TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.455 | Formula: C19H21N3S
H donors: 0 H acceptors: 0 LogP: 5.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC/N=c/1\nc(n(s1)c1ccccc1)c1ccccc1
InChi: 1S/C19H21N3S/c1-2-3-10-15-20-19-21-18(16-11-6-4-7-12-16)22(23-19)17-13-8-5-9-14-17/h4-9,11-14H,2-3,10,15H2,1H3/b20-19+
InChiKey: HLRCZBSGPVNOHJ-FMQUCBEESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0592
Echinococcus granulosus	nervana 2	0.004	0.0042	0.0042
Toxoplasma gondii	FATC domain-containing protein	0.0833	0.1851	0.24
Trichomonas vaginalis	conserved hypothetical protein	0.0549	0.1203	0.1196
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0061	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0898	0.1998	0.1998
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0284	0.0599	0.0592
Entamoeba histolytica	hypothetical protein	0.0284	0.0599	0.0558
Schistosoma mansoni	voltage-gated potassium channel	0.0082	0.0138	0.0138
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2607	0.5896	0.5893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1182	0.2647	0.2641
Entamoeba histolytica	protein kinase, putative	0.0066	0.01	0.0057
Echinococcus multilocularis	nervana 2	0.004	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0644	0.142	0.142
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3505	0.7944	0.7942
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0833	0.1851	0.1845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Mycobacterium leprae	conserved hypothetical protein	0.0284	0.0599	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.238	0.5377	0.5373
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0284	0.0599	0.0599
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0284	0.0599	0.0558
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1478	0.332	0.3315
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4407	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0284	0.0599	0.0592
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0284	0.0599	0.0693
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3763	0.8531	0.8529
Plasmodium vivax	hypothetical protein, conserved	0.0284	0.0599	1
Loa Loa (eye worm)	hypothetical protein	0.0549	0.1203	0.1203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2633	0.5955	0.5952
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0644	0.142	0.142
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0284	0.0599	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2607	0.5896	0.5893
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0284	0.0599	0.0514
Brugia malayi	Protein kinase domain containing protein	0.0066	0.01	0.01
Loa Loa (eye worm)	phosphatidylinositol 3	0.0284	0.0599	0.0599
Echinococcus multilocularis	Zinc finger, PHD finger	0.0284	0.0599	0.0599
Entamoeba histolytica	hypothetical protein	0.0284	0.0599	0.0558
Brugia malayi	p70 ribosomal S6 kinase beta	0.0062	0.0091	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2376	0.5368	0.5365
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.238	0.5377	0.5373
Giardia lamblia	Hypothetical protein	0.0284	0.0599	0.0558
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0833	0.1851	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0284	0.0599	0.0693
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0061	0.0089	0.0089
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.4407	1	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0284	0.0599	0.0514
Schistosoma mansoni	serine/threonine-protein kinase	0.0045	0.0053	0.0053
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0284	0.0599	0.0599
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0061	0.0089	0.0082
Loa Loa (eye worm)	phosphatidylinositol 3	0.0284	0.0599	0.0599
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0061	0.0089	0.0827
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0284	0.0599	0.0558
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0284	0.0599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0644	0.142	0.1413
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0061	0.0089	0.0082
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0833	0.1851	0.1851
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.4407	1	1
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0833	0.1851	0.1815
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0558
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1478	0.332	0.3291
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1478	0.332	0.3315
Entamoeba histolytica	protein kinase, putative	0.0062	0.0091	0.0047
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1478	0.332	0.326
Echinococcus multilocularis	fk506 binding protein	0.0061	0.0089	0.0089
Entamoeba histolytica	protein kinase rad3, putative	0.0833	0.1851	0.1815
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0284	0.0599	0.0592
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0075	0.0122	0.0122
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0284	0.0599	0.0599
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0061	0.0089	0.0046
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0061	0.0089	0.0089
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0053	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0929	0.2068	0.2068
Echinococcus multilocularis	rac serine:threonine kinase	0.0045	0.0053	0.0053
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.01	0.01
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0061	0.0089	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.3509	0.7952	0.7943
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0284	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0549	0.1203	0.1196
Echinococcus granulosus	serine protein kinase ATM	0.0833	0.1851	0.1851
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0833	0.1851	0.1777
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1478	0.332	0.3291
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0284	0.0599	0.0599
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.4407	1	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0284	0.0599	0.0514
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0284	0.0599	0.0592
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2376	0.5368	0.5365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2633	0.5955	0.5952
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0284	0.0599	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0284	0.0599	0.0558
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.3509	0.7952	0.7933
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0053	0.007	0.007
Schistosoma mansoni	immunophilin	0.0053	0.007	0.007
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0833	0.1851	0.1815
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3278	0.7425	1
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0592
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	1
Onchocerca volvulus		0.0284	0.0599	0.5
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0061	0.0089	0.0089
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0514
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.4407	1	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0066	0.01	0.001
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.4407	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4407	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0284	0.0599	0.0592
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.004	0.0042	0.0042
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1478	0.332	0.3315
Echinococcus multilocularis	serine protein kinase ATM	0.0833	0.1851	0.1851
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0284	0.0599	0.0558
Entamoeba histolytica	hypothetical protein	0.0284	0.0599	0.0558
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0284	0.0599	0.0693
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.004	0.0042	0.0042
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.007	0.0111	0.0103
Leishmania major	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0514
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0284	0.0599	0.0558
Schistosoma mansoni	voltage-gated potassium channel	0.0082	0.0138	0.0138
Entamoeba histolytica	protein kinase, putative	0.0066	0.01	0.0057
Leishmania major	hypothetical protein, unknown function	0.0284	0.0599	0.0514
Trichomonas vaginalis	fk506-binding protein, putative	0.0061	0.0089	0.0082
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0549	0.1203	0.1164
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0284	0.0599	0.0592
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0061	0.0089	0.0827
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1478	0.332	0.332
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.4407	1	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0284	0.0599	0.0599
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0045	0.0053	0.0009
Echinococcus granulosus	nervana 2	0.004	0.0042	0.0042
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.4407	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.183	0.4124	0.4071
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0284	0.0599	0.0514
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0061	0.0089	0.0046
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1478	0.332	0.332
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0284	0.0599	0.0693
Loa Loa (eye worm)	FKBP5 protein	0.0061	0.0089	0.0089
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.4407	1	1
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0061	0.0089	0.0046
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1478	0.332	0.326
Loa Loa (eye worm)	phosphatidylinositol 3	0.0284	0.0599	0.0599
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.4407	1	1
Trypanosoma cruzi	Protein kinase B	0.0045	0.0053	0.0009
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0061	0.0089	0.0046
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0075	0.0122	0.0122
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2861	0.6474	0.6472
Echinococcus granulosus	serine threonine protein kinase nrc	0.0041	0.0043	0.0043
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1478	0.332	0.332
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0284	0.0599	0.0599
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0284	0.0599	0.0693
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0833	0.1851	0.1845
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1478	0.332	0.3315
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0045	0.0053	0.0009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.238	0.5377	0.5373
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0284	0.0599	0.0592
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0284	0.0599	0.0599
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0833	0.1851	0.1851
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0599	0.0599
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0592
Plasmodium vivax	hypothetical protein	0.0284	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4407	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3505	0.7944	0.7942
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2084	0.4703	0.4655
Loa Loa (eye worm)	phosphatidylinositol 3	0.0284	0.0599	0.0599
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0061	0.0089	0.0046
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0284	0.0599	0.0599
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0061	0.0089	0.0046
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0041	0.0043	0.0043
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0053	0.007	0.007
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.3509	0.7952	0.7933
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0075	0.0122	0.0122
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0284	0.0599	0.0558
Echinococcus multilocularis	Glutaredoxin protein 5	0.004	0.0042	0.0042
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0284	0.0599	0.0599
Echinococcus granulosus	serine/threonine protein kinase	0.0045	0.0053	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Entamoeba histolytica	hypothetical protein	0.0284	0.0599	0.0558
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0284	0.0599	0.0592
Leishmania major	hypothetical protein, conserved	0.0284	0.0599	0.0514
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0833	0.1851	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3505	0.7944	0.7942
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0284	0.0599	0.0558
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0833	0.1851	0.1815
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0061	0.0089	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0284	0.0599	0.0599
Loa Loa (eye worm)	phosphatidylinositol 3	0.0284	0.0599	0.0599
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1478	0.332	0.332
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0061	0.0089	0.0046
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0041	0.0043	0.0043
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1478	0.332	0.326
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3505	0.7944	0.7942
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1478	0.332	0.3315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2633	0.5955	0.5952
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1478	0.332	0.326
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0075	0.0122	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0284	0.0599	0.0592
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.4407	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0284	0.0599	0.0592
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0284	0.0599	0.0599
Schistosoma mansoni	immunophilin	0.0061	0.0089	0.0089
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Loa Loa (eye worm)	phosphatidylinositol 3	0.4407	1	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0045	0.0053	0.0053
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0062	0.0091	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.2068	0.2062
Giardia lamblia	GTOR	0.4407	1	1
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0061	0.0089	0.0089
Trichomonas vaginalis	immunophilin, putative	0.0061	0.0089	0.0082
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0284	0.0599	0.0599
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0061	0.0089	0.0089
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0284	0.0599	0.0599
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.0599	0.0599
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0284	0.0599	1
Schistosoma mansoni	hypothetical protein	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Loa Loa (eye worm)	hypothetical protein	0.0053	0.007	0.007
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0284	0.0599	0.0599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0558
Brugia malayi	FAT domain containing protein	0.0644	0.142	0.142
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.007	0.0111	0.0103
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2956	0.6691	0.6689
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0284	0.0599	0.0599
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0284	0.0599	0.0599
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.4407	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0284	0.0599	0.0599
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0644	0.142	0.142
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0929	0.2068	0.2696
Echinococcus granulosus	Glutaredoxin protein 5	0.004	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0833	0.1851	0.1851
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	0.0514
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0284	0.0599	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2376	0.5368	0.5365
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0284	0.0599	0.0514
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Trichomonas vaginalis	PIKK family atypical protein kinase	0.238	0.5377	0.5373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3505	0.7944	0.7942
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0284	0.0599	0.0558
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0558
Entamoeba histolytica	hypothetical protein	0.0833	0.1851	0.1815
Loa Loa (eye worm)	phosphatidylinositol 3	0.1478	0.332	0.332
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0833	0.1851	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3278	0.7425	0.7423
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0284	0.0599	0.0599
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0284	0.0599	0.0592
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0833	0.1851	0.1851
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0284	0.0599	0.0599
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0061	0.0089	0.0089
Onchocerca volvulus		0.0284	0.0599	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.01	0.0092
Echinococcus multilocularis	nervana 2	0.004	0.0042	0.0042
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0284	0.0599	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0061	0.0089	0.0046
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0284	0.0599	0.0599
Schistosoma mansoni	immunophilin	0.0061	0.0089	0.0089
Echinococcus multilocularis		0.0284	0.0599	0.0599
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0099	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0833	0.1851	0.1845
Schistosoma mansoni	hypothetical protein	0.0644	0.142	0.142

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2027979

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1638487