Detailed information for compound 1638257

Basic information

Technical information
  • TDR Targets ID: 1638257
  • Name: spiro[1,3-dihydroindene-2,6'-2,3,5,7-tetrahyd ro-s-indacene]-1'-one
  • MW: 274.356 | Formula: C20H18O
  • H donors: 0 H acceptors: 1 LogP: 4.07 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c1cc1CC3(Cc1c2)Cc1c(C3)cccc1
  • InChi: 1S/C20H18O/c21-19-6-5-13-7-16-11-20(12-17(16)8-18(13)19)9-14-3-1-2-4-15(14)10-20/h1-4,7-8H,5-6,9-12H2
  • InChiKey: ISLTYRHFOQTLHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • spiro[2,3,5,7-tetrahydro-s-indacene-6,2'-indane]-1-one
  • 1-spiro[2,3,5,7-tetrahydro-s-indacene-6,2'-indane]one
  • AIDS145554
  • NSC670404
  • Spiro[s-indacene-2(5H),2'-[2H]inden]-5-one, 1,1',3,3',6,7-hexahydro-
  • NCI60_024786
  • AIDS-145554

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0054 0.083 0.0822
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi jmjC domain containing protein 0.0107 0.1873 0.1865
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Mycobacterium ulcerans lipase LipD 0.004 0.0558 0.0905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0132 0.0123
Brugia malayi PHD-finger family protein 0.0033 0.0406 0.0397
Echinococcus multilocularis sodium channel protein 0.0151 0.2746 0.3654
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0558 0.0742
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0473 0.7566
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0013 0.5
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0138 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1272 0.1693
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0558 0.0905
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium vivax CDK-related protein kinase 6, putative 0.051 0.9831 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.2134 0.284
Loa Loa (eye worm) sugar transporter 0.0017 0.0095 0.0086
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Loa Loa (eye worm) fibroinase 0.0019 0.0132 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0406 0.0488
Onchocerca volvulus 0.0017 0.0095 0.0086
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0406 0.0488
Brugia malayi RNA binding protein 0.0076 0.1272 0.1264
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0095 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0558 0.0549
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0095 0.0136
Onchocerca volvulus 0.0019 0.0132 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1272 0.1264
Onchocerca volvulus Putative transporter 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0019 0.0132 0.0123
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0591 0.0779
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0363 0.042
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0497 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0132 0.0203
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0497 0.081
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0924
Brugia malayi hypothetical protein 0.003 0.0363 0.0353
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0095 0.0127
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0138 0.0091
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0363 0.2482
Echinococcus granulosus tumor protein p63 0.0393 0.7514 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0558 0.0905
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0542 0.0721
Schistosoma mansoni glutaminase 0.0318 0.6033 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0132 0.0175
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0558 0.0973
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0558 0.091
Entamoeba histolytica protein kinase, putative 0.0037 0.0488 0.3614
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Loa Loa (eye worm) beta-lactamase 0.004 0.0558 0.0549
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0291 0.0387
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Onchocerca volvulus 0.0017 0.0095 0.0086
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0489 0.0404
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0488 0.0479
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0558 0.0742
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0365 0.0486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Mycobacterium leprae Probable lipase LipE 0.004 0.0558 1
Brugia malayi beta-lactamase family protein 0.004 0.0558 0.0549
Brugia malayi Bromodomain containing protein 0.0033 0.0406 0.0397
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0095 0.0127
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0291 0.0387
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0558 0.091
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0489 0.0404
Loa Loa (eye worm) ctsf protein 0.0019 0.0132 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0017 0.0095 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0406 0.0541
Onchocerca volvulus 0.0019 0.0132 0.0123
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1272 0.1264
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi jmjC domain containing protein 0.004 0.0542 0.0533
Trichomonas vaginalis set domain proteins, putative 0.0252 0.4736 0.7847
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0291 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Mycobacterium ulcerans hypothetical protein 0.004 0.0558 0.0905
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0519 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0389 0.0461
Trypanosoma cruzi hexose transporter 0.0037 0.0497 0.3735
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0138 0.04
Loa Loa (eye worm) glutaminase 0.0318 0.6033 0.603
Loa Loa (eye worm) hypothetical protein 0.0037 0.0488 0.0479
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0194 0.3595 0.3595
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0132 0.0123
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0473 0.063
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0489 0.0617
Onchocerca volvulus 0.0019 0.0132 0.0123
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.1872
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.1272 0.1693
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0057 0.0896 0.0888
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus granulosus cathepsin l1 0.0019 0.0132 0.0175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0389 0.0379
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0489 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0542 0.0721
Loa Loa (eye worm) hypothetical protein 0.0056 0.0867 0.0858
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0054 0.083 0.1105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Onchocerca volvulus 0.0019 0.0132 0.0123
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4132 0.4127
Echinococcus multilocularis geminin 0.0205 0.3801 0.5059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0031 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0473 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0132 0.0038
Brugia malayi beta-lactamase family protein 0.004 0.0558 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Brugia malayi Pre-SET motif family protein 0.0032 0.0389 0.0379
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0132 0.0038
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0489 0.0617
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Schistosoma mansoni transcription factor LCR-F1 0.008 0.1334 0.2199
Loa Loa (eye worm) glutaminase 2 0.0318 0.6033 0.603
Echinococcus granulosus cathepsin l1 0.0013 0.0009 0.0013
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0211 0.0244
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0054 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0132 0.0123
Echinococcus granulosus General substrate transporter 0.0103 0.1801 0.2396
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0473 0.0464
Toxoplasma gondii cathepsin CPL 0.0019 0.0132 0.0058
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.4848 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0558 0.0973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0443 0.059
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Brugia malayi Sugar transporter family protein 0.0017 0.0095 0.0086
Echinococcus granulosus sodium channel protein 0.0151 0.2746 0.3654
Plasmodium vivax vivapain-2 0.0019 0.0132 0.0038
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0406 0.0319
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.0163
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Loa Loa (eye worm) cysteine protease 0.0019 0.0132 0.0123
Trichomonas vaginalis glutaminase, putative 0.0318 0.6033 1
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Schistosoma mansoni glucose transporter 0.0017 0.0095 0.0142
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Brugia malayi hypothetical protein 0.008 0.1334 0.1326
Plasmodium falciparum hexose transporter 0.012 0.2134 0.2094
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0291 0.5182
Schistosoma mansoni hypothetical protein 0.0205 0.3801 0.6295
Mycobacterium ulcerans glutaminase 0.0318 0.6033 1
Onchocerca volvulus 0.0017 0.0095 0.0086
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0291 0.182
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0095 0.0086
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0138 0.0214
Trypanosoma cruzi hexose transporter, putative 0.002 0.0164 0.0637
Brugia malayi Sugar transporter family protein 0.012 0.2134 0.2127
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0095 0.0136
Brugia malayi TAR-binding protein 0.0076 0.1272 0.1264
Schistosoma mansoni hypothetical protein 0.0014 0.0031 0.0036
Leishmania major hypothetical protein, conserved 0.003 0.0363 0.1009
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1172 1
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Onchocerca volvulus 0.0017 0.0095 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0558 0.0973
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0489 0.0404
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0132 0.0203
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0558 0.0973
Loa Loa (eye worm) hypothetical protein 0.0054 0.083 0.0822
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0542 0.0884
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1093 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0226 0.0359
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.083 0.1105
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0473 0.0464
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0473 0.077
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi major facilitator superfamily protein 0.0017 0.0095 0.0086
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0132 0.0203
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0488 0.065
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0363 0.0275
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0389 0.0517
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Toxoplasma gondii ABC1 family protein 0.004 0.0558 0.0726
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0054 0.083 0.1105
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0291 1
Loa Loa (eye worm) sugar transporter 0.012 0.2134 0.2127
Trypanosoma brucei glucose transporter 2A 0.0037 0.0497 0.3735
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1873 0.2492
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0488 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni hypothetical protein 0.0033 0.0406 0.0659
Onchocerca volvulus 0.0017 0.0095 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0138 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0443 0.059
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0497 0.1517
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0132 0.034
Plasmodium falciparum phd finger protein, putative 0.0033 0.0406 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.1872
Brugia malayi hypothetical protein 0.002 0.015 0.014
Brugia malayi MH2 domain containing protein 0.0144 0.2608 0.2601
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0389 0.0629
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0095 0.0136
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0591 0.051
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0497 0.081
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0389 0.0517
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0132 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.012 0.2134 0.3527
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Echinococcus granulosus peregrin 0.0033 0.0406 0.0541
Brugia malayi Pre-SET motif family protein 0.0221 0.4132 0.4127
Trichomonas vaginalis esterase, putative 0.004 0.0558 0.091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Leishmania major glucose transporter, lmgt2 0.0037 0.0497 0.1517
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0017 0.0095 0.0086
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0095 0.0127
Schistosoma mansoni hypothetical protein 0.012 0.2134 0.3527
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0095 0.0142
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0497 0.081
Plasmodium falciparum protein kinase 6 0.051 0.9831 1
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0027 0.0291 0.0282
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0132 0.0123
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0406 0.0541
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0558 0.0549
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi major facilitator superfamily protein 0.0017 0.0095 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0542 0.0884
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.083 0.0822
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Plasmodium vivax hypothetical protein, conserved 0.004 0.0558 0.0475
Echinococcus granulosus geminin 0.0205 0.3801 0.5059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major glucose transporter, lmgt3 0.0037 0.0497 0.1517
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0171 0.3139 0.3133
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Onchocerca volvulus Alhambra homolog 0.0033 0.0406 0.0397
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0542 0.0533
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0291 0.2305
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium falciparum mitogen-activated protein kinase 2 0.0194 0.3595 0.3595
Onchocerca volvulus 0.004 0.0558 0.0549
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1873 0.2492
Onchocerca volvulus 0.0032 0.0389 0.0379
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0363 0.2482
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0095 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0138 0.0129
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0138 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus granulosus GPCR family 2 0.0054 0.083 0.1105
Brugia malayi isocitrate dehydrogenase 0.0019 0.0138 0.0129
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0363 0.0275
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0659 0.0877
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0095 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0138 0.0044
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.087 0.7197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0171 0.3139 0.3133
Plasmodium vivax SET domain protein, putative 0.0032 0.0389 0.0301
Trypanosoma brucei glucose transporter 1E 0.0037 0.0497 0.3735
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Loa Loa (eye worm) RNA binding protein 0.0076 0.1272 0.1264
Onchocerca volvulus 0.0017 0.0095 0.0086
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0489 0.0404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0171 0.3139 0.3133
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0558 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0558 0.4294
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.04
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0132 0.0123
Echinococcus multilocularis cysteine protease 0.0019 0.0132 0.0175
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0138 0.0184
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Echinococcus multilocularis tumor protein p63 0.0393 0.7514 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Brugia malayi latrophilin 2 splice variant baaae 0.0117 0.2071 0.2063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0138 0.04
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0489 0.0404
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.04
Brugia malayi beta-lactamase 0.004 0.0558 0.0549
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0363 0.0275
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0291 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0291 0.0282
Loa Loa (eye worm) hypothetical protein 0.0171 0.3139 0.3133
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Leishmania major glucose transporter, lmgt1 0.0037 0.0497 0.1517
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Schistosoma mansoni hypothetical protein 0.0117 0.2071 0.3422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0033 0.0406 0.0397
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0132 0.0924
Brugia malayi glutaminase DH11.1 0.0318 0.6033 0.603
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.105 0.8864
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0138 0.0068
Echinococcus multilocularis GPCR, family 2 0.0054 0.083 0.1105
Onchocerca volvulus 0.0017 0.0095 0.0086
Echinococcus multilocularis General substrate transporter 0.0103 0.1801 0.2396
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0151 0.2746 0.3654
Onchocerca volvulus 0.0017 0.0095 0.0086
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0291 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Plasmodium vivax vivapain-2 0.0019 0.0132 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Entamoeba histolytica hypothetical protein 0.0027 0.0291 0.2127
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Schistosoma mansoni hypothetical protein 0.0205 0.3801 0.6295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0151 0.2746 1
Onchocerca volvulus 0.0017 0.0095 0.0086
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Onchocerca volvulus 0.0019 0.0132 0.0123
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0406 0.0397
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0558 0.4294
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0489 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0132 0.0203
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0291 0.0462
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0291 0.0468
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0363 0.2482
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0291 0.0308
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0558 0.091
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.083 0.1105
Toxoplasma gondii protein kinase, putative 0.034 0.6465 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0132 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0019 0.0132 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Entamoeba histolytica protein kinase, putative 0.0037 0.0488 0.3614
Mycobacterium ulcerans sugar transporter 0.0017 0.0095 0.0136
Onchocerca volvulus 0.004 0.0558 0.0549
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0488 0.3648
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Onchocerca volvulus 0.0017 0.0095 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0558 0.4294
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0591 0.051
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.1334 0.1775
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0489 0.0617
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0031 0.0041
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0291 0.0462
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0558 0.0973
Schistosoma mansoni jumonji domain containing protein 0.0085 0.1439 0.2373
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0896 0.1472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0488 0.0795
Echinococcus multilocularis cysteine protease 0.0019 0.0132 0.0175
Plasmodium falciparum protein kinase 7 0.034 0.6465 0.6542
Onchocerca volvulus 0.0519 1 1
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.2134 0.3201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0473 0.063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0473 0.0464
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2608 0.2601
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0489 0.0404
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Giardia lamblia PHD finger protein 15 0.0033 0.0406 0.8224
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0473 0.0464
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.1334 0.1775
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0291 0.182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0558 0.091
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0473 0.077
Onchocerca volvulus 0.004 0.0558 0.0549
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Onchocerca volvulus 0.0252 0.4736 0.4731
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1272 0.1264
Loa Loa (eye worm) hypothetical protein 0.003 0.0363 0.0353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Leishmania major hypothetical protein, conserved 0.004 0.0558 0.1745
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0389 0.0517
Loa Loa (eye worm) hypothetical protein 0.0057 0.0896 0.0888
Onchocerca volvulus 0.0017 0.0095 0.0086
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0132 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0291 0.0739
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0331
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0132 0.0138
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Leishmania major protein kinase, putative 0.0037 0.0488 0.1482
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0132 0.0924
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Mycobacterium ulcerans beta-lactamase 0.004 0.0558 0.0905
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0406 0.0659
Plasmodium vivax hexose transporter 0.012 0.2134 0.2094
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0473 0.3503
Onchocerca volvulus 0.0017 0.0095 0.0086
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) hypothetical protein 0.0117 0.2071 0.2063
Mycobacterium leprae conserved hypothetical protein 0.004 0.0558 1
Echinococcus multilocularis peregrin 0.0033 0.0406 0.0541
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0095 0.0142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0138 0.0044
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0194 0.3595 0.5495
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0558 0.0973
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0132 0.0175
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0473 0.077
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Brugia malayi Cam kinase protein 1 0.0037 0.0488 0.0479
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.083 0.0822
Schistosoma mansoni hypothetical protein 0.008 0.1334 0.2199
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0211 0.0244
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0488 0.0795
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0489 0.0404
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2608 0.2601
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0291 0.0468
Brugia malayi Sugar transporter family protein 0.0017 0.0095 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0659 0.0877
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.666 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.615 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.396 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.239 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.199 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.04 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.774 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.704 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.701 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.682 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.571 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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