Detailed information for compound 1647362

Basic information

Technical information
  • TDR Targets ID: 1647362
  • Name: (2,2,5-Trimethyl-1,3-dioxan-5-yl)methanol
  • MW: 160.211 | Formula: C8H16O3
  • H donors: 1 H acceptors: 1 LogP: 0.39 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1(C)COC(OC1)(C)C
  • InChi: 1S/C8H16O3/c1-7(2)10-5-8(3,4-9)6-11-7/h9H,4-6H2,1-3H3
  • InChiKey: MBENEXSAQJBPKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,2,5-Trimethyl-[1,3]dioxan-5-yl)methanol
  • 2,2,5-Trimethyl-1,3-dioxane-5-methanol
  • 5-hydroxymethyl-2,2,5-trimethyl-1,3-dioxane
  • 598100_ALDRICH
  • AIDS-139940
  • AIDS139940
  • NSC650610
  • NCI60_017600

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.047 0.0599 0.0599
Brugia malayi Protein kinase domain containing protein 0.1098 0.149 0.149
Trichomonas vaginalis conserved hypothetical protein 0.1519 0.2087 0.2087
Trichomonas vaginalis PIKK family atypical protein kinase 0.1376 0.1884 0.1884
Onchocerca volvulus 0.047 0.0599 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.076 0.101 0.101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0123 0.0108 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7104 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.047 0.0599 0.0599
Loa Loa (eye worm) TKL/LRRK protein kinase 0.1098 0.149 0.149
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.4766 0.6687 0.6687
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.047 0.0599 0.9498
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0073 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Toxoplasma gondii target of rapamycin (TOR), putative 0.5296 0.7438 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0492 0.0631 0.0631
Echinococcus multilocularis Zinc finger, PHD finger 0.0492 0.0631 0.0631
Plasmodium vivax hypothetical protein 0.047 0.0599 0.9498
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Echinococcus multilocularis 0.047 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0106 0.0084 0.0084
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0073 0.0037 0.0622
Loa Loa (eye worm) phosphatidylinositol 3 0.0835 0.1117 0.1117
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Entamoeba histolytica hypothetical protein 0.047 0.0599 0.0599
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0685 0.0904 0.0904
Leishmania major fk506-binding protein 1-like protein 0.0123 0.0108 0.0108
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1519 0.2087 0.2175
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7104 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0685 0.0904 0.0904
Leishmania major peptidylprolyl isomerase-like protein 0.0123 0.0108 0.0108
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1376 0.1884 0.1884
Loa Loa (eye worm) hypothetical protein 0.105 0.1421 0.1421
Loa Loa (eye worm) hypothetical protein 0.047 0.0599 0.0599
Schistosoma mansoni immunophilin 0.0106 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.0599 0.0599
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0108 0.0108
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1364 0.1867 0.1867
Loa Loa (eye worm) hypothetical protein 0.0607 0.0794 0.0794
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0123 0.0108 0.1719
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0616 0.0806 0.0806
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0151 0.0151
Echinococcus granulosus serine protein kinase ATM 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0492 0.0631 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0881 0.1181 0.1181
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1364 0.1867 0.1867
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2426 0.3371 0.3371
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.0166 0.0166
Plasmodium vivax hypothetical protein, conserved 0.047 0.0599 0.9498
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.047 0.0599 0.0599
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3352 0.4683 0.4683
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0084 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.064 0.084 0.084
Loa Loa (eye worm) FKBP5 protein 0.0123 0.0108 0.0108
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1364 0.1867 0.1867
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Leishmania major phosphatidylinositol 3-kinase, putative 0.0492 0.0631 0.0631
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7104 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.047 0.0599 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0537 0.0695 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.1867 0.1867
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.047 0.0599 0.0599
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.2426 0.3371 0.3371
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Plasmodium falciparum phosphatidylinositol 4-kinase 0.047 0.0599 0.9498
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0492 0.0631 0.0631
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0195 0.0211 0.0211
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0492 0.0631 0.0631
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.461 0.6467 0.6467
Echinococcus multilocularis voltage gated potassium channel 0.0048 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0123 0.0108 0.0108
Leishmania major hypothetical protein, conserved 0.0573 0.0745 0.0745
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2426 0.3371 0.3371
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7104 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0001 0.0001
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0084 0.0084
Giardia lamblia GTOR 0.7104 1 1
Entamoeba histolytica hypothetical protein 0.064 0.084 0.084
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0123 0.0108 0.0071
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7104 1 1
Giardia lamblia Hypothetical protein 0.047 0.0599 0.0564
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0068 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2471 0.3435 0.3435
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0188 0.0188
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7104 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0537 0.0695 0.0695
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0562 0.0729 0.0729
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Loa Loa (eye worm) hypothetical protein 0.0078 0.0044 0.0044
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0492 0.0631 0.0631
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2471 0.3435 0.3435
Echinococcus multilocularis fk506 binding protein 0.0123 0.0108 0.0108
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0607 0.0794 0.0794
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2471 0.3435 0.3435
Echinococcus granulosus voltage gated potassium channel 0.0048 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Toxoplasma gondii FATC domain-containing protein 0.1364 0.1867 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1364 0.1867 0.1867
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0037 0.0037
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0685 0.0904 0.0904
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0492 0.0631 0.0631
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.0166 0.0166
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.047 0.0599 0.9498
Loa Loa (eye worm) hypothetical protein 0.0048 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.0073 0.0037 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0492 0.0631 0.0631
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5666 0.7962 0.7962
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.0151 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0607 0.0794 0.0794
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0616 0.0806 0.0806
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Trypanosoma cruzi hypothetical protein, conserved 0.0103 0.0079 0.0079
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7104 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Leishmania major phosphatidylinositol kinase related protein, putative 0.047 0.0599 0.0599
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.9498
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5666 0.7962 0.7962
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0073 0.0037 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0073 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Mycobacterium leprae conserved hypothetical protein 0.047 0.0599 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2471 0.3435 0.3435
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.047 0.0599 0.0599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0537 0.0695 0.0695
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7104 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.047 0.0599 0.0599
Brugia malayi FAT domain containing protein 0.105 0.1421 0.1421
Schistosoma mansoni fkbp-rapamycin associated protein 0.1364 0.1867 0.1867
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0123 0.0108 0.0108
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0108 0.0108
Trypanosoma cruzi target of rapamycin kinase 3 0.5666 0.7962 0.7962
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2963 0.4132 0.4132
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Loa Loa (eye worm) TTK protein kinase 0.0073 0.0037 0.0037
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2414 0.3354 0.3354
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0492 0.0631 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0537 0.0695 0.0695
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0492 0.0631 0.0631
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0048 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7104 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.105 0.1421 0.1421
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0537 0.0695 0.0695
Leishmania major phosphatidylinositol 3-kinase, putative 0.2414 0.3354 0.3354
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0123 0.0108 0.0108
Loa Loa (eye worm) phosphatidylinositol 3 0.7104 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0108 0.0108
Giardia lamblia Phosphatidylinositol 4-kinase 0.047 0.0599 0.0564
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0881 0.1181 0.1181
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0215 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0142 0.0135 0.0135
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0492 0.0631 0.0631
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.0166 0.0166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.047 0.0599 0.0599
Echinococcus multilocularis serine protein kinase ATM 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol 4-kinase 0.047 0.0599 0.0599
Onchocerca volvulus 0.047 0.0599 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7104 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0895 0.1201 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.2426 0.3371 0.3371
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0515 0.0663 0.0629
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0492 0.0631 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0123 0.0108 0.0108
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.9498
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0492 0.0631 0.0631
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0492 0.0631 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.6054 0.8513 0.8513
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0492 0.0631 0.0631
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.047 0.0599 0.0599
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0685 0.0904 0.0904
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Trichomonas vaginalis conserved hypothetical protein 0.0895 0.1201 0.1201
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Trichomonas vaginalis PIKK family atypical protein kinase 0.566 0.7954 0.7954
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0492 0.0631 0.0631
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.1106 0.15 0.15
Leishmania major hypothetical protein, unknown function 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.4222 0.5916 0.5916
Trichomonas vaginalis PIKK family atypical protein kinase 0.1908 0.2637 0.2637
Trichomonas vaginalis immunophilin, putative 0.0123 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.105 0.1421 0.1421
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0123 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.1438 0.1971 0.1971
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0895 0.1201 0.1201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0685 0.0904 0.0904
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.047 0.0599 0.0599
Entamoeba histolytica protein kinase rad3, putative 0.1364 0.1867 0.1867
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0537 0.0695 0.0695
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0607 0.0794 0.0794
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.0188 0.0188
Loa Loa (eye worm) phosphatidylinositol 3 0.047 0.0599 0.0599
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0123 0.0108 0.0108
Schistosoma mansoni immunophilin 0.0123 0.0108 0.0108
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1519 0.2087 0.2087
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.2414 0.3354 0.3354
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0123 0.0108 0.1719
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2471 0.3435 0.3435
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.1364 0.1867 0.1867
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0108 0.0108
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1364 0.1867 0.1867
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7104 1 1
Entamoeba histolytica hypothetical protein 0.1364 0.1867 0.1867
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2471 0.3435 0.3435
Schistosoma mansoni hypothetical protein 0.047 0.0599 0.0599
Trichomonas vaginalis conserved hypothetical protein 0.105 0.1421 0.1421
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0073 0.0037 0.0037
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0123 0.0108 0.0071
Leishmania major phosphatidylinositol 4-kinase, putative 0.047 0.0599 0.0599
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.057 0.0742 0.0707
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.076 0.101 0.101
Schistosoma mansoni immunophilin 0.0123 0.0108 0.0108
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0881 0.1181 0.1181
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.54 0.54
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1364 0.1867 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.5296 0.7438 0.7438
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0123 0.0108 0.0108
Leishmania major phosphatidylinositol kinase, putative 0.047 0.0599 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.7104 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.4222 0.5916 0.5916
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.047 0.0599 0.0599
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0537 0.0695 0.0695
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0685 0.0904 0.0904
Loa Loa (eye worm) hypothetical protein 0.0895 0.1201 0.1201
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0123 0.0108 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3852 0.5392 0.5392
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.047 0.0599 0.0599
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.105 0.1421 0.1421
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0492 0.0631 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.4246 0.595 0.595
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.1098 0.149 0.149
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0685 0.0904 0.0904

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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