Detailed information for compound 1637046

Basic information

Technical information
  • TDR Targets ID: 1637046
  • Name: 2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)h ydrazinylidene)-2-phenylacetic acid
  • MW: 260.292 | Formula: C13H16N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.17 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C(=N\N(C1=NCCCN1)C)/c1ccccc1
  • InChi: 1S/C13H16N4O2/c1-17(13-14-8-5-9-15-13)16-11(12(18)19)10-6-3-2-4-7-10/h2-4,6-7H,5,8-9H2,1H3,(H,14,15)(H,18,19)/b16-11-
  • InChiKey: QOZFMRQOYJEEPI-WJDWOHSUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazinylidene)-2-phenylacetic acid
  • (2Z)-2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazono)-2-phenyl-acetic acid
  • 2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazono)-2-phenyl-acetic acid
  • (2Z)-2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazono)-2-phenylacetic acid
  • 2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazono)-2-phenylacetic acid
  • (2Z)-2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazinylidene)-2-phenyl-ethanoic acid
  • 2-(methyl-(1,4,5,6-tetrahydropyrimidin-2-yl)hydrazinylidene)-2-phenyl-ethanoic acid
  • AIDS-158708
  • AIDS158708
  • NSC676141 (HYDROIODIDE SALT)
  • (Methyl(1,4,5,6-tetrahydro-2-pyrimidinyl)hydrazono)(phenyl)acetic acid hydroiodide
  • NCI60_026868

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0067 0.0181
Leishmania major hypothetical protein, conserved 0.0041 0.009 0.0244
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0015 0.0034
Schistosoma mansoni importin beta-1 0.003 0.0062 0.0059
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0003 0.0005
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0048 0.0334
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.3774
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0007
Schistosoma mansoni cpg binding protein 0.0022 0.004 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0003 0.0005
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0001
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0003 0.0002
Mycobacterium tuberculosis Conserved protein 0.0041 0.009 0.0182
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0103 0.0101
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0207 0.0513 0.2717
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0207 0.0513 0.0512
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0743 0.1885 0.5271
Entamoeba histolytica hypothetical protein 0.0025 0.0047 0.9805
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0207 0.0513 0.2717
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.009 0.047
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0003 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0536 0.1355 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.009 0.0087
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0743 0.1885 0.1883
Loa Loa (eye worm) hypothetical protein 0.0207 0.0513 0.0512
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis conserved hypothetical protein 0.0536 0.1355 0.2473
Leishmania major GTP-binding protein, putative 0.0022 0.0041 0.0108
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0048 0.0091
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0536 0.1355 0.2741
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Onchocerca volvulus 0.0037 0.0079 0.8701
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0085 0.0232
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2146 0.5474 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0037 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0048 0.0091
Plasmodium falciparum GAF domain-related protein, putative 0.0536 0.1355 1
Trichomonas vaginalis conserved hypothetical protein 0.0536 0.1355 0.2473
Mycobacterium ulcerans putative regulatory protein 0.0536 0.1355 0.2737
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0207 0.0513 1
Plasmodium falciparum importin beta, putative 0.003 0.0062 0.0436
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.009 0.016
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.009 0.0182
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0012 0.0015 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.009 0.0244
Schistosoma mansoni survival motor neuron protein 0.0037 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0036
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0047 0.0081
Brugia malayi beta-lactamase family protein 0.0041 0.009 0.0089
Loa Loa (eye worm) CXXC zinc finger family protein 0.0022 0.004 0.0039
Brugia malayi CXXC zinc finger family protein 0.0022 0.004 0.0039
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0207 0.0513 0.143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0046
Leishmania major importin beta-1 subunit, putative 0.0025 0.0047 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0232 0.0577 0.1608
Plasmodium vivax importin-beta 2, putative 0.003 0.0062 0.0436
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.0513 0.143
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0041 0.0211
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0082 0.0081
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0207 0.0513 0.0512
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0743 0.1885 0.1884
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0049
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0015 0.0072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0032 0.0064
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0207 0.0513 0.2717
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2146 0.5474 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Echinococcus granulosus intermediate filament protein 0.0021 0.0037 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.2146 0.5474 1
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0015 0.0014
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0743 0.1885 0.344
Loa Loa (eye worm) hypothetical protein 0.0207 0.0513 0.0512
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.0015 0.0091
Echinococcus granulosus lamin dm0 0.0021 0.0037 0.0189
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0048 0.0047
Trichomonas vaginalis esterase, putative 0.0041 0.009 0.016
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0015 0.0091
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2146 0.5474 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0047 0.0124
Toxoplasma gondii GAF domain-containing protein 0.0536 0.1355 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0062 0.0436
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1939 0.4945 1
Loa Loa (eye worm) hypothetical protein 0.3914 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0743 0.1885 0.5271
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0037 0.0079 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0059
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.161 0.4103 0.7493
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.0933
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0067 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0046
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0041 0.0211
Leishmania major cAMP-specific phosphodiesterase, putative 0.0207 0.0513 0.143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.009 0.016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Echinococcus granulosus lamin 0.0021 0.0037 0.0189
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0015 0.0091
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0067 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0005
Entamoeba histolytica Ran family GTPase 0.0022 0.0041 0.8515
Leishmania major mitochondrial DNA polymerase beta 0.0232 0.0577 0.1608
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0041 0.0284
Loa Loa (eye worm) hypothetical protein 0.0038 0.0082 0.008
Schistosoma mansoni hypothetical protein 0.0026 0.0051 0.0048
Mycobacterium tuberculosis Conserved hypothetical protein 0.0122 0.0296 0.0599
Mycobacterium ulcerans beta-lactamase 0.0041 0.009 0.0177
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0207 0.0513 0.0512
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0012
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0207 0.0513 0.2717
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.0284
Echinococcus granulosus snurportin 1 0.0324 0.0813 0.431
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0015 0.0072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Onchocerca volvulus 0.0022 0.004 0.4312
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0012 0.0011
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0032 0.0214
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.0933
Onchocerca volvulus 0.0041 0.009 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0015 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.0661 0.1338
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0015 0.0072
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0743 0.1885 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Loa Loa (eye worm) PDE1B protein 0.0207 0.0513 0.0512
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.3774
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0015 0.0072
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0207 0.0513 0.2717
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0003 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.009 0.0244
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0012
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0743 0.1885 1
Mycobacterium ulcerans hypothetical protein 0.0122 0.0296 0.0594
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.009 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0041 0.009 0.0645
Loa Loa (eye worm) beta-lactamase 0.0041 0.009 0.0089
Brugia malayi isocitrate dehydrogenase 0.0012 0.0015 0.0014
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1939 0.4945 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.009 0.016
Trichomonas vaginalis ran, putative 0.0022 0.0041 0.007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0082 0.0081
Echinococcus multilocularis snurportin 1 0.0324 0.0813 0.431
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0048 0.0126
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0207 0.0513 0.143
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Schistosoma mansoni hypothetical protein 0.0037 0.0079 0.0076
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0048 0.0126
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0032 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0015 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0048 0.0126
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0207 0.0513 0.2717
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0207 0.0513 0.2717
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0032 0.5
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.3774
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0232 0.0577 0.1608
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0015 0.0072
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0743 0.1885 0.5271
Echinococcus multilocularis lamin 0.0021 0.0037 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0008
Giardia lamblia hypothetical protein 0.0207 0.0513 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.0015 0.0034
Brugia malayi RNA, U transporter 1 0.0086 0.0205 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0062 0.0165
Plasmodium falciparum phosphodiesterase delta, putative 0.0207 0.0513 0.3774
Trichomonas vaginalis conserved hypothetical protein 0.0536 0.1355 0.2473
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0037 0.0036
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0003 0.0005
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0207 0.0513 0.2717
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0015 0.0072
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0015 0.0014
Plasmodium falciparum phosphodiesterase gamma, putative 0.0207 0.0513 0.3774
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.1403 0.3573 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0048 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.009 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.009 0.0244
Leishmania major hypothetical protein, conserved 0.0207 0.0513 0.143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0014
Echinococcus granulosus GPCR family 2 0.0012 0.0015 0.0072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Trichomonas vaginalis conserved hypothetical protein 0.0536 0.1355 0.2473
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.009 0.0087
Echinococcus granulosus dnaJ subfamily B 0.0314 0.0787 0.4172
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0082 0.008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0048 0.0091
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Toxoplasma gondii ABC1 family protein 0.0041 0.009 0.0645
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0015 0.0034
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0207 0.0513 0.0511
Echinococcus multilocularis dnaJ subfamily B 0.0314 0.0787 0.4172
Schistosoma mansoni cpg binding protein 0.0023 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0003 0.0002
Echinococcus multilocularis cpg binding protein 0.0023 0.0043 0.0224
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Onchocerca volvulus 0.0021 0.0037 0.3918
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0743 0.1885 0.5271
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0015 0.0072
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0743 0.1885 0.344
Loa Loa (eye worm) hypothetical protein 0.0536 0.1355 0.1354
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0003 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0048 0.0334
Plasmodium vivax hypothetical protein, conserved 0.0041 0.009 0.0645
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.004
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.009 0.0182
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0048 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0207 0.0513 0.143
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.3914 1 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0062 0.0165
Loa Loa (eye worm) hypothetical protein 0.0181 0.0448 0.0447
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0048 0.0091
Mycobacterium ulcerans hypothetical protein 0.0025 0.0048 0.0091
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.143
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.001 0.0009 0.0043
Echinococcus granulosus cytoplasmic intermediate filament protein 0.001 0.0009 0.0043
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0207 0.0513 0.143
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0207 0.0513 0.3774
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Loa Loa (eye worm) oxidoreductase 0.0007 0.0003 0.0001
Toxoplasma gondii hypothetical protein 0.0536 0.1355 1
Schistosoma mansoni ran 0.0022 0.0041 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0048 0.0097
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Brugia malayi intermediate filament protein 0.0021 0.0037 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.009 0.047
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Mycobacterium tuberculosis Conserved protein 0.0041 0.009 0.0182
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0002
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0743 0.1885 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0207 0.0513 0.0512
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.0933
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0265 0.0734
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.009 0.0182
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Leishmania major hypothetical protein, conserved 0.0207 0.0513 0.143
Onchocerca volvulus 0.0021 0.0037 0.3918
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0003 0.0005
Echinococcus multilocularis musashi 0.0021 0.0037 0.0189
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0048 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0743 0.1885 0.5271
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Mycobacterium leprae Probable lipase LipE 0.0041 0.009 0.0645
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.161 0.4103 0.7493
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0207 0.0513 0.143
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.009 0.0177
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0015 0.0014
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.3774
Plasmodium vivax hypothetical protein, conserved 0.0536 0.1355 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0091 0.0651
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0015 0.0014
Echinococcus multilocularis GPCR, family 2 0.0012 0.0015 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0062 0.006
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0207 0.0513 0.2717
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0207 0.0513 0.0933
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.0015 0.0034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Toxoplasma gondii hypothetical protein 0.0536 0.1355 1
Giardia lamblia Hypothetical protein 0.0207 0.0513 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.143
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0048 0.0047
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.009 0.0177
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0207 0.0513 0.0512
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0108
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0015 0.0072
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0047 0.0081
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0048 0.0097
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.009 0.0182
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0059
Onchocerca volvulus 0.0025 0.0048 0.5168
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0015 0.0014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0003 0.0007
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Schistosoma mansoni ran 0.0022 0.0041 0.0038
Schistosoma mansoni cpg binding protein 0.0023 0.0043 0.0041
Leishmania major hypothetical protein, conserved 0.1403 0.3573 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0207 0.0513 0.2717
Brugia malayi cytoplasmic intermediate filament protein 0.0011 0.0012 0.0011
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0513 0.0933
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Echinococcus multilocularis lamin dm0 0.0021 0.0037 0.0189
Echinococcus granulosus importin subunit beta 1 0.003 0.0062 0.032
Schistosoma mansoni lamin 0.0021 0.0037 0.0034
Mycobacterium ulcerans putative regulatory protein 0.0536 0.1355 0.2737
Mycobacterium tuberculosis Conserved hypothetical protein 0.1403 0.3573 0.7226
Brugia malayi hypothetical protein 0.0181 0.0448 0.0447
Onchocerca volvulus 0.0041 0.009 1
Echinococcus granulosus cpg binding protein 0.0023 0.0043 0.0224
Schistosoma mansoni hypothetical protein 0.0012 0.0015 0.0012
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0005
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.009 0.0182
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.0015 0.0091
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0041 0.0284
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0048 0.0091
Toxoplasma gondii hypothetical protein 0.0536 0.1355 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0089
Echinococcus granulosus survival motor neuron protein 1 0.0181 0.0448 0.2373
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.011 0.0265 0.0734
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0067 0.0181
Toxoplasma gondii hypothetical protein 0.0037 0.008 0.0568
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0207 0.0513 0.143
Loa Loa (eye worm) hypothetical protein 0.0207 0.0513 0.0512
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1403 0.3573 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0003 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0051 0.005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0265 0.0734
Plasmodium vivax phosphodiesterase gamma, putative 0.0207 0.0513 0.3774
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0048 0.0091
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0207 0.0513 0.0933
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0207 0.0513 0.2717
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0743 0.1885 0.344
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0015 0.0072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0046
Schistosoma mansoni lamin 0.0021 0.0037 0.0034
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0207 0.0513 0.0933
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0003 0.0007
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0207 0.0513 0.143
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1403 0.3573 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0041 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0181 0.0448 0.2373
Mycobacterium ulcerans lipase LipD 0.0041 0.009 0.0177
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0035
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0207 0.0513 0.3774
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0207 0.0513 0.0933
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0032 0.0059
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0048 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.009 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0207 0.0513 0.3774
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.009 0.016
Onchocerca volvulus 0.0041 0.009 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0743 0.1885 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0207 0.0513 0.2717
Brugia malayi beta-lactamase family protein 0.0041 0.009 0.0089
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.009 0.0182
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0232 0.0577 0.1608
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0207 0.0513 0.143
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0813 0.0812
Mycobacterium tuberculosis Conserved protein 0.0041 0.009 0.0182
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0015 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0207 0.0513 0.0933
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0059
Schistosoma mansoni intermediate filament proteins 0.0021 0.0037 0.0034
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0037 0.0036
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0047 0.0081
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0207 0.0513 0.0933
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0207 0.0513 0.0933
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0003 0.0005
Brugia malayi Importin beta-1 subunit 0.003 0.0062 0.006
Schistosoma mansoni hypothetical protein 0.0314 0.0787 0.0785
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0207 0.0513 0.0511
Brugia malayi beta-lactamase 0.0041 0.009 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.003
Schistosoma mansoni hypothetical protein 0.0324 0.0813 0.0811
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0513 0.143
Echinococcus multilocularis importin subunit beta 1 0.003 0.0062 0.032
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0622 0.1576 0.8362
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0001
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0041 0.0108
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.0933
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0207 0.0513 0.0511
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0743 0.1885 0.344
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0207 0.0513 0.3774

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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