Detailed information for compound 1632792

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 584.596 | Formula: C27H41N2O10P
  • H donors: 2 H acceptors: 5 LogP: 2.63 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOP(=O)(C/C(=C/1\C(=O)C(N(C1=O)Cc1ccc(c(c1)OC)OC)CCCNC(=O)OC(C)(C)C)/O)OCC
  • InChi: 1S/C27H41N2O10P/c1-8-37-40(34,38-9-2)17-20(30)23-24(31)19(11-10-14-28-26(33)39-27(3,4)5)29(25(23)32)16-18-12-13-21(35-6)22(15-18)36-7/h12-13,15,19,30H,8-11,14,16-17H2,1-7H3,(H,28,33)/b23-20-
  • InChiKey: UDLFPEYNAPIXET-ATJXCDBQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0507 0.0581 0.0581
Brugia malayi FAT domain containing protein 0.1136 0.1404 0.1401
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1475 0.1848 0.1845
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0137 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.7701 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1475 0.1848 0.1848
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2661 0.3401 0.3399
Schistosoma mansoni hypothetical protein 0.0507 0.0581 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.2611 0.3335 0.3302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2661 0.3401 0.3399
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0137 0.0137
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1475 0.1848 0.1848
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0107 0.0107
Echinococcus multilocularis 0.0507 0.0581 0.0581
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0588 0.0687 0.0687
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0228 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0069 0.0008 0.0004
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0168 0.0137 0.226
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0137 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.1643 0.2068 0.2028
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0008 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.1184 0.114
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0527 0.0607 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.4603 0.5943 0.5923
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1136 0.1404 0.1404
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0698 0.0831 0.0831
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0137 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.4573 0.5905 0.5884
Plasmodium vivax hypothetical protein, conserved 0.0507 0.0581 0.9572
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0567 0.0659 0.0612
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0168 0.0137 0.0134
Entamoeba histolytica hypothetical protein 0.0658 0.0778 0.0778
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0871 0.1058 0.1058
Leishmania major phosphatidylinositol kinase, putative 0.0507 0.0581 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.4172 0.5379 0.5355
Trichomonas vaginalis PIKK family atypical protein kinase 0.4178 0.5387 0.5364
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0764 0.0918 0.0918
Echinococcus granulosus serine protein kinase ATM 0.1475 0.1848 0.1848
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7701 1 1
Entamoeba histolytica hypothetical protein 0.0507 0.0581 0.0581
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0168 0.0137 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0507 0.0581 0.0729
Giardia lamblia Phosphatidylinositol 4-kinase 0.0507 0.0581 0.0581
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0168 0.0137 0.5
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0145 0.0107 0.0103
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0698 0.0831 0.0785
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0567 0.0659 0.0612
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0507 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.6134 0.7948 0.7938
Schistosoma mansoni hypothetical protein 0.1136 0.1404 0.1401
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0527 0.0607 0.0765
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1475 0.1848 0.1848
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Trichomonas vaginalis PIKK family atypical protein kinase 0.4178 0.5387 0.5364
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0871 0.1058 0.1055
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0507 0.0581 0.0533
Loa Loa (eye worm) phosphatidylinositol 3 0.0507 0.0581 0.0577
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0698 0.0831 0.0785
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0527 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2622 0.3349 0.3316
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7701 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0527 0.0607 0.0559
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0527 0.0607 0.0607
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0527 0.0607 0.0607
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0507 0.0581 0.0729
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.6566 0.8513 0.8505
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0547 0.0633 0.0633
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1475 0.1848 0.1848
Loa Loa (eye worm) hypothetical protein 0.0968 0.1184 0.1181
Loa Loa (eye worm) hypothetical protein 0.1561 0.1961 0.1958
Loa Loa (eye worm) phosphatidylinositol 3 0.0831 0.1005 0.1002
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0107 0.0107
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0636 0.075 0.0704
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0243 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.4573 0.5905 0.5884
Trichomonas vaginalis PIKK family atypical protein kinase 0.2068 0.2624 0.2587
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0507 0.0581 0.0533
Echinococcus multilocularis fk506 binding protein 0.0168 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0968 0.1184 0.114
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0527 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.7701 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2611 0.3335 0.3302
Schistosoma mansoni immunophilin 0.0168 0.0137 0.0134
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0567 0.0659 0.0659
Echinococcus granulosus voltage gated potassium channel 0.0066 0.0004 0.0004
Leishmania major phosphatidylinositol 3-kinase, putative 0.0527 0.0607 0.0476
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7701 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0507 0.0581 0.0577
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.321 0.412 0.409
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0095 0.0042 0.0038
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0527 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.2611 0.3335 0.3302
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0507 0.0581 0.0581
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7701 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0871 0.1058 0.1058
Leishmania major phosphatidylinositol 3-kinase, putative 0.2611 0.3335 0.3242
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0507 0.0581 0.0577
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0507 0.0581 0.9572
Leishmania major phosphatidylinositol kinase related protein, putative 0.0507 0.0581 0.045
Loa Loa (eye worm) hypothetical protein 0.1475 0.1848 0.1845
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0196 0.0147
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0527 0.0607 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0698 0.0831 0.0831
Schistosoma mansoni voltage-gated potassium channel 0.0249 0.0243 0.024
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0507 0.0581 0.0581
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0168 0.0137 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.9572
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6141 0.7956 0.7928
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0137 0.0137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1475 0.1848 0.1845
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0037 0.0037
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0507 0.0581 0.0581
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0629 0.074 0.074
Onchocerca volvulus 0.0507 0.0581 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0567 0.0659 0.0659
Loa Loa (eye worm) AGC/AKT protein kinase 0.0102 0.005 0.0047
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.0581
Loa Loa (eye worm) phosphatidylinositol 3 0.7701 1 1
Giardia lamblia GTOR 0.7701 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0191 0.0167 0.0167
Schistosoma mansoni immunophilin 0.0168 0.0137 0.0134
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0168 0.0137 0.226
Trypanosoma cruzi target of rapamycin kinase 3 0.6141 0.7956 0.7956
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1475 0.1848 0.1807
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0507 0.0581 0.0729
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0968 0.1184 0.1184
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2661 0.3401 0.3401
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0527 0.0607 0.0603
Toxoplasma gondii FATC domain-containing protein 0.1475 0.1848 0.2445
Trichomonas vaginalis PIKK family atypical protein kinase 0.7701 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0527 0.0607 0.0607
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0507 0.0581 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.4172 0.5379 0.5355
Mycobacterium tuberculosis Conserved hypothetical protein 0.0507 0.0581 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4603 0.5943 0.5923
Leishmania major hypothetical protein, conserved 0.0598 0.07 0.0571
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2661 0.3401 0.3401
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0137 0.0137
Brugia malayi p70 ribosomal S6 kinase beta 0.0095 0.0042 0.0038
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0527 0.0607 0.0603
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2661 0.3401 0.3401
Trichomonas vaginalis PIKK family atypical protein kinase 0.6134 0.7948 0.7938
Onchocerca volvulus 0.0507 0.0581 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2611 0.3335 0.3302
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2661 0.3401 0.3401
Trichomonas vaginalis PIKK family atypical protein kinase 0.4603 0.5943 0.5923
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0228 0.0216 0.0212
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7701 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0567 0.0659 0.0656
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0567 0.0659 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0629 0.074 0.0737
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7701 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0507 0.0581 0.0533
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0168 0.0137 0.0137
Trypanosoma cruzi rac serine-threonine kinase, putative 0.007 0.0008 0.0008
Echinococcus multilocularis rac serine:threonine kinase 0.007 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0527 0.0607 0.0603
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6141 0.7956 0.7946
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0507 0.0581 0.0577
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0228 0.0216 0.0212
Leishmania major hypothetical protein, unknown function 0.0507 0.0581 0.045
Echinococcus granulosus serine/threonine protein kinase 0.007 0.0008 0.0008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0658 0.0778 0.0778
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0168 0.0137 0.0134
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0527 0.0607 0.0559
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0507 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.1475 0.1848 0.1807
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.6134 0.7948 0.7938
Trichomonas vaginalis PIKK family atypical protein kinase 0.1475 0.1848 0.1807
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0507 0.0581 0.0577
Schistosoma mansoni fkbp-rapamycin associated protein 0.1475 0.1848 0.1845
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2622 0.3349 0.3316
Trypanosoma cruzi Protein kinase B 0.007 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.4178 0.5387 0.5364
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0567 0.0659 0.0612
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1475 0.1848 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0507 0.0581 0.0533
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0507 0.0581 0.9572
Loa Loa (eye worm) phosphatidylinositol 3 0.0507 0.0581 0.0577
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0567 0.0659 0.0656
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7701 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0527 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.6134 0.7948 0.7938
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3635 0.4676 0.4649
Echinococcus multilocularis Zinc finger, PHD finger 0.0527 0.0607 0.0607
Loa Loa (eye worm) hypothetical protein 0.0629 0.074 0.0737
Brugia malayi Protein kinase domain containing protein 0.0102 0.005 0.0047
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0168 0.0137 0.0137
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0066 0.0004 0.0004
Entamoeba histolytica protein kinase, putative 0.0102 0.005 0.005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7701 1 1
Trichomonas vaginalis immunophilin, putative 0.0168 0.0137 0.0088
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0567 0.0659 0.0659
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2622 0.3349 0.3257
Echinococcus multilocularis voltage gated potassium channel 0.0066 0.0004 0.0004
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7701 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4998 0.6461 0.6443
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0228 0.0216 0.0216
Mycobacterium leprae conserved hypothetical protein 0.0507 0.0581 0.5
Trichomonas vaginalis fk506-binding protein, putative 0.0168 0.0137 0.0088
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0527 0.0607 0.0765
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0066 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.2611 0.3335 0.3302
Entamoeba histolytica hypothetical protein 0.0507 0.0581 0.0581
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0527 0.0607 0.0559
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0137 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0507 0.0581 0.0577
Loa Loa (eye worm) FKBP5 protein 0.0168 0.0137 0.0134
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0507 0.0581 0.0581
Entamoeba histolytica protein kinase, putative 0.0102 0.005 0.005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0636 0.075 0.0704
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0168 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.1136 0.1404 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.1486 0.1862 0.1821
Trichomonas vaginalis PIKK family atypical protein kinase 0.4172 0.5379 0.5355
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0507 0.0581 0.9572
Trichomonas vaginalis PIKK family atypical protein kinase 0.4178 0.5387 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.6134 0.7948 0.7938
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0507 0.0581 0.0577
Loa Loa (eye worm) hypothetical protein 0.0198 0.0176 0.0173
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0507 0.0581 0.0577
Loa Loa (eye worm) phosphatidylinositol 3 0.2622 0.3349 0.3347
Entamoeba histolytica protein kinase rad3, putative 0.1475 0.1848 0.1848
Entamoeba histolytica hypothetical protein 0.1475 0.1848 0.1848
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0527 0.0607 0.0607
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0764 0.0918 0.0918
Echinococcus multilocularis serine protein kinase ATM 0.1475 0.1848 0.1848
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0168 0.0137 0.0137
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0596 0.0698 0.0698
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0173 0.0144 0.0141
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0629 0.074 0.074
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1136 0.1404 0.1404
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0213 0.0196 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Giardia lamblia Hypothetical protein 0.0507 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.5166 0.6681 0.6664
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0507 0.0581 0.0581
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0168 0.0137 0.0134
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7701 1 1
Loa Loa (eye worm) hypothetical protein 0.1136 0.1404 0.1401
Plasmodium vivax hypothetical protein 0.0507 0.0581 0.9572
Loa Loa (eye worm) hypothetical protein 0.1643 0.2068 0.2065
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1486 0.1862 0.1862
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0507 0.0581 0.0577
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0698 0.0831 0.0785
Loa Loa (eye worm) phosphatidylinositol kinase 0.0507 0.0581 0.0577
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0137 0.0137
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1643 0.2068 0.2742
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7701 1 1
Schistosoma mansoni immunophilin 0.0145 0.0107 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0698 0.0831 0.0828
Entamoeba histolytica protein kinase, putative 0.0095 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0507 0.0581 0.0581
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0168 0.0137 0.0137
Leishmania major phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.045
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0698 0.0831 0.0831
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.9572
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0527 0.0607 0.0603
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0527 0.0607 0.0559
Loa Loa (eye worm) hypothetical protein 0.0507 0.0581 0.0577
Toxoplasma gondii target of rapamycin (TOR), putative 0.5739 0.743 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0507 0.0581 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Trichomonas vaginalis PIKK family atypical protein kinase 0.5739 0.743 0.7417
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0507 0.0581 0.0581

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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