Detailed information for compound 1632788

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.397 | Formula: C17H23N5O
  • H donors: 1 H acceptors: 3 LogP: 1.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N1CCC(CC1)c1nn2c(n1)ccc(c2)NC1CCC1
  • InChi: 1S/C17H23N5O/c1-12(23)21-9-7-13(8-10-21)17-19-16-6-5-15(11-22(16)20-17)18-14-3-2-4-14/h5-6,11,13-14,18H,2-4,7-10H2,1H3
  • InChiKey: RGYNGVVFYOZYPT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0589 0.0789 0.0789
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0795 0.1099 0.1099
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0165 0.0152 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.3642 0.5375 0.5349
Leishmania major phosphatidylinositol kinase, putative 0.0443 0.057 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0443 0.057 0.952
Trichomonas vaginalis PIKK family atypical protein kinase 0.3992 0.5902 0.5878
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0152 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0657 0.0603
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0628 0.0847 0.0847
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0462 0.0599 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.1174 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.4016 0.5938 0.5915
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0992 0.1394 0.1394
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0009 0.0007
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0165 0.0152 0.5
Giardia lamblia Phosphatidylinositol 4-kinase 0.0443 0.057 0.057
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0501 0.0657 0.0603
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0628 0.0847 0.0794
Loa Loa (eye worm) hypothetical protein 0.0142 0.0117 0.0115
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0443 0.057 0.0707
Entamoeba histolytica hypothetical protein 0.0443 0.057 0.057
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0165 0.0152 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.672 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0692 0.0944 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.3647 0.5384 0.5357
Echinococcus granulosus serine protein kinase ATM 0.1289 0.184 0.184
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1289 0.184 0.184
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2329 0.3404 0.3402
Schistosoma mansoni hypothetical protein 0.0443 0.057 0.0568
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0152 0.0094
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1289 0.184 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.672 1 1
Brugia malayi FAT domain containing protein 0.0992 0.1394 0.1392
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0443 0.057 0.057
Trichomonas vaginalis conserved hypothetical protein 0.1435 0.206 0.2014
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0009 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0226 0.0243 0.0243
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0522 0.0688 0.0688
Echinococcus multilocularis 0.0443 0.057 0.057
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0165 0.0152 0.0094
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0152 0.253
Loa Loa (eye worm) hypothetical protein 0.0067 0.0005 0.0002
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0117 0.0117
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1289 0.184 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.2281 0.3331 0.3292
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0152 0.0152
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2329 0.3404 0.3402
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1289 0.184 0.184
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0482 0.0629 0.0629
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.3992 0.5902 0.5878
Trichomonas vaginalis PIKK family atypical protein kinase 0.1804 0.2615 0.2572
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0568 0.0758 0.0704
Schistosoma mansoni voltage-gated potassium channel 0.0246 0.0274 0.0272
Loa Loa (eye worm) hypothetical protein 0.0845 0.1174 0.1172
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0142 0.0117 0.0117
Loa Loa (eye worm) phosphatidylinositol 3 0.0756 0.1041 0.1038
Loa Loa (eye worm) hypothetical protein 0.1361 0.1949 0.1947
Trichomonas vaginalis PIKK family atypical protein kinase 0.3647 0.5384 0.5357
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0795 0.1099 0.1097
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1289 0.184 0.184
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0462 0.0599 0.0746
Schistosoma mansoni hypothetical protein 0.0992 0.1394 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.5353 0.7947 0.7935
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0443 0.057 0.057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0443 0.057 0.0707
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0152 0.0152
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0462 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0462 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5728 0.851 0.8501
Trichomonas vaginalis PIKK family atypical protein kinase 0.2291 0.3346 0.3307
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0462 0.0599 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0462 0.0599 0.0544
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.672 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0443 0.057 0.0568
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0628 0.0847 0.0794
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0443 0.057 0.0515
Loa Loa (eye worm) hypothetical protein 0.1289 0.184 0.1838
Leishmania major phosphatidylinositol kinase related protein, putative 0.0443 0.057 0.0425
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0443 0.057 0.952
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0443 0.057 0.0568
Leishmania major phosphatidylinositol 3-kinase, putative 0.2281 0.3331 0.3228
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0795 0.1099 0.1099
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0443 0.057 0.057
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.672 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0443 0.057 0.057
Schistosoma mansoni voltage-gated potassium channel 0.0246 0.0274 0.0272
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0628 0.0847 0.0847
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0165 0.0152 0.5
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0462 0.0599 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0211 0.0221 0.0164
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0462 0.0599 0.0599
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2281 0.3331 0.3292
Schistosoma mansoni immunophilin 0.0165 0.0152 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.672 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0845 0.1174 0.1123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0443 0.057 0.0515
Echinococcus multilocularis fk506 binding protein 0.0165 0.0152 0.0152
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0096 0.0048 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.2281 0.3331 0.3292
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0462 0.0599 0.0599
Loa Loa (eye worm) phosphatidylinositol 3 0.0443 0.057 0.0568
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2802 0.4114 0.4079
Leishmania major phosphatidylinositol 3-kinase, putative 0.0462 0.0599 0.0454
Echinococcus granulosus voltage gated potassium channel 0.0065 0.0002 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.672 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0657 0.0657
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0845 0.1174 0.1174
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0443 0.057 0.0707
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1289 0.184 0.1793
Trypanosoma cruzi target of rapamycin kinase 3 0.5359 0.7955 0.7955
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0165 0.0152 0.253
Schistosoma mansoni immunophilin 0.0165 0.0152 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.3642 0.5375 0.5349
Mycobacterium tuberculosis Conserved hypothetical protein 0.0443 0.057 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4016 0.5938 0.5915
Toxoplasma gondii FATC domain-containing protein 0.1289 0.184 0.2428
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0462 0.0599 0.0597
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2329 0.3404 0.3404
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0462 0.0599 0.0599
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0443 0.057 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.672 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0443 0.057 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0037 0.0037
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0009 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1289 0.184 0.1838
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.952
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0152 0.0152
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5359 0.7955 0.7924
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0184 0.0181 0.0181
Giardia lamblia GTOR 0.672 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.672 1 1
Onchocerca volvulus 0.0443 0.057 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0657 0.0657
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.0747 0.0747
Loa Loa (eye worm) AGC/AKT protein kinase 0.0102 0.0058 0.0056
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.057
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0226 0.0243 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0443 0.057 0.0568
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5359 0.7955 0.7943
Echinococcus multilocularis rac serine:threonine kinase 0.007 0.0009 0.0009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0462 0.0599 0.0597
Trichomonas vaginalis PIKK family atypical protein kinase 0.5353 0.7947 0.7935
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.184 0.1793
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0443 0.057 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1289 0.184 0.1793
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0589 0.0789 0.0789
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0165 0.0152 0.0149
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0462 0.0599 0.0544
Leishmania major hypothetical protein, unknown function 0.0443 0.057 0.0425
Echinococcus granulosus serine/threonine protein kinase 0.007 0.0009 0.0009
Onchocerca volvulus 0.0443 0.057 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5353 0.7947 0.7935
Trichomonas vaginalis PIKK family atypical protein kinase 0.2281 0.3331 0.3292
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2329 0.3404 0.3404
Brugia malayi p70 ribosomal S6 kinase beta 0.0096 0.0048 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0462 0.0599 0.0597
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2329 0.3404 0.3404
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0165 0.0152 0.0152
Leishmania major hypothetical protein, conserved 0.0531 0.0703 0.056
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0165 0.0152 0.0152
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0443 0.057 0.0515
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.672 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.007 0.0009 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0561 0.0747 0.0745
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.672 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0657 0.0655
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0657 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.4016 0.5938 0.5915
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2329 0.3404 0.3404
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0226 0.0243 0.0241
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.672 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0065 0.0002 0.0002
Trichomonas vaginalis immunophilin, putative 0.0165 0.0152 0.0094
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2291 0.3346 0.3244
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0501 0.0657 0.0657
Entamoeba histolytica protein kinase, putative 0.0102 0.0058 0.0058
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.672 1 1
Entamoeba histolytica hypothetical protein 0.0443 0.057 0.057
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0462 0.0599 0.0544
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0065 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.2281 0.3331 0.3292
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.0152 0.0094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0462 0.0599 0.0746
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0226 0.0243 0.0243
Mycobacterium leprae conserved hypothetical protein 0.0443 0.057 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4361 0.6457 0.6436
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0462 0.0599 0.0599
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0657 0.0655
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.672 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0443 0.057 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0443 0.057 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1289 0.184 0.1838
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0443 0.057 0.952
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0501 0.0657 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.3647 0.5384 0.5357
Schistosoma mansoni fkbp-rapamycin associated protein 0.1289 0.184 0.1838
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0443 0.057 0.0568
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2291 0.3346 0.3307
Trypanosoma cruzi Protein kinase B 0.007 0.0009 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0065 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0102 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0561 0.0747 0.0745
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0165 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.5353 0.7947 0.7935
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3171 0.4668 0.4637
Echinococcus multilocularis Zinc finger, PHD finger 0.0462 0.0599 0.0599
Entamoeba histolytica protein kinase rad3, putative 0.1289 0.184 0.184
Loa Loa (eye worm) phosphatidylinositol 3 0.2291 0.3346 0.3345
Loa Loa (eye worm) hypothetical protein 0.0196 0.0198 0.0196
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0443 0.057 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.5353 0.7947 0.7935
Trichomonas vaginalis PIKK family atypical protein kinase 0.3647 0.5384 0.5357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0443 0.057 0.0568
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0443 0.057 0.952
Trichomonas vaginalis PIKK family atypical protein kinase 0.3642 0.5375 0.5349
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0529 0.07 0.07
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.0152 0.0152
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0561 0.0747 0.0747
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0156 0.0153
Echinococcus multilocularis serine protein kinase ATM 0.1289 0.184 0.184
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0462 0.0599 0.0599
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0692 0.0944 0.0944
Entamoeba histolytica hypothetical protein 0.1289 0.184 0.184
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Loa Loa (eye worm) phosphatidylinositol 3 0.0443 0.057 0.0568
Loa Loa (eye worm) FKBP5 protein 0.0165 0.0152 0.0149
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.0152 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.1299 0.1856 0.1809
Trichomonas vaginalis conserved hypothetical protein 0.0992 0.1394 0.1344
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0568 0.0758 0.0704
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0165 0.0152 0.0152
Entamoeba histolytica protein kinase, putative 0.0102 0.0058 0.0058
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0443 0.057 0.057
Leishmania major phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.0425
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0165 0.0152 0.0152
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0628 0.0847 0.0847
Schistosoma mansoni immunophilin 0.0142 0.0117 0.0115
Entamoeba histolytica hypothetical protein 0.0443 0.057 0.057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0628 0.0847 0.0845
Entamoeba histolytica protein kinase, putative 0.0096 0.0048 0.0048
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1435 0.206 0.2726
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.672 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0165 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0443 0.057 0.057
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0009 0.0009
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Toxoplasma gondii target of rapamycin (TOR), putative 0.5008 0.7429 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.057 0.0568
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0462 0.0599 0.0544
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0462 0.0599 0.0597
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0443 0.057 0.952
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0443 0.057 0.057
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0211 0.0221 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.4508 0.6677 0.6657
Giardia lamblia Hypothetical protein 0.0443 0.057 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.5008 0.7429 0.7414
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0992 0.1394 0.1394
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1299 0.1856 0.1856
Loa Loa (eye worm) phosphatidylinositol kinase 0.0443 0.057 0.0568
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0628 0.0847 0.0794
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0443 0.057 0.0568
Plasmodium vivax hypothetical protein 0.0443 0.057 0.952
Loa Loa (eye worm) hypothetical protein 0.0992 0.1394 0.1392
Loa Loa (eye worm) hypothetical protein 0.1435 0.206 0.2059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.672 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0165 0.0152 0.0149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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