Detailed information for compound 1635443

Basic information

Technical information
  • TDR Targets ID: 1635443
  • Name: N,N'-bis[3-(2-chloroethyl-ethylamino)-5-(dime thylaminomethyl)phenyl]-1-methylpyrazole-3,5- dicarboxamide
  • MW: 645.666 | Formula: C32H46Cl2N8O2
  • H donors: 2 H acceptors: 3 LogP: 4.4 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 2
  • SMILES: ClCCN(c1cc(cc(c1)CN(C)C)NC(=O)c1cc(n(n1)C)C(=O)Nc1cc(CN(C)C)cc(c1)N(CCCl)CC)CC
  • InChi: 1S/C32H46Cl2N8O2/c1-8-41(12-10-33)27-16-23(21-38(3)4)14-25(18-27)35-31(43)29-20-30(40(7)37-29)32(44)36-26-15-24(22-39(5)6)17-28(19-26)42(9-2)13-11-34/h14-20H,8-13,21-22H2,1-7H3,(H,35,43)(H,36,44)
  • InChiKey: FLUPBKABXMFGEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N'-bis[3-(2-chloroethyl-ethyl-amino)-5-(dimethylaminomethyl)phenyl]-1-methyl-pyrazole-3,5-dicarboxamide
  • NCI60_026629

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0018 0.0005
Schistosoma mansoni immunophilin 0.0061 0.0105 0.0105
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4396 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0284 0.0614 0.0601
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0284 0.0614 0.0614
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4396 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0284 0.0614 0.0614
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.2627 0.5962 0.5962
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1474 0.3331 0.3331
Leishmania major phosphatidylinositol 3-kinase, putative 0.1474 0.3331 0.3261
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0284 0.0614 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3496 0.7947 0.7947
Trichomonas vaginalis PIKK family atypical protein kinase 0.1474 0.3331 0.3331
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0016 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Loa Loa (eye worm) phosphatidylinositol 3 0.0284 0.0614 0.0614
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0284 0.0614 0.0614
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0061 0.0105 0.1521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1474 0.3331 0.3331
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0831 0.1864 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3496 0.7947 0.7947
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0284 0.0614 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0831 0.1864 0.183
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0284 0.0614 0.0574
Loa Loa (eye worm) phosphatidylinositol 3 0.0284 0.0614 0.0614
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0105 0.0091
Entamoeba histolytica hypothetical protein 0.0284 0.0614 0.0601
Trypanosoma cruzi Protein kinase B 0.0023 0.0018 0.0005
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0284 0.0614 0.0601
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0016 0.0016
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0137 0.0137
Leishmania major phosphatidylinositol kinase related protein, putative 0.0284 0.0614 0.0514
Trypanosoma brucei target of rapamycin kinase 3, putative 0.35 0.7955 0.7947
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0284 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0016 0.0016
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0061 0.0105 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0284 0.0614 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2079 0.4711 0.4689
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.3496 0.7947 0.7947
Loa Loa (eye worm) hypothetical protein 0.0284 0.0614 0.0614
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0284 0.0614 0.0614
Loa Loa (eye worm) phosphatidylinositol kinase 0.0284 0.0614 0.0614
Loa Loa (eye worm) phosphatidylinositol 3 0.4396 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0284 0.0614 0.0514
Plasmodium vivax hypothetical protein, conserved 0.0284 0.0614 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0831 0.1864 0.1853
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5384 0.5384
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1474 0.3331 0.3322
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0018 0.0018
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0831 0.1864 0.1853
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0284 0.0614 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0013 0.0013
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0284 0.0614 0.0614
Entamoeba histolytica hypothetical protein 0.0284 0.0614 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1474 0.3331 0.3331
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0018 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Schistosoma mansoni immunophilin 0.0061 0.0105 0.0105
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0137 0.0137
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0284 0.0614 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2854 0.648 0.648
Trichomonas vaginalis PIKK family atypical protein kinase 0.4396 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1474 0.3331 0.3331
Loa Loa (eye worm) hypothetical protein 0.0284 0.0614 0.0614
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0061 0.0105 0.0105
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4396 1 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.0042 0.0042
Echinococcus multilocularis serine protein kinase ATM 0.0831 0.1864 0.1864
Loa Loa (eye worm) hypothetical protein 0.0643 0.1433 0.1433
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0061 0.0105 0.0091
Onchocerca volvulus 0.0284 0.0614 0.5
Entamoeba histolytica protein kinase, putative 0.0033 0.0042 0.0029
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0284 0.0614 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0284 0.0614 0.0614
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0016 0.0016
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0013 0.0013
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0105 0.0063
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0284 0.0614 0.0601
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0105 0.0091
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0284 0.0614 0.0614
Trichomonas vaginalis fk506-binding protein, putative 0.0061 0.0105 0.0105
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0831 0.1864 0.1864
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0284 0.0614 0.0614
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0284 0.0614 0.0614
Entamoeba histolytica hypothetical protein 0.0831 0.1864 0.1853
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0831 0.1864 0.1864
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1474 0.3331 0.3261
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0601
Loa Loa (eye worm) hypothetical protein 0.0065 0.0115 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.3496 0.7947 0.7947
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5384 0.5384
Trichomonas vaginalis PIKK family atypical protein kinase 0.237 0.5376 0.5376
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0574
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Giardia lamblia Hypothetical protein 0.0284 0.0614 0.0601
Leishmania major phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0831 0.1864 0.1864
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0926 0.2081 0.2081
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0284 0.0614 0.0601
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0643 0.1433 0.1433
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4396 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0061 0.0105 0.0105
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0284 0.0614 0.078
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.2949 0.6697 0.6697
Toxoplasma gondii target of rapamycin (TOR), putative 0.3269 0.7429 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0126 0.0126
Schistosoma mansoni hypothetical protein 0.0643 0.1433 0.1433
Leishmania major hypothetical protein, unknown function 0.0284 0.0614 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0037 0.0037
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0284 0.0614 0.0614
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0284 0.0614 0.0614
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0284 0.0614 0.078
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0284 0.0614 0.0614
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0284 0.0614 0.0601
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0061 0.0105 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0284 0.0614 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0284 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0033 0.0042 0.0029
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4396 1 1
Loa Loa (eye worm) hypothetical protein 0.0926 0.2081 0.2081
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0105 0.0091
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0018 0.0005
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0926 0.2081 0.2765
Schistosoma mansoni immunophilin 0.0052 0.0086 0.0086
Trichomonas vaginalis immunophilin, putative 0.0061 0.0105 0.0105
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0018 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0284 0.0614 0.0614
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0137 0.0137
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0284 0.0614 0.0614
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0831 0.1864 0.1864
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.1474 0.3331 0.3331
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1474 0.3331 0.3322
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1474 0.3331 0.3331
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0284 0.0614 0.0601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0831 0.1864 0.1864
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4396 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0061 0.0105 0.5
Loa Loa (eye worm) hypothetical protein 0.0831 0.1864 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.0643 0.1433 0.1433
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0013 0.0013
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0284 0.0614 0.0574
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0284 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0052 0.0086 0.0086
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0037 0.0037
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0105 0.0091
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0284 0.0614 0.0614
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0574
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0105 0.0105
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0284 0.0614 0.0614
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4396 1 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0831 0.1864 0.1864
Echinococcus multilocularis 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5384 0.5384
Trichomonas vaginalis PIKK family atypical protein kinase 0.237 0.5376 0.5376
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0284 0.0614 0.0614
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0284 0.0614 0.0614
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0614
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0061 0.0105 0.0091
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0284 0.0614 0.0614
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0284 0.0614 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2601 0.5902 0.5902
Echinococcus multilocularis fk506 binding protein 0.0061 0.0105 0.0105
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2627 0.5962 0.5962
Brugia malayi FAT domain containing protein 0.0643 0.1433 0.1433
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0548 0.1217 0.1217
Trichomonas vaginalis PIKK family atypical protein kinase 0.3753 0.8533 0.8533
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0284 0.0614 0.0601
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0061 0.0105 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.4396 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.1474 0.3331 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0284 0.0614 0.0614
Entamoeba histolytica hypothetical protein 0.0284 0.0614 0.0601
Plasmodium vivax hypothetical protein 0.0284 0.0614 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5384 0.5384
Toxoplasma gondii FATC domain-containing protein 0.0831 0.1864 0.2471
Trichomonas vaginalis PIKK family atypical protein kinase 0.3496 0.7947 0.7947
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0643 0.1433 0.1433
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0284 0.0614 0.078
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0061 0.0105 0.0105
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0016 0.0016
Echinococcus granulosus nervana 2 0.002 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.1179 0.2658 0.2658
Trichomonas vaginalis PIKK family atypical protein kinase 0.2601 0.5902 0.5902
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0153 0.0153
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0284 0.0614 0.0601
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0896 0.2011 0.2011
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0284 0.0614 0.0614
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0548 0.1217 0.1205
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0831 0.1864 0.1864
Echinococcus multilocularis nervana 2 0.002 0.0013 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0284 0.0614 0.0614
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1474 0.3331 0.3303
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0042 0.0042
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1826 0.4134 0.4109
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0284 0.0614 0.0601
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4396 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0013 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0284 0.0614 0.078
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0018 0.0018
Onchocerca volvulus 0.0284 0.0614 0.5
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1474 0.3331 0.3303
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0061 0.0105 0.0105
Giardia lamblia GTOR 0.4396 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0548 0.1217 0.1217
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0061 0.0105 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0284 0.0614 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0061 0.0105 0.0105
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0284 0.0614 0.0614
Echinococcus multilocularis Zinc finger, PHD finger 0.0284 0.0614 0.0614
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0153 0.0153
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0013 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0284 0.0614 0.078
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0016 0.0016
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0126 0.0126
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0284 0.0614 0.0601
Entamoeba histolytica protein kinase rad3, putative 0.0831 0.1864 0.1853
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0284 0.0614 0.0601
Leishmania major hypothetical protein, conserved 0.0284 0.0614 0.0514
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1474 0.3331 0.3331
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0284 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4396 1 1
Echinococcus granulosus nervana 2 0.002 0.0013 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0284 0.0614 0.0614
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0061 0.0105 0.1521
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4396 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4396 1 1
Echinococcus multilocularis nervana 2 0.002 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Leishmania major phosphatidylinositol kinase, putative 0.0284 0.0614 0.0514
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0284 0.0614 0.0614
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0284 0.0614 0.0601
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.3269 0.7429 0.7429
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0042 0.0042
Entamoeba histolytica protein kinase, putative 0.0031 0.0037 0.0024
Echinococcus granulosus serine protein kinase ATM 0.0831 0.1864 0.1864
Loa Loa (eye worm) FKBP5 protein 0.0061 0.0105 0.0105
Trypanosoma cruzi target of rapamycin kinase 3 0.35 0.7955 0.7952
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0284 0.0614 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2627 0.5962 0.5962
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0284 0.0614 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.237 0.5376 0.5376
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0284 0.0614 0.0614
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0284 0.0614 0.0614
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4396 1 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0831 0.1864 0.1864
Loa Loa (eye worm) phosphatidylinositol 3 0.1474 0.3331 0.3331
Loa Loa (eye worm) phosphatidylinositol 3 0.0284 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0548 0.1217 0.1217
Leishmania major phosphatidylinositol 4-kinase, putative 0.0284 0.0614 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0831 0.1864 0.1864
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.35 0.7955 0.7934
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0061 0.0105 0.0105
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0061 0.0105 0.0091

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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