Detailed information for compound 1638499

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1057.2 | Formula: C51H72N14O11
  • H donors: 13 H acceptors: 12 LogP: -2.17 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)C1CCCC1)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)N)N)N
  • InChi: 1S/C51H72N14O11/c1-28(2)41(63-44(69)35(14-8-20-57-51(54)55)59-43(68)34(52)25-40(53)67)47(72)60-36(22-30-16-18-33(66)19-17-30)45(70)64-42(31-12-6-7-13-31)48(73)61-37(24-32-26-56-27-58-32)49(74)65-21-9-15-39(65)46(71)62-38(50(75)76)23-29-10-4-3-5-11-29/h3-5,10-11,16-19,26-28,31,34-39,41-42,66H,6-9,12-15,20-25,52H2,1-2H3,(H2,53,67)(H,56,58)(H,59,68)(H,60,72)(H,61,73)(H,62,71)(H,63,69)(H,64,70)(H,75,76)(H4,54,55,57)/t34-,35-,36-,37-,38-,39-,41-,42-/m0/s1
  • InChiKey: GKURABCWZIRTSE-ACEDZQOISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/AKT protein kinase 0.0103 0.0044 0.0042
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.8829 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.8829 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0067 0.0003 0.0003
Trichomonas vaginalis immunophilin, putative 0.0169 0.0119 0.0075
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0638 0.0654 0.0654
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2999 0.3348 0.3267
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0067 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.2988 0.3336 0.3306
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0231 0.019 0.019
Loa Loa (eye worm) FKBP5 protein 0.0169 0.0119 0.0116
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0599 0.061 0.0774
Mycobacterium leprae conserved hypothetical protein 0.0579 0.0588 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.573 0.6465 0.6449
Entamoeba histolytica hypothetical protein 0.0579 0.0588 0.0588
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0599 0.061 0.0568
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0638 0.0654 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.4786 0.5387 0.5367
Schistosoma mansoni fkbp-rapamycin associated protein 0.1688 0.1852 0.185
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0579 0.0588 0.0585
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2999 0.3348 0.3318
Trypanosoma cruzi Protein kinase B 0.0071 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0599 0.061 0.061
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.8829 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0579 0.0588 0.0585
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0638 0.0654 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0588 0.0546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1688 0.1852 0.185
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0579 0.0588 0.964
Entamoeba histolytica protein kinase, putative 0.0103 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0698 0.0722 0.072
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0169 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.7031 0.7948 0.7939
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.4168 0.4682 0.4659
Echinococcus multilocularis Zinc finger, PHD finger 0.0599 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0003 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.7038 0.7957 0.7948
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0007 0.0007
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0599 0.061 0.0607
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0231 0.019 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0579 0.0588 0.0585
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0119 0.0075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0726 0.0755 0.0755
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0599 0.061 0.0568
Leishmania major hypothetical protein, unknown function 0.0579 0.0588 0.0474
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0071 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.7031 0.7948 0.7939
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.1852 0.1816
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0579 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1688 0.1852 0.1816
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.3037 0.3392 0.3392
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0599 0.061 0.0607
Brugia malayi p70 ribosomal S6 kinase beta 0.0097 0.0037 0.0034
Trichomonas vaginalis fk506-binding protein, putative 0.0169 0.0119 0.0075
Leishmania major hypothetical protein, conserved 0.0668 0.0689 0.0576
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.3037 0.3392 0.3392
Onchocerca volvulus 0.0579 0.0588 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.7031 0.7948 0.7939
Trichomonas vaginalis PIKK family atypical protein kinase 0.2988 0.3336 0.3306
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0638 0.0654 0.0652
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.8829 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0638 0.0654 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.5947 0.5929
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.3037 0.3392 0.3392
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0231 0.019 0.019
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0169 0.0119 0.5
Leishmania major phosphatidylinositol kinase, putative 0.0579 0.0588 0.0474
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.8829 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.0007 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0698 0.0722 0.072
Toxoplasma gondii non-specific serine/threonine protein kinase 0.188 0.2071 0.2751
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.8829 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0119 0.0119
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0579 0.0588 0.0546
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0169 0.0119 0.0116
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0765 0.0799 0.0799
Schistosoma mansoni immunophilin 0.0146 0.0093 0.009
Entamoeba histolytica hypothetical protein 0.0579 0.0588 0.0588
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0097 0.0037 0.0034
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0765 0.0799 0.0797
Loa Loa (eye worm) hypothetical protein 0.0579 0.0588 0.0585
Toxoplasma gondii target of rapamycin (TOR), putative 0.6577 0.7431 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0599 0.061 0.0568
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0599 0.061 0.0607
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.964
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0579 0.0588 0.0588
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.0546
Schistosoma mansoni serine/threonine-protein kinase 0.0071 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0216 0.0173 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Trichomonas vaginalis PIKK family atypical protein kinase 0.5922 0.6684 0.6669
Giardia lamblia Hypothetical protein 0.0579 0.0588 0.0588
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.13 0.141 0.141
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0579 0.0588 0.0588
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.8829 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0119 0.0119
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1698 0.1864 0.1864
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0765 0.0799 0.0758
Loa Loa (eye worm) phosphatidylinositol kinase 0.0579 0.0588 0.0585
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0579 0.0588 0.0585
Plasmodium vivax hypothetical protein 0.0579 0.0588 0.964
Loa Loa (eye worm) hypothetical protein 0.13 0.141 0.1408
Loa Loa (eye worm) hypothetical protein 0.188 0.2071 0.2069
Loa Loa (eye worm) hypothetical protein 0.02 0.0155 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.7031 0.7948 0.7939
Trichomonas vaginalis PIKK family atypical protein kinase 0.4786 0.5387 0.5367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0579 0.0588 0.0585
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0579 0.0588 0.0585
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0579 0.0588 0.964
Trichomonas vaginalis PIKK family atypical protein kinase 0.4779 0.5379 0.5358
Entamoeba histolytica protein kinase rad3, putative 0.1688 0.1852 0.1852
Loa Loa (eye worm) phosphatidylinositol 3 0.2999 0.3348 0.3346
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0599 0.061 0.061
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.083 0.0873 0.0873
Entamoeba histolytica hypothetical protein 0.1688 0.1852 0.1852
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0666 0.0686 0.0686
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0119 0.0119
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0722 0.0722
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0169 0.0119 0.5
Echinococcus multilocularis serine protein kinase ATM 0.1688 0.1852 0.1852
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0169 0.0119 0.0116
Loa Loa (eye worm) phosphatidylinositol 3 0.0579 0.0588 0.0585
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0169 0.0119 0.0119
Entamoeba histolytica protein kinase, putative 0.0103 0.0044 0.0044
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0579 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1698 0.1864 0.1828
Trichomonas vaginalis conserved hypothetical protein 0.13 0.141 0.1372
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0705 0.0731 0.069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0119 0.0119
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0619 0.0632 0.0632
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1688 0.1852 0.1852
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0705 0.0731 0.069
Schistosoma mansoni voltage-gated potassium channel 0.0252 0.0214 0.0211
Loa Loa (eye worm) hypothetical protein 0.1108 0.1191 0.1188
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.1791 0.197 0.1968
Loa Loa (eye worm) phosphatidylinositol 3 0.0894 0.0947 0.0944
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.524 0.5905 0.5887
Trichomonas vaginalis PIKK family atypical protein kinase 0.237 0.2631 0.2598
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0599 0.061 0.0774
Schistosoma mansoni hypothetical protein 0.13 0.141 0.1408
Trichomonas vaginalis PIKK family atypical protein kinase 0.7031 0.7948 0.7939
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0579 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0934 0.0992 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.4786 0.5387 0.5367
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1688 0.1852 0.1852
Loa Loa (eye worm) phosphatidylinositol 3 0.0579 0.0588 0.0585
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0765 0.0799 0.0758
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0579 0.0588 0.0546
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0579 0.0588 0.0744
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0169 0.0119 0.0119
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0599 0.061 0.061
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0599 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.7528 0.8516 0.851
Trichomonas vaginalis PIKK family atypical protein kinase 0.2999 0.3348 0.3318
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0599 0.061 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.8829 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0599 0.061 0.0568
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0765 0.0799 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.1108 0.1191 0.1152
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0599 0.061 0.0496
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.13 0.141 0.141
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.5947 0.5929
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0934 0.0992 0.0992
Entamoeba histolytica hypothetical protein 0.0726 0.0755 0.0755
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.4779 0.5379 0.5358
Leishmania major phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.0474
Plasmodium vivax hypothetical protein, conserved 0.0579 0.0588 0.964
Trichomonas vaginalis PIKK family atypical protein kinase 0.524 0.5905 0.5887
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0119 0.0075
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0638 0.0654 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Entamoeba histolytica hypothetical protein 0.0579 0.0588 0.0588
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0169 0.0119 0.1956
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.8829 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.083 0.0873 0.0873
Trichomonas vaginalis PIKK family atypical protein kinase 0.4786 0.5387 0.5367
Echinococcus granulosus serine protein kinase ATM 0.1688 0.1852 0.1852
Echinococcus multilocularis rac serine:threonine kinase 0.0071 0.0007 0.0007
Giardia lamblia Phosphatidylinositol 4-kinase 0.0579 0.0588 0.0588
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0119 0.0119
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0638 0.0654 0.0612
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.0093 0.0093
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0765 0.0799 0.0758
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0579 0.0588 0.0744
Brugia malayi FAT domain containing protein 0.13 0.141 0.1408
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0579 0.0588 0.0588
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1688 0.1852 0.1852
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.3037 0.3392 0.339
Schistosoma mansoni hypothetical protein 0.0579 0.0588 0.0585
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0119 0.0075
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1688 0.1852 0.185
Trichomonas vaginalis PIKK family atypical protein kinase 0.8829 1 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0093 0.009
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1688 0.1852 0.1852
Trichomonas vaginalis PIKK family atypical protein kinase 0.2988 0.3336 0.3306
Echinococcus multilocularis fk506 binding protein 0.0169 0.0119 0.0119
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.3037 0.3392 0.339
Trichomonas vaginalis conserved hypothetical protein 0.188 0.2071 0.2036
Echinococcus granulosus serine/threonine protein kinase 0.0071 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0659 0.0678 0.0678
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0231 0.019 0.0187
Echinococcus multilocularis 0.0579 0.0588 0.0588
Schistosoma mansoni immunophilin 0.0169 0.0119 0.0116
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0168 0.0119 0.0116
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0067 0.0003 0.0003
Trypanosoma cruzi target of rapamycin kinase 3 0.7038 0.7957 0.7957
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0119 0.0075
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0169 0.0119 0.0116
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1108 0.1191 0.1191
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0579 0.0588 0.0744
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1688 0.1852 0.1816
Toxoplasma gondii FATC domain-containing protein 0.1688 0.1852 0.2455
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.3037 0.3392 0.3392
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0599 0.061 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.8829 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0579 0.0588 0.0546
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0599 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.4779 0.5379 0.5358
Mycobacterium tuberculosis Conserved hypothetical protein 0.0579 0.0588 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5277 0.5947 0.5929
Entamoeba histolytica PH domain containing protein kinase, putative 0.0071 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0089 0.0028 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1688 0.1852 0.185
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.964
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0169 0.0119 0.0116
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.7038 0.7957 0.7932
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0579 0.0588 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.6577 0.7431 0.7419
Loa Loa (eye worm) phosphatidylinositol 3 0.8829 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0638 0.0654 0.0654
Onchocerca volvulus 0.0579 0.0588 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0698 0.0722 0.0722
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0579 0.0588 0.0588
Brugia malayi Protein kinase domain containing protein 0.0103 0.0044 0.0042
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0186 0.0138 0.0138
Giardia lamblia GTOR 0.8829 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0934 0.0992 0.0992
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0579 0.0588 0.0588
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.8829 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0579 0.0588 0.0474
Loa Loa (eye worm) hypothetical protein 0.1688 0.1852 0.185
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0579 0.0588 0.964
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0579 0.0588 0.0585
Leishmania major phosphatidylinositol 3-kinase, putative 0.2988 0.3336 0.3255
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0599 0.061 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0216 0.0173 0.0129
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0579 0.0588 0.0588
Schistosoma mansoni voltage-gated potassium channel 0.0252 0.0214 0.0211
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0765 0.0799 0.0799
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0169 0.0119 0.1956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0579 0.0588 0.0546
Schistosoma mansoni immunophilin 0.0169 0.0119 0.0116
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0599 0.061 0.061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2988 0.3336 0.3306
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0169 0.0119 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.8829 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1108 0.1191 0.1152
Leishmania major phosphatidylinositol 3-kinase, putative 0.0599 0.061 0.0496
Echinococcus granulosus voltage gated potassium channel 0.0067 0.0003 0.0003
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.8829 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0638 0.0654 0.0654
Entamoeba histolytica protein kinase, putative 0.0097 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.2988 0.3336 0.3306
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0599 0.061 0.061
Loa Loa (eye worm) phosphatidylinositol 3 0.0579 0.0588 0.0585
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3678 0.4123 0.4097

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.