TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 385.633 | Formula: C10H10ClN5NaO6P
H donors: 3 H acceptors: 6 LogP: -1.6 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: OC1C2OP(=O)([O-])OCC2OC1n1c(Cl)nc2c1ncnc2N.[Na+]
InChi: 1S/C10H11ClN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1
InChiKey: NAYRKCVLBMVLNQ-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nervana 2	0.0063	0.0032	0.0024
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0113	0.0099	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2021	0.2645	0.2645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4456	0.5895	0.5895
Schistosoma mansoni	voltage-gated potassium channel	0.017	0.0174	0.0167
Onchocerca volvulus		0.0486	0.0596	0.5
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0596
Loa Loa (eye worm)	hypothetical protein	0.1535	0.1996	0.199
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0939	0.12	0.1193
Echinococcus multilocularis	serine protein kinase ATM	0.1425	0.1849	0.1843
Echinococcus granulosus	Glutaredoxin protein 5	0.0063	0.0032	0.0024
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6431	0.853	0.853
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0486	0.0596	0.0708
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0486	0.0596	0.0589
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0565
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0113	0.0099	0.0099
Loa Loa (eye worm)	phosphatidylinositol 3	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7533	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0596
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2526	0.3319	0.3252
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0486	0.0596	0.0565
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4067	0.5376	0.5376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1425	0.1849	0.1843
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0486	0.0596	0.0589
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.1101	0.1417	0.1411
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5991	0.7943	0.7943
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0486	0.0596	0.0565
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0102	0.0084	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0486	0.0596	0.0589
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0113	0.0099	0.0066
Leishmania major	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0503
Brugia malayi	p70 ribosomal S6 kinase beta	0.0096	0.0076	0.0068
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0486	0.0596	0.0503
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.7533	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Trichomonas vaginalis	immunophilin, putative	0.0113	0.0099	0.0099
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1425	0.1849	0.1843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4067	0.5376	0.5376
Entamoeba histolytica	hypothetical protein	0.0486	0.0596	0.0565
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4061	0.5367	0.5367
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0113	0.0099	0.0066
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0486	0.0596	0.0589
Echinococcus multilocularis		0.0486	0.0596	0.0589
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0596
Echinococcus multilocularis	fk506 binding protein	0.0113	0.0099	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4456	0.5895	0.5895
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0486	0.0596	0.0516
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0486	0.0596	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4501	0.5954	0.5954
Trichomonas vaginalis	conserved hypothetical protein	0.1101	0.1417	0.1417
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0939	0.12	0.1171
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	1
Echinococcus multilocularis	rac serine:threonine kinase	0.007	0.0041	0.0034
Trichomonas vaginalis	conserved hypothetical protein	0.1587	0.2066	0.2066
Trypanosoma cruzi	Protein kinase B	0.007	0.0041	0.0008
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0113	0.0099	0.0091
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Schistosoma mansoni	hypothetical protein	0.0486	0.0596	0.0589
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0156	0.0155	0.0148
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0486	0.0596	0.0589
Echinococcus granulosus	serine protein kinase ATM	0.1425	0.1849	0.1843
Entamoeba histolytica	protein kinase, putative	0.0102	0.0084	0.0052
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2526	0.3319	0.3314
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0113	0.0099	0.0066
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2526	0.3319	0.3297
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2526	0.3319	0.3297
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0486	0.0596	0.0565
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1425	0.1849	0.1822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7533	1	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1425	0.1849	0.1843
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0113	0.0099	0.0066
Loa Loa (eye worm)	hypothetical protein	0.1101	0.1417	0.1411
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0516
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4501	0.5954	0.5954
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4061	0.5367	0.5367
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0503
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0486	0.0596	0.0589
Giardia lamblia	GTOR	0.7533	1	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2526	0.3319	0.3319
Toxoplasma gondii	FATC domain-containing protein	0.1425	0.1849	0.2413
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1425	0.1849	0.1849
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0486	0.0596	0.0516
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0939	0.12	0.12
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.5998	0.7951	0.7934
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0113	0.0099	0.0099
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0113	0.0099	0.0014
Loa Loa (eye worm)	phosphatidylinositol 3	0.7533	1	1
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0113	0.0099	0.0091
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.7533	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0516
Brugia malayi	Protein kinase domain containing protein	0.0102	0.0084	0.0077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0486	0.0596	0.0596
Plasmodium vivax	hypothetical protein, conserved	0.0486	0.0596	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0486	0.0596	0.0589
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1425	0.1849	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0078	0.007
Entamoeba histolytica	protein kinase, putative	0.0096	0.0076	0.0043
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.5998	0.7951	0.7931
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0113	0.0099	0.0066
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0486	0.0596	0.0565
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0113	0.0099	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0486	0.0596	0.0589
Schistosoma mansoni	voltage-gated potassium channel	0.017	0.0174	0.0167
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0142	0.0142
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0063	0.0032	0.0024
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0486	0.0596	0.0708
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0486	0.0596	0.0589
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0486	0.0596	0.0565
Entamoeba histolytica	hypothetical protein	0.1425	0.1849	0.1822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2526	0.3319	0.3319
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Echinococcus multilocularis	nervana 2	0.0063	0.0032	0.0024
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0486	0.0596	0.0596
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.7533	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0486	0.0596	0.0708
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2526	0.3319	0.3262
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0078	0.007
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0486	0.0596	0.0503
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.3129	0.4123	0.4073
Echinococcus multilocularis	Glutaredoxin protein 5	0.0063	0.0032	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7533	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0041	0.0008
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0486	0.0596	0.0596
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.7533	1	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0113	0.0099	0.0091
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2526	0.3319	0.3314
Onchocerca volvulus		0.0486	0.0596	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0939	0.12	0.12
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0113	0.0099	0.1165
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0486	0.0596	0.0565
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0486	0.0596	0.0708
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2526	0.3319	0.3319
Echinococcus granulosus	serine/threonine protein kinase	0.007	0.0041	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.489	0.6473	0.6473
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0156	0.0155	0.0148
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0113	0.0099	0.1165
Entamoeba histolytica	PH domain containing protein kinase, putative	0.007	0.0041	0.0008
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.7533	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0486	0.0596	0.0596
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2526	0.3319	0.3252
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0113	0.0099	0.0091
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.7533	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0064	0.0033	0.0025
Loa Loa (eye worm)	FKBP5 protein	0.0113	0.0099	0.0091
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0486	0.0596	0.0596
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.3562	0.4702	0.4656
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5991	0.7943	0.7943
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0486	0.0596	0.0589
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.7533	1	1
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0486	0.0596	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0486	0.0596	0.0596
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0503
Loa Loa (eye worm)	hypothetical protein	0.1425	0.1849	0.1843
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4067	0.5376	0.5376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0486	0.0596	0.0596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2526	0.3319	0.3319
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.007	0.0041	0.0008
Entamoeba histolytica	hypothetical protein	0.0486	0.0596	0.0565
Echinococcus granulosus	nervana 2	0.0063	0.0032	0.0024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1425	0.1849	0.1849
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1425	0.1849	0.1843
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0486	0.0596	0.0565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5991	0.7943	0.7943
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1425	0.1849	0.178
Leishmania major	hypothetical protein, conserved	0.0486	0.0596	0.0503
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0486	0.0596	0.0596
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0113	0.0099	0.0091
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0486	0.0596	0.0565
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0041	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Echinococcus granulosus	serine threonine protein kinase nrc	0.0064	0.0033	0.0025
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0156	0.0155	0.0148
Trypanosoma cruzi	target of rapamycin kinase 3	0.5998	0.7951	0.7945
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0486	0.0596	0.0589
Schistosoma mansoni	immunophilin	0.0098	0.0078	0.007
Schistosoma mansoni	serine/threonine-protein kinase	0.007	0.0041	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0486	0.0596	0.0565
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.7533	1	1
Trichomonas vaginalis	fk506-binding protein, putative	0.0113	0.0099	0.0099
Mycobacterium leprae	conserved hypothetical protein	0.0486	0.0596	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0486	0.0596	0.0589
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.7533	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0486	0.0596	0.0596
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0156	0.0155	0.0148
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2526	0.3319	0.3314
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4501	0.5954	0.5954
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2526	0.3319	0.3262
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5991	0.7943	0.7943
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0486	0.0596	0.0589
Loa Loa (eye worm)	phosphatidylinositol 3	0.2526	0.3319	0.3314
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0064	0.0033	0.0025
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2526	0.3319	0.3314
Schistosoma mansoni	immunophilin	0.0113	0.0099	0.0091
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0486	0.0596	0.0596
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0565
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0486	0.0596	0.0565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0486	0.0596	0.0589
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0096	0.0076	0.0068
Toxoplasma gondii	target of rapamycin (TOR), putative	0.5602	0.7424	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0486	0.0596	0.0589
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0486	0.0596	0.0565
Loa Loa (eye worm)	phosphatidylinositol 3	0.0486	0.0596	0.0589
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0486	0.0596	0.0589
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0486	0.0596	0.0589
Schistosoma mansoni	immunophilin	0.0113	0.0099	0.0091
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0486	0.0596	0.0708
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0078	0.007
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0486	0.0596	0.0565
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0486	0.0596	0.0589
Entamoeba histolytica	protein kinase, putative	0.0102	0.0084	0.0052
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.7533	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1587	0.2066	0.2708
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0113	0.0099	0.5
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0565
Giardia lamblia	Hypothetical protein	0.0486	0.0596	0.0565
Leishmania major	hypothetical protein, unknown function	0.0486	0.0596	0.0503
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1425	0.1849	0.1843
Echinococcus multilocularis	nervana 2	0.0063	0.0032	0.0024
Loa Loa (eye worm)	hypothetical protein	0.1587	0.2066	0.206
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.1101	0.1417	0.1411
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0486	0.0596	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.7533	1	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0113	0.0099	0.0014
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0486	0.0596	0.0589
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5053	0.6691	0.6691
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0486	0.0596	0.0589
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0142	0.0142
Brugia malayi	FAT domain containing protein	0.1101	0.1417	0.1411
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0113	0.0099	0.0066
Loa Loa (eye worm)	phosphatidylinositol 3	0.0486	0.0596	0.0589
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0113	0.0099	0.0091
Loa Loa (eye worm)	phosphatidylinositol 3	0.0486	0.0596	0.0589
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1425	0.1849	0.1843
Entamoeba histolytica	hypothetical protein	0.0486	0.0596	0.0565
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0486	0.0596	0.0596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5602	0.7424	0.7424
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1425	0.1849	0.1849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2526	0.3319	0.3319
Entamoeba histolytica	protein kinase rad3, putative	0.1425	0.1849	0.1822
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0486	0.0596	0.0565
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0486	0.0596	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5991	0.7943	0.7943
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4067	0.5376	0.5376
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0128	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4061	0.5367	0.5367
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0486	0.0596	1
Schistosoma mansoni	hypothetical protein	0.1101	0.1417	0.1411
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1425	0.1849	0.1822
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0113	0.0099	0.0066
Entamoeba histolytica	hypothetical protein	0.0486	0.0596	0.0565
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0486	0.0596	0.0589
Trichomonas vaginalis	AGC family protein kinase	0.0102	0.0084	0.0084
Plasmodium vivax	hypothetical protein	0.0486	0.0596	1
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0063	0.0032	0.0024
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0113	0.0099	0.0091

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.911	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.302	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.231	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.192	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.176	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.14	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.92	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.801	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.572	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.432	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.324	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2028506

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1638494