Detailed information for compound 1635450

Basic information

Technical information
  • TDR Targets ID: 1635450
  • Name: 1-(4-fluorophenyl)-4-(7-fluoro-1,3,4,5-tetrah ydropyrido[4,3-b]indol-2-yl)butan-1-one
  • MW: 354.393 | Formula: C21H20F2N2O
  • H donors: 1 H acceptors: 1 LogP: 3.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)CCCN1CCc2c(C1)c1ccc(cc1[nH]2)F
  • InChi: 1S/C21H20F2N2O/c22-15-5-3-14(4-6-15)21(26)2-1-10-25-11-9-19-18(13-25)17-8-7-16(23)12-20(17)24-19/h3-8,12,24H,1-2,9-11,13H2
  • InChiKey: OMLJBRXRJHEWQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCI60_022517
  • 1-(4-Fluorophenyl)-4-(7-fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-1-butanone hydrochloride
  • AIDS-158247
  • AIDS158247
  • NSC665306 (HYDROCHLORIDE SALT)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.1793 0.3327 0.3275
Trichomonas vaginalis PIKK family atypical protein kinase 0.3415 0.6447 0.6419
Schistosoma mansoni immunophilin 0.0113 0.0095 0.0081
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.037 0.0589 0.0588
Loa Loa (eye worm) phosphatidylinositol 3 0.035 0.055 0.0538
Schistosoma mansoni voltage-gated potassium channel 0.0166 0.0197 0.0183
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.035 0.055 0.055
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.037 0.0589 1
Schistosoma mansoni immunophilin 0.0098 0.0065 0.0051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5263 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5263 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0113 0.0095 0.1592
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1804 0.3348 0.3297
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0411 0.0667 0.0595
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0473 0.0787 0.0728
Loa Loa (eye worm) hypothetical protein 0.0098 0.0065 0.0053
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.0095 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.7946 0.793
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.037 0.0589 0.0577
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2482 0.4651 0.461
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0411 0.0667 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.2861 0.5381 0.5346
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.035 0.055 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.1828 0.1765
Echinococcus granulosus serine threonine protein kinase nrc 0.0064 0.0001 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1804 0.3348 0.3284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0411 0.0667 0.0607
Giardia lamblia GTOR 0.5263 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.035 0.055 0.0538
Leishmania major phosphatidylinositol 3-kinase, putative 0.037 0.0589 0.0499
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1014 0.1828 0.1828
Mycobacterium leprae conserved hypothetical protein 0.035 0.055 0.5
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.035 0.055 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0502 0.0844 0.0843
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0095 0.0094
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.037 0.0589 0.0517
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.035 0.055 0.0489
Trypanosoma cruzi Protein kinase B 0.0071 0.0014 0.0012
Schistosoma mansoni hypothetical protein 0.035 0.055 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.7946 0.793
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1014 0.1828 0.1765
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.035 0.055 0.9343
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1014 0.1828 0.1775
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4199 0.7954 0.7938
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0071 0.0014 0.0012
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.037 0.0589 0.0589
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.035 0.055 0.0549
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0152 0.017 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0411 0.0667 0.0666
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5263 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0411 0.0667 0.0666
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1844 0.3425 0.3424
Trichomonas vaginalis PIKK family atypical protein kinase 0.3146 0.5928 0.5897
Schistosoma mansoni voltage-gated potassium channel 0.0166 0.0197 0.0183
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5263 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.035 0.055 0.055
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0113 0.0095 0.0019
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0064 0.0001 0.0001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0473 0.0787 0.0787
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1844 0.3425 0.3425
Leishmania major hypothetical protein, conserved 0.0442 0.0728 0.0639
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0113 0.0095 0.0031
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1844 0.3425 0.3424
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.037 0.0589 0.0713
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0097 0.0064 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.7946 0.793
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.035 0.055 0.0478
Leishmania major phosphatidylinositol 3-kinase, putative 0.1793 0.3327 0.3263
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.035 0.055 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Leishmania major phosphatidylinositol kinase, putative 0.035 0.055 0.046
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.037 0.0589 0.0517
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.037 0.0589 0.0588
Toxoplasma gondii target of rapamycin (TOR), putative 0.3925 0.7427 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.035 0.055 0.0537
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.035 0.055 0.0549
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0014 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1129 0.2049 0.2696
Trichomonas vaginalis PIKK family atypical protein kinase 0.5263 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0113 0.0095 0.0094
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0113 0.0095 0.0083
Giardia lamblia Phosphatidylinositol 4-kinase 0.035 0.055 0.0549
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0543 0.0922 0.0852
Entamoeba histolytica protein kinase, putative 0.0103 0.0076 0.0075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0543 0.0922 0.0921
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0055 0.0054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.035 0.055 0.0489
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5263 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0095 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.1025 0.1849 0.1786
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.035 0.055 0.0537
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0543 0.0922 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.055 0.0478
Schistosoma mansoni hypothetical protein 0.0779 0.1376 0.1365
Leishmania major phosphatidylinositol kinase related protein, putative 0.035 0.055 0.046
Loa Loa (eye worm) hypothetical protein 0.1129 0.2049 0.2039
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0152 0.017 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.035 0.055 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.353 0.6668 0.6643
Trichomonas vaginalis conserved hypothetical protein 0.0779 0.1376 0.131
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.035 0.055 0.0549
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.037 0.0589 0.0499
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.061 0.1051 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1014 0.1828 0.1827
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0113 0.0095 0.0094
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.044 0.0724 0.0723
Loa Loa (eye worm) hypothetical protein 0.0132 0.0131 0.0119
Loa Loa (eye worm) hypothetical protein 0.0473 0.0787 0.0776
Schistosoma mansoni fkbp-rapamycin associated protein 0.1014 0.1828 0.1817
Trichomonas vaginalis PIKK family atypical protein kinase 0.2861 0.5381 0.5346
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.7946 0.793
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.035 0.055 0.0489
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.0151 0.0075
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.035 0.055 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.2857 0.5373 0.5337
Plasmodium vivax hypothetical protein 0.035 0.055 0.9343
Trichomonas vaginalis PIKK family atypical protein kinase 0.1804 0.3348 0.3297
Loa Loa (eye worm) hypothetical protein 0.1014 0.1828 0.1818
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0098 0.0065 0.0065
Onchocerca volvulus 0.035 0.055 0.5
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0779 0.1376 0.1376
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1025 0.1849 0.1848
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0481 0.0802 0.0732
Echinococcus multilocularis fk506 binding protein 0.0113 0.0095 0.0095
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0095 0.0019
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.035 0.055 0.0478
Schistosoma mansoni immunophilin 0.0113 0.0095 0.0081
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0481 0.0802 0.0732
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0193 0.0249 0.0248
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0719 0.126 0.1248
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0664 0.1155 0.1154
Loa Loa (eye worm) hypothetical protein 0.1064 0.1924 0.1913
Entamoeba histolytica protein kinase, putative 0.0103 0.0076 0.0075
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0113 0.0095 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.3131 0.59 0.5868
Trichomonas vaginalis PIKK family atypical protein kinase 0.1414 0.2596 0.254
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.039 0.0629 0.0627
Entamoeba histolytica protein kinase rad3, putative 0.1014 0.1828 0.1827
Loa Loa (eye worm) phosphatidylinositol 3 0.035 0.055 0.0538
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0543 0.0922 0.0921
Echinococcus multilocularis 0.035 0.055 0.055
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.037 0.0589 0.0588
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.037 0.0589 0.0576
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.035 0.055 0.0478
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0095 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.4483 0.8501 0.849
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.037 0.0589 0.0589
Loa Loa (eye worm) phosphatidylinositol 3 0.1804 0.3348 0.3339
Trichomonas vaginalis PIKK family atypical protein kinase 0.5263 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.037 0.0589 0.0589
Entamoeba histolytica hypothetical protein 0.035 0.055 0.0549
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.037 0.0589 0.0517
Loa Loa (eye worm) hypothetical protein 0.0779 0.1376 0.1366
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.7946 0.793
Trichomonas vaginalis PIKK family atypical protein kinase 0.2861 0.5381 0.5346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0664 0.1155 0.1087
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1014 0.1828 0.1828
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5263 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Entamoeba histolytica hypothetical protein 0.035 0.055 0.0549
Trichomonas vaginalis fk506-binding protein, putative 0.0113 0.0095 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.2861 0.5381 0.5346
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.061 0.1051 0.1051
Echinococcus multilocularis serine protein kinase ATM 0.1014 0.1828 0.1828
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0113 0.0095 0.0094
Giardia lamblia Hypothetical protein 0.035 0.055 0.0549
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0014 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0543 0.0922 0.0921
Brugia malayi Protein kinase domain containing protein 0.0103 0.0076 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0411 0.0667 0.0595
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.035 0.055 0.0537
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0543 0.0922 0.0852
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.037 0.0589 0.0589
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0719 0.126 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.3146 0.5928 0.5897
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0779 0.1376 0.1376
Trichomonas vaginalis immunophilin, putative 0.0113 0.0095 0.0019
Loa Loa (eye worm) hypothetical protein 0.0664 0.1155 0.1144
Entamoeba histolytica hypothetical protein 0.0502 0.0844 0.0843
Entamoeba histolytica hypothetical protein 0.035 0.055 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.2857 0.5373 0.5337
Trichomonas vaginalis PIKK family atypical protein kinase 0.3131 0.59 0.5868
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.035 0.055 0.0661
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0113 0.0095 0.1592
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0411 0.0667 0.0595
Echinococcus granulosus serine protein kinase ATM 0.1014 0.1828 0.1828
Loa Loa (eye worm) AGC/AKT protein kinase 0.0103 0.0076 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.1793 0.3327 0.3275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1844 0.3425 0.3383
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0113 0.0095 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.1129 0.2049 0.1988
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0064 0.0001 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.035 0.055 0.055
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0152 0.017 0.017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0432 0.0709 0.0708
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0113 0.0095 0.0095
Loa Loa (eye worm) FKBP5 protein 0.0113 0.0095 0.0083
Brugia malayi FAT domain containing protein 0.0779 0.1376 0.1321
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.035 0.055 0.9343
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1014 0.1828 0.1775
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.035 0.055 0.0661
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1844 0.3425 0.3425
Trichomonas vaginalis PIKK family atypical protein kinase 0.1014 0.1828 0.1765
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.0095 0.0095
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5263 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.037 0.0589 0.0517
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1844 0.3425 0.3416
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1014 0.1828 0.1827
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5263 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.037 0.0589 1
Loa Loa (eye worm) hypothetical protein 0.035 0.055 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.2857 0.5373 0.5337
Loa Loa (eye worm) phosphatidylinositol kinase 0.035 0.055 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.3146 0.5928 0.5897
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4199 0.7954 0.7934
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0113 0.0095 0.0094
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0113 0.0095 0.5
Entamoeba histolytica hypothetical protein 0.1014 0.1828 0.1827
Leishmania major hypothetical protein, unknown function 0.035 0.055 0.046
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0719 0.126 0.126
Loa Loa (eye worm) phosphatidylinositol 3 0.5263 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0473 0.0787 0.0787
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0411 0.0667 0.0654
Mycobacterium tuberculosis Conserved hypothetical protein 0.035 0.055 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0098 0.0065 0.0065
Plasmodium vivax hypothetical protein, conserved 0.035 0.055 0.9343
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5263 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.0151 0.0075
Toxoplasma gondii FATC domain-containing protein 0.1014 0.1828 0.2395
Echinococcus multilocularis rac serine:threonine kinase 0.0071 0.0014 0.0014
Echinococcus granulosus serine/threonine protein kinase 0.0071 0.0014 0.0014
Leishmania major phosphatidylinositol 4-kinase, putative 0.035 0.055 0.046
Trypanosoma cruzi target of rapamycin kinase 3 0.4199 0.7954 0.7954
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0113 0.0095 0.5
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.035 0.055 0.9343
Trichomonas vaginalis PIKK family atypical protein kinase 0.3925 0.7427 0.7407
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0152 0.017 0.0158
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.037 0.0589 0.0528
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0543 0.0922 0.0864
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0176 0.0215 0.0152
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.035 0.055 0.0549
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0095 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0664 0.1155 0.1087
Loa Loa (eye worm) phosphatidylinositol 3 0.035 0.055 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.5263 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.035 0.055 0.0549
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1014 0.1828 0.1817
Plasmodium falciparum phosphatidylinositol 4-kinase 0.035 0.055 0.9343
Trichomonas vaginalis PIKK family atypical protein kinase 0.1793 0.3327 0.3275
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.035 0.055 0.9343
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.037 0.0589 0.0588
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5263 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0411 0.0667 0.0595
Entamoeba histolytica protein kinase, putative 0.0097 0.0064 0.0063
Schistosoma mansoni phosphatidylinositol 4-kinase 0.037 0.0589 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.1793 0.3327 0.3275
Onchocerca volvulus 0.035 0.055 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2197 0.4104 0.4058
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.055 0.0478
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0095 0.0094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.037 0.0589 0.0713
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5263 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0113 0.0095 0.0019
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1793 0.3327 0.3275
Loa Loa (eye worm) phosphatidylinositol 3 0.0678 0.1181 0.117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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