Detailed information for compound 1638473

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 514.041 | Formula: C28H24ClN5OS
  • H donors: 3 H acceptors: 2 LogP: 5.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: S=C1NC(=C(C(N1)c1cn(nc1c1ccc(cc1)Cl)c1ccccc1)C(=O)Nc1ccc(cc1)C)C
  • InChi: 1S/C28H24ClN5OS/c1-17-8-14-21(15-9-17)31-27(35)24-18(2)30-28(36)32-26(24)23-16-34(22-6-4-3-5-7-22)33-25(23)19-10-12-20(29)13-11-19/h3-16,26H,1-2H3,(H,31,35)(H2,30,32,36)
  • InChiKey: XLIKRYWSHQCOKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.121 0.2642 0.2642
Trichomonas vaginalis PIKK family atypical protein kinase 0.2667 0.5893 0.5893
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0091 0.0015
Echinococcus multilocularis nervana 2 0.0041 0.0034 0.002
Loa Loa (eye worm) hypothetical protein 0.0919 0.1993 0.1981
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0291 0.0592 0.0592
Echinococcus multilocularis fk506 binding protein 0.0059 0.0076 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0562 0.1197 0.1197
Schistosoma mansoni voltage-gated potassium channel 0.012 0.021 0.0196
Entamoeba histolytica hypothetical protein 0.0291 0.0592 0.0559
Toxoplasma gondii FATC domain-containing protein 0.0853 0.1845 0.2402
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0041 0.0036 0.0021
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.0592 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.4508 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0291 0.0592 0.0592
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.3316 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.3849 0.853 0.853
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0291 0.0592 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.0592 0.0695
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0291 0.0592 0.0559
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0291 0.0592 0.0579
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0291 0.0592 0.0579
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0853 0.1845 0.1845
Trichomonas vaginalis PIKK family atypical protein kinase 0.2434 0.5374 0.5374
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Mycobacterium leprae conserved hypothetical protein 0.0291 0.0592 0.5
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.0559
Loa Loa (eye worm) hypothetical protein 0.0659 0.1414 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.3586 0.7942 0.7942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Leishmania major phosphatidylinositol kinase related protein, putative 0.0291 0.0592 0.052
Giardia lamblia Phosphatidylinositol 4-kinase 0.0291 0.0592 0.0559
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0059 0.0076 0.0062
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.0592 0.0579
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0291 0.0592 0.0579
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0076 0.004
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0045 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0853 0.1845 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.2434 0.5374 0.5374
Giardia lamblia Hypothetical protein 0.0291 0.0592 0.0559
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4508 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0076 0.004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0291 0.0592 0.0579
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.0592 0.0579
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0291 0.0592 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2667 0.5893 0.5893
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.2431 0.5365 0.5365
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0082 0.0068
Echinococcus multilocularis Zinc finger, PHD finger 0.0291 0.0592 0.0579
Entamoeba histolytica hypothetical protein 0.0291 0.0592 0.0559
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0659 0.1414 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.2694 0.5953 0.5953
Plasmodium vivax hypothetical protein, conserved 0.0291 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0562 0.1197 0.1184
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0291 0.0592 0.0559
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0045 0.0009
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0059 0.0076 0.0062
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0076 0.0724
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0592 0.0592
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.011 0.0188 0.0174
Echinococcus granulosus serine/threonine protein kinase 0.0045 0.0045 0.0031
Loa Loa (eye worm) hypothetical protein 0.095 0.2063 0.2051
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1512 0.3316 0.3265
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0082 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.3316 0.3316
Entamoeba histolytica protein kinase rad3, putative 0.0853 0.1845 0.1816
Schistosoma mansoni immunophilin 0.0059 0.0076 0.0062
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4508 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0853 0.1845 0.1834
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0059 0.0076 0.004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1512 0.3316 0.3292
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.0559
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0853 0.1845 0.1816
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0291 0.0592 1
Trichomonas vaginalis conserved hypothetical protein 0.0659 0.1414 0.1414
Trichomonas vaginalis PIKK family atypical protein kinase 0.2694 0.5953 0.5953
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0291 0.0592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2431 0.5365 0.5365
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0291 0.0592 0.052
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4508 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0291 0.0592 0.0592
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1512 0.3316 0.3292
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0291 0.0592 0.0579
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0853 0.1845 0.1783
Echinococcus granulosus serine protein kinase ATM 0.0853 0.1845 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0562 0.1197 0.1197
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0291 0.0592 1
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0059 0.0076 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.359 0.7951 0.7943
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4508 1 1
Entamoeba histolytica protein kinase, putative 0.0066 0.0091 0.0056
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0059 0.0076 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.052
Onchocerca volvulus 0.0291 0.0592 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0291 0.0592 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.0592 0.0592
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4508 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.3353 0.7423 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.359 0.7951 0.7935
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0091 0.0077
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0291 0.0592 0.0559
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0853 0.1845 0.1816
Schistosoma mansoni immunophilin 0.0051 0.0058 0.0043
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0058 0.0043
Entamoeba histolytica protein kinase, putative 0.0066 0.0091 0.0056
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0291 0.0592 0.0559
Schistosoma mansoni voltage-gated potassium channel 0.012 0.021 0.0196
Leishmania major phosphatidylinositol kinase, putative 0.0291 0.0592 0.052
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0102 0.0172 0.0172
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0034 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.0592 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.3316 0.3316
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0291 0.0592 0.0559
Entamoeba histolytica hypothetical protein 0.0291 0.0592 0.0559
Echinococcus multilocularis serine protein kinase ATM 0.0853 0.1845 0.1834
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.4508 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0291 0.0592 0.0579
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0034 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0291 0.0592 0.0592
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0291 0.0592 0.052
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1873 0.412 0.4075
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.0592 0.0695
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1512 0.3316 0.3306
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0059 0.0076 0.004
Loa Loa (eye worm) phosphatidylinositol kinase 0.0291 0.0592 0.0579
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0041 0.0036 0.0021
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4508 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0045 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0562 0.1197 0.1165
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4508 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1512 0.3316 0.3306
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0076 0.0062
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0291 0.0592 0.0592
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0076 0.0076
Leishmania major hypothetical protein, unknown function 0.0291 0.0592 0.052
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.0592 0.0695
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6472 0.6472
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.011 0.0188 0.0174
Schistosoma mansoni immunophilin 0.0059 0.0076 0.0062
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1512 0.3316 0.3306
Echinococcus granulosus serine threonine protein kinase nrc 0.0041 0.0036 0.0021
Leishmania major phosphatidylinositol 3-kinase, putative 0.1512 0.3316 0.3265
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.0592 0.0579
Trichomonas vaginalis immunophilin, putative 0.0059 0.0076 0.0076
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0045 0.0009
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4508 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4508 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0059 0.0076 0.5
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0034 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2132 0.4699 0.4659
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.3586 0.7942 0.7942
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0059 0.0076 0.0062
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0291 0.0592 0.0579
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0059 0.0076 0.0724
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.052
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0853 0.1845 0.1834
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0291 0.0592 0.0579
Plasmodium vivax hypothetical protein 0.0291 0.0592 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.4508 1 1
Loa Loa (eye worm) hypothetical protein 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.3316 0.3316
Trypanosoma cruzi Protein kinase B 0.0045 0.0045 0.0009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0853 0.1845 0.1845
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0291 0.0592 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.2434 0.5374 0.5374
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0853 0.1845 0.1834
Leishmania major hypothetical protein, conserved 0.0291 0.0592 0.052
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0853 0.1845 0.1816
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.3586 0.7942 0.7942
Echinococcus multilocularis rac serine:threonine kinase 0.0045 0.0045 0.0031
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0291 0.0592 0.0579
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0291 0.0592 0.0592
Entamoeba histolytica hypothetical protein 0.0291 0.0592 0.0559
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Echinococcus granulosus nervana 2 0.0041 0.0034 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0291 0.0592 0.0559
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.011 0.0188 0.0174
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0051 0.0058 0.0043
Trypanosoma brucei target of rapamycin kinase 3, putative 0.359 0.7951 0.7935
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0291 0.0592 0.0579
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0045 0.0031
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.0592 0.0695
Loa Loa (eye worm) phosphatidylinositol 3 0.4508 1 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0059 0.0076 0.004
Echinococcus granulosus potassium voltage gated channel subfamily H 0.011 0.0188 0.0174
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1512 0.3316 0.3265
Trichomonas vaginalis PIKK family atypical protein kinase 0.2694 0.5953 0.5953
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0291 0.0592 0.0592
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4508 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.0592 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.1512 0.3316 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.3586 0.7942 0.7942
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0291 0.0592 0.0579
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.0592 0.0579
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1512 0.3316 0.3306
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0059 0.0076 0.004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0291 0.0592 0.0579
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0059 0.0076 0.0062
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1512 0.3316 0.3265
Echinococcus granulosus nervana 2 0.0041 0.0034 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Loa Loa (eye worm) hypothetical protein 0.0051 0.0058 0.0043
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.0592 0.0579
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0291 0.0592 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.0592 0.0579
Loa Loa (eye worm) hypothetical protein 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Schistosoma mansoni hypothetical protein 0.0291 0.0592 0.0579
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis fk506-binding protein, putative 0.0059 0.0076 0.0076
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.0592 0.0579
Loa Loa (eye worm) FKBP5 protein 0.0059 0.0076 0.0062
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.0592 0.0592
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0059 0.0076 0.0076
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Entamoeba histolytica protein kinase, putative 0.0062 0.0082 0.0047
Giardia lamblia GTOR 0.4508 1 1
Trichomonas vaginalis conserved hypothetical protein 0.095 0.2063 0.2063
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0034 0.002
Toxoplasma gondii non-specific serine/threonine protein kinase 0.095 0.2063 0.2698
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0659 0.1414 0.1402
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0291 0.0592 0.0579
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.0559
Leishmania major phosphatidylinositol 4-kinase, putative 0.0291 0.0592 0.052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0291 0.0592 0.5
Loa Loa (eye worm) hypothetical protein 0.0853 0.1845 0.1834
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4508 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.0592 0.0579
Brugia malayi FAT domain containing protein 0.0659 0.1414 0.1402
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Trichomonas vaginalis PIKK family atypical protein kinase 0.3024 0.6689 0.6689
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0102 0.0172 0.0172
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0853 0.1845 0.1834
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Onchocerca volvulus 0.0291 0.0592 0.5
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0059 0.0076 0.0062
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0291 0.0592 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.3353 0.7423 0.7423
Schistosoma mansoni fkbp-rapamycin associated protein 0.0853 0.1845 0.1834
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.0592 0.0592
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0291 0.0592 0.0579
Loa Loa (eye worm) phosphatidylinositol 3 0.1512 0.3316 0.3306
Entamoeba histolytica hypothetical protein 0.0853 0.1845 0.1816
Trichomonas vaginalis PIKK family atypical protein kinase 0.2431 0.5365 0.5365
Leishmania major phosphatidylinositol 3-kinase, putative 0.0291 0.0592 0.052
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0291 0.0592 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.2434 0.5374 0.5374
Trichomonas vaginalis PIKK family atypical protein kinase 0.3586 0.7942 0.7942
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0291 0.0592 0.0559
Loa Loa (eye worm) hypothetical protein 0.0095 0.0155 0.0141
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0091 0.0091
Echinococcus multilocularis 0.0291 0.0592 0.0579
Schistosoma mansoni hypothetical protein 0.0659 0.1414 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0853 0.1845 0.1845
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0291 0.0592 0.0579
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0059 0.0076 0.004
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0059 0.0076 0.0062
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0291 0.0592 1
Echinococcus multilocularis nervana 2 0.0041 0.0034 0.002
Brugia malayi Protein kinase domain containing protein 0.0066 0.0091 0.0077

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 43.5 uM Growth inhibition of human MCF7 cells after 24 hrs by SRB assay ChEMBL. 22437116
MIC (functional) = 2 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv after 5 days by microplate Alamar blue assay ChEMBL. 22437116

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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