Detailed information for compound 1635413

Basic information

Technical information
  • TDR Targets ID: 1635413
  • Name: ZINC03592532
  • MW: 322.424 | Formula: C19H18N2OS
  • H donors: 0 H acceptors: 0 LogP: 3.37 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@]12N=C3SCc4c(CN3[C@@H](C2)c2c(O1)cccc2)cccc4
  • InChi: 1S/C19H18N2OS/c1-19-10-16(15-8-4-5-9-17(15)22-19)21-11-13-6-2-3-7-14(13)12-23-18(21)20-19/h2-9,16H,10-12H2,1H3/t16-,19-/m0/s1
  • InChiKey: GOPKBGORRFGSNU-LPHOPBHVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi p70 ribosomal S6 kinase beta 0.0096 0.0051 0.0045
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0443 0.0599 0.0593
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0162 0.0155 0.0155
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2225 0.3411 0.3411
Leishmania major hypothetical protein, conserved 0.0515 0.0712 0.0565
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2225 0.3411 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.3331 0.329
Onchocerca volvulus 0.0423 0.0567 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7947 0.7934
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0232 0.0265 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.3824 0.5937 0.5912
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2225 0.3411 0.3411
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0483 0.0662 0.0605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0483 0.0662 0.0657
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6398 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0545 0.076 0.0755
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.001 0.0005
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0162 0.0155 0.0155
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0423 0.0567 0.0509
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6398 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0443 0.0599 0.0593
Loa Loa (eye worm) hypothetical protein 0.007 0.0009 0.0004
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5103 0.7955 0.7943
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0232 0.0265 0.026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.0567 0.0562
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.001 0.0005
Leishmania major hypothetical protein, unknown function 0.0423 0.0567 0.0418
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0443 0.0599 0.0541
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0575 0.0807 0.0807
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0162 0.0155 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.1229 0.1839 0.1789
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0423 0.0567 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.1229 0.1839 0.1789
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7947 0.7934
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.0567
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2185 0.3348 0.3308
Echinococcus granulosus serine/threonine protein kinase 0.007 0.001 0.001
Schistosoma mansoni fkbp-rapamycin associated protein 0.1229 0.1839 0.1834
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0423 0.0567 0.0562
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0483 0.0662 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5384 0.5356
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0423 0.0567 0.9474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0567 0.0509
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1229 0.1839 0.1834
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0443 0.0599 0.0599
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6398 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0567 0.0562
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0483 0.0662 0.0657
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3019 0.4665 0.4632
Echinococcus multilocularis Zinc finger, PHD finger 0.0443 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7947 0.7934
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0162 0.0155 0.0155
Brugia malayi Protein kinase domain containing protein 0.0102 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0545 0.076 0.0755
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0067 0.0005 0.0005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6398 1 1
Entamoeba histolytica protein kinase, putative 0.0102 0.0061 0.0061
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2185 0.3348 0.3243
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0483 0.0662 0.0662
Trichomonas vaginalis immunophilin, putative 0.0162 0.0155 0.0095
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6398 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0067 0.0005 0.0005
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0443 0.0599 0.0742
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0232 0.0265 0.0265
Trichomonas vaginalis fk506-binding protein, putative 0.0162 0.0155 0.0095
Mycobacterium leprae conserved hypothetical protein 0.0423 0.0567 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4153 0.6455 0.6433
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.3331 0.329
Echinococcus granulosus voltage gated potassium channel 0.0067 0.0005 0.0005
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0443 0.0599 0.0541
Entamoeba histolytica hypothetical protein 0.0423 0.0567 0.0567
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0162 0.0155 0.0095
Loa Loa (eye worm) FKBP5 protein 0.0162 0.0155 0.015
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0567 0.0562
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0423 0.0567 0.0567
Entamoeba histolytica protein kinase, putative 0.0102 0.0061 0.0061
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0162 0.0155 0.0155
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0553 0.0773 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.1239 0.1856 0.1806
Trichomonas vaginalis conserved hypothetical protein 0.0945 0.1392 0.1339
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0423 0.0567 0.9474
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.5376 0.5348
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.0567 0.0562
Loa Loa (eye worm) hypothetical protein 0.0201 0.0217 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7947 0.7934
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.0567 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5384 0.5356
Entamoeba histolytica protein kinase rad3, putative 0.1229 0.1839 0.1839
Loa Loa (eye worm) phosphatidylinositol 3 0.2185 0.3348 0.3345
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Entamoeba histolytica hypothetical protein 0.1229 0.1839 0.1839
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0682 0.0976 0.0976
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0443 0.0599 0.0599
Echinococcus multilocularis serine protein kinase ATM 0.1229 0.1839 0.1839
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0545 0.076 0.076
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0174 0.0175 0.0169
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0513 0.0709 0.0709
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0162 0.0155 0.0155
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0945 0.1392 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.4292 0.6675 0.6655
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Giardia lamblia Hypothetical protein 0.0423 0.0567 0.0567
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0241 0.0182
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0423 0.0567 0.0567
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0162 0.0155 0.015
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6398 1 1
Loa Loa (eye worm) hypothetical protein 0.1368 0.2059 0.2055
Plasmodium vivax hypothetical protein 0.0423 0.0567 0.9474
Loa Loa (eye worm) hypothetical protein 0.0945 0.1392 0.1387
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0615 0.087 0.0815
Loa Loa (eye worm) phosphatidylinositol kinase 0.0423 0.0567 0.0562
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0423 0.0567 0.0562
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1239 0.1856 0.1856
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0162 0.0155 0.0155
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6398 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1368 0.2059 0.2722
Entamoeba histolytica hypothetical protein 0.0423 0.0567 0.0567
Entamoeba histolytica protein kinase, putative 0.0096 0.0051 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0615 0.087 0.0866
Schistosoma mansoni immunophilin 0.014 0.012 0.0115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0615 0.087 0.087
Leishmania major phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.0418
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0162 0.0155 0.0155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0443 0.0599 0.0541
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0443 0.0599 0.0593
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.9474
Loa Loa (eye worm) hypothetical protein 0.0423 0.0567 0.0562
Toxoplasma gondii target of rapamycin (TOR), putative 0.477 0.7429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.0509
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.001 0.001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0423 0.0567 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0423 0.0567 0.0567
Brugia malayi FAT domain containing protein 0.0945 0.1392 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.6398 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0162 0.0155 0.0095
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1229 0.1839 0.1834
Schistosoma mansoni hypothetical protein 0.0423 0.0567 0.0562
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2225 0.3411 0.3408
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1229 0.1839 0.1839
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0162 0.0155 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2225 0.3411 0.3408
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.3331 0.329
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.014 0.012 0.012
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1229 0.1839 0.1839
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0162 0.0155 0.0095
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0162 0.0155 0.2597
Trypanosoma cruzi rac serine-threonine kinase, putative 0.007 0.001 0.001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0505 0.0696 0.0696
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0232 0.0265 0.0265
Echinococcus multilocularis 0.0423 0.0567 0.0567
Trypanosoma cruzi Protein kinase B 0.007 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.1368 0.2059 0.2011
Trichomonas vaginalis PIKK family atypical protein kinase 0.3824 0.5937 0.5912
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0945 0.1392 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0806 0.1171 0.1117
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0443 0.0599 0.045
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0615 0.087 0.087
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0483 0.0662 0.0605
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0162 0.0155 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0423 0.0567 0.9474
Trichomonas vaginalis PIKK family atypical protein kinase 0.3803 0.5902 0.5877
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.5376 0.5348
Leishmania major phosphatidylinositol kinase, putative 0.0423 0.0567 0.0418
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.079 0.1146 0.1146
Entamoeba histolytica hypothetical protein 0.0575 0.0807 0.0807
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0162 0.0155 0.015
Echinococcus granulosus serine protein kinase ATM 0.1229 0.1839 0.1839
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0682 0.0976 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5384 0.5356
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Entamoeba histolytica hypothetical protein 0.0423 0.0567 0.0567
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0162 0.0155 0.015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6398 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0423 0.0567 0.07
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0483 0.0662 0.0605
Loa Loa (eye worm) hypothetical protein 0.014 0.012 0.0115
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0615 0.087 0.0815
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.001 0.001
Giardia lamblia Phosphatidylinositol 4-kinase 0.0423 0.0567 0.0567
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0162 0.0155 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0443 0.0599 0.0742
Schistosoma mansoni hypothetical protein 0.0945 0.1392 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7947 0.7934
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0423 0.0567 0.0567
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1229 0.1839 0.1839
Trichomonas vaginalis PIKK family atypical protein kinase 0.3474 0.5384 0.5356
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.079 0.1146 0.1141
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0423 0.0567 0.0509
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0615 0.087 0.0815
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0567 0.0562
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6398 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0443 0.0599 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.2185 0.3348 0.3308
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0443 0.0599 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5453 0.8508 0.8499
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0423 0.0567 0.07
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0162 0.0155 0.0155
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0443 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0443 0.0599 0.0599
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0463 0.0631 0.0631
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1229 0.1839 0.1839
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.014 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1295 0.1944 0.194
Loa Loa (eye worm) phosphatidylinositol 3 0.0749 0.1082 0.1077
Loa Loa (eye worm) hypothetical protein 0.0806 0.1171 0.1166
Schistosoma mansoni voltage-gated potassium channel 0.0253 0.0299 0.0294
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0553 0.0773 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.1718 0.2612 0.2567
Trichomonas vaginalis PIKK family atypical protein kinase 0.3803 0.5902 0.5877
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0162 0.0155 0.0155
Echinococcus multilocularis fk506 binding protein 0.0162 0.0155 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0567 0.0509
Trichomonas vaginalis conserved hypothetical protein 0.0806 0.1171 0.1117
Schistosoma mansoni immunophilin 0.0162 0.0155 0.015
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2174 0.3331 0.329
Trichomonas vaginalis PIKK family atypical protein kinase 0.6398 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0443 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0483 0.0662 0.0662
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6398 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0443 0.0599 0.045
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0067 0.0005 0.0005
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2669 0.4112 0.4076
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0567 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.2174 0.3331 0.329
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0443 0.0599 0.0599
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0096 0.0051 0.0045
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6398 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0423 0.0567 0.0567
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.079 0.1146 0.1146
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0423 0.0567 0.0562
Leishmania major phosphatidylinositol 3-kinase, putative 0.2174 0.3331 0.3226
Loa Loa (eye worm) hypothetical protein 0.1229 0.1839 0.1834
Leishmania major phosphatidylinositol kinase related protein, putative 0.0423 0.0567 0.0418
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0423 0.0567 0.9474
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0443 0.0599 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0241 0.0182
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0162 0.0155 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0423 0.0567 0.0567
Schistosoma mansoni voltage-gated potassium channel 0.0253 0.0299 0.0294
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0615 0.087 0.087
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0162 0.0155 0.0155
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5103 0.7955 0.7923
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.9474
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0044 0.0044
Echinococcus multilocularis rac serine:threonine kinase 0.007 0.001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1229 0.1839 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.477 0.7429 0.7413
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0423 0.0567 0.0567
Loa Loa (eye worm) AGC/AKT protein kinase 0.0102 0.0061 0.0055
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0423 0.0567 0.0567
Onchocerca volvulus 0.0423 0.0567 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0483 0.0662 0.0662
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0545 0.076 0.076
Loa Loa (eye worm) phosphatidylinositol 3 0.6398 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0192 0.0203 0.0203
Giardia lamblia GTOR 0.6398 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0162 0.0155 0.2597
Schistosoma mansoni immunophilin 0.0162 0.0155 0.015
Trypanosoma cruzi target of rapamycin kinase 3 0.5103 0.7955 0.7955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0806 0.1171 0.1171
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0423 0.0567 0.07
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1229 0.1839 0.1789
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.0567 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.6398 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0443 0.0599 0.0599
Toxoplasma gondii FATC domain-containing protein 0.1229 0.1839 0.2423
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0443 0.0599 0.0593
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2225 0.3411 0.3411
Mycobacterium tuberculosis Conserved hypothetical protein 0.0423 0.0567 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3824 0.5937 0.5912
Trichomonas vaginalis PIKK family atypical protein kinase 0.3469 0.5376 0.5348

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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