Detailed information for compound 1635402

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.722 | Formula: C17H10ClF3N2O2
  • H donors: 2 H acceptors: 2 LogP: 4.68 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)Nc1[nH]c2c(Cl)ccc(c2c(=O)c1C(=O)C)F
  • InChi: 1S/C17H10ClF3N2O2/c1-7(24)13-16(25)14-10(20)4-3-9(18)15(14)23-17(13)22-12-5-2-8(19)6-11(12)21/h2-6H,1H3,(H2,22,23,25)
  • InChiKey: ALDOLXCPNDPNSI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0351 0.0574 0.057
Echinococcus granulosus Glutaredoxin protein 5 0.0066 0.0046 0.0042
Echinococcus multilocularis serine protein kinase ATM 0.1028 0.183 0.1826
Loa Loa (eye worm) hypothetical protein 0.0677 0.118 0.1175
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.1107 0.1977 0.1974
Onchocerca volvulus 0.0351 0.0574 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0228 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.3215 0.5885 0.5885
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.2627 0.2627
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0108 0.0125 0.5
Echinococcus granulosus nervana 2 0.0066 0.0046 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.7938 0.7938
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0795 0.1397 0.1393
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0574 0.057
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1028 0.183 0.1826
Echinococcus multilocularis Zinc finger, PHD finger 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.2934 0.5365 0.5365
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0351 0.0574 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0351 0.0574 0.0529
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1822 0.3303 0.3218
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0574 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.5434 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0574 0.057
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0351 0.0574 0.0529
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0125 0.0125
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0574 0.0635
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4639 0.8527 0.8527
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0351 0.0574 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0677 0.118 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.3247 0.5945 0.5945
Trichomonas vaginalis conserved hypothetical protein 0.0795 0.1397 0.1397
Mycobacterium tuberculosis Conserved hypothetical protein 0.0351 0.0574 0.5
Echinococcus multilocularis fk506 binding protein 0.0108 0.0125 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.3215 0.5885 0.5885
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0351 0.0574 0.0457
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0574 0.0574
Echinococcus multilocularis 0.0351 0.0574 0.057
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0574 0.057
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0108 0.0125 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.2929 0.5356 0.5356
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.2934 0.5365 0.5365
Entamoeba histolytica hypothetical protein 0.0351 0.0574 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1028 0.183 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Trichomonas vaginalis immunophilin, putative 0.0108 0.0125 0.0125
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5434 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0351 0.0574 0.0455
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0097 0.0093
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0125 0.0077
Leishmania major phosphatidylinositol kinase, putative 0.0351 0.0574 0.0455
Loa Loa (eye worm) hypothetical protein 0.0351 0.0574 0.057
Loa Loa (eye worm) AGC/AKT protein kinase 0.0107 0.0122 0.0118
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0351 0.0574 0.0529
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0457
Loa Loa (eye worm) hypothetical protein 0.0795 0.1397 0.1393
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0108 0.0125 0.0077
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1028 0.183 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.5434 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1028 0.183 0.1791
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1822 0.3303 0.3271
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0351 0.0574 0.0529
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1822 0.3303 0.3271
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0125 0.0077
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1822 0.3303 0.33
Entamoeba histolytica protein kinase, putative 0.0107 0.0122 0.0075
Echinococcus granulosus serine protein kinase ATM 0.1028 0.183 0.1826
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.015 0.0203 0.0198
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0574 0.057
Schistosoma mansoni hypothetical protein 0.0351 0.0574 0.057
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0108 0.0125 0.012
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Trypanosoma cruzi Protein kinase B 0.0073 0.006 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.1145 0.2047 0.2047
Echinococcus multilocularis rac serine:threonine kinase 0.0073 0.006 0.0055
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0125 0.0125
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0125 0.0002
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4326 0.7947 0.7921
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0574 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0677 0.118 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.183 0.183
Toxoplasma gondii FATC domain-containing protein 0.1028 0.183 0.2353
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.3303 0.3303
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.0574 0.057
Leishmania major phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0455
Giardia lamblia GTOR 0.5434 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2929 0.5356 0.5356
Trichomonas vaginalis PIKK family atypical protein kinase 0.3247 0.5945 0.5945
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0351 0.0574 0.057
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0351 0.0574 0.0529
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0108 0.0125 0.0077
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4326 0.7947 0.7921
Loa Loa (eye worm) hypothetical protein 0.0093 0.0097 0.0093
Entamoeba histolytica protein kinase, putative 0.01 0.011 0.0063
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1028 0.183 0.1791
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0351 0.0574 0.057
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0351 0.0574 0.057
Plasmodium vivax hypothetical protein, conserved 0.0351 0.0574 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0574 0.0574
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0457
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5434 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0108 0.0125 0.012
Loa Loa (eye worm) phosphatidylinositol 3 0.5434 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0351 0.0574 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5434 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0351 0.0574 0.0574
Echinococcus multilocularis nervana 2 0.0066 0.0046 0.0042
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.3303 0.3303
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0351 0.0574 0.0529
Entamoeba histolytica hypothetical protein 0.1028 0.183 0.1791
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0351 0.0574 0.057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0574 0.0635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0066 0.0046 0.0042
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0184 0.0184
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Loa Loa (eye worm) hypothetical protein 0.0351 0.0574 0.057
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0228 0.0224
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0125 0.0077
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0574 0.0529
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0108 0.0125 0.1465
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.118 0.118
Onchocerca volvulus 0.0351 0.0574 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0108 0.0125 0.012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1822 0.3303 0.33
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5434 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0574 0.0574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.006 0.0012
Echinococcus multilocularis Glutaredoxin protein 5 0.0066 0.0046 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.5434 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2257 0.4109 0.4036
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0574 0.0455
Brugia malayi p70 ribosomal S6 kinase beta 0.01 0.011 0.0106
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1822 0.3303 0.322
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0574 0.0635
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5434 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0108 0.0125 0.012
Leishmania major phosphatidylinositol 3-kinase, putative 0.1822 0.3303 0.3218
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0351 0.0574 0.0574
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5434 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.006 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Echinococcus granulosus potassium voltage gated channel subfamily H 0.015 0.0203 0.0198
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0108 0.0125 0.1465
Trichomonas vaginalis PIKK family atypical protein kinase 0.3527 0.6465 0.6465
Echinococcus granulosus serine/threonine protein kinase 0.0073 0.006 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.3303 0.3303
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0351 0.0574 0.057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0574 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.183 0.183
Echinococcus granulosus nervana 2 0.0066 0.0046 0.0042
Entamoeba histolytica hypothetical protein 0.0351 0.0574 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.3303 0.3303
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0073 0.006 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.2934 0.5365 0.5365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.0574 0.0574
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0351 0.0574 0.057
Loa Loa (eye worm) hypothetical protein 0.1028 0.183 0.1826
Leishmania major phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0455
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0351 0.0574 0.0574
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0351 0.0574 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5434 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.7938 0.7938
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0351 0.0574 0.057
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.257 0.4689 0.4623
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0574 0.0574
Loa Loa (eye worm) FKBP5 protein 0.0108 0.0125 0.012
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0067 0.0048 0.0043
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0097 0.0093
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0574 0.057
Trypanosoma cruzi target of rapamycin kinase 3 0.4326 0.7947 0.7937
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.015 0.0203 0.0198
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Echinococcus granulosus serine threonine protein kinase nrc 0.0067 0.0048 0.0043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Schistosoma mansoni serine/threonine-protein kinase 0.0073 0.006 0.0055
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0108 0.0125 0.012
Giardia lamblia Phosphatidylinositol 4-kinase 0.0351 0.0574 0.0529
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0351 0.0574 0.0574
Leishmania major hypothetical protein, conserved 0.0351 0.0574 0.0455
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1028 0.183 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.7938 0.7938
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0351 0.0574 0.0529
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1028 0.183 0.1826
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0529
Brugia malayi Protein kinase domain containing protein 0.0107 0.0122 0.0118
Schistosoma mansoni immunophilin 0.0108 0.0125 0.012
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0351 0.0574 0.0574
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1822 0.3303 0.33
Loa Loa (eye worm) phosphatidylinositol 3 0.1822 0.3303 0.33
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0067 0.0048 0.0043
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.7938 0.7938
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1822 0.3303 0.322
Trichomonas vaginalis PIKK family atypical protein kinase 0.3247 0.5945 0.5945
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1822 0.3303 0.33
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.015 0.0203 0.0198
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5434 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0351 0.0574 0.0574
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0574 0.057
Mycobacterium leprae conserved hypothetical protein 0.0351 0.0574 0.5
Trichomonas vaginalis fk506-binding protein, putative 0.0108 0.0125 0.0125
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0351 0.0574 0.0529
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5434 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0073 0.006 0.0055
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0108 0.0125 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1145 0.2047 0.2651
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5434 1 1
Entamoeba histolytica protein kinase, putative 0.0107 0.0122 0.0075
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0351 0.0574 0.057
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0351 0.0574 0.0529
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.01 0.011 0.0106
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0351 0.0574 0.0635
Schistosoma mansoni immunophilin 0.0108 0.0125 0.012
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0351 0.0574 0.057
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0574 0.057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.0574 0.057
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0351 0.0574 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0351 0.0574 0.057
Toxoplasma gondii target of rapamycin (TOR), putative 0.4041 0.7418 1
Schistosoma mansoni immunophilin 0.0093 0.0097 0.0093
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0351 0.0574 0.0529
Brugia malayi FAT domain containing protein 0.0795 0.1397 0.1393
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.3645 0.6683 0.6683
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0351 0.0574 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0351 0.0574 0.057
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0125 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5434 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0351 0.0574 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0795 0.1397 0.1393
Loa Loa (eye worm) hypothetical protein 0.1145 0.2047 0.2044
Echinococcus multilocularis nervana 2 0.0066 0.0046 0.0042
Schistosoma mansoni fkbp-rapamycin associated protein 0.1028 0.183 0.1826
Giardia lamblia Hypothetical protein 0.0351 0.0574 0.0529
Leishmania major hypothetical protein, unknown function 0.0351 0.0574 0.0455
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0529
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0351 0.0574 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2929 0.5356 0.5356
Loa Loa (eye worm) hypothetical protein 0.013 0.0166 0.0161
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0351 0.0574 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2934 0.5365 0.5365
Trichomonas vaginalis PIKK family atypical protein kinase 0.4322 0.7938 0.7938
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0351 0.0574 0.0529
Entamoeba histolytica protein kinase rad3, putative 0.1028 0.183 0.1791
Trichomonas vaginalis PIKK family atypical protein kinase 0.1822 0.3303 0.3303
Trichomonas vaginalis PIKK family atypical protein kinase 0.4041 0.7418 0.7418
Trichomonas vaginalis PIKK family atypical protein kinase 0.1028 0.183 0.183
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0351 0.0574 0.0574
Entamoeba histolytica hypothetical protein 0.0351 0.0574 0.0529
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1028 0.183 0.1826
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0574 0.057
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0108 0.0125 0.012
Loa Loa (eye worm) phosphatidylinositol 3 0.0351 0.0574 0.057
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0125 0.0077
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0108 0.0125 0.012
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0066 0.0046 0.0042
Plasmodium vivax hypothetical protein 0.0351 0.0574 1
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0351 0.0574 0.057
Trichomonas vaginalis AGC family protein kinase 0.0107 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0351 0.0574 0.0529
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0108 0.0125 0.0077
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1028 0.183 0.1791
Schistosoma mansoni hypothetical protein 0.0795 0.1397 0.1393

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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