TDR Targets

Basic information

Technical information

TDR Targets ID: 1651741
Name: NSC104154
MW: 411.534 | Formula: C25H33NO4
H donors: 3 H acceptors: 4 LogP: 2.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(c1ccccc1)C(=O)O.CCC1C2Cc3c(C1(CC)CCN2C)cc(cc3)O
InChi: 1S/C17H25NO.C8H8O3/c1-4-14-16-10-12-6-7-13(19)11-15(12)17(14,5-2)8-9-18(16)3;9-7(8(10)11)6-4-2-1-3-5-6/h6-7,11,14,16,19H,4-5,8-10H2,1-3H3;1-5,7,9H,(H,10,11)
InChiKey: LFCDVWUIVQLIDW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCI60_000102

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nck2/grb4	0.007	0.0166	0.0166
Echinococcus multilocularis	epidermal growth factor receptor	0.0187	0.1506	0.2359
Plasmodium falciparum	plasmepsin VII	0.0075	0.022	0.0595
Trichomonas vaginalis	AGC family protein kinase	0.006	0.0054	0.0027
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0046	0.0274
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0141	0.0972	0.7188
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0278	0.2541	0.3788
Echinococcus granulosus	roundabout 2	0.0107	0.0591	0.0881
Plasmodium falciparum	plasmepsin IV	0.0316	0.2974	1
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0069	0.0154	0.0917
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0046	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0351	0.0464
Brugia malayi	aspartic protease BmAsp-2, identical	0.0075	0.022	0.0291
Onchocerca volvulus		0.0075	0.022	0.0322
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0272	0.2476	0.3691
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1522
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0135	0.0906	0.142
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0272	0.2476	0.3878
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.007	0.0166	0.022
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1448
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0154	0.0349
Schistosoma mansoni	nephrin	0.009	0.0399	0.0399
Onchocerca volvulus		0.0075	0.022	0.0322
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0272	0.2476	0.3878
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1522
Echinococcus granulosus	aurora kinase A	0.0069	0.0154	0.0229
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0134	0.0899	0.2914
Giardia lamblia	Thymus-specific serine protease precursor	0.0134	0.0899	0.6625
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0272	0.2476	0.3691
Schistosoma mansoni	growth factor receptor-bound protein	0.007	0.0166	0.0166
Toxoplasma gondii	aspartyl protease	0.0075	0.022	0.0595
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0059	0.0046	0.0046
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1522
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0134	0.0899	0.6625
Brugia malayi	Fibronectin type III domain containing protein	0.0069	0.0158	0.0209
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0086	0.0351	0.0523
Schistosoma mansoni	tyrosine kinase	0.0272	0.2476	0.2476
Brugia malayi	SRC-1	0.0272	0.2476	0.3271
Onchocerca volvulus	Tyrosine kinase homolog	0.0653	0.6825	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0152	0.1106	0.1461
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0069	0.0154	0.0368
Brugia malayi	SH2 domain containing protein	0.0091	0.0408	0.0539
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0272	0.2476	0.3691
Schistosoma mansoni	cathepsin D (A01 family)	0.0931	1	1
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0134	0.0899	0.5362
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0154	0.0203
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0172	0.1334	1
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0134	0.0899	0.0899
Schistosoma mansoni	glutaminase	0.033	0.3136	0.3136
Echinococcus granulosus	defective proboscis extension response	0.0069	0.0158	0.0236
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Schistosoma mansoni	tyrosine kinase	0.0126	0.0802	0.0802
Brugia malayi	Cytochrome P450 family protein	0.0057	0.002	0.0026
Plasmodium falciparum	plasmepsin X	0.0075	0.022	0.0595
Brugia malayi	Variant SH3 domain containing protein	0.007	0.0166	0.022
Brugia malayi	serine/threonine-protein kinase 6	0.0069	0.0154	0.0203
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0069	0.0158	0.0158
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.007	0.0166	0.0166
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0141	0.0972	0.7188
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0141	0.0972	0.1284
Trichomonas vaginalis	STE family protein kinase	0.0172	0.1334	0.4167
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Brugia malayi	intracellular kinase	0.0059	0.0046	0.0061
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Schistosoma mansoni	vesicular amine transporter	0.0069	0.0158	0.0158
Echinococcus granulosus	c src tyrosine kinase	0.0126	0.0802	0.1196
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0073	0.0199	0.0311
Schistosoma mansoni	tyrosine kinase	0.0073	0.0199	0.0199
Schistosoma mansoni	tyrosine kinase	0.0089	0.0389	0.0389
Schistosoma mansoni	serine/threonine protein kinase	0.0525	0.536	0.536
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.006	0.0054	0.0072
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0069	0.0158	0.0248
Echinococcus multilocularis	roundabout 2	0.0107	0.0591	0.0926
Brugia malayi	Pepsin A precursor	0.0075	0.022	0.0291
Plasmodium falciparum	plasmepsin VI	0.0316	0.2974	1
Schistosoma mansoni	adapter molecule crk	0.007	0.0166	0.0166
Brugia malayi	Protein kinase domain containing protein	0.006	0.0054	0.0072
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0615	0.6383	0.6383
Echinococcus multilocularis	protein kinase shaggy	0.0059	0.0046	0.0072
Trichomonas vaginalis	glutaminase, putative	0.033	0.3136	1
Echinococcus granulosus	dual specificity mitogen activated protein	0.0172	0.1334	0.1988
Plasmodium falciparum	plasmepsin V	0.0075	0.022	0.0595
Leishmania major	protein kinase, putative	0.0069	0.0154	0.0836
Brugia malayi	hypothetical protein	0.0075	0.022	0.0291
Schistosoma mansoni	tyrosine kinase	0.0109	0.0617	0.0617
Schistosoma mansoni	tyrosine kinase	0.0109	0.0617	0.0617
Trichomonas vaginalis	AGC family protein kinase	0.006	0.0054	0.0027
Trypanosoma cruzi	putative prolyl carboxypeptidase, putative	0.0134	0.0899	0.6625
Echinococcus multilocularis	aurora kinase A	0.0069	0.0154	0.0241
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0272	0.2476	0.3878
Schistosoma mansoni	memapsin-2 (A01 family)	0.0075	0.022	0.022
Echinococcus multilocularis	Immunoglobulin	0.0069	0.0158	0.0248
Brugia malayi	serine/threonine protein kinase 6	0.0069	0.0154	0.0203
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0069	0.0158	0.0158
Echinococcus granulosus	protein kinase shaggy	0.0059	0.0046	0.0069
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0643	0.6708	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0238	0.2081	0.326
Giardia lamblia	Serine peptidase, putative	0.0134	0.0899	0.6625
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Echinococcus granulosus	tyrosine kinase	0.0238	0.2081	0.3103
Schistosoma mansoni	growth factor receptor-bound protein	0.007	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0899	0.1188
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0272	0.2476	0.3691
Echinococcus granulosus	twitchin	0.0096	0.0464	0.0692
Schistosoma mansoni	tyrosine kinase	0.0089	0.0389	0.0389
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0069	0.0154	0.0241
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0131	0.0866	0.129
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0134	0.0899	0.134
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0141	0.0972	0.5794
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0054	0.0054
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0004	0.0006
Brugia malayi	Sex muscle abnormal protein 5	0.007	0.0166	0.022
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0316	0.2974	0.3929
Echinococcus granulosus	tyrosine protein kinase HCK	0.0202	0.1677	0.25
Brugia malayi	Variant SH3 domain containing protein	0.007	0.0166	0.022
Plasmodium falciparum	plasmepsin II	0.0316	0.2974	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0272	0.2476	0.3691
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0202	0.1677	0.2627
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0591	0.0781
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0218	0.1853	0.2763
Loa Loa (eye worm)	TK protein kinase	0.0152	0.1106	0.1461
Loa Loa (eye worm)	TK/INSR protein kinase	0.0073	0.0199	0.0262
Echinococcus granulosus	c-Jun N-terminal kinases	0.0525	0.536	0.799
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0059	0.0046	0.0069
Loa Loa (eye worm)	SH2 domain-containing protein	0.0071	0.018	0.0238
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0069	0.0154	0.0917
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0141	0.0972	0.7188
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0288	0.2657	0.3962
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.0525	0.536	0.8397
Schistosoma mansoni	cell adhesion molecule	0.0086	0.0351	0.0351
Schistosoma mansoni	tyrosine kinase	0.0073	0.0199	0.0199
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0238	0.2081	0.3103
Loa Loa (eye worm)	hypothetical protein	0.007	0.0166	0.022
Brugia malayi	aspartic protease BmAsp-1, identical	0.0075	0.022	0.0291
Echinococcus multilocularis	NCK adaptor protein	0.007	0.0166	0.0261
Entamoeba histolytica	protein kinase, putative	0.0069	0.0154	0.0917
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0141	0.0972	0.5794
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.0899	0.2761
Brugia malayi	Furin-like cysteine rich region family protein	0.0187	0.1506	0.199
Brugia malayi	Serine protease Z688.6 precursor	0.0134	0.0899	0.1188
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0141	0.0972	0.3162
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0135	0.0906	0.1351
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0316	0.2974	0.4658
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0272	0.2476	0.3878
Echinococcus multilocularis	c src tyrosine kinase	0.0126	0.0802	0.1257
Plasmodium vivax	aspartyl protease, putative	0.0075	0.022	0.0595
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0141	0.0972	0.1284
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0059	0.0046	0.0072
Entamoeba histolytica	protein kinase, putative	0.0202	0.1677	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0131	0.0866	0.1356
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0046	0.0274
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.006	0.0054	0.0072
Plasmodium vivax	aspartyl protease, putative	0.0075	0.022	0.0595
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0272	0.2476	0.3878
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0172	0.1334	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0004	0.0006
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0615	0.6383	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0272	0.2476	0.3878
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0718	0.7568	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0131	0.0866	0.1356
Trypanosoma cruzi	serine carboxypeptidase S28, putative	0.0134	0.0899	0.6625
Schistosoma mansoni	tyrosine kinase	0.009	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0075	0.022	0.0291
Plasmodium vivax	aspartyl proteinase, putative	0.0316	0.2974	1
Plasmodium vivax	aspartyl protease, putative	0.0075	0.022	0.0595
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0238	0.2081	0.326
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0187	0.1506	0.199
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0179	0.141	0.221
Loa Loa (eye worm)	glutaminase	0.033	0.3136	0.4144
Toxoplasma gondii	aspartyl protease ASP1	0.0316	0.2974	1
Echinococcus multilocularis	neuroglian	0.009	0.0399	0.0624
Loa Loa (eye worm)	SRC-1	0.0272	0.2476	0.3271
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0172	0.1334	1
Toxoplasma gondii	AGC kinase	0.0141	0.0972	0.3162
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.0899	0.2761
Loa Loa (eye worm)	TK/ABL protein kinase	0.0288	0.2657	0.3511
Plasmodium vivax	aspartyl proteinase, putative	0.0075	0.022	0.0595
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0046	0.0061
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0.0154	0.0917
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0075	0.022	0.0291
Brugia malayi	Serine protease Z688.6 precursor	0.0134	0.0899	0.1188
Echinococcus granulosus	Immunoglobulin	0.0069	0.0158	0.0236
Plasmodium falciparum	plasmepsin I	0.0316	0.2974	1
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0134	0.0899	0.2761
Echinococcus multilocularis	epidermal growth factor receptor	0.0109	0.0617	0.0967
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0718	0.7568	1
Schistosoma mansoni	tyrosine kinase	0.0089	0.0389	0.0389
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0272	0.2476	0.3691
Loa Loa (eye worm)	TK protein kinase	0.0202	0.1677	0.2216
Brugia malayi	Stress-activated protein kinase jnk-1	0.0525	0.536	0.7082
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Plasmodium vivax	plasmepsin IV, putative	0.0316	0.2974	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0316	0.2974	1
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0154	0.0203
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1448
Onchocerca volvulus		0.0059	0.0046	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Giardia lamblia	Kinase, STE STE20	0.0172	0.1334	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.007	0.0166	0.022
Mycobacterium ulcerans	glutaminase	0.033	0.3136	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0187	0.1506	0.2245
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0154	0.0349
Brugia malayi	hypothetical protein	0.0075	0.022	0.0291
Plasmodium falciparum	plasmepsin VIII, putative	0.0075	0.022	0.0595
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0154	0.0349
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0075	0.022	0.0595
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0141	0.0972	0.7188
Onchocerca volvulus		0.0134	0.0899	0.1318
Trichomonas vaginalis	AGC family protein kinase	0.006	0.0054	0.0027
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0004	0.0006
Schistosoma mansoni	tyrosine kinase	0.0253	0.2253	0.2253
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0141	0.0972	0.7188
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0141	0.0972	0.7188
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.0972	0.0972
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Plasmodium falciparum	plasmepsin IX	0.0075	0.022	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0615	0.6383	0.8435
Leishmania major	protein kinase A catalytic subunit	0.0141	0.0972	0.7188
Echinococcus granulosus	growth factor receptor bound protein 2	0.007	0.0166	0.0248
Trypanosoma brucei	aurora B kinase	0.0069	0.0154	0.0836
Schistosoma mansoni	protein kinase	0.0172	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0972	0.1284
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0591	0.0781
Echinococcus granulosus	NCK adaptor protein	0.007	0.0166	0.0248
Brugia malayi	hypothetical protein	0.0069	0.0158	0.0209
Trichomonas vaginalis	lysosomal pro-X carboxypeptidase, putative	0.0134	0.0899	0.2761
Echinococcus multilocularis	growth factor receptor bound protein 2	0.007	0.0166	0.0261
Trichomonas vaginalis	prolylcarboxypeptidase, putative	0.0134	0.0899	0.2761
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0141	0.0972	0.1448
Brugia malayi	Protein kinase domain containing protein	0.0073	0.0199	0.0262
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0109	0.0617	0.092
Loa Loa (eye worm)	hypothetical protein	0.0615	0.6383	0.8435
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0141	0.0972	0.7188
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.006	0.0054	0.0085
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0141	0.0972	0.1284
Trichomonas vaginalis	STE family protein kinase	0.0172	0.1334	0.4167
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0218	0.1853	0.2903
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Echinococcus multilocularis	Immunoglobulin	0.0069	0.0158	0.0248
Schistosoma mansoni	tyrosine kinase	0.0272	0.2476	0.2476
Loa Loa (eye worm)	AUR protein kinase	0.0069	0.0154	0.0203
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.0972	0.0972
Loa Loa (eye worm)	TK protein kinase	0.0238	0.2081	0.275
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0069	0.0154	0.0368
Toxoplasma gondii	aspartyl protease ASP3	0.0075	0.022	0.0595
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0069	0.0158	0.0209
Brugia malayi	glutaminase DH11.1	0.033	0.3136	0.4144
Schistosoma mansoni	serine/threonine protein kinase	0.0141	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0615	0.6383	0.8435
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0134	0.0899	0.1409
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0141	0.0972	0.3162
Echinococcus granulosus	insulin receptor	0.0073	0.0199	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0612	0.0808
Loa Loa (eye worm)	TK/CSK protein kinase	0.0056	0.0004	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0272	0.2476	0.3878
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0141	0.0972	0.3162
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0615	0.6383	0.9516
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0272	0.2476	0.3878
Echinococcus granulosus	tyrosine protein kinase Blk	0.0238	0.2081	0.3103
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0141	0.0972	0.7188
Echinococcus multilocularis	tyrosine protein kinase csk	0.0056	0.0004	0.0006
Entamoeba histolytica	protein kinase, putative	0.006	0.0054	0.0325
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.009	0.0394	0.0394
Schistosoma mansoni	tyrosine kinase	0.0058	0.0028	0.0028
Brugia malayi	phosphoinositide-dependent protein kinase I	0.006	0.0054	0.0072
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.006	0.0054	0.0081
Onchocerca volvulus		0.0612	0.6356	0.9314
Trichomonas vaginalis	AGC family protein kinase	0.0141	0.0972	0.2995
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0272	0.2476	0.3691
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0172	0.1334	0.1762
Toxoplasma gondii	AGC kinase	0.0141	0.0972	0.3162
Loa Loa (eye worm)	hypothetical protein	0.0075	0.022	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0316	0.2974	0.3929
Schistosoma mansoni	tyrosine kinase	0.0187	0.1506	0.1506
Entamoeba histolytica	protein kinase, putative	0.0069	0.0154	0.0917
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0238	0.2081	0.326
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0069	0.0154	0.0917
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0272	0.2476	0.3878
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0004	0.0005
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.009	0.0394	0.0588
Giardia lamblia	Aurora kinase	0.0069	0.0154	0.0836
Onchocerca volvulus		0.0091	0.0408	0.0598
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0172	0.1334	0.2089
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0075	0.022	0.0291
Schistosoma mansoni	protein kinase	0.0069	0.0154	0.0154
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0316	0.2974	0.9474
Brugia malayi	protein-tyrosine kinase	0.0238	0.2081	0.275
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Loa Loa (eye worm)	glutaminase 2	0.033	0.3136	0.4144
Trypanosoma cruzi	aurora B kinase, putative	0.0069	0.0154	0.0836
Trichomonas vaginalis	AGC family protein kinase	0.0069	0.0154	0.0349
Schistosoma mansoni	tyrosine kinase	0.0131	0.0866	0.0866
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0615	0.6383	0.8435
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0172	0.1334	0.1762
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0288	0.2657	0.4163
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0134	0.0899	0.5362
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0141	0.0972	0.7188
Giardia lamblia	Kinase, AGC PKA	0.0141	0.0972	0.7188
Echinococcus granulosus	neuroglian	0.009	0.0399	0.0594
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0131	0.0866	0.129
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.002	0.0026
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.0525	0.536	0.7082
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Toxoplasma gondii	aurora kinase	0.0069	0.0154	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0158	0.0209
Entamoeba histolytica	protein kinase , putative	0.0069	0.0154	0.0917
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0154	0.0154
Echinococcus granulosus	epidermal growth factor receptor	0.0109	0.0617	0.092
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.009	0.0394	0.0618
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0075	0.022	0.022
Trichomonas vaginalis	Clan SC, family S28, unassigned serine peptidase	0.0134	0.0899	0.2761
Brugia malayi	Tyrosine-protein kinase abl-1	0.0144	0.1009	0.1333
Plasmodium vivax	plasmepsin V, putative	0.0075	0.022	0.0595
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0073	0.0199	0.0296
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0134	0.0899	0.5362
Brugia malayi	serine/threonine kinase 12	0.0069	0.0154	0.0203
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0316	0.2974	0.4433
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0004	0.0005
Trichomonas vaginalis	STE family protein kinase	0.0172	0.1334	0.4167
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0069	0.0154	0.0229
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0316	0.2974	0.2974
Brugia malayi	Tyrosine-protein kinase abl-1	0.0179	0.141	0.1864
Entamoeba histolytica	protein kinase, putative	0.0059	0.0046	0.0274
Loa Loa (eye worm)	aspartyl protease 6	0.0075	0.022	0.0291
Echinococcus multilocularis	insulin receptor	0.0073	0.0199	0.0311
Plasmodium falciparum	plasmepsin III	0.0075	0.022	0.0595
Echinococcus granulosus	tyrosine protein kinase csk	0.0056	0.0004	0.0005

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2005450

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1651741