Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0127 | 0.1185 | 0.0941 | |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0357 | 0.4697 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1185 | 0.2524 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1533 | 0.0395 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.4697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1185 | 0.0941 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0049 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Trypanosoma brucei | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0127 | 0.1185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1185 | 0.2524 |
Plasmodium vivax | hypothetical protein, conserved | 0.0357 | 0.4697 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0357 | 0.4697 | 0.3984 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0357 | 0.4697 | 1 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0357 | 0.4697 | 1 |
Schistosoma mansoni | TRABID protein (C64 family) | 0.0127 | 0.1185 | 0.0941 |
Onchocerca volvulus | 0.0357 | 0.4697 | 1 | |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0357 | 0.4697 | 0.3984 |
Schistosoma mansoni | fusion | 0.0127 | 0.1185 | 0.0941 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.4697 | 1 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0357 | 0.4697 | 0.3984 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others/FYVE zinc finger, putative | 0.0127 | 0.1185 | 1 |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0127 | 0.1185 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.1533 | 0.0395 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0357 | 0.4697 | 0.5 |
Onchocerca volvulus | Ubiquitin thioesterase ZRANB1 homolog | 0.0127 | 0.1185 | 0.0941 |
Brugia malayi | brahma associated protein 60 kDa | 0.0357 | 0.4697 | 1 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0357 | 0.4697 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0357 | 0.4697 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.1185 | 0.2524 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.1533 | 0.1839 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0357 | 0.4697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.4697 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0127 | 0.1185 | 1 |
Brugia malayi | YY1-associated factor 2 | 0.0127 | 0.1185 | 0.2524 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0357 | 0.4697 | 1 |
Trypanosoma cruzi | mitochondrial RNA binding complex 1 subunit, putative | 0.0127 | 0.1185 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0357 | 0.4697 | 0.3984 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0357 | 0.4697 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1185 | 0.2524 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0357 | 0.4697 | 0.3984 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0127 | 0.1185 | 1 |
Loa Loa (eye worm) | brahma associated protein | 0.0357 | 0.4697 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0357 | 0.4697 | 0.5 |
Schistosoma mansoni | RNA binding protein | 0.0127 | 0.1185 | 0.0941 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0357 | 0.4697 | 0.3984 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1185 | 0.2524 |
Onchocerca volvulus | 0.0127 | 0.1185 | 0.0941 | |
Echinococcus multilocularis | tumor protein p63 | 0.0705 | 1 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0357 | 0.4697 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.1185 | 0.2524 |
Trypanosoma cruzi | WLM domain containing protein, putative | 0.0127 | 0.1185 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1533 | 0.3264 |
Onchocerca volvulus | 0.0127 | 0.1185 | 0.0941 | |
Trypanosoma cruzi | Zn-finger in Ran binding protein and others, putative | 0.0127 | 0.1185 | 1 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.1185 | 0.2524 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Chlamydia trachomatis | SWIB complex protein | 0.0357 | 0.4697 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1533 | 0.3264 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.1185 | 0.2524 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.082 | 0.1747 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.1533 | 0.0395 |
Leishmania major | hypothetical protein, conserved | 0.0127 | 0.1185 | 1 |
Onchocerca volvulus | 0.0127 | 0.1185 | 0.0941 | |
Trypanosoma brucei | mitochondrial RNA binding complex 1 subunit | 0.0127 | 0.1185 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0127 | 0.1185 | 0.0941 |
Brugia malayi | Zn-finger in Ran binding protein and others containing protein | 0.0127 | 0.1185 | 0.2524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.