Detailed information for compound 1644989

Basic information

Technical information
  • TDR Targets ID: 1644989
  • Name: (5R)-5-(4-fluorophenyl)-3-hydroxy-1-methylpyr rolidin-2-one
  • MW: 209.217 | Formula: C11H12FNO2
  • H donors: 1 H acceptors: 2 LogP: 0.86 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1C[C@@H](N(C1=O)C)c1ccc(cc1)F
  • InChi: 1S/C11H12FNO2/c1-13-9(6-10(14)11(13)15)7-2-4-8(12)5-3-7/h2-5,9-10,14H,6H2,1H3/t9-,10?/m1/s1
  • InChiKey: BBVGEIFNTZBCIB-YHMJZVADSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5R)-5-(4-fluorophenyl)-3-hydroxy-1-methyl-pyrrolidin-2-one
  • (5R)-5-(4-fluorophenyl)-3-hydroxy-1-methyl-2-pyrrolidinone
  • (5R)-5-(4-fluorophenyl)-3-hydroxy-1-methyl-2-pyrrolidone
  • NCI60_030433

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0181 0.0428 0.0428
Leishmania major phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.0445
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0395 0.1139 0.0974
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0207 0.0515 0.0496
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0188 0.045 0.0272
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0227 0.058 0.0618
Loa Loa (eye worm) hypothetical protein 0.0068 0.0052 0.0052
Plasmodium vivax hypothetical protein 0.0207 0.0515 0.8564
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0597 0.181 0.181
Plasmodium vivax hypothetical protein, conserved 0.0207 0.0515 0.8564
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.3329 0.3205
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.0496
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0073 0.0053
Loa Loa (eye worm) hypothetical protein 0.0457 0.1345 0.1345
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.306 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.0515 0.0515
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0059 0.0022 0.0002
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0227 0.058 0.0404
Leishmania major phosphatidylinositol 3-kinase, putative 0.1054 0.3329 0.328
Brugia malayi Probable ClpP-like protease 0.0091 0.0129 0.0129
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0207 0.0515 0.0338
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1282 0.4088 0.4044
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.306 1 1
Echinococcus granulosus peptidase Clp S14 family 0.006 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0073 0.0053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0227 0.058 0.0404
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0266 0.0711 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.306 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0183 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.3329 0.3205
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0266 0.0711 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.0457 0.1345 0.1184
Schistosoma mansoni immunophilin 0.0107 0.0183 0.0183
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.183 0.5909 0.5833
Echinococcus multilocularis 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.1669 0.5375 0.5288
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0266 0.0711 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.306 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.0515 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1103 0.3494 0.3494
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0266 0.0711 0.0538
Echinococcus granulosus serine protein kinase ATM 0.0597 0.181 0.181
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0607 0.1845 0.1693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.0515 0.0338
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.046 0.1356 0.1356
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2445 0.7955 0.794
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0183 0.0163
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0169 0.0388 0.0209
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.306 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0181 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0058 0.0017 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.306 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0207 0.0515 0.0338
Loa Loa (eye worm) hypothetical protein 0.0091 0.0129 0.0129
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0356 0.1008 0.084
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0227 0.058 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0912 0.0912
Entamoeba histolytica hypothetical protein 0.0207 0.0515 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Entamoeba histolytica hypothetical protein 0.0597 0.181 0.1657
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0091 0.0129 0.2131
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0071 0.0071
Trypanosoma cruzi target of rapamycin kinase 3 0.2445 0.7955 0.7951
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0169 0.0388 0.0209
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0207 0.0515 0.0515
Schistosoma mansoni immunophilin 0.0093 0.0134 0.0134
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0395 0.1139 0.0974
Leishmania major hypothetical protein, conserved 0.0297 0.0813 0.0745
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.0445
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0183 0.0163
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0071 0.0071
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0207 0.0515 0.0515
Loa Loa (eye worm) phosphatidylinositol 3 0.306 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0107 0.0183 0.1193
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0207 0.0515 0.8564
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Echinococcus multilocularis serine protein kinase ATM 0.0597 0.181 0.181
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0395 0.1139 0.0974
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 0.5383 0.5297
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.1669 0.5375 0.5288
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0107 0.0183 0.0183
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0457 0.1345 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.0389 0.112 0.0955
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0266 0.0711 0.0538
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0107 0.0183 0.0183
Loa Loa (eye worm) phosphatidylinositol kinase 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.1827 0.5901 0.5825
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.1139 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.183 0.5909 0.5833
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0565 0.1705 0.1705
Loa Loa (eye worm) phosphatidylinositol 3 0.0526 0.1574 0.1574
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0227 0.058 0.058
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0071 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.0805 0.2503 0.2503
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0071 0.0071
Schistosoma mansoni immunophilin 0.0107 0.0183 0.0183
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0134 0.0134
Loa Loa (eye worm) phosphatidylinositol 3 0.0207 0.0515 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0327 0.0912 0.0912
Entamoeba histolytica protein kinase rad3, putative 0.0597 0.181 0.1657
Loa Loa (eye worm) hypothetical protein 0.0093 0.0134 0.0134
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1103 0.3494 0.3494
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0183 0.0163
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1054 0.3329 0.328
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1103 0.3494 0.3494
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0207 0.0515 0.0515
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0597 0.181 0.1793
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.306 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0597 0.181 0.181
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0107 0.0183 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0565 0.1705 0.1705
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0207 0.0515 0.0515
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0017 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0071 0.0071
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0392 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.256 0.2422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1827 0.5901 0.5825
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0207 0.0515 0.0445
Loa Loa (eye worm) hypothetical protein 0.0389 0.112 0.112
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0664 0.2034 0.261
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0457 0.1345 0.1345
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0134 0.0134
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.046 0.1356 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0607 0.1845 0.1693
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.0024 0.0024
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0266 0.0711 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.2603 0.8481 0.8452
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0227 0.058 0.051
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0227 0.058 0.058
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0207 0.0515 0.0515
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0247 0.0646 0.0472
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.306 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0266 0.0711 0.0643
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1064 0.3364 0.3316
Echinococcus granulosus tumor protein p63 0.0394 0.1137 0.1137
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0207 0.0515 0.0515
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0227 0.058 0.0404
Schistosoma mansoni hypothetical protein 0.0457 0.1345 0.1345
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 0.5383 0.5297
Toxoplasma gondii target of rapamycin (TOR), putative 0.2286 0.7428 1
Loa Loa (eye worm) hypothetical protein 0.0615 0.1871 0.1871
Giardia lamblia Phosphatidylinositol 4-kinase 0.0207 0.0515 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.7946 0.7908
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0227 0.058 0.0618
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0597 0.181 0.175
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0181 0.0428 0.0428
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0334 0.0938 0.0769
Echinococcus multilocularis fk506 binding protein 0.0107 0.0183 0.0183
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0327 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0597 0.181 0.181
Brugia malayi FAT domain containing protein 0.0457 0.1345 0.1345
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0227 0.058 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0597 0.181 0.181
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1064 0.3364 0.3316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.181 0.1657
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.0515 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.7946 0.7908
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 0.5383 0.5297
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0181 0.0428 0.0428
Trichomonas vaginalis PIKK family atypical protein kinase 0.1669 0.5375 0.5288
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0207 0.0515 0.0529
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0565 0.1705 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0664 0.2034 0.1886
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0107 0.0183 0.0183
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0389 0.112 0.1103
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0091 0.0129 0.0129
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0227 0.058 0.058
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0107 0.0183 0.011
Mycobacterium tuberculosis Conserved hypothetical protein 0.0207 0.0515 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0071 0.0071
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0107 0.0183 0.0163
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0207 0.0515 0.0338
Echinococcus granulosus tar DNA binding protein 0.0074 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Onchocerca volvulus 0.0207 0.0515 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0207 0.0515 0.0529
Leishmania major phosphatidylinositol 3-kinase, putative 0.0227 0.058 0.051
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0227 0.058 0.058
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0395 0.1139 0.1121
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0107 0.0183 0.0183
Leishmania major hypothetical protein, unknown function 0.0207 0.0515 0.0445
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0395 0.1139 0.0974
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0207 0.0515 0.0515
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0129 0.5
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0091 0.0129 0.0129
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.306 1 1
Schistosoma mansoni microtubule-associated protein tau 0.0805 0.2503 0.2503
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0107 0.0183 0.0183
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0207 0.0515 0.0496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0395 0.1139 0.1139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.0515 0.0338
Loa Loa (eye worm) hypothetical protein 0.0664 0.2034 0.2034
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0052 0.0032
Echinococcus granulosus microtubule associated protein 2 0.0805 0.2503 0.2503
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0597 0.181 0.1793
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0207 0.0515 0.8564
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.306 1 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0107 0.0183 0.1193
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0207 0.0515 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.2053 0.6652 0.6589
Entamoeba histolytica hypothetical protein 0.0207 0.0515 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.2286 0.7428 0.738
Schistosoma mansoni voltage-gated potassium channel 0.0198 0.0483 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.181 0.1657
Toxoplasma gondii FATC domain-containing protein 0.0597 0.181 0.2303
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0207 0.0515 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.7946 0.7908
Schistosoma mansoni fkbp-rapamycin associated protein 0.0597 0.181 0.181
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0207 0.0515 0.8564
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0227 0.058 0.0404
Echinococcus multilocularis tumor protein p63 0.0394 0.1137 0.1137
Loa Loa (eye worm) hypothetical protein 0.0157 0.0348 0.0348
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0071 0.0071
Giardia lamblia Hypothetical protein 0.0207 0.0515 0.0338
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0071 0.0071
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.8564
Schistosoma mansoni voltage-gated potassium channel 0.0198 0.0483 0.0483
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2445 0.7955 0.794
Echinococcus multilocularis Zinc finger, PHD finger 0.0227 0.058 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0124 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0071 0.0071
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0207 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.306 1 1
Leishmania major peptidylprolyl isomerase-like protein 0.0107 0.0183 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0389 0.112 0.0955
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0295 0.0806 0.0635
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.306 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0266 0.0711 0.0692
Leishmania major phosphatidylinositol kinase, putative 0.0207 0.0515 0.0445
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1103 0.3494 0.3481
Trichomonas vaginalis PIKK family atypical protein kinase 0.183 0.5909 0.5833
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.3329 0.3205
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.7946 0.7908
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0227 0.058 0.0404
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1103 0.3494 0.3494
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0073 0.0053
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0107 0.0183 0.0183
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0334 0.0938 0.0769
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1103 0.3494 0.3481
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0227 0.058 0.058
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0091 0.0129 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0227 0.058 0.0561
Entamoeba histolytica hypothetical protein 0.0207 0.0515 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.3329 0.3205
Brugia malayi TAR-binding protein 0.0074 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.1985 0.6427 0.6361
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0227 0.058 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0107 0.0183 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0207 0.0515 0.0445
Onchocerca volvulus 0.0207 0.0515 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.0071 0.0071
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.306 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.1064 0.3364 0.3364
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0327 0.0912 0.0912
Leishmania major fk506-binding protein 1-like protein 0.0107 0.0183 0.011
Giardia lamblia GTOR 0.306 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0091 0.0129 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0073 0.0053
Loa Loa (eye worm) FKBP5 protein 0.0107 0.0183 0.0183
Entamoeba histolytica hypothetical protein 0.0356 0.1008 0.084
Schistosoma mansoni peptidase Clp (S14 family) 0.0091 0.0129 0.0129
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.144 0.4614 0.4574
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0227 0.058 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.7946 0.7908
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.306 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0287 0.0781 0.0609
Mycobacterium leprae conserved hypothetical protein 0.0207 0.0515 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0227 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0207 0.0515 0.0515
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0597 0.181 0.181
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0227 0.058 0.0561
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0266 0.0711 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 0.5383 0.5297
Brugia malayi RNA binding protein 0.0074 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.1064 0.3364 0.3241
Loa Loa (eye worm) phosphatidylinositol 3 0.0059 0.0022 0.0022
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0207 0.0515 0.8564
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0597 0.181 0.181

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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