TDR Targets

Basic information

Technical information

TDR Targets ID: 1635110
Name: N-[(4-chlorophenyl)methylideneamino]-5-(1-met hylpyrrol-2-yl)-2H-pyrazole-3-carboxamide
MW: 327.768 | Formula: C16H14ClN5O
H donors: 2 H acceptors: 2 LogP: 2.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)/C=N/NC(=O)c1[nH]nc(c1)c1cccn1C
InChi: 1S/C16H14ClN5O/c1-22-8-2-3-15(22)13-9-14(20-19-13)16(23)21-18-10-11-4-6-12(17)7-5-11/h2-10H,1H3,(H,19,20)(H,21,23)/b18-10+
InChiKey: MMCDFYRPLROSNM-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-chlorophenyl)methyleneamino]-5-(1-methylpyrrol-2-yl)-2H-pyrazole-3-carboxamide
N-[(4-chlorophenyl)methyleneamino]-5-(1-methyl-2-pyrrolyl)-2H-pyrazole-3-carboxamide
N-[(4-chlorobenzylidene)amino]-5-(1-methylpyrrol-2-yl)-2H-pyrazole-3-carboxamide
ST5256493
BAS 01858814

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0981	1	1
Onchocerca volvulus	Alhambra homolog	0.0035	0.0226	0.0181
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0311	0.0267
Schistosoma mansoni	hypothetical protein	0.0349	0.3468	0.3438
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0221	0.0219
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.0091	0.0089
Leishmania major	hypothetical protein, conserved	0.0349	0.3468	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0241	0.0196
Entamoeba histolytica	SPRY domain protein	0.0018	0.0046	0.5
Trypanosoma cruzi	WLM domain containing protein, putative	0.0349	0.3468	1
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.0981	1	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0221	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0221	0.0219
Brugia malayi	jmjC domain containing protein	0.0045	0.0323	0.0322
Brugia malayi	SWIB/MDM2 domain containing protein	0.0981	1	1
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0018	0.0046	0.0043
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0349	0.3468	0.3468
Loa Loa (eye worm)	hypothetical protein	0.006	0.0486	0.0484
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0311	0.5
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0484	0.0483
Echinococcus granulosus	ring and YY1 binding protein	0.0349	0.3468	0.3468
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0018	0.0046	0.0046
Toxoplasma gondii	ABC1 family protein	0.0043	0.0311	0.0267
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0311	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0349	0.3468	0.3467
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0059	0.0058
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0311	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0349	0.3468	0.3467
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0311	0.0777
Echinococcus multilocularis	ring finger protein 170	0.0018	0.0046	0.0046
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Onchocerca volvulus		0.0349	0.3468	0.3438
Onchocerca volvulus		0.0349	0.3468	0.3438
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0349	0.3468	0.3468
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1748	0.1747
Brugia malayi	beta-lactamase family protein	0.0043	0.0311	0.031
Echinococcus granulosus	RING finger protein 185	0.0018	0.0046	0.0046
Echinococcus granulosus	geminin	0.0205	0.1977	0.1977
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0311	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0323	0.0279
Schistosoma mansoni	hypothetical protein	0.0019	0.0059	0.0013
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0311	0.031
Plasmodium falciparum	zinc finger protein, putative	0.0018	0.0046	0.0043
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Brugia malayi	RING finger protein 20	0.0018	0.0046	0.0044
Echinococcus granulosus	lysine specific demethylase 5A	0.0045	0.0323	0.0323
Leishmania major	hypothetical protein, conserved	0.0349	0.3468	1
Echinococcus multilocularis	zinc finger protein Ran binding	0.0349	0.3468	0.3468
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.007	0.0025
Onchocerca volvulus		0.0182	0.1748	0.171
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0311	0.0267
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0349	0.3468	0.3467
Brugia malayi	Zinc finger protein 183 homolog	0.0018	0.0046	0.0044
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0018	0.0046	0.0046
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0349	0.3468	0.3438
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0059	0.0059
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0059	0.0059
Trypanosoma brucei	hypothetical protein, conserved	0.0349	0.3468	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0323	0.0279
Plasmodium falciparum	trophozoite exported protein 1	0.0018	0.0046	0.0043
Mycobacterium ulcerans	lipase LipD	0.0043	0.0311	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0349	0.3468	0.3467
Echinococcus multilocularis	SWI:SNF matrix associated	0.0981	1	1
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0368	0.0368
Brugia malayi	Neuralized family protein	0.0018	0.0046	0.0044
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0311	0.0267
Leishmania major	hypothetical protein, conserved	0.0349	0.3468	1
Echinococcus multilocularis	ring finger protein 113a	0.0018	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Schistosoma mansoni	hypothetical protein	0.0205	0.1977	0.194
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0349	0.3468	0.3438
Brugia malayi	B-box zinc finger family protein	0.0018	0.0046	0.0044
Schistosoma mansoni	hypothetical protein	0.0019	0.0059	0.0013
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0226	0.0181
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Schistosoma mansoni	TRABID protein (C64 family)	0.0349	0.3468	0.3438
Plasmodium falciparum	RING zinc finger protein, putative	0.0018	0.0046	0.0043
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0311	0.031
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1054	0.1054
Onchocerca volvulus		0.0981	1	1
Schistosoma mansoni	hypothetical protein	0.0981	1	1
Echinococcus granulosus	GPCR family 2	0.0019	0.0059	0.0059
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0809	0.0767
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0541	0.0498
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0981	1	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0226	0.0181
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Trypanosoma cruzi	hypothetical protein, conserved	0.0349	0.3468	1
Onchocerca volvulus		0.0349	0.3468	0.3438
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0226	0.0225
Brugia malayi	brahma associated protein 60 kDa	0.0981	1	1
Schistosoma mansoni	fusion	0.0349	0.3468	0.3438
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0226	0.0223
Echinococcus granulosus	ring finger protein 170	0.0018	0.0046	0.0046
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0311	0.0311
Loa Loa (eye worm)	brahma associated protein	0.0981	1	1
Brugia malayi	PHD-finger family protein	0.0035	0.0226	0.0225
Brugia malayi	beta-lactamase	0.0043	0.0311	0.031
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0226	0.0223
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0311	0.0777
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.4967	0.4967
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Schistosoma mansoni	cpg binding protein	0.0037	0.0241	0.0196
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.2733	1
Trypanosoma brucei	hypothetical protein, conserved	0.0349	0.3468	1
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Echinococcus multilocularis		0.0018	0.0046	0.0046
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0018	0.0046	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0226	0.0181
Plasmodium vivax	hypothetical protein, conserved	0.0981	1	1
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0226	0.0225
Echinococcus multilocularis	geminin	0.0205	0.1977	0.1977
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0046	0.0046
Echinococcus granulosus	cpg binding protein	0.0037	0.0241	0.0241
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0059	0.0059
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0311	0.0309
Echinococcus multilocularis	SWI:SNF matrix associated	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Onchocerca volvulus		0.0043	0.0311	0.0267
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0018	0.0046	0.0046
Brugia malayi	hypothetical protein	0.0182	0.1748	0.1747
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0311	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0059	0.0058
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0368	0.0368
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0059	0.0059
Schistosoma mansoni	RNA binding protein	0.0349	0.3468	0.3438
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0018	0.0046	0.0043
Schistosoma mansoni	hypothetical protein	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0349	0.3468	0.3467
Onchocerca volvulus		0.0035	0.0221	0.0176
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0018	0.0046	0.0046
Onchocerca volvulus		0.0043	0.0311	0.0267
Plasmodium vivax	zinc finger protein, putative	0.0018	0.0046	0.0043
Trypanosoma cruzi	hypothetical protein, conserved	0.0349	0.3468	1
Brugia malayi	RING zinc finger protein	0.0018	0.0046	0.0044
Echinococcus multilocularis	RING finger protein 185	0.0018	0.0046	0.0046
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0311	0.031
Echinococcus granulosus	SWI:SNF matrix associated	0.0981	1	1
Echinococcus multilocularis	cpg binding protein	0.0037	0.0241	0.0241
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.0981	1	1
Echinococcus granulosus	ring finger protein 113a	0.0018	0.0046	0.0046
Onchocerca volvulus		0.0043	0.0311	0.0267
Brugia malayi	jmjC domain containing protein	0.0115	0.1054	0.1052
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1054	0.1054
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0622	0.0579
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0311	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0287	0.0286
Trichomonas vaginalis	esterase, putative	0.0043	0.0311	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0303	0.0303
Schistosoma mansoni	hypothetical protein	0.0205	0.1977	0.194
Brugia malayi	Bromodomain containing protein	0.0035	0.0226	0.0225
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0349	0.3468	0.3467
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0018	0.0046	0.0046
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0018	0.0046	0.0046
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0287	0.0286
Echinococcus granulosus	zinc finger protein Ran binding	0.0349	0.3468	0.3468
Schistosoma mansoni	hypothetical protein	0.0019	0.0059	0.0013
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0226	0.0226
Schistosoma mansoni	hypothetical protein	0.0041	0.0287	0.0243
Brugia malayi	beta-lactamase family protein	0.0043	0.0311	0.031
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0349	0.3468	0.3467
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0226	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0981	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Entamoeba histolytica	hypothetical protein	0.0018	0.0046	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0484	0.0483
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0018	0.0046	0.0043
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0484	0.0483
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0018	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0349	0.3468	0.3467
Brugia malayi	YY1-associated factor 2	0.0349	0.3468	0.3467
Echinococcus multilocularis	peregrin	0.0035	0.0226	0.0226
Toxoplasma gondii	ran binding protein	0.0349	0.3468	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0349	0.3468	0.3467
Leishmania major	hypothetical protein, conserved	0.0349	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0046	0.0044
Schistosoma mansoni	hypothetical protein	0.0494	0.4967	0.4944
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0613	0.0612
Echinococcus granulosus	Zinc finger RanBP2 type	0.0349	0.3468	0.3468
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0059	0.0059
Giardia lamblia	PHD finger protein 15	0.0035	0.0226	1
Echinococcus granulosus	peregrin	0.0035	0.0226	0.0226
Schistosoma mansoni	zinc finger protein	0.0349	0.3468	0.3438
Loa Loa (eye worm)	RiNg Finger protein family member	0.0018	0.0046	0.0044
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0349	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0484	0.0483
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0349	0.3468	1
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0059	0.0058
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0018	0.0046	0.0046
Plasmodium vivax	DNA repair protein RAD5, putative	0.0018	0.0046	0.0043
Plasmodium vivax	RING zinc finger protein, putative	0.0018	0.0046	0.0043
Echinococcus multilocularis	ring and YY1 binding protein	0.0349	0.3468	0.3468
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0981	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0059	0.0058
Loa Loa (eye worm)	RING finger protein 20	0.0018	0.0046	0.0044
Entamoeba histolytica	hypothetical protein	0.0018	0.0046	0.5
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0349	0.3468	1
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.0981	1	1
Schistosoma mansoni	brg-1 associated factor	0.0981	1	1
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0018	0.0046	0.0046
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0349	0.3468	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0311	0.031
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0311	0.5
Trypanosoma cruzi	WLM domain containing protein, putative	0.0349	0.3468	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.0981	1	1
Schistosoma mansoni	hypothetical protein	0.0981	1	1
Brugia malayi	hypothetical protein	0.0018	0.0046	0.0044
Leishmania major	hypothetical protein, conserved	0.0349	0.3468	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0311	0.0267
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.4967	0.4967
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0311	0.0311
Schistosoma mansoni	hypothetical protein	0.0019	0.0059	0.0013
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0018	0.0046	0.0046
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0349	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0349	0.3468	0.3467
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0018	0.0046	0.0046
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0311	0.5
Chlamydia trachomatis	DNA topoisomerase I	0.0981	1	0.5
Chlamydia trachomatis	SWIB complex protein	0.0981	1	0.5
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0349	0.3468	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0349	0.3468	1
Onchocerca volvulus		0.0349	0.3468	0.3438
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0349	0.3468	0.3468
Plasmodium vivax	trophozoite exported protein 1, putative	0.0018	0.0046	0.0043
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0226	0.0226
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0018	0.0046	0.0044
Brugia malayi	Zinc finger, C2H2 type family protein	0.0018	0.0046	0.0044
Leishmania major	hypothetical protein, conserved	0.0043	0.0311	0.0777
Entamoeba histolytica	zinc finger domain containing protein	0.0018	0.0046	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0045	0.0323	0.0322
Trypanosoma cruzi	hypothetical protein, conserved	0.0349	0.3468	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.5623 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	2.3323 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2003153

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1635110