Detailed information for compound 1635409

Basic information

Technical information
  • TDR Targets ID: 1635409
  • Name: 2-[[3-methyl-6-(3-nitrophenyl)imidazo[2,3-b][ 1,3]thiazol-5-yl]methylideneamino]guanidine
  • MW: 343.364 | Formula: C14H13N7O2S
  • H donors: 2 H acceptors: 3 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N/N=C/c1c(nc2n1c(C)cs2)c1cccc(c1)[N+](=O)[O-])N
  • InChi: 1S/C14H13N7O2S/c1-8-7-24-14-18-12(9-3-2-4-10(5-9)21(22)23)11(20(8)14)6-17-19-13(15)16/h2-7H,1H3,(H4,15,16,19)/b17-6+
  • InChiKey: RWFWMBWLSYLVMD-UBKPWBPPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[3-methyl-6-(3-nitrophenyl)imidazo[2,3-b]thiazol-5-yl]methyleneamino]guanidine
  • 2-[[3-methyl-6-(3-nitrophenyl)-5-imidazo[2,3-b]thiazolyl]methyleneamino]guanidine
  • NCI60_041113

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Echinococcus multilocularis serine threonine protein kinase 0.0046 0.0038 0.0023
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0046 0.0038 0.0023
Loa Loa (eye worm) hypothetical protein 0.0511 0.1381 0.1381
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1814 0.1809
Brugia malayi p70 ribosomal S6 kinase beta 0.0134 0.0292 0.0278
Loa Loa (eye worm) phosphatidylinositol 3 0.3492 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.066 0.1814 0.1768
Schistosoma mansoni atypical protein kinase C 0.0046 0.0038 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.0556 0.0371
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1171 0.3291 0.3281
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1171 0.3291 0.3281
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1171 0.3291 0.3252
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.066 0.1814 0.1768
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0089 0.0162 0.2119
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0225 0.0556 0.0533
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0225 0.0556 0.0543
Trypanosoma cruzi adenosine kinase, putative 0.0178 0.0419 0.0365
Loa Loa (eye worm) FKBP5 protein 0.0052 0.0057 0.0057
Giardia lamblia Kinase, AGC PKA 0.0089 0.0162 0.0107
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0188 0.0164
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0736 0.2033 0.2444
Loa Loa (eye worm) hypothetical protein 0.0046 0.0038 0.0038
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0052 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0435 0.1163 0.1163
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0225 0.0556 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0511 0.1381 0.1369
Trichomonas vaginalis PIKK family atypical protein kinase 0.2086 0.5937 0.5934
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0521
Echinococcus multilocularis serine:threonine protein kinase 38 0.0046 0.0038 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.2066 0.5877 0.5874
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0225 0.0556 0.0543
Mycobacterium leprae conserved hypothetical protein 0.0225 0.0556 0.5
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0521
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0521
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.1883 0.5348 0.5344
Trichomonas vaginalis PIKK family atypical protein kinase 0.1885 0.5356 0.5353
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0225 0.0556 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1814 0.1809
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3492 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Echinococcus multilocularis rac serine:threonine kinase 0.0098 0.0188 0.0174
Leishmania major phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0038 0.0031
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.0503
Entamoeba histolytica protein kinase, putative 0.0134 0.0292 0.0255
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.0556 0.0543
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0052 0.0057 0.0032
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0225 0.0556 0.0503
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0089 0.0162 0.0148
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0225 0.0556 0.0543
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.2777 0.7935 0.7933
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0225 0.0556 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0511 0.1381 0.1375
Brugia malayi Hr1 repeat family protein 0.0046 0.0038 0.0023
Echinococcus multilocularis serine protein kinase ATM 0.066 0.1814 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1885 0.5356 0.5353
Schistosoma mansoni hypothetical protein 0.0225 0.0556 0.0533
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0046 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.0556 0.0533
Entamoeba histolytica hypothetical protein 0.0225 0.0556 0.0521
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.1171 0.3291 0.3286
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.0556 0.055
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3492 1 1
Plasmodium vivax hypothetical protein 0.0225 0.0556 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.0556 0.055
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0225 0.0556 1
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.8524 0.8523
Onchocerca volvulus 0.0225 0.0556 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0046 0.0038 0.0023
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0036 0.0021
Echinococcus multilocularis serine:threonine protein kinase N2 0.0046 0.0038 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.066 0.1814 0.1809
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0435 0.1163 0.1113
Loa Loa (eye worm) hypothetical protein 0.0712 0.1962 0.1962
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0521
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0089 0.0162 0.0148
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.0556 0.055
Echinococcus granulosus protein kinase c iota type 0.0046 0.0038 0.0023
Toxoplasma gondii kinase, pfkB family protein 0.0178 0.0419 0.0178
Trichomonas vaginalis PIKK family atypical protein kinase 0.2066 0.5877 0.5874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0937 0.2614 0.2608
Echinococcus granulosus protein kinase C gamma type 0.0046 0.0038 0.0023
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0014 0.0014
Echinococcus multilocularis fk506 binding protein 0.0052 0.0057 0.0042
Loa Loa (eye worm) AGC/AKT protein kinase 0.0143 0.0318 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Loa Loa (eye worm) hypothetical protein 0.0045 0.0036 0.0036
Leishmania major phosphatidylinositol kinase related protein, putative 0.0225 0.0556 0.0503
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0134 0.0292 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.1163 0.1157
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0556 0.0556
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3492 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1171 0.3291 0.3252
Echinococcus granulosus serine/threonine protein kinase 0.0098 0.0188 0.0174
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0046 0.0038 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0225 0.0556 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0057 0.0042
Loa Loa (eye worm) hypothetical protein 0.0225 0.0556 0.0556
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3492 1 1
Echinococcus granulosus protein kinase c epsilon type 0.0046 0.0038 0.0023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.145 0.4098 0.4064
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0225 0.0556 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0088 0.016 0.0145
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0225 0.0556 0.055
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1171 0.3291 0.3252
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0225 0.0556 0.0503
Echinococcus granulosus NDR protein kinase 0.0046 0.0038 0.0023
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3492 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0052 0.0057 0.0042
Entamoeba histolytica hypothetical protein 0.0225 0.0556 0.0521
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1171 0.3291 0.3281
Schistosoma mansoni serine/threonine kinase 0.0046 0.0038 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.0556 0.0371
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0225 0.0556 0.0503
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0503
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.066 0.1814 0.1768
Echinococcus multilocularis adenosine kinase 0.0178 0.0419 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.055
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0046 0.0038 0.0023
Schistosoma mansoni immunophilin 0.0045 0.0036 0.0011
Echinococcus granulosus serine:threonine protein kinase N2 0.0046 0.0038 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.0556 0.055
Loa Loa (eye worm) hypothetical protein 0.0178 0.0419 0.0419
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.0556 0.0543
Schistosoma mansoni adenosine kinase 0.0178 0.0419 0.0395
Plasmodium vivax hypothetical protein, conserved 0.0225 0.0556 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.278 0.7943 0.7931
Entamoeba histolytica protein kinase, putative 0.0143 0.0318 0.0281
Echinococcus granulosus serine:threonine protein kinase SMG1 0.066 0.1814 0.1803
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0063 0.0056
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0052 0.0057 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.0556 0.0533
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0556 0.0556
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.0556 0.0543
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0225 0.0556 0.0533
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0225 0.0556 0.0503
Echinococcus granulosus nervana 2 0.0088 0.016 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.3492 1 1
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0046 0.0038 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0038 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.3492 1 1
Echinococcus granulosus adenosine kinase 0.0178 0.0419 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0188 0.0164
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0046 0.0038 0.0023
Trypanosoma cruzi target of rapamycin kinase 3 0.278 0.7943 0.7931
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.066 0.1814 0.1794
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0435 0.1163 0.1157
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0556 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.1171 0.3291 0.3286
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.066 0.1814 0.1803
Loa Loa (eye worm) AGC/PKN protein kinase 0.0046 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0225 0.0556 0.0503
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3492 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0556 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.1883 0.5348 0.5344
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0225 0.0556 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.2086 0.5937 0.5934
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0045 0.0035 0.0028
Loa Loa (eye worm) phosphatidylinositol kinase 0.0225 0.0556 0.0556
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0188 0.0151
Leishmania major phosphatidylinositol 3-kinase, putative 0.1171 0.3291 0.3252
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0225 0.0556 0.055
Echinococcus granulosus nervana 2 0.0088 0.016 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.1171 0.3291 0.3286
Trichomonas vaginalis fk506-binding protein, putative 0.0052 0.0057 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.2777 0.7935 0.7933
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0225 0.0556 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.1171 0.3291 0.3286
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1171 0.3291 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.2086 0.5937 0.5934
Trypanosoma brucei adenosine kinase, putative 0.0178 0.0419 0.0365
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3492 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0225 0.0556 0.0543
Echinococcus multilocularis Zinc finger, PHD finger 0.0225 0.0556 0.0543
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0038 0.0013
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0521
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3492 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0225 0.0556 1
Trichomonas vaginalis AGC family protein kinase 0.0046 0.0038 0.0031
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0188 0.0132
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0057 0.0042
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0052 0.0057 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0556 0.055
Trypanosoma brucei target of rapamycin kinase 3, putative 0.278 0.7943 0.7931
Leishmania major hypothetical protein, unknown function 0.0225 0.0556 0.0503
Schistosoma mansoni adenosine kinase 0.0178 0.0419 0.0395
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0052 0.0057 0.0019
Loa Loa (eye worm) AGC/NDR protein kinase 0.0046 0.0038 0.0038
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0225 0.0556 0.0503
Schistosoma mansoni immunophilin 0.0052 0.0057 0.0032
Giardia lamblia Phosphatidylinositol 4-kinase 0.0225 0.0556 0.0503
Entamoeba histolytica protein kinase, putative 0.0143 0.0318 0.0281
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.0556 0.055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.066 0.1814 0.1783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.2777 0.7935 0.7933
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.066 0.1814 0.1803
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0225 0.0556 0.0543
Echinococcus granulosus Protein kinase C brain isozyme 0.0046 0.0038 0.0023
Loa Loa (eye worm) hypothetical protein 0.066 0.1814 0.1814
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0052 0.0057 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.1171 0.3291 0.3291
Echinococcus multilocularis 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.1885 0.5356 0.5353
Entamoeba histolytica hypothetical protein 0.066 0.1814 0.1783
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0225 0.0556 0.0503
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0225 0.0556 0.0543
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3492 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0556 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.2777 0.7935 0.7933
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0225 0.0556 0.055
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1651 0.4679 0.4649
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0225 0.0556 0.055
Echinococcus multilocularis nervana 2 0.0088 0.016 0.0145
Entamoeba histolytica protein kinase 2, putative 0.0089 0.0162 0.0125
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0057 0.0049
Echinococcus multilocularis nervana 2 0.0088 0.016 0.0145
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3492 1 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0089 0.0162 0.0148
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1171 0.3291 0.3252
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0225 0.0556 0.0543
Trichomonas vaginalis immunophilin, putative 0.0052 0.0057 0.0049
Giardia lamblia GTOR 0.3492 1 1
Echinococcus multilocularis protein kinase c epsilon type 0.0046 0.0038 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.2267 0.6458 0.6456
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Trypanosoma cruzi Protein kinase B 0.0098 0.0188 0.0132
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0225 0.0556 0.0503
Brugia malayi Adenosine kinase-like 0.0178 0.0419 0.0405
Schistosoma mansoni immunophilin 0.0052 0.0057 0.0032
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1171 0.3291 0.3252
Leishmania major phosphatidylinositol kinase, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0225 0.0556 0.055
Trypanosoma brucei rac serine-threonine kinase, putative 0.0143 0.0318 0.0263
Echinococcus multilocularis protein kinase c iota type 0.0046 0.0038 0.0023
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0052 0.0057 0.5
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0225 0.0556 0.0533
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0089 0.0162 0.2119
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0046 0.0038 0.0038
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.0503
Echinococcus multilocularis Glutaredoxin protein 5 0.0088 0.016 0.0145
Entamoeba histolytica hypothetical protein 0.0225 0.0556 0.0521
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Brugia malayi FAT domain containing protein 0.0511 0.1381 0.1369
Schistosoma mansoni fkbp-rapamycin associated protein 0.066 0.1814 0.1794
Trichomonas vaginalis PIKK family atypical protein kinase 0.1883 0.5348 0.5344
Brugia malayi Protein kinase domain containing protein 0.0046 0.0038 0.0023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.1885 0.5356 0.5353
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0225 0.0556 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2777 0.7935 0.7933
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0046 0.0038 0.0038
Trypanosoma cruzi adenosine kinase, putative 0.0178 0.0419 0.0365
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.0556 0.0371
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0046 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.1171 0.3291 0.3286
Echinococcus multilocularis serine:threonine protein kinase N2 0.0046 0.0038 0.0023
Entamoeba histolytica protein kinase rad3, putative 0.066 0.1814 0.1783
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.066 0.1814 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0225 0.0556 0.055
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0036 0.0021
Entamoeba histolytica hypothetical protein 0.0225 0.0556 0.0521
Echinococcus granulosus serine protein kinase ATM 0.066 0.1814 0.1803
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0089 0.0162 0.0107
Loa Loa (eye worm) hypothetical protein 0.0225 0.0556 0.0556
Leishmania major adenosine kinase, putative 0.0178 0.0419 0.0365
Loa Loa (eye worm) phosphatidylinositol 3 0.0225 0.0556 0.0556
Schistosoma mansoni hypothetical protein 0.0511 0.1381 0.136
Trypanosoma brucei adenosine kinase, putative 0.0178 0.0419 0.0365
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0225 0.0556 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Trichomonas vaginalis PIKK family atypical protein kinase 0.2342 0.6677 0.6674
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis AGC family protein kinase 0.0143 0.0318 0.0311
Trichomonas vaginalis PIKK family atypical protein kinase 0.3492 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0511 0.1381 0.1369
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0225 0.0556 1
Trichomonas vaginalis conserved hypothetical protein 0.0736 0.2033 0.2027
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0057 0.0049
Brugia malayi Protein kinase domain containing protein 0.0046 0.0038 0.0023
Toxoplasma gondii FATC domain-containing protein 0.066 0.1814 0.2138
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.0556 0.0371
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0225 0.0556 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0225 0.0556 0.0503
Brugia malayi Protein kinase domain containing protein 0.0143 0.0318 0.0304
Loa Loa (eye worm) hypothetical protein 0.0736 0.2033 0.2033
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3492 1 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0088 0.016 0.0145
Echinococcus granulosus Glutaredoxin protein 5 0.0088 0.016 0.0145
Leishmania major phosphatidylinositol 4-kinase, putative 0.0225 0.0556 0.0503
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0225 0.0556 0.0521
Brugia malayi protein kinase C II. 0.0046 0.0038 0.0023
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0188 0.0151
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0225 0.0556 0.0543
Giardia lamblia Hypothetical protein 0.0225 0.0556 0.0503
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0225 0.0556 0.0371
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0046 0.0038 0.0023
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0225 0.0556 0.055
Onchocerca volvulus 0.0225 0.0556 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0225 0.0556 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0052 0.0057 0.5
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0225 0.0556 0.0543
Toxoplasma gondii target of rapamycin (TOR), putative 0.2597 0.7413 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.7413 0.7411
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0225 0.0556 0.0503

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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