Detailed information for compound 1648259

Basic information

Technical information
  • TDR Targets ID: 1648259
  • Name: N-(5-phenyl-5H-chromeno[4,3-d]pyrimidin-2-yl) acetamide
  • MW: 317.341 | Formula: C19H15N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.61 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ncc2c(n1)c1ccccc1OC2c1ccccc1
  • InChi: 1S/C19H15N3O2/c1-12(23)21-19-20-11-15-17(22-19)14-9-5-6-10-16(14)24-18(15)13-7-3-2-4-8-13/h2-11,18H,1H3,(H,20,21,22,23)
  • InChiKey: FFLDHULLIYWEEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-phenyl-5H-chromeno[4,3-d]pyrimidin-2-yl)ethanamide
  • NCI60_031809
  • NSC688116

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0026 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0708
Brugia malayi leucyl aminopeptidase 0.0054 0.0475 0.1127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0475 0.1132
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0108
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0206 0.4016
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0244 0.0795
Schistosoma mansoni hypothetical protein 0.0036 0.0242 0.0557
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0677
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0088 0.0615
Brugia malayi jmjC domain containing protein 0.004 0.0294 0.0684
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0244 0.2178
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1029 0.2483
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.2276
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0244 0.0795
Entamoeba histolytica Ran family GTPase 0.0021 0.0056 0.0303
Brugia malayi jmjC domain containing protein 0.0107 0.1155 0.2793
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0152 0.0138
Entamoeba histolytica hypothetical protein 0.0036 0.0242 0.2156
Toxoplasma gondii hypothetical protein 0.0054 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0504 0.1204
Brugia malayi CHE-14 protein 0.0042 0.0321 0.075
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1631
Leishmania major importin beta-1 subunit, putative 0.0023 0.0084 0.1283
Loa Loa (eye worm) leucyl aminopeptidase 0.0054 0.0475 0.1132
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0026 0.0546
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0054 0.0475 0.0461
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0054 0.0475 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.1841 0.4471
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0502 0.1194
Plasmodium falciparum phd finger protein, putative 0.0033 0.0206 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0677
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.1841 0.4474
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0502 0.1194
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0165 0.015
Onchocerca volvulus Fxna peptidase homolog 0.0054 0.0475 0.0965
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0338 0.4099 1
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0206 0.0475
Mycobacterium ulcerans hypothetical protein 0.0054 0.0475 1
Schistosoma mansoni ran 0.0021 0.0056 0.0102
Echinococcus multilocularis expressed conserved protein 0.0091 0.0954 0.094
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.1841 0.4471
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1841 0.1829
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.065 0.1562
Leishmania major GTP-binding protein, putative 0.0021 0.0056 0.0677
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0244 0.0795
Entamoeba histolytica hypothetical protein 0.0036 0.0242 0.2156
Schistosoma mansoni alpha glucosidase 0.0036 0.0244 0.0562
Brugia malayi Peptidase family M28 containing protein 0.0338 0.4099 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0026 0.0011
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0012 0.5
Onchocerca volvulus Alhambra homolog 0.0033 0.0206 0.0296
Schistosoma mansoni importin beta-1 0.0028 0.0152 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0244 0.4865
Entamoeba histolytica hypothetical protein 0.0036 0.0242 0.2156
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0054 0.0475 0.1635
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.021
Leishmania major hypothetical protein, conserved 0.0054 0.0475 1
Schistosoma mansoni nicalin (M28 family) 0.0054 0.0475 0.1127
Schistosoma mansoni Fxna peptidase (M28 family) 0.0054 0.0475 0.1127
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0165 0.0368
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0165 0.0368
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0677
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0054 0.0475 0.1127
Schistosoma mansoni alpha-glucosidase 0.0139 0.1555 0.3771
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1631
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0321 0.0756
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.1375
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0084 0.021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0056 0.2276
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0088 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0244 0.0795
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0244 0.4865
Brugia malayi Importin beta-1 subunit 0.0028 0.0152 0.0336
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0056 0.0677
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0088 0.1631
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.1841 0.1829
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.037 0.0355
Giardia lamblia PHD finger protein 15 0.0033 0.0206 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0244 0.4865
Loa Loa (eye worm) hypothetical protein 0.0054 0.0475 0.1132
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0054 0.0475 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.1375
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0242 0.0557
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0026 0.0027
Schistosoma mansoni hypothetical protein 0.0304 0.3665 0.8939
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1155 0.2793
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0026 0.0027
Brugia malayi Pre-SET motif family protein 0.0206 0.241 0.5864
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0165 0.0368
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0338 0.4099 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.1029 0.2488
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0502 0.1199
Schistosoma mansoni hypothetical protein 0.0048 0.0396 0.0935
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0088 0.1631
Loa Loa (eye worm) hypothetical protein 0.0054 0.0475 0.1132
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0294 0.069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0026 0.0708
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0054 0.0475 0.1127
Schistosoma mansoni hypothetical protein 0.0033 0.0206 0.0469
Echinococcus multilocularis protein dispatched 1 0.0048 0.0396 0.0382
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1048 0.253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0165 0.3098
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0396 0.0935
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1029 1
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1561 0.3786
Onchocerca volvulus Glutaminyl cyclase homolog 0.0338 0.4099 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0502 0.1199
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0338 0.4099 0.409
Echinococcus multilocularis snurportin 1 0.0304 0.3665 0.3656
Loa Loa (eye worm) hypothetical protein 0.0338 0.4099 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0185
Onchocerca volvulus 0.0029 0.0165 0.0193
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0054 0.0475 0.1127
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0206 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0244 0.0795
Brugia malayi hypothetical protein 0.0036 0.0242 0.0557
Entamoeba histolytica hypothetical protein 0.0036 0.0242 0.2156
Echinococcus granulosus snurportin 1 0.0304 0.3665 0.8939
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0294 0.0684
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0012 0.0257
Onchocerca volvulus 0.0234 0.2772 0.6692
Schistosoma mansoni ran 0.0021 0.0056 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0165 0.0374
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0277 0.0641
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1029 0.1016
Entamoeba histolytica hypothetical protein 0.0023 0.0084 0.0574
Schistosoma mansoni alpha-glucosidase 0.0139 0.1555 0.3771
Brugia malayi hypothetical protein 0.0234 0.2767 0.6739
Schistosoma mansoni patched 1 0.0042 0.0321 0.075
Echinococcus multilocularis protein patched 0.0042 0.0321 0.0307
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0244 0.0795
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.1631
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0054 0.0475 0.0461
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0152 0.2813
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2767 0.2756
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0321 0.0307
Onchocerca volvulus 0.0048 0.0396 0.077
Onchocerca volvulus Fxna peptidase homolog 0.0054 0.0475 0.0965
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0206 0.0192
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0703
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0088 0.1631
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0178
Echinococcus granulosus importin subunit beta 1 0.0028 0.0152 0.0336
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0026 0.0297
Loa Loa (eye worm) hypothetical protein 0.0054 0.0475 0.1132
Brugia malayi PHD-finger family protein 0.0033 0.0206 0.0469
Plasmodium falciparum importin beta, putative 0.0028 0.0152 0.7216
Plasmodium vivax importin-beta 2, putative 0.0028 0.0152 0.7216
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0084 0.021
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0054 0.0475 0.1127
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0244 0.023
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0084 0.1283
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0088 0.1631
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0703
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0244 0.0562
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2772 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0206 0.0469
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0244 0.0795
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0006
Echinococcus granulosus peregrin 0.0033 0.0206 0.0469
Echinococcus granulosus expressed conserved protein 0.0091 0.0954 0.2299
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0242 0.0228
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0294 0.0684
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0244 0.4865
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0088 0.0615
Schistosoma mansoni survival motor neuron protein 0.0048 0.0396 0.0935
Onchocerca volvulus 0.0054 0.0475 0.0965
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1561 0.1548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0165 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0475 0.1635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0206 0.0475
Loa Loa (eye worm) hypothetical protein 0.0038 0.0277 0.0647
Loa Loa (eye worm) hypothetical protein 0.0051 0.0441 0.1049
Schistosoma mansoni ap endonuclease 0.0019 0.0026 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0088 0.1846
Loa Loa (eye worm) hypothetical protein 0.0028 0.0152 0.0343
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0244 0.2178
Loa Loa (eye worm) hypothetical protein 0.0234 0.2767 0.6741
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0165 0.015
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0756
Brugia malayi RNA, U transporter 1 0.0081 0.0822 0.1976
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0026 0.5
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0321 0.075
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0088 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.241 0.5867
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.3665 0.8939
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0321 0.075
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0185
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0056 0.0102
Trichomonas vaginalis ran, putative 0.0021 0.0056 0.0111
Echinococcus multilocularis peregrin 0.0033 0.0206 0.0192
Leishmania major glutaminyl cyclase, putative 0.0054 0.0475 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0152 0.2813
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0056 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0475 0.1635
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0102
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1029 0.2483
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0206 0.4016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0015 0.0006
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0703
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0242 0.0557
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0088 0.0615
Trypanosoma brucei glutaminyl cyclase, putative 0.0054 0.0475 1
Trypanosoma cruzi glutaminyl cyclase, putative 0.0054 0.0475 1
Onchocerca volvulus Fxna peptidase homolog 0.0054 0.0475 0.0965
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0185
Mycobacterium ulcerans hypothetical protein 0.0023 0.0088 0.1631
Brugia malayi nicalin 0.0054 0.0475 0.1127
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0874 0.2105
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0244 0.0562
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0294 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0475 0.1635
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0206 0.0469
Brugia malayi Pre-SET motif family protein 0.0029 0.0165 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0321 0.1075
Echinococcus granulosus jumonji domain containing protein 0.0046 0.037 0.0869
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0165 0.0368
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0152 0.2813
Onchocerca volvulus 0.0093 0.0976 0.2214
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0054 0.0475 0.0461
Trypanosoma brucei glucosidase, putative 0.0036 0.0244 0.4865
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0244 0.0568
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.1687
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0244 0.0795
Schistosoma mansoni hypothetical protein 0.004 0.0302 0.0703
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.1375
Brugia malayi FXNA 0.0054 0.0475 0.1127
Brugia malayi Bromodomain containing protein 0.0033 0.0206 0.0469
Toxoplasma gondii peptidase, M28 family protein 0.0054 0.0475 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0151 0.0334
Trypanosoma cruzi glutaminyl cyclase, putative 0.0054 0.0475 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0244 0.0795
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2767 0.6739
Schistosoma mansoni hypothetical protein 0.0038 0.0277 0.0641
Mycobacterium tuberculosis Conserved protein 0.0054 0.0475 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0294 0.0684
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0088 0.1846
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1155 0.1142
Plasmodium vivax SET domain protein, putative 0.0029 0.0165 0.7876

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.96 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.879 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.83 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.583 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.056 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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