Detailed information for compound 1647159

Basic information

Technical information
  • TDR Targets ID: 1647159
  • Name: [5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-5- yl]methanol
  • MW: 176.21 | Formula: C8H16O4
  • H donors: 2 H acceptors: 2 LogP: -0.83 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1(CO)COC(OC1)(C)C
  • InChi: 1S/C8H16O4/c1-7(2)11-5-8(3-9,4-10)6-12-7/h9-10H,3-6H2,1-2H3
  • InChiKey: RECJHOHNSXVBQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2,2-dimethyl-5-methylol-1,3-dioxan-5-yl)methanol
  • NSC650609
  • STOCK2S-87434
  • NCI60_017599
  • ZINC00528819
  • 1,3-Dioxane-5,5-dimethanol, 2,2-dimethyl-
  • AIDS-139939
  • AIDS139939

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0881 0.1181 0.1181
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0492 0.0631 1
Echinococcus granulosus serine protein kinase ATM 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0616 0.0806 0.0806
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0607 0.0794 0.0794
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0123 0.0108 0.1719
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.047 0.0599 0.0599
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.0166 0.0166
Plasmodium vivax hypothetical protein, conserved 0.047 0.0599 0.9498
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1364 0.1867 0.1867
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2426 0.3371 0.3371
Schistosoma mansoni immunophilin 0.0106 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.047 0.0599 0.0599
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1376 0.1884 0.1884
Loa Loa (eye worm) hypothetical protein 0.105 0.1421 0.1421
Leishmania major peptidylprolyl isomerase-like protein 0.0123 0.0108 0.0108
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0685 0.0904 0.0904
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.0108 0.0108
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Echinococcus multilocularis 0.047 0.0599 0.0599
Echinococcus multilocularis Zinc finger, PHD finger 0.0492 0.0631 0.0631
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0492 0.0631 0.0631
Plasmodium vivax hypothetical protein 0.047 0.0599 0.9498
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Toxoplasma gondii target of rapamycin (TOR), putative 0.5296 0.7438 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0073 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7104 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1519 0.2087 0.2175
Leishmania major fk506-binding protein 1-like protein 0.0123 0.0108 0.0108
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0685 0.0904 0.0904
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0073 0.0037 0.0622
Loa Loa (eye worm) phosphatidylinositol 3 0.0835 0.1117 0.1117
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0106 0.0084 0.0084
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7104 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0123 0.0108 0.5
Onchocerca volvulus 0.047 0.0599 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.076 0.101 0.101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.1376 0.1884 0.1884
Trichomonas vaginalis conserved hypothetical protein 0.1519 0.2087 0.2087
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.047 0.0599 0.0599
Brugia malayi Protein kinase domain containing protein 0.1098 0.149 0.149
Trichomonas vaginalis PIKK family atypical protein kinase 0.4766 0.6687 0.6687
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.047 0.0599 0.9498
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.0166 0.0166
Loa Loa (eye worm) TKL/LRRK protein kinase 0.1098 0.149 0.149
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.047 0.0599 0.0599
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0492 0.0631 0.0631
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0685 0.0904 0.0904
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0037 0.0037
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.047 0.0599 0.0599
Toxoplasma gondii FATC domain-containing protein 0.1364 0.1867 0.1854
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5666 0.7962 0.7962
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0492 0.0631 0.0631
Brugia malayi Protein kinase domain containing protein 0.0073 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.0166 0.0166
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.047 0.0599 0.9498
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0562 0.0729 0.0729
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0537 0.0695 0.0695
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7104 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2471 0.3435 0.3435
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0068 0.0029 0.0029
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0123 0.0108 0.0071
Giardia lamblia Hypothetical protein 0.047 0.0599 0.0564
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7104 1 1
Entamoeba histolytica hypothetical protein 0.064 0.084 0.084
Echinococcus granulosus voltage gated potassium channel 0.0048 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2471 0.3435 0.3435
Loa Loa (eye worm) hypothetical protein 0.0078 0.0044 0.0044
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0607 0.0794 0.0794
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2471 0.3435 0.3435
Echinococcus multilocularis fk506 binding protein 0.0123 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Echinococcus multilocularis voltage gated potassium channel 0.0048 0.0001 0.0001
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0195 0.0211 0.0211
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.461 0.6467 0.6467
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0492 0.0631 0.0631
Plasmodium falciparum phosphatidylinositol 4-kinase 0.047 0.0599 0.9498
Giardia lamblia GTOR 0.7104 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0084 0.0084
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7104 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0001 0.0001
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2426 0.3371 0.3371
Leishmania major hypothetical protein, conserved 0.0573 0.0745 0.0745
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0123 0.0108 0.0108
Loa Loa (eye worm) FKBP5 protein 0.0123 0.0108 0.0108
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0084 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.064 0.084 0.084
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3352 0.4683 0.4683
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.2426 0.3371 0.3371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.1867 0.1867
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.047 0.0599 0.0599
Leishmania major phosphatidylinositol 3-kinase, putative 0.0492 0.0631 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.047 0.0599 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0537 0.0695 0.0695
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7104 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1364 0.1867 0.1867
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0492 0.0631 0.0631
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0142 0.0135 0.0135
Giardia lamblia Phosphatidylinositol 4-kinase 0.047 0.0599 0.0564
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.0239 0.0239
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0881 0.1181 0.1181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0895 0.1201 0.1201
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7104 1 1
Onchocerca volvulus 0.047 0.0599 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.047 0.0599 0.0599
Echinococcus multilocularis serine protein kinase ATM 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol 4-kinase 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7104 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0492 0.0631 0.0631
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0048 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0537 0.0695 0.0695
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2414 0.3354 0.3354
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0492 0.0631 1
Loa Loa (eye worm) TTK protein kinase 0.0073 0.0037 0.0037
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2963 0.4132 0.4132
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0108 0.0108
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Leishmania major phosphatidylinositol 3-kinase, putative 0.2414 0.3354 0.3354
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0123 0.0108 0.0108
Loa Loa (eye worm) phosphatidylinositol 3 0.7104 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0537 0.0695 0.0695
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.105 0.1421 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7104 1 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2471 0.3435 0.3435
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Mycobacterium leprae conserved hypothetical protein 0.047 0.0599 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Trypanosoma cruzi target of rapamycin kinase 3 0.5666 0.7962 0.7962
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0123 0.0108 0.0108
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0108 0.0108
Brugia malayi FAT domain containing protein 0.105 0.1421 0.1421
Loa Loa (eye worm) phosphatidylinositol kinase 0.047 0.0599 0.0599
Schistosoma mansoni fkbp-rapamycin associated protein 0.1364 0.1867 0.1867
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7104 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0079 0.0079
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0492 0.0631 0.0631
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0607 0.0794 0.0794
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0616 0.0806 0.0806
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0151 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0073 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.1867 0.1867
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5666 0.7962 0.7962
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.9498
Leishmania major phosphatidylinositol kinase related protein, putative 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0123 0.0108 0.0108
Leishmania major phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1364 0.1867 0.1867
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0881 0.1181 0.1181
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.057 0.0742 0.0707
Schistosoma mansoni immunophilin 0.0123 0.0108 0.0108
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.076 0.101 0.101
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0073 0.0037 0.0037
Leishmania major phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0123 0.0108 0.0071
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0685 0.0904 0.0904
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.1098 0.149 0.149
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.105 0.1421 0.1421
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0492 0.0631 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.047 0.0599 0.0599
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0685 0.0904 0.0904
Loa Loa (eye worm) hypothetical protein 0.0895 0.1201 0.1201
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0123 0.0108 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0537 0.0695 0.0695
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.4222 0.5916 0.5916
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.1364 0.1867 0.1867
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0123 0.0108 0.1719
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2471 0.3435 0.3435
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.1519 0.2087 0.2087
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0123 0.0108 0.0108
Schistosoma mansoni immunophilin 0.0123 0.0108 0.0108
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0001 0.0001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0607 0.0794 0.0794
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0188 0.0188
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.105 0.1421 0.1421
Schistosoma mansoni hypothetical protein 0.047 0.0599 0.0599
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2471 0.3435 0.3435
Entamoeba histolytica hypothetical protein 0.1364 0.1867 0.1867
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7104 1 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1364 0.1867 0.1867
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0685 0.0904 0.0904
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0123 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0895 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.1438 0.1971 0.1971
Schistosoma mansoni hypothetical protein 0.105 0.1421 0.1421
Trichomonas vaginalis immunophilin, putative 0.0123 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.2637 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.4222 0.5916 0.5916
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0537 0.0695 0.0695
Entamoeba histolytica protein kinase rad3, putative 0.1364 0.1867 0.1867
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0685 0.0904 0.0904
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.047 0.0599 0.0599
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.6054 0.8513 0.8513
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0123 0.0108 0.0108
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.9498
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0492 0.0631 0.0046
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.2426 0.3371 0.3371
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0515 0.0663 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0492 0.0631 0.0631
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.1106 0.15 0.15
Leishmania major hypothetical protein, unknown function 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Trichomonas vaginalis conserved hypothetical protein 0.0895 0.1201 0.1201
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1364 0.1867 0.1867

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.