothetical protein 0.1552 0.206 0.2052
Giardia lamblia GTOR 0.7363 1 1
Entamoeba histolytica protein kinase, putative 0.0125 0.011 0.0058
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0099 0.009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0475 0.0589 0.058
Loa Loa (eye worm) FKBP5 protein 0.0117 0.0099 0.0099
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0589 0.0589
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis fk506-binding protein, putative 0.0117 0.0099 0.009
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7363 1 1
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.1393 0.1842 0.1842
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0538
Mycobacterium tuberculosis Conserved hypothetical protein 0.0475 0.0589 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0475 0.0589 0.0494
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1077 0.1411 0.1411
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0475 0.0589 0.0589
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1552 0.206 0.2666
Echinococcus multilocularis Glutaredoxin protein 5 0.0082 0.0052 0.0052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0143 0.0135 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.4939 0.6688 0.6685
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0475 0.0589 0.0589
Brugia malayi FAT domain containing protein 0.1077 0.1411 0.1411
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0589 0.0589
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0475 0.0589 0.0589
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0475 0.0589 0.058
Schistosoma mansoni fkbp-rapamycin associated protein 0.1393 0.1842 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.5476 0.7422 0.742
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0117 0.0099 0.0099
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0475 0.0589 0.0589
Entamoeba histolytica protein kinase, putative 0.0133 0.0122 0.0069
Onchocerca volvulus 0.0475 0.0589 0.5
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1393 0.1842 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.3976 0.5372 0.5368
Trichomonas vaginalis PIKK family atypical protein kinase 0.5856 0.7942 0.794
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0475 0.0589 0.0538
Entamoeba histolytica protein kinase, putative 0.0133 0.0122 0.0069
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0475 0.0589 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.397 0.5364 0.5359
Leishmania major phosphatidylinositol 3-kinase, putative 0.0475 0.0589 0.0494
Loa Loa (eye worm) phosphatidylinositol 3 0.2469 0.3313 0.3313
Entamoeba histolytica hypothetical protein 0.1393 0.1842 0.1799
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0117 0.0099 0.0046
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0475 0.0589 0.0589
Schistosoma mansoni hypothetical protein 0.1077 0.1411 0.1411
Trichomonas vaginalis PIKK family atypical protein kinase 0.1393 0.1842 0.1835
Echinococcus multilocularis 0.0475 0.0589 0.0589
Trichomonas vaginalis AGC family protein kinase 0.0133 0.0122 0.0112
Brugia malayi Protein kinase domain containing protein 0.0133 0.0122 0.0122
Echinococcus granulosus nervana 2 0.0082 0.0052 0.0052
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0475 0.0589 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0117 0.0099 0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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