Detailed information for compound 1638472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.975 | Formula: C28H24ClN5O2
  • H donors: 3 H acceptors: 3 LogP: 4.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=C(C(N1)c1cn(nc1c1ccc(cc1)Cl)c1ccccc1)C(=O)Nc1ccc(cc1)C)C
  • InChi: 1S/C28H24ClN5O2/c1-17-8-14-21(15-9-17)31-27(35)24-18(2)30-28(36)32-26(24)23-16-34(22-6-4-3-5-7-22)33-25(23)19-10-12-20(29)13-11-19/h3-16,26H,1-2H3,(H,31,35)(H2,30,32,36)
  • InChiKey: XBRPOHQJDKCOJN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3489 0.7955 0.7947
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0283 0.0613 0.0613
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0017 0.0005
Leishmania major phosphatidylinositol kinase related protein, putative 0.0283 0.0613 0.0516
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0138 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.0613 0.0613
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0102 0.009
Entamoeba histolytica hypothetical protein 0.0283 0.0613 0.0602
Trypanosoma cruzi Protein kinase B 0.0022 0.0017 0.0005
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0283 0.0613 0.0602
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0829 0.1864 0.1854
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0283 0.0613 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3486 0.7947 0.7947
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0829 0.1864 0.1831
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0283 0.0613 0.0575
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0017 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.147 0.3331 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.147 0.3331 0.3331
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0283 0.0613 0.0613
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0059 0.0102 0.1493
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.0613 0.0613
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Leishmania major phosphatidylinositol 3-kinase, putative 0.147 0.3331 0.3262
Trichomonas vaginalis PIKK family atypical protein kinase 0.3486 0.7947 0.7947
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0283 0.0613 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0283 0.0613 0.0613
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.0613 0.0613
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4382 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0138 0.0138
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.147 0.3331 0.3331
Trichomonas vaginalis PIKK family atypical protein kinase 0.2619 0.5962 0.5962
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0017 0.0017
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4382 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Schistosoma mansoni immunophilin 0.0059 0.0102 0.0102
Giardia lamblia Phosphatidylinositol 4-kinase 0.0283 0.0613 0.0602
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4382 1 1
Brugia malayi Protein kinase domain containing protein 0.0033 0.004 0.004
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0017 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.4382 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.147 0.3331 0.3331
Loa Loa (eye worm) hypothetical protein 0.0283 0.0613 0.0613
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0059 0.0102 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.147 0.3331 0.3331
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.2845 0.648 0.648
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0138 0.0138
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0283 0.0613 1
Schistosoma mansoni immunophilin 0.0059 0.0102 0.0102
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0283 0.0613 0.0613
Entamoeba histolytica hypothetical protein 0.0283 0.0613 0.0602
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.2366 0.5384 0.5384
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.147 0.3331 0.3323
Echinococcus granulosus nervana 2 0.002 0.0012 0.0012
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0283 0.0613 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0829 0.1864 0.1854
Loa Loa (eye worm) phosphatidylinositol kinase 0.0283 0.0613 0.0613
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0283 0.0613 0.0613
Loa Loa (eye worm) phosphatidylinositol 3 0.4382 1 1
Loa Loa (eye worm) hypothetical protein 0.0283 0.0613 0.0613
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0283 0.0613 0.0516
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0829 0.1864 0.1854
Plasmodium vivax hypothetical protein, conserved 0.0283 0.0613 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0059 0.0102 0.0102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0283 0.0613 0.5
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0283 0.0613 0.0613
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2073 0.4711 0.469
Trichomonas vaginalis PIKK family atypical protein kinase 0.3486 0.7947 0.7947
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0016 0.0016
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.3486 0.7947 0.7947
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.2366 0.5384 0.5384
Loa Loa (eye worm) hypothetical protein 0.0065 0.0116 0.0116
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.2363 0.5376 0.5376
Leishmania major phosphatidylinositol 3-related kinase, putative 0.147 0.3331 0.3262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0829 0.1864 0.1864
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.0613 0.0613
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0283 0.0613 0.0613
Entamoeba histolytica hypothetical protein 0.0829 0.1864 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0102 0.009
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0283 0.0613 0.0602
Trichomonas vaginalis fk506-binding protein, putative 0.0059 0.0102 0.0102
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.0613 0.0613
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0829 0.1864 0.1864
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0017 0.0005
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0102 0.0062
Echinococcus multilocularis nervana 2 0.002 0.0012 0.0012
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0283 0.0613 0.0613
Entamoeba histolytica protein kinase, putative 0.0033 0.004 0.0028
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0283 0.0613 1
Loa Loa (eye worm) hypothetical protein 0.0641 0.1433 0.1433
Echinococcus multilocularis serine protein kinase ATM 0.0829 0.1864 0.1864
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0059 0.0102 0.009
Onchocerca volvulus 0.0283 0.0613 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4382 1 1
Loa Loa (eye worm) hypothetical protein 0.0924 0.208 0.208
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0102 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0613 0.0613
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0059 0.0102 0.009
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0283 0.0613 0.0602
Mycobacterium leprae conserved hypothetical protein 0.0283 0.0613 0.5
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0283 0.0613 0.0613
Entamoeba histolytica protein kinase, putative 0.0033 0.004 0.0028
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0283 0.0613 0.0602
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.0613 0.0781
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0283 0.0613 0.0613
Leishmania major hypothetical protein, unknown function 0.0283 0.0613 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0036 0.0036
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.294 0.6697 0.6697
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0283 0.0613 0.0613
Toxoplasma gondii target of rapamycin (TOR), putative 0.3259 0.7429 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0641 0.1433 0.1433
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.0613 0.0781
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4382 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0059 0.0102 0.0102
Leishmania major phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0516
Giardia lamblia Hypothetical protein 0.0283 0.0613 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0829 0.1864 0.1864
Trichomonas vaginalis conserved hypothetical protein 0.0924 0.208 0.208
Loa Loa (eye worm) hypothetical protein 0.0022 0.0016 0.0016
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0641 0.1433 0.1433
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0283 0.0613 0.0602
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0602
Brugia malayi FAT domain containing protein 0.0641 0.1433 0.1433
Trichomonas vaginalis PIKK family atypical protein kinase 0.2619 0.5962 0.5962
Trichomonas vaginalis conserved hypothetical protein 0.0546 0.1216 0.1216
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.2363 0.5376 0.5376
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0059 0.0102 0.009
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0283 0.0613 0.0613
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0613
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0283 0.0613 0.0613
Echinococcus multilocularis fk506 binding protein 0.0059 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.2593 0.5902 0.5902
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0283 0.0613 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4382 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0283 0.0613 0.0613
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0102 0.0102
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0829 0.1864 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.2366 0.5384 0.5384
Echinococcus multilocularis 0.0283 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0051 0.0083 0.0083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0283 0.0613 0.0613
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0283 0.0613 0.0613
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0102 0.009
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0641 0.1433 0.1433
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0283 0.0613 0.0575
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0283 0.0613 0.0602
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.147 0.3331 0.3331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0829 0.1864 0.1864
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4382 1 1
Loa Loa (eye worm) hypothetical protein 0.0829 0.1864 0.1864
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0059 0.0102 0.5
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0829 0.1864 0.1864
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.147 0.3331 0.3331
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0102 0.0102
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.147 0.3331 0.3323
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0017 0.0017
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0924 0.208 0.2766
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0017 0.0017
Schistosoma mansoni immunophilin 0.0051 0.0083 0.0083
Trichomonas vaginalis immunophilin, putative 0.0059 0.0102 0.0102
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0283 0.0613 0.0613
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0138 0.0138
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0283 0.0613 0.0613
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0829 0.1864 0.1864
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0012 0.0012
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0012 0.0012
Echinococcus multilocularis nervana 2 0.002 0.0012 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0154 0.0154
Entamoeba histolytica hypothetical protein 0.0283 0.0613 0.0602
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0283 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.0893 0.2011 0.2011
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0083 0.0083
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0546 0.1216 0.1205
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0016 0.0016
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0102 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.1176 0.2658 0.2658
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.2593 0.5902 0.5902
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.0613 0.0781
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0641 0.1433 0.1433
Trichomonas vaginalis PIKK family atypical protein kinase 0.3486 0.7947 0.7947
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.2366 0.5384 0.5384
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Toxoplasma gondii FATC domain-containing protein 0.0829 0.1864 0.2472
Entamoeba histolytica hypothetical protein 0.0283 0.0613 0.0602
Plasmodium vivax hypothetical protein 0.0283 0.0613 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3742 0.8533 0.8533
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0283 0.0613 0.0613
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0283 0.0613 0.0602
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0102 0.0062
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.4382 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.147 0.3331 0.3331
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0016 0.0016
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0283 0.0613 0.0613
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4382 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0283 0.0613 0.0613
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0012 0.0012
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0283 0.0613 0.0602
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Entamoeba histolytica protein kinase rad3, putative 0.0829 0.1864 0.1854
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.147 0.3331 0.3331
Leishmania major hypothetical protein, conserved 0.0283 0.0613 0.0516
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0127 0.0127
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.0613 0.0781
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0016 0.0016
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0059 0.0102 0.0102
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0154 0.0154
Echinococcus multilocularis Zinc finger, PHD finger 0.0283 0.0613 0.0613
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0283 0.0613 0.0613
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0012 0.0012
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0059 0.0102 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0283 0.0613 1
Giardia lamblia GTOR 0.4382 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.147 0.3331 0.3304
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0102 0.0102
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0546 0.1216 0.1216
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4382 1 1
Echinococcus granulosus nervana 2 0.002 0.0012 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0016 0.0016
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0283 0.0613 0.0781
Onchocerca volvulus 0.0283 0.0613 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0283 0.0613 0.0602
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.147 0.3331 0.3304
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.004 0.004
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.182 0.4134 0.411
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0283 0.0613 0.0602
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3489 0.7955 0.7934
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0059 0.0102 0.0102
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0102 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0829 0.1864 0.1864
Loa Loa (eye worm) hypothetical protein 0.0546 0.1216 0.1216
Leishmania major phosphatidylinositol 4-kinase, putative 0.0283 0.0613 0.0516
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0283 0.0613 0.0613
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4382 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Loa Loa (eye worm) phosphatidylinositol 3 0.147 0.3331 0.3331
Loa Loa (eye worm) phosphatidylinositol 3 0.0283 0.0613 0.0613
Schistosoma mansoni fkbp-rapamycin associated protein 0.0829 0.1864 0.1864
Trichomonas vaginalis PIKK family atypical protein kinase 0.2619 0.5962 0.5962
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.2363 0.5376 0.5376
Echinococcus granulosus serine protein kinase ATM 0.0829 0.1864 0.1864
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Entamoeba histolytica protein kinase, putative 0.0031 0.0036 0.0023
Trypanosoma cruzi target of rapamycin kinase 3 0.3489 0.7955 0.7953
Loa Loa (eye worm) FKBP5 protein 0.0059 0.0102 0.0102
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0283 0.0613 0.0602
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0283 0.0613 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3259 0.7429 0.7429
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0012 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.4382 1 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.004 0.004
Leishmania major phosphatidylinositol kinase, putative 0.0283 0.0613 0.0516
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0283 0.0613 0.0602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0283 0.0613 0.0613
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0283 0.0613 0.0613
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4382 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0102 0.1493

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 69.7 uM Growth inhibition of human MCF7 cells after 24 hrs by SRB assay ChEMBL. 22437116
MIC (functional) = 32 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv after 5 days by microplate Alamar blue assay ChEMBL. 22437116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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