Detailed information for compound 1648448

Basic information

Technical information
  • TDR Targets ID: 1648448
  • Name: 6-pyridin-3-ylindeno[3,2-c]isoquinoline-5,11- dione
  • MW: 324.332 | Formula: C21H12N2O2
  • H donors: 0 H acceptors: 3 LogP: 2.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2c3ccccc3c(=O)n(c2c2c1cccc2)c1cccnc1
  • InChi: 1S/C21H12N2O2/c24-20-16-9-3-2-8-15(16)19-18(20)14-7-1-4-10-17(14)21(25)23(19)13-6-5-11-22-12-13/h1-12H
  • InChiKey: CXCKDYOPDOUJTL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(3-pyridyl)indeno[3,2-c]isoquinoline-5,11-dione
  • 6-(3-pyridyl)indeno[3,2-c]isoquinoline-5,11-quinone
  • 81721-83-7
  • 6-(3-Pyridinyl)-5H-indeno(1,2-c)isoquinoline-5,11(6H)-dione
  • NSC 342610
  • NCI60_003042
  • 6-(3-Pyridinyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione
  • AIDS-129357
  • AIDS129357
  • NSC342610

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0025 0.0184 0.0837
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0124 0.0548
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.004 0.0449 0.044
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.001 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0069 0.0978 0.0969
Plasmodium falciparum glutathione reductase 0.0045 0.055 0.26
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.055 0.1656
Leishmania major hypothetical protein, conserved 0.0029 0.0261 0.0729
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0261 0.0786
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.0138 0.0128
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.004 0.0449 0.0607
Echinococcus multilocularis tissue type plasminogen activator 0.0027 0.0217 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Brugia malayi FAT domain containing protein 0.0017 0.0046 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.055 0.26
Brugia malayi follicle stimulating hormone receptor 0.0167 0.2735 0.3178
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0045 0.055 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Toxoplasma gondii kringle domain-containing protein 0.0027 0.0217 0.0998
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Brugia malayi beta-lactamase 0.0029 0.0261 0.0294
Schistosoma mansoni hypothetical protein 0.0051 0.0643 0.0874
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0261 0.0347
Echinococcus multilocularis snurportin 1 0.0232 0.389 0.3885
Schistosoma mansoni inositol transporter 0.0031 0.0296 0.0394
Loa Loa (eye worm) hypothetical protein 0.0022 0.0124 0.0144
Plasmodium falciparum thioredoxin reductase 0.0131 0.209 1
Echinococcus multilocularis solute carrier family 5 0.0031 0.0296 0.0286
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0334 0.0378
Loa Loa (eye worm) transcription factor SMAD2 0.0093 0.1403 0.1635
Trichomonas vaginalis importin beta-1, putative 0.0018 0.005 0.0051
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0045 0.055 0.26
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0054 0.0163
Onchocerca volvulus 0.0071 0.1004 0.082
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0054 0.0163
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0299 0.5107 0.8948
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.0261 0.0252
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0069 0.0978 0.1139
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.004 0.0449 0.1274
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.055 0.1656
Onchocerca volvulus 0.0031 0.0296 0.0082
Schistosoma mansoni inositol transporter 0.0031 0.0296 0.0394
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0045 0.055 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0978 0.1335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.005 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Onchocerca volvulus 0.0029 0.0261 0.0046
Trypanosoma cruzi trypanothione reductase, putative 0.0131 0.209 0.6285
Plasmodium vivax glutathione reductase, putative 0.0131 0.209 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Leishmania major hypothetical protein, conserved 0.0208 0.3462 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.004 0.0449 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.004 0.0449 0.0607
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0031 0.0296 0.0286
Echinococcus granulosus serine protein kinase ATM 0.0022 0.0138 0.0128
Echinococcus multilocularis thioredoxin glutathione reductase 0.0132 0.2104 0.2096
Echinococcus granulosus solute carrier family 5 0.0031 0.0296 0.0286
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.0261 0.0442
Echinococcus multilocularis GPCR, family 2 0.0023 0.0155 0.0146
Echinococcus granulosus thioredoxin glutathione reductase 0.0132 0.2104 0.2096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0069 0.0978 0.1129
Mycobacterium tuberculosis Probable reductase 0.0299 0.5107 0.8948
Mycobacterium tuberculosis Conserved protein 0.0029 0.0261 0.0442
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0261 0.0267
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0261 0.0267
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.055 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0184 0.0214
Entamoeba histolytica hypothetical protein 0.0018 0.005 0.0917
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Trichomonas vaginalis mercuric reductase, putative 0.0045 0.055 0.0561
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0023 0.0155 0.017
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.004 0.0449 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0299 0.5107 0.8948
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Leishmania major trypanothione reductase 0.0131 0.209 0.6024
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0071 0.1004 0.0995
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.0261 0.0267
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0572 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.0261 0.4656
Plasmodium vivax importin-beta 2, putative 0.0022 0.0124 0.0548
Echinococcus granulosus GPCR family 2 0.0023 0.0155 0.0146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0138 0.0149
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0045 0.055 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0074 0.1064 0.123
Echinococcus multilocularis serine protein kinase ATM 0.0022 0.0138 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0261 0.1211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0071 0.1004 0.4778
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.004 0.0449 0.1352
Echinococcus granulosus snurportin 1 0.0232 0.389 0.3885
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.1004 0.1371
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0045 0.055 0.0541
Onchocerca volvulus 0.0029 0.0261 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.0261 0.0442
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.0201
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0232 0.389 0.4532
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0031 0.0296 0.0286
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0045 0.055 0.0541
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0031 0.0296 0.0286
Treponema pallidum NADH oxidase 0.0045 0.055 1
Echinococcus granulosus high affinity choline transporter 1 0.0283 0.4824 0.4819
Brugia malayi Latrophilin receptor protein 2 0.0023 0.0155 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0138 0.0149
Mycobacterium ulcerans lipase LipD 0.0029 0.0261 0.4656
Loa Loa (eye worm) hypothetical protein 0.0031 0.0296 0.0344
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0022 0.0138 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0184 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0217 0.0653
Schistosoma mansoni hypothetical protein 0.0232 0.389 0.5353
Loa Loa (eye worm) MH2 domain-containing protein 0.0093 0.1403 0.1635
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0022 0.0138 0.291
Trypanosoma brucei trypanothione reductase 0.0131 0.209 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0045 0.055 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0031 0.0296 0.0286
Trypanosoma brucei importin beta-1 subunit, putative 0.0022 0.0124 0.0548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0023 0.0155 0.0146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0071 0.1004 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.004 0.0449 0.044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0493 0.8584 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0449 0.1274
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0449 0.2114
Loa Loa (eye worm) hypothetical protein 0.0051 0.0643 0.075
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0449 0.2114
Echinococcus multilocularis importin subunit beta 1 0.0022 0.0124 0.0114
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.1004 0.1371
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Schistosoma mansoni hypothetical protein 0.0027 0.0217 0.0286
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.004 0.0449 0.1352
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.004 0.0449 0.2114
Schistosoma mansoni importin beta-1 0.0022 0.0124 0.0157
Brugia malayi Thioredoxin reductase 0.0131 0.209 0.2426
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0261 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0184 0.0187
Trichomonas vaginalis set domain proteins, putative 0.0561 0.9806 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0333 0.5707 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Leishmania major hypothetical protein, conserved 0.0027 0.0217 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.1004 0.1371
Giardia lamblia GTOR 0.004 0.0449 0.8132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0023 0.0155 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Onchocerca volvulus 0.0561 0.9806 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0023 0.0155 0.0146
Loa Loa (eye worm) hypothetical protein 0.0071 0.1004 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.004 0.0449 0.1274
Brugia malayi Calcitonin receptor-like protein seb-1 0.0074 0.1064 0.123
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0046 0.0047
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.004 0.0449 0.2114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.0261 0.0442
Toxoplasma gondii HEAT repeat-containing protein 0.0022 0.0124 0.0548
Toxoplasma gondii FATC domain-containing protein 0.0022 0.0138 0.0615
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.001 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Echinococcus granulosus importin subunit beta 1 0.0022 0.0124 0.0114
Plasmodium vivax SET domain protein, putative 0.0071 0.1004 0.4778
Loa Loa (eye worm) hypothetical protein 0.0027 0.0217 0.0253
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0299 0.5107 0.8948
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.001 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1566
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.005
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.0138 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Onchocerca volvulus 0.0029 0.0261 0.0046
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0018 0.005 0.0051
Loa Loa (eye worm) beta-lactamase 0.0029 0.0261 0.0305
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.0261 0.0305
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0045 0.055 0.26
Brugia malayi beta-lactamase family protein 0.0029 0.0261 0.0294
Entamoeba histolytica protein kinase rad3, putative 0.0022 0.0138 0.291
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1566
Entamoeba histolytica hypothetical protein 0.0022 0.0138 0.291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0333 0.5707 1
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.0261 0.4656
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0045 0.055 0.26
Echinococcus granulosus sodium:glucose cotransporter 2 0.0031 0.0296 0.0286
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0031 0.0296 0.1375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0978 0.1335
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0054 0.0215
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0138 0.0414
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0299 0.5107 0.8948
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0449 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Leishmania major phosphatidylinositol 3-related kinase, putative 0.004 0.0449 0.1274
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0184 0.0837
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0054 0.0215
Trypanosoma cruzi importin beta-1 subunit, putative 0.0018 0.005 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0261 0.0786
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0333 0.5707 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0023 0.0155 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0155 0.0181
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0045 0.055 0.0631
Schistosoma mansoni sodium/solute symporter 0.0031 0.0296 0.0394
Brugia malayi beta-lactamase family protein 0.0029 0.0261 0.0294
Loa Loa (eye worm) hypothetical protein 0.0283 0.4824 0.562
Mycobacterium ulcerans hypothetical protein 0.0029 0.0261 0.4656
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0188 0.3102 0.5428
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0045 0.055 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0074 0.1064 0.124
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.004 0.0449 0.2114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0299 0.5107 0.8948
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.004 0.0449 0.044
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0054 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0054 0.0215
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0017 0.0046 0.0037
Brugia malayi MH2 domain containing protein 0.0093 0.1403 0.1625
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.004 0.0449 0.044
Plasmodium vivax thioredoxin reductase, putative 0.0131 0.209 1
Brugia malayi GH02984p 0.0283 0.4824 0.5615
Brugia malayi hypothetical protein 0.0018 0.0054 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.0261 0.0294
Loa Loa (eye worm) TK/ROR protein kinase 0.0027 0.0217 0.0253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0449 0.0513
Brugia malayi RNA, U transporter 1 0.0062 0.0841 0.097
Brugia malayi Kringle domain containing protein 0.0027 0.0217 0.0242
Toxoplasma gondii NADPH-glutathione reductase 0.0045 0.055 0.26
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0071 0.1004 0.1371
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.0261 0.0442
Loa Loa (eye worm) hypothetical protein 0.0074 0.1064 0.124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0069 0.0978 0.1335
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0023 0.0155 0.0146
Leishmania major hypothetical protein, conserved 0.0018 0.0054 0.013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0449 0.0513
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.0261 0.0442
Plasmodium falciparum cysteine repeat modular protein 1 0.0027 0.0217 0.0998
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.0201
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.0138 0.0177
Plasmodium falciparum thioredoxin reductase 0.0045 0.055 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0334 0.0378
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0017 0.0046 0.0037
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0045 0.055 1
Brugia malayi Sodium:solute symporter family protein 0.0031 0.0296 0.0334
Echinococcus granulosus histone lysine methyltransferase setb 0.0071 0.1004 0.0995
Mycobacterium tuberculosis Conserved protein 0.0029 0.0261 0.0442
Brugia malayi latrophilin 2 splice variant baaae 0.0051 0.0643 0.0739
Brugia malayi Pre-SET motif family protein 0.0493 0.8584 1
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.0261 0.0442
Leishmania major importin beta-1 subunit, putative 0.0018 0.005 0.0117
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0167 0.2735 0.3186
Echinococcus granulosus tissue type plasminogen activator 0.0027 0.0217 0.0208
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0299 0.5107 0.8899
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0045 0.055 0.26
Plasmodium falciparum glutathione reductase 0.0131 0.209 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0045 0.055 0.5
Schistosoma mansoni hypothetical protein 0.0023 0.0155 0.0201
Mycobacterium tuberculosis Conserved protein 0.0029 0.0261 0.0442
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.0261 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Brugia malayi Protein kinase domain containing protein 0.0027 0.0217 0.0242
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0045 0.055 0.0949
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0031 0.0296 0.0286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0022 0.0138 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0449 0.2114
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0045 0.055 0.1656
Brugia malayi glutathione reductase 0.0131 0.209 0.2426
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0045 0.055 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0045 0.055 0.1566
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.0261 0.0267
Loa Loa (eye worm) thioredoxin reductase 0.0131 0.209 0.2434
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.0261 0.0252
Leishmania major phosphatidylinositol 3-kinase, putative 0.004 0.0449 0.1274
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0131 0.209 0.3651
Toxoplasma gondii ABC1 family protein 0.0029 0.0261 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0449 0.0524
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0054 0.0215
Giardia lamblia NADH oxidase lateral transfer candidate 0.0045 0.055 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.004 0.0449 0.1352
Echinococcus granulosus sodium:glucose cotransporter 0.0031 0.0296 0.0286
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.0261 0.0347
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0449 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Schistosoma mansoni high-affinity choline transporter 0.0283 0.4824 0.664
Brugia malayi Pre-SET motif family protein 0.0071 0.1004 0.1159
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Mycobacterium tuberculosis Probable oxidoreductase 0.0333 0.5707 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0045 0.055 0.26
Echinococcus multilocularis high affinity choline transporter 1 0.0283 0.4824 0.4819
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.004 0.0449 1
Mycobacterium ulcerans beta-lactamase 0.0029 0.0261 0.4656
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.3325 1
Loa Loa (eye worm) glutathione reductase 0.0131 0.209 0.2434
Trichomonas vaginalis glutathione reductase, putative 0.0045 0.055 0.0561
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0069 0.0978 0.0969
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0045 0.055 0.1656
Trichomonas vaginalis esterase, putative 0.0029 0.0261 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0045 0.055 0.1566
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0027 0.0217 0.0998
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0069 0.0978 0.0969
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0045 0.055 0.26
Brugia malayi Importin beta-1 subunit 0.0022 0.0124 0.0133
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0261 0.1211
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.001 0.001
Toxoplasma gondii thioredoxin reductase 0.0131 0.209 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0069 0.0978 0.0969
Plasmodium falciparum importin beta, putative 0.0022 0.0124 0.0548
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0449 0.0458
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0138 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0138 0.014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0068 0.0957 0.0948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0054

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.088 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.672 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.634 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.423 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.312 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.282 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.134 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.021 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.