Detailed information for compound 1647139

Basic information

Technical information
  • TDR Targets ID: 1647139
  • Name: 1-[4-(4-amino-6-methylfuro[5,4-d]pyrimidin-5- yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phe nyl]urea
  • MW: 445.37 | Formula: C21H15F4N5O2
  • H donors: 3 H acceptors: 3 LogP: 4.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(ccc1F)C(F)(F)F)Nc1ccc(cc1)c1c(C)oc2c1c(N)ncn2
  • InChi: 1S/C21H15F4N5O2/c1-10-16(17-18(26)27-9-28-19(17)32-10)11-2-5-13(6-3-11)29-20(31)30-15-8-12(21(23,24)25)4-7-14(15)22/h2-9H,1H3,(H2,26,27,28)(H2,29,30,31)
  • InChiKey: KACVTGKCOLBAOJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(4-amino-6-methyl-furo[5,4-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
  • 1-[4-(4-amino-6-methyl-5-furo[5,4-d]pyrimidinyl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens aurora kinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0361 0.0521 0.0499
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.509 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0404 0.0608 0.0578
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0117 0.0032 0.0032
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0361 0.0521 0.0521
Leishmania major phosphatidylinositol 3-kinase, putative 0.1737 0.328 0.3258
Onchocerca volvulus 0.0339 0.0478 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2126 0.406 0.404
Loa Loa (eye worm) phosphatidylinositol 3 0.0339 0.0478 0.0478
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0071 0.0071
Leishmania major phosphatidylinositol 3-kinase, putative 0.0361 0.0521 0.049
Loa Loa (eye worm) phosphatidylinositol 3 0.509 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.328 0.3264
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.012 0.0039 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.069 0.1181 0.1181
Loa Loa (eye worm) AUR protein kinase 0.0136 0.0071 0.0071
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0361 0.0521 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0188 0.0174 0.0142
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0546 0.0892 0.0871
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.9121
Loa Loa (eye worm) AUR protein kinase 0.0136 0.0071 0.0071
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0643 0.1087 0.1058
Loa Loa (eye worm) hypothetical protein 0.0339 0.0478 0.0478
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.509 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0339 0.0478 0.0447
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.0447
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0983 0.1767 0.1741
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1737 0.328 0.3258
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0339 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.509 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0471 0.0742 0.0742
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0404 0.0608 0.0578
Mycobacterium leprae conserved hypothetical protein 0.0339 0.0478 0.5
Entamoeba histolytica hypothetical protein 0.0339 0.0478 0.0447
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0117 0.0032 0.0032
Giardia lamblia GTOR 0.509 1 1
Brugia malayi serine/threonine-protein kinase 6 0.0136 0.0071 0.0039
Entamoeba histolytica protein kinase rad3, putative 0.0983 0.1767 0.1741
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0032 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.0478 0.0447
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4062 0.794 0.7933
Entamoeba histolytica protein kinase , putative 0.0136 0.0071 0.0039
Plasmodium vivax hypothetical protein 0.0339 0.0478 0.9121
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1792 0.339 0.339
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0361 0.0521 0.0499
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0983 0.1767 0.1741
Loa Loa (eye worm) phosphatidylinositol 3 0.0339 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0361 0.0521 0.049
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.509 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2765 0.534 0.533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0478 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.3043 0.5896 0.5887
Trypanosoma cruzi target of rapamycin kinase 3 0.4062 0.794 0.7933
Brugia malayi serine/threonine kinase 12 0.0136 0.0071 0.0039
Echinococcus granulosus potassium voltage gated channel subfamily H 0.012 0.0039 0.0039
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0983 0.1767 0.1767
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0339 0.0478 0.0447
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0734 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0983 0.1767 0.1767
Loa Loa (eye worm) FKBP5 protein 0.0117 0.0032 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.328 0.3264
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1792 0.339 0.339
Entamoeba histolytica protein kinase domain containing protein 0.0136 0.0071 0.0039
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1094 0.1991 0.2616
Onchocerca volvulus 0.0339 0.0478 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0427 0.0655 0.0625
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0136 0.0071 0.0071
Trichomonas vaginalis immunophilin, putative 0.0117 0.0032 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0071 0.0048
Schistosoma mansoni hypothetical protein 0.0755 0.1311 0.1311
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.0447
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0983 0.1767 0.1767
Plasmodium vivax hypothetical protein, conserved 0.0339 0.0478 0.9121
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1792 0.339 0.339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.1767 0.1748
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0136 0.0071 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.509 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.509 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0339 0.0478 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0061 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5349 0.5338
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0618 0.1036 0.1036
Toxoplasma gondii FATC domain-containing protein 0.0983 0.1767 0.2312
Giardia lamblia Hypothetical protein 0.0339 0.0478 0.0447
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0071 0.0048
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0546 0.0892 0.0871
Schistosoma mansoni immunophilin 0.0117 0.0032 0.0032
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0404 0.0608 0.0578
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0339 0.0478 0.0478
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0546 0.0892 0.0863
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0734 0.1268 0.1268
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0361 0.0521 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.3043 0.5896 0.5887
Loa Loa (eye worm) hypothetical protein 0.0755 0.1311 0.1311
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0136 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0643 0.1087 0.1066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0503 0.0805 0.0775
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.0478 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.2765 0.534 0.533
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.303 0.5871 0.5861
Giardia lamblia Aurora kinase 0.0136 0.0071 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0404 0.0608 0.0586
Loa Loa (eye worm) phosphatidylinositol 3 0.0339 0.0478 0.0478
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0546 0.0892 0.0863
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0339 0.0478 0.0478
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0361 0.0521 0.0521
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0361 0.0521 0.0499
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0339 0.0478 0.0555
Echinococcus granulosus aurora kinase A 0.0136 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.4335 0.8487 0.8484
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0361 0.0521 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1749 0.3303 0.3288
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0361 0.0521 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.509 1 1
Entamoeba histolytica hypothetical protein 0.0339 0.0478 0.0447
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0755 0.1311 0.1311
Trichomonas vaginalis PIKK family atypical protein kinase 0.4058 0.7931 0.7926
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0361 0.0521 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5349 0.5338
Trichomonas vaginalis conserved hypothetical protein 0.0643 0.1087 0.1066
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0983 0.1767 0.1741
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0479 0.0759 0.0737
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0207 0.0212 0.0181
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0734 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0643 0.1087 0.1087
Loa Loa (eye worm) hypothetical protein 0.1028 0.1858 0.1858
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0117 0.0032 0.0032
Loa Loa (eye worm) AUR protein kinase 0.0136 0.0071 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.303 0.5871 0.5861
Trichomonas vaginalis PIKK family atypical protein kinase 0.1367 0.2538 0.2521
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0383 0.0565 0.0535
Entamoeba histolytica hypothetical protein 0.0983 0.1767 0.1741
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0117 0.0032 0.0032
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0339 0.0478 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0755 0.1311 0.129
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0994 0.1791 0.1764
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0479 0.0759 0.0737
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0136 0.0071 0.0039
Entamoeba histolytica protein kinase, putative 0.0136 0.0071 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0478 0.0456
Schistosoma mansoni immunophilin 0.0117 0.0032 0.0032
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0361 0.0521 0.0613
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0618 0.1036 0.1036
Echinococcus multilocularis serine protein kinase ATM 0.0983 0.1767 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.012 0.0039 0.0039
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0436 0.0671 0.0641
Brugia malayi serine/threonine protein kinase 6 0.0136 0.0071 0.0039
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0471 0.0742 0.0742
Schistosoma mansoni fkbp-rapamycin associated protein 0.0983 0.1767 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5349 0.5338
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0339 0.0478 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.4058 0.7931 0.7926
Trypanosoma cruzi aurora B kinase, putative 0.0136 0.0071 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0339 0.0478 0.0447
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0339 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.2765 0.534 0.533
Loa Loa (eye worm) phosphatidylinositol 3 0.1749 0.3303 0.3303
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0983 0.1767 0.1767
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.509 1 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0136 0.0071 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0994 0.1791 0.1771
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0339 0.0478 0.0478
Loa Loa (eye worm) phosphatidylinositol kinase 0.0339 0.0478 0.0478
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0546 0.0892 0.0863
Brugia malayi FAT domain containing protein 0.0755 0.1311 0.1283
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0339 0.0478 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.1094 0.1991 0.1972
Leishmania major protein kinase, putative 0.0136 0.0071 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0339 0.0478 0.9121
Trichomonas vaginalis PIKK family atypical protein kinase 0.3415 0.6642 0.6634
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0755 0.1311 0.1311
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0339 0.0478 0.0447
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0339 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0339 0.0478 0.0447
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0361 0.0521 0.049
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0361 0.0521 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.3798 0.7409 0.7403
Leishmania major hypothetical protein, unknown function 0.0339 0.0478 0.0447
Giardia lamblia Phosphatidylinositol 4-kinase 0.0339 0.0478 0.0447
Toxoplasma gondii target of rapamycin (TOR), putative 0.3798 0.7409 1
Loa Loa (eye worm) hypothetical protein 0.1094 0.1991 0.1991
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.509 1 1
Entamoeba histolytica protein kinase, putative 0.0136 0.0071 0.0039
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0136 0.0071 0.0039
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0339 0.0478 0.9121
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0546 0.0892 0.0871
Echinococcus multilocularis fk506 binding protein 0.0117 0.0032 0.0032
Trichomonas vaginalis fk506-binding protein, putative 0.0117 0.0032 0.0009
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0339 0.0478 0.0478
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0546 0.0892 0.0863
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0404 0.0608 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.509 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0404 0.0608 0.0578
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1792 0.339 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.3043 0.5896 0.5887
Echinococcus multilocularis aurora kinase A 0.0136 0.0071 0.0071
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.509 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0339 0.0478 0.0447
Schistosoma mansoni protein kinase 0.0136 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0471 0.0742 0.0742
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1792 0.339 0.3368
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0071 0.0048
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1792 0.339 0.3368
Leishmania major hypothetical protein, conserved 0.0438 0.0676 0.0646
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0117 0.0032 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0361 0.0521 0.049
Trichomonas vaginalis PIKK family atypical protein kinase 0.4058 0.7931 0.7926
Mycobacterium tuberculosis Conserved hypothetical protein 0.0339 0.0478 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.328 0.3264
Trichomonas vaginalis AGC family protein kinase 0.0136 0.0071 0.0048
Entamoeba histolytica hypothetical protein 0.0503 0.0805 0.0775
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0361 0.0521 0.049
Leishmania major phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.0447
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0339 0.0478 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.4058 0.7931 0.7926
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0983 0.1767 0.1741
Schistosoma mansoni hypothetical protein 0.0339 0.0478 0.0478
Echinococcus granulosus serine protein kinase ATM 0.0983 0.1767 0.1767
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4062 0.794 0.7933
Loa Loa (eye worm) hypothetical protein 0.0104 0.0007 0.0007
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0361 0.0521 0.0521
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0339 0.0478 0.9121
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0136 0.0071 0.0793
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0471 0.0742 0.0712
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0117 0.0032 0.5
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0032 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.4058 0.7931 0.7926
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.24 0.4607 0.459
Echinococcus multilocularis Zinc finger, PHD finger 0.0361 0.0521 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.277 0.5349 0.5338
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0404 0.0608 0.0578
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0339 0.0478 0.9121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0983 0.1767 0.1741
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1749 0.3303 0.3282
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0404 0.0608 0.0586
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0339 0.0478 0.0456
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.509 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0361 0.0521 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.0983 0.1767 0.1748
Echinococcus multilocularis 0.0339 0.0478 0.0478
Entamoeba histolytica hypothetical protein 0.0339 0.0478 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.328 0.3264
Trichomonas vaginalis PIKK family atypical protein kinase 0.3303 0.6419 0.641
Schistosoma mansoni voltage-gated potassium channel 0.0131 0.0061 0.0061
Loa Loa (eye worm) phosphatidylinositol 3 0.0339 0.0478 0.0478
Trypanosoma brucei aurora B kinase 0.0136 0.0071 0.0039
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0361 0.0521 0.0521
Leishmania major phosphatidylinositol kinase, putative 0.0339 0.0478 0.0447
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0361 0.0521 0.049
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0117 0.0032 0.0032
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.509 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.509 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.012 0.0039 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0404 0.0608 0.0586
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1749 0.3303 0.3282

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 6.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 ChEMBL. No reference
Ki (functional) = 8.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.