Detailed information for compound 1635406

Basic information

Technical information
  • TDR Targets ID: 1635406
  • Name: 1-[(4-ethyl-3,4,5,6-tetrahydropyrimidin-2-yl) methyl]-5-methylpyrimidine-2,4-dione
  • MW: 250.297 | Formula: C12H18N4O2
  • H donors: 2 H acceptors: 2 LogP: -0.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cn(CC2=NCCC(N2)CC)c(=O)[nH]c1=O
  • InChi: 1S/C12H18N4O2/c1-3-9-4-5-13-10(14-9)7-16-6-8(2)11(17)15-12(16)18/h6,9H,3-5,7H2,1-2H3,(H,13,14)(H,15,17,18)
  • InChiKey: UXVZUEGMJVNHKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-ethyl-3,4,5,6-tetrahydropyrimidin-2-yl)methyl]-5-methyl-pyrimidine-2,4-dione
  • 1-[(4-ethyl-3,4,5,6-tetrahydropyrimidin-2-yl)methyl]-5-methyl-pyrimidine-2,4-quinone
  • AIDS159335
  • NSC697869 (HYDROCHLORIDE SALT)
  • NCI60_034947
  • 1-((6-Ethyl-1,4,5,6-tetrahydro-2-pyrimidinyl)methyl)-5-methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
  • AIDS-159335

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Giardia lamblia Hypothetical protein 0.0598 0.0585 0.0567
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0028 0.0009
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0598 0.0585 0.0558
Toxoplasma gondii target of rapamycin (TOR), putative 0.6792 0.743 1
Leishmania major phosphatidylinositol kinase, putative 0.0598 0.0585 0.0479
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0618 0.0607 0.0535
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0618 0.0607 0.0589
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0598 0.0585 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0789 0.0795 0.0733
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0598 0.0585 0.0522
Echinococcus granulosus serine/threonine protein kinase 0.0095 0.0028 0.001
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0147 0.0086 0.0068
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0789 0.0795 0.0778
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.017 0.0112 0.0112
Entamoeba histolytica hypothetical protein 0.0598 0.0585 0.0567
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.017 0.0112 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.9117 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1941 0.2069 0.2719
Loa Loa (eye worm) hypothetical protein 0.1941 0.2069 0.2069
Loa Loa (eye worm) hypothetical protein 0.1343 0.1408 0.1408
Leishmania major phosphatidylinositol kinase related protein, putative 0.0598 0.0585 0.0479
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0598 0.0585 0.0558
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0789 0.0795 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.0585 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.1753 0.1862 0.1799
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.017 0.0112 0.0093
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.9117 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0598 0.0585 0.0567
Schistosoma mansoni hypothetical protein 0.1343 0.1408 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.6116 0.6683 0.6658
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0598 0.0585 0.9629
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0164 0.0088
Schistosoma mansoni fkbp-rapamycin associated protein 0.1743 0.185 0.1827
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0173 0.0115 0.0048
Loa Loa (eye worm) hypothetical protein 0.072 0.0719 0.0719
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.017 0.0112 0.0093
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0687 0.0683 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1743 0.185 0.1834
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0855 0.0868 0.0852
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0618 0.0607 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.3096 0.3346 0.3295
Loa Loa (eye worm) hypothetical protein 0.1743 0.185 0.185
Trichomonas vaginalis PIKK family atypical protein kinase 0.4935 0.5378 0.5342
Plasmodium vivax hypothetical protein 0.0598 0.0585 0.9629
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0598 0.0585 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.726 0.7948 0.7932
Trichomonas vaginalis PIKK family atypical protein kinase 0.4942 0.5386 0.5351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0598 0.0585 0.0522
Loa Loa (eye worm) hypothetical protein 0.0202 0.0147 0.0147
Echinococcus multilocularis fk506 binding protein 0.017 0.0112 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0727 0.0727 0.0656
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1343 0.1408 0.1392
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1753 0.1862 0.1846
Onchocerca volvulus 0.0598 0.0585 0.5
Brugia malayi Protein kinase domain containing protein 0.0138 0.0076 0.0009
Schistosoma mansoni immunophilin 0.017 0.0112 0.0084
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0598 0.0585 0.0513
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.017 0.0112 0.0036
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0618 0.0607 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0598 0.0585 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.5917 0.6464 0.6437
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0618 0.0607 0.0589
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0232 0.0181 0.0115
Schistosoma mansoni immunophilin 0.017 0.0112 0.0084
Loa Loa (eye worm) phosphatidylinositol 3 0.0598 0.0585 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.3085 0.3334 0.3283
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0658 0.0651 0.0579
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.3096 0.3346 0.3295
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.017 0.0112 0.1579
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.9117 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.9117 1 1
Entamoeba histolytica protein kinase, putative 0.0138 0.0076 0.0057
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.4305 0.4681 0.464
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0618 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.726 0.7948 0.7932
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.017 0.0112 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.072 0.0719 0.0657
Loa Loa (eye worm) AGC/AKT protein kinase 0.0138 0.0076 0.0076
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.0513
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1743 0.185 0.1835
Mycobacterium leprae conserved hypothetical protein 0.0598 0.0585 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0598 0.0585 0.0585
Giardia lamblia GTOR 0.9117 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0658 0.0651 0.0588
Leishmania major phosphatidylinositol 3-kinase, putative 0.0618 0.0607 0.0501
Echinococcus granulosus serine threonine protein kinase nrc 0.0086 0.0019 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.3096 0.3346 0.327
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1743 0.185 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.4942 0.5386 0.5351
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0658 0.0651 0.0633
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1743 0.185 0.1795
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0598 0.0585 0.9629
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1743 0.185 0.1834
Schistosoma mansoni hypothetical protein 0.0598 0.0585 0.0558
Trichomonas vaginalis PIKK family atypical protein kinase 0.726 0.7948 0.7932
Trypanosoma cruzi hypothetical protein, conserved 0.0091 0.0024 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0598 0.0585 0.0522
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0618 0.0607 0.0535
Entamoeba histolytica hypothetical protein 0.0749 0.0751 0.0734
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.017 0.0112 0.0093
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0598 0.0585 0.0567
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0232 0.0181 0.0163
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0618 0.0607 0.059
Echinococcus multilocularis rac serine:threonine kinase 0.0095 0.0028 0.001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.7268 0.7956 0.794
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.072 0.0719 0.0702
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0086 0.0019 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.9117 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0598 0.0585 0.0567
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.017 0.0112 0.0036
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0232 0.0181 0.0181
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.3136 0.3389 0.3377
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.5946 0.5915
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0658 0.0651 0.0633
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0658 0.0651 0.0633
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.9117 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.3085 0.3334 0.3258
Trichomonas vaginalis PIKK family atypical protein kinase 0.726 0.7948 0.7932
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0598 0.0585 0.0513
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.017 0.0112 0.0045
Leishmania major hypothetical protein, conserved 0.0689 0.0685 0.058
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.3136 0.3389 0.3377
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0618 0.0607 0.0733
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0129 0.0067 0.0067
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.3136 0.3389 0.3378
Loa Loa (eye worm) phosphatidylinositol kinase 0.0598 0.0585 0.0585
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.5946 0.5915
Trichomonas vaginalis PIKK family atypical protein kinase 0.4935 0.5378 0.5342
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.9117 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0618 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0598 0.0585 0.0585
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0618 0.0607 0.0535
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.3136 0.3389 0.3371
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1743 0.185 0.1787
Entamoeba histolytica hypothetical protein 0.1743 0.185 0.1834
Leishmania major hypothetical protein, unknown function 0.0598 0.0585 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.1144 0.1188 0.1121
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.017 0.0112 0.5
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.017 0.0112 0.0093
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.7268 0.7956 0.7933
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.9117 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.019 0.0134 0.0115
Entamoeba histolytica protein kinase, putative 0.0138 0.0076 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0598 0.0585 0.9629
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.072 0.0719 0.0702
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0658 0.0651 0.0625
Mycobacterium tuberculosis Conserved hypothetical protein 0.0598 0.0585 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.9117 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Entamoeba histolytica hypothetical protein 0.0598 0.0585 0.0567
Trypanosoma cruzi target of rapamycin kinase 3 0.7268 0.7956 0.7952
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.017 0.0112 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.0479
Toxoplasma gondii FATC domain-containing protein 0.1743 0.185 0.2421
Entamoeba histolytica PH domain containing protein kinase, putative 0.0095 0.0028 0.0009
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0095 0.0028 0.0009
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.017 0.0112 0.0093
Schistosoma mansoni voltage-gated potassium channel 0.0254 0.0204 0.0177
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0789 0.0795 0.0778
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.0567
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0164 0.0088
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0618 0.0607 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.3085 0.3334 0.3283
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.9629
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0598 0.0585 0.0567
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1743 0.185 0.1827
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0598 0.0585 0.9629
Trichomonas vaginalis PIKK family atypical protein kinase 0.9117 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0598 0.0585 0.0585
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0961 0.0986 0.097
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3798 0.4121 0.4076
Onchocerca volvulus 0.0598 0.0585 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0618 0.0607 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.3085 0.3334 0.3283
Entamoeba histolytica protein kinase, putative 0.0129 0.0067 0.0048
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0658 0.0651 0.0579
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.9117 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0618 0.0607 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1144 0.1188 0.1121
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.9117 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.017 0.0112 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.3085 0.3334 0.3283
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0618 0.0607 0.0733
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.017 0.0112 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.0585 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.2448 0.2629 0.2572
Trichomonas vaginalis PIKK family atypical protein kinase 0.5411 0.5904 0.5872
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.017 0.0112 0.0045
Loa Loa (eye worm) phosphatidylinositol 3 0.0921 0.0942 0.0942
Loa Loa (eye worm) hypothetical protein 0.1849 0.1968 0.1968
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0147 0.0086 0.0068
Loa Loa (eye worm) hypothetical protein 0.1144 0.1188 0.1188
Schistosoma mansoni voltage-gated potassium channel 0.0254 0.0204 0.0177
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0727 0.0727 0.0656
Entamoeba histolytica protein kinase rad3, putative 0.1743 0.185 0.1834
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0638 0.0629 0.0612
Echinococcus multilocularis Zinc finger, PHD finger 0.0618 0.0607 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.9117 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0618 0.0607 0.059
Loa Loa (eye worm) phosphatidylinositol 3 0.3096 0.3346 0.3346
Trichomonas vaginalis PIKK family atypical protein kinase 0.7774 0.8516 0.8505
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0618 0.0607 0.0589
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0618 0.0607 0.058
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0598 0.0585 0.0513
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.017 0.0112 0.0036
Echinococcus multilocularis 0.0598 0.0585 0.0568
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0789 0.0795 0.0725
Loa Loa (eye worm) phosphatidylinositol 3 0.0598 0.0585 0.0585
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1743 0.185 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.4942 0.5386 0.5351
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0961 0.0986 0.097
Entamoeba histolytica hypothetical protein 0.0598 0.0585 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.1343 0.1408 0.1342
Trichomonas vaginalis PIKK family atypical protein kinase 0.726 0.7948 0.7932
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0618 0.0607 0.0535
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0598 0.0585 0.0558
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0789 0.0795 0.0778
Schistosoma mansoni immunophilin 0.0147 0.0086 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0658 0.0651 0.0579
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0598 0.0585 0.0568
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.017 0.0112 0.0093
Trypanosoma cruzi Protein kinase B 0.0095 0.0028 0.0009
Echinococcus multilocularis serine protein kinase ATM 0.1743 0.185 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.4942 0.5386 0.5351
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0855 0.0868 0.0852
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.9117 1 1
Trichomonas vaginalis fk506-binding protein, putative 0.017 0.0112 0.0036
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0598 0.0585 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.6792 0.743 0.741
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0658 0.0651 0.0579
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.017 0.0112 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.5411 0.5904 0.5872
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0598 0.0585 0.0704
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0598 0.0585 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.4935 0.5378 0.5342
Trichomonas vaginalis immunophilin, putative 0.017 0.0112 0.0036
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0749 0.0751 0.0734
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0961 0.0986 0.0961
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1343 0.1408 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.5946 0.5915
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0618 0.0607 0.059
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1144 0.1188 0.1172
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0789 0.0795 0.0725
Loa Loa (eye worm) FKBP5 protein 0.017 0.0112 0.0112
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.017 0.0112 0.0094
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0598 0.0585 0.0568
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0679 0.0675 0.0657
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0232 0.0181 0.0163
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0086 0.0019 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1941 0.2069 0.2008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.3136 0.3389 0.3345
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.017 0.0112 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.3085 0.3334 0.3283
Echinococcus granulosus serine protein kinase ATM 0.1743 0.185 0.1835
Loa Loa (eye worm) hypothetical protein 0.0147 0.0086 0.0086
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.9117 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1743 0.185 0.1787
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.017 0.0112 0.0094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0598 0.0585 0.0704
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.3136 0.3389 0.3378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1743 0.185 0.1795
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0598 0.0585 0.9629
Brugia malayi FAT domain containing protein 0.1343 0.1408 0.135

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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