Detailed information for compound 1638501

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1071.23 | Formula: C52H74N14O11
  • H donors: 13 H acceptors: 12 LogP: -1.63 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)C1CCCCC1)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)N)N)N
  • InChi: 1S/C52H74N14O11/c1-29(2)42(64-45(70)36(15-9-21-58-52(55)56)60-44(69)35(53)26-41(54)68)48(73)61-37(23-31-17-19-34(67)20-18-31)46(71)65-43(32-13-7-4-8-14-32)49(74)62-38(25-33-27-57-28-59-33)50(75)66-22-10-16-40(66)47(72)63-39(51(76)77)24-30-11-5-3-6-12-30/h3,5-6,11-12,17-20,27-29,32,35-40,42-43,67H,4,7-10,13-16,21-26,53H2,1-2H3,(H2,54,68)(H,57,59)(H,60,69)(H,61,73)(H,62,74)(H,63,72)(H,64,70)(H,65,71)(H,76,77)(H4,55,56,58)/t35-,36-,37-,38-,39-,40-,42-,43-/m0/s1
  • InChiKey: JEOOPTWICDJSIA-NVUNDZOBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.008 0.008
Schistosoma mansoni immunophilin 0.0116 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Entamoeba histolytica protein kinase, putative 0.01 0.0088 0.0088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0501 0.0606 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0523
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0116 0.0108 0.1216
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7769 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1469 0.1858 0.1785
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.0606 0.0606
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Leishmania major phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.5899 0.5899
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0116 0.0108 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.0968 0.121 0.121
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Trichomonas vaginalis conserved hypothetical protein 0.1136 0.1427 0.1427
Loa Loa (eye worm) hypothetical protein 0.1637 0.2075 0.2075
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0047 0.0047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.0164 0.0164
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0501 0.0606 0.0606
Entamoeba histolytica protein kinase, putative 0.01 0.0088 0.0088
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0116 0.0108 0.0108
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Schistosoma mansoni fkbp-rapamycin associated protein 0.1469 0.1858 0.1858
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2605 0.3326 0.3326
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0108 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0501 0.0606 0.0569
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.002
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1469 0.1858 0.1858
Loa Loa (eye worm) phosphatidylinositol 3 0.7769 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1136 0.1427 0.1427
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0018 0.0018
Leishmania major phosphatidylinositol kinase, putative 0.0501 0.0606 0.0504
Echinococcus multilocularis nervana 2 0.0062 0.0038 0.0038
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0116 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.4596 0.5899 0.5899
Trichomonas vaginalis PIKK family atypical protein kinase 0.2084 0.2653 0.2653
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0018 0.0018
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0046 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0968 0.121 0.121
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.1583 0.2005 0.2005
Mycobacterium leprae conserved hypothetical protein 0.0501 0.0606 0.5
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0018 0.0018
Echinococcus granulosus nervana 2 0.0062 0.0038 0.0038
Toxoplasma gondii FATC domain-containing protein 0.1469 0.1858 0.242
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0015
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0569
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0116 0.0108 0.0108
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.6633 0.8532 0.8532
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.3253
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0501 0.0606 0.0606
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7769 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0501 0.0606 0.0606
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0501 0.0606 1
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1469 0.1858 0.1858
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0501 0.0606 1
Brugia malayi FAT domain containing protein 0.1136 0.1427 0.1427
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Echinococcus multilocularis 0.0501 0.0606 0.0606
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.0182 0.0182
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0116 0.0108 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0018 0.0018
Echinococcus multilocularis nervana 2 0.0062 0.0038 0.0038
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.015 0.015
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1469 0.1858 0.1858
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0501 0.0606 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0501 0.0606 0.0569
Leishmania major phosphatidylinositol kinase related protein, putative 0.0501 0.0606 0.0504
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.33
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0606
Echinococcus granulosus Glutaredoxin protein 5 0.0062 0.0038 0.0038
Echinococcus multilocularis Glutaredoxin protein 5 0.0062 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0501 0.0606 0.0606
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7769 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0087 0.0087
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.3267
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3227 0.4129 0.4077
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.0047 0.0047
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7769 1 1
Echinococcus granulosus nervana 2 0.0062 0.0038 0.0038
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis immunophilin, putative 0.0116 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2605 0.3326 0.33
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7769 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0968 0.121 0.121
Plasmodium vivax hypothetical protein 0.0501 0.0606 1
Echinococcus multilocularis fk506 binding protein 0.0116 0.0108 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0501 0.0606 0.0606
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0501 0.0606 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7769 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0504
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0968 0.121 0.1175
Loa Loa (eye worm) hypothetical protein 0.1469 0.1858 0.1858
Trypanosoma cruzi target of rapamycin kinase 3 0.6186 0.7954 0.7946
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0108 0.0108
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0108 0.0108
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0018 0.0018
Giardia lamblia GTOR 0.7769 1 1
Loa Loa (eye worm) hypothetical protein 0.0501 0.0606 0.0606
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0501 0.0606 0.0569
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Leishmania major hypothetical protein, unknown function 0.0501 0.0606 0.0504
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.01 0.0087 0.0087
Entamoeba histolytica protein kinase, putative 0.0094 0.008 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1469 0.1858 0.1858
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0569
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0116 0.0108 0.0069
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6186 0.7954 0.7931
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0523
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1469 0.1858 0.1858
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0501 0.0606 0.0523
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1469 0.1858 0.1826
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0116 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0501 0.0606 0.0606
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0501 0.0606 0.0606
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0501 0.0606 1
Trypanosoma cruzi Protein kinase B 0.0069 0.0047 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0008 0.0008
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.0164 0.0164
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0606 0.0569
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0063 0.0039 0.0039
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6186 0.7954 0.7935
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0606 0.0606
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.002
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0501 0.0606 0.0606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7769 1 1
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Giardia lamblia Phosphatidylinositol 4-kinase 0.0501 0.0606 0.0569
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7769 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4642 0.5959 0.5959
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.0164 0.0164
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Loa Loa (eye worm) phosphatidylinositol 3 0.2605 0.3326 0.3326
Echinococcus granulosus serine threonine protein kinase nrc 0.0063 0.0039 0.0039
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0606 0.0606
Giardia lamblia Hypothetical protein 0.0501 0.0606 0.0569
Trichomonas vaginalis fk506-binding protein, putative 0.0116 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.2605 0.3326 0.3326
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0501 0.0606 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0501 0.0606 0.0606
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0047 0.0047
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2605 0.3326 0.3267
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.0164 0.0164
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0501 0.0606 0.0606
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0116 0.0108 0.0108
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.5043 0.6477 0.6477
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.0047 0.0008
Schistosoma mansoni immunophilin 0.0116 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0501 0.0606 0.0606
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2605 0.3326 0.3326
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7769 1 1
Entamoeba histolytica protein kinase 2, putative 0.0063 0.0039 0.0039
Brugia malayi Protein kinase domain containing protein 0.01 0.0088 0.0088
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0501 0.0606 0.0606
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0116 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0501 0.0606 0.0606
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3674 0.4707 0.466
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7769 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0501 0.0606 0.0606
Loa Loa (eye worm) phosphatidylinositol kinase 0.0501 0.0606 0.0606
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0501 0.0606 1
Echinococcus granulosus serine protein kinase ATM 0.1469 0.1858 0.1858
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0501 0.0606 0.0606
Entamoeba histolytica hypothetical protein 0.1469 0.1858 0.1858
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0501 0.0606 0.0569
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0062 0.0038 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.2605 0.3326 0.3253
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0047 0.0047
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0501 0.0606 0.0606
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0116 0.0108 0.0108
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0501 0.0606 0.0569
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0116 0.0108 0.5
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1469 0.1858 0.1858
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1469 0.1858 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.1469 0.1858 0.1858
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2605 0.3326 0.3326
Loa Loa (eye worm) hypothetical protein 0.0138 0.0136 0.0136
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.4195 0.538 0.538
Trichomonas vaginalis PIKK family atypical protein kinase 0.6179 0.7945 0.7945
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0501 0.0606 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.4188 0.5372 0.5372
Leishmania major phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0504
Echinococcus multilocularis serine protein kinase ATM 0.1469 0.1858 0.1858
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1136 0.1427 0.1427
Onchocerca volvulus 0.0501 0.0606 0.5
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0116 0.0108 0.0069
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0088 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0501 0.0606 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.01 0.0087 0.0087
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0018 0.0018
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0116 0.0108 0.0108
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0063 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0523
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.008 0.008
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0501 0.0606 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.5778 0.7427 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0606 0.0606
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0501 0.0606 0.0716
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0606 0.0569
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0501 0.0606 0.0606
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0116 0.0108 0.0108
Onchocerca volvulus 0.0501 0.0606 0.5
Schistosoma mansoni immunophilin 0.01 0.0087 0.0087
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis AGC family protein kinase 0.01 0.0088 0.0088
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0501 0.0606 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.1637 0.2075 0.2075
Trichomonas vaginalis PIKK family atypical protein kinase 0.7769 1 1
Loa Loa (eye worm) FKBP5 protein 0.0116 0.0108 0.0108
Entamoeba histolytica protein kinase rad3, putative 0.1469 0.1858 0.1858
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0501 0.0606 0.0606
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Leishmania major hypothetical protein, conserved 0.0501 0.0606 0.0504
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0501 0.0606 0.0569
Schistosoma mansoni hypothetical protein 0.1136 0.1427 0.1427
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1637 0.2075 0.2715
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0062 0.0038 0.0038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7769 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0116 0.0108 0.0069
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0501 0.0606 0.0606
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.015 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.5211 0.6694 0.6694
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0606 0.0606
Trichomonas vaginalis PIKK family atypical protein kinase 0.5778 0.7427 0.7427
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1136 0.1427 0.1427

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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