Detailed information for compound 1656954

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.52 | Formula: C27H26N4O4
  • H donors: 3 H acceptors: 4 LogP: 4.14 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)c1cccc(c1)/C=c/1\[nH]c(=O)/c(=C/c2nc[nH]c2C(C)(C)C)/[nH]c1=O
  • InChi: 1S/C27H26N4O4/c1-27(2,3)24-19(28-15-29-24)14-21-26(34)30-20(25(33)31-21)13-16-8-7-9-17(12-16)23(32)18-10-5-6-11-22(18)35-4/h5-15H,1-4H3,(H,28,29)(H,30,34)(H,31,33)/b20-13-,21-14-
  • InChiKey: VDEHYCNNNDKYTL-NMGXZBPKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.1275
Trypanosoma brucei beta tubulin 0.0139 0.0529 0.199
Loa Loa (eye worm) BEN-1 protein 0.0139 0.0529 0.443
Loa Loa (eye worm) BEN-1 protein 0.0139 0.0529 0.443
Brugia malayi Tubulin alpha chain 0.0061 0.0119 0.0164
Trypanosoma brucei alpha tubulin, putative 0.0079 0.0214 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0119 0.0756
Loa Loa (eye worm) tubulin beta-4 chain 0.0139 0.0529 0.443
Giardia lamblia Beta tubulin 0.0139 0.0529 0.1661
Toxoplasma gondii beta-tubulin, putative 0.0139 0.0529 0.1891
Echinococcus multilocularis beta tubulin 0.0139 0.0529 0.1252
Echinococcus granulosus expressed conserved protein 0.0097 0.0308 0.2677
Schistosoma mansoni tubulin subunit beta 0.0061 0.0119 0.1031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.4225 1
Loa Loa (eye worm) tubulin alpha chain 0.0259 0.1151 1
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Brugia malayi Telomerase reverse transcriptase 0.1425 0.7215 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.1213
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.4454
Echinococcus multilocularis tubulin alpha chain 0.0259 0.1151 0.2724
Plasmodium falciparum alpha tubulin 1 0.0259 0.1151 0.4179
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0529 0.1252
Schistosoma mansoni alpha tubulin 0.0259 0.1151 1
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus granulosus tubulin alpha 3 chain 0.0259 0.1151 1
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Loa Loa (eye worm) tubulin beta chain 0.0139 0.0529 0.443
Trypanosoma cruzi alpha tubulin, putative 0.0259 0.1151 0.4409
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Echinococcus granulosus tubulin alpha chain 0.0259 0.1151 1
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Loa Loa (eye worm) tubulin alpha 2 0.0198 0.0836 0.7181
Entamoeba histolytica tubulin alpha chain, putative 0.0259 0.1151 1
Brugia malayi Cell division protein ftsZ 0.0061 0.0119 0.0164
Schistosoma mansoni tubulin subunit gamma 0.0139 0.0529 0.4595
Trypanosoma brucei alpha tubulin 0.0259 0.1151 0.4409
Leishmania major epsilon tubulin, putative 0.0139 0.0529 0.1661
Echinococcus multilocularis tubulin alpha chain 0.0259 0.1151 0.2724
Schistosoma mansoni alpha tubulin 0.0259 0.1151 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0139 0.0529 0.1252
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.1275
Schistosoma mansoni tubulin subunit alpha 0.0259 0.1151 1
Trichomonas vaginalis tubulin, putative 0.0079 0.0214 0.1611
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0259 0.1151 1
Echinococcus multilocularis protein patched 0.0044 0.0034 0.0081
Schistosoma mansoni hypothetical protein 0.0043 0.0026 0.0225
Mycobacterium leprae cell division protein FtsZ 0.0061 0.0119 0.5
Brugia malayi Tubulin alpha-2 chain 0.0259 0.1151 0.1595
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0529 0.1252
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0138 0.0522 0.1963
Schistosoma mansoni tubulin subunit delta 0.0061 0.0119 0.1031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0513 0.4284
Trypanosoma brucei zeta tubulin 0.0061 0.0119 0.0394
Echinococcus granulosus beta tubulin 0.0139 0.0529 0.4595
Echinococcus granulosus tubulin epsilon chain 0.0139 0.0529 0.4595
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0341 0.0806
Echinococcus multilocularis tubulin alpha 1C chain 0.0259 0.1151 0.2724
Loa Loa (eye worm) hypothetical protein 0.0198 0.0836 0.7181
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.0214 0.1611
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.018 0.0741 0.6327
Toxoplasma gondii alpha-tubulin I, putative 0.0259 0.1151 0.434
Leishmania major mitochondrial DNA polymerase beta 0.0292 0.1322 0.487
Echinococcus multilocularis peroxisome assembly protein 26 0.0259 0.1151 0.2724
Trichomonas vaginalis tubulin epsilon chain, putative 0.0061 0.0119 0.0756
Echinococcus multilocularis beta tubulin 0.0139 0.0529 0.1252
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0522 0.1963
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0529 0.1252
Schistosoma mansoni tubulin subunit alpha 0.0259 0.1151 1
Entamoeba histolytica tubulin family protein 0.0139 0.0529 0.4595
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.1275
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0529 0.4595
Schistosoma mansoni tubulin subunit alpha 0.0061 0.0119 0.1031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.4454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0513 0.4454
Trichomonas vaginalis tubulin epsilon chain, putative 0.0139 0.0529 0.443
Trypanosoma brucei epsilon tubulin 0.0139 0.0529 0.199
Trypanosoma brucei alpha tubulin 0.0259 0.1151 0.4409
Schistosoma mansoni hypothetical protein 0.0043 0.0026 0.0225
Trichomonas vaginalis tubulin, putative 0.0139 0.0529 0.443
Treponema pallidum cell division protein FtsZ 0.0061 0.0119 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0198 0.0836 0.7181
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0535 0.2589 1
Loa Loa (eye worm) beta-tubulin 0.0139 0.0529 0.443
Toxoplasma gondii beta-1 tubulin, putative 0.0139 0.0529 0.1891
Toxoplasma gondii beta tubulin 0.0139 0.0529 0.1891
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.0214 0.1611
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.4454
Schistosoma mansoni tubulin subunit epsilon 0.0139 0.0529 0.4595
Toxoplasma gondii RNA-directed DNA polymerase 0.0535 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0314 0.2507
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.1151 0.2724
Echinococcus granulosus tubulin alpha 1C chain 0.0259 0.1151 1
Entamoeba histolytica tubulin alpha-1 chain 0.0259 0.1151 1
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Brugia malayi Tubulin beta chain 0.0079 0.0214 0.0297
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0064 0.0182
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0341 0.0472
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0341 0.2959
Plasmodium falciparum tubulin beta chain 0.0139 0.0529 0.1661
Giardia lamblia Telomerase catalytic subunit 0.0535 0.2589 1
Giardia lamblia Beta tubulin 0.0139 0.0529 0.1661
Trichomonas vaginalis tubulin epsilon chain, putative 0.0139 0.0529 0.443
Echinococcus multilocularis tubulin alpha chain 0.0259 0.1151 0.2724
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0529 0.1252
Brugia malayi alpha-tubulin 0.0259 0.1151 0.1595
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Loa Loa (eye worm) alpha-tubulin 0.0259 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0741 0.6327
Echinococcus granulosus tubulin delta chain 0.0061 0.0119 0.1031
Leishmania major telomerase reverse transcriptase, putative 0.0535 0.2589 1
Echinococcus multilocularis tubulin alpha chain 0.0259 0.1151 0.2724
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0139 0.0529 0.1891
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0349 0.3032
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Echinococcus granulosus tubulin alpha chain 0.0259 0.1151 1
Giardia lamblia Alpha-tubulin 0.0259 0.1151 0.4179
Schistosoma mansoni hypothetical protein 0.0043 0.0026 0.0225
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0314 0.0435
Loa Loa (eye worm) tubulin gamma chain 0.0139 0.0529 0.443
Echinococcus granulosus tar DNA binding protein 0.0066 0.0147 0.1275
Echinococcus multilocularis tubulin alpha chain 0.0259 0.1151 0.2724
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0529 0.4595
Trichomonas vaginalis tubulin epsilon chain, putative 0.0259 0.1151 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.0214 0.1611
Plasmodium falciparum alpha tubulin 2 0.0259 0.1151 0.4179
Echinococcus multilocularis expressed conserved protein 0.0097 0.0308 0.0729
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0034 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0571 0.1351
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0513 0.4454
Loa Loa (eye worm) hypothetical protein 0.0103 0.0341 0.2744
Trichomonas vaginalis tubulin epsilon chain, putative 0.0259 0.1151 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0086 0.0464
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0529 0.443
Trypanosoma brucei zeta tubulin, putative 0.0061 0.0119 0.0394
Mycobacterium ulcerans hypothetical protein 0.0154 0.0603 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0259 0.1151 0.2724
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.1275
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0529 0.1252
Trichomonas vaginalis tubulin, putative 0.0061 0.0119 0.0756
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Brugia malayi beta-tubulin, identical 0.0139 0.0529 0.0733
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.1151 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0292 0.1322 0.5072
Trypanosoma brucei alpha tubulin 0.0259 0.1151 0.4409
Plasmodium vivax tubulin gamma chain, putative 0.0139 0.0529 0.1661
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0119 0.0394
Trypanosoma brucei telomerase reverse transcriptase 0.0535 0.2589 1
Plasmodium vivax tubulin alpha chain, putative 0.0259 0.1151 0.4179
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0061 0.0119 0.0756
Schistosoma mansoni alpha tubulin 0.0259 0.1151 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0198 0.0836 0.7181
Brugia malayi Tubulin gamma chain 0.0139 0.0529 0.0733
Echinococcus multilocularis tubulin subunit TubB 0.0259 0.1151 0.2724
Loa Loa (eye worm) hypothetical protein 0.0259 0.1151 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0147 0.0203
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0314 0.0435
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Leishmania major gamma-tubulin 0.0139 0.0529 0.1661
Loa Loa (eye worm) hypothetical protein 0.0067 0.0153 0.1061
Loa Loa (eye worm) tubulin beta chain 0.0061 0.0119 0.0756
Entamoeba histolytica tubulin family protein 0.0139 0.0529 0.4595
Plasmodium falciparum tubulin gamma chain 0.0139 0.0529 0.1661
Loa Loa (eye worm) tubulin alpha-2 chain 0.0259 0.1151 1
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0529 0.4595
Trichomonas vaginalis tubulin alpha chain, putative 0.0139 0.0529 0.443
Echinococcus granulosus tubulin alpha 3 chain 0.0259 0.1151 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0535 0.2589 1
Plasmodium falciparum telomerase reverse transcriptase 0.0535 0.2589 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0147 0.1008
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus granulosus tubulin alpha 1C chain 0.0259 0.1151 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.018 0.0741 0.6327
Echinococcus granulosus tubulin beta 1 chain 0.0139 0.0529 0.4595
Plasmodium vivax tubulin beta chain, putative 0.0139 0.0529 0.1661
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0034 0.0297
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.1151 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0119 0.0276
Loa Loa (eye worm) tubulin alpha chain 0.0259 0.1151 1
Schistosoma mansoni tubulin subunit alpha 0.0259 0.1151 1
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0529 0.4595
Brugia malayi Tubulin beta-1 chain 0.0139 0.0529 0.0733
Echinococcus granulosus alpha tubulin 0.0259 0.1151 1
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus granulosus Tubulin alpha 1 chain 0.0259 0.1151 1
Trypanosoma brucei tubulin delta chain 0.0061 0.0119 0.0394
Echinococcus multilocularis tubulin alpha 0.0139 0.0529 0.1252
Loa Loa (eye worm) tubulin beta-2A chain 0.0139 0.0529 0.443
Loa Loa (eye worm) tubulin alpha 2 0.012 0.0426 0.3508
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0147 0.0347
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Echinococcus multilocularis protein dispatched 1 0.0051 0.0067 0.0158
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0571 0.4961
Trichomonas vaginalis tubulin alpha chain, putative 0.0139 0.0529 0.443
Plasmodium vivax tubulin alpha chain, putative 0.0259 0.1151 0.4179
Trypanosoma cruzi tubulin delta chain 0.0061 0.0119 0.0394
Trypanosoma cruzi epsilon tubulin, putative 0.0139 0.0529 0.199
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0529 0.443
Trypanosoma cruzi beta tubulin, putative 0.0139 0.0529 0.199
Loa Loa (eye worm) alpha-tubulin 0.0259 0.1151 1
Plasmodium vivax tubulin epsilon chain, putative 0.0139 0.0529 0.1661
Echinococcus multilocularis tubulin alpha 1C chain 0.0259 0.1151 0.2724
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0061 0.0119 0.0276
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus multilocularis tubulin subunit beta 0.0139 0.0529 0.1252
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Brugia malayi tubulin alpha-2 chain 0.0259 0.1151 0.1595
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Trypanosoma brucei beta tubulin 0.0139 0.0529 0.199
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus granulosus tubulin subunit TubB 0.0259 0.1151 1
Trypanosoma brucei epsilon tubulin 0.0139 0.0529 0.199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0314 0.2507
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0119 0.0756
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.0214 0.1611
Brugia malayi Tubulin alpha chain 0.0259 0.1151 0.1595
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Brugia malayi Tubulin alpha-2 chain 0.0259 0.1151 0.1595
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0147 0.1008
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.1151 0.2724
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0341 0.2959
Brugia malayi CHE-14 protein 0.0044 0.0034 0.0047
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Echinococcus multilocularis tubulin alpha 3 chain 0.0259 0.1151 0.2724
Echinococcus granulosus beta tubulin 0.0139 0.0529 0.4595
Echinococcus granulosus tubulin alpha chain 0.0259 0.1151 1
Trypanosoma brucei beta tubulin 0.0139 0.0529 0.199
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0513 0.071
Echinococcus multilocularis tubulin beta 1 chain 0.0139 0.0529 0.1252
Trypanosoma brucei epsilon tubulin 0.0139 0.0529 0.199
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Trichomonas vaginalis tubulin, putative 0.0079 0.0214 0.1611
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0535 0.2589 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0198 0.0836 0.7181
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0529 0.443
Toxoplasma gondii alpha tubulin TUBA1 0.0259 0.1151 0.434
Schistosoma mansoni hypothetical protein 0.0067 0.0153 0.1327
Echinococcus multilocularis tubulin delta chain 0.0061 0.0119 0.0281
Brugia malayi TAR-binding protein 0.0066 0.0147 0.0203
Echinococcus granulosus tubulin beta 4A class IVa 0.0139 0.0529 0.4595
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0153 0.0212
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0529 0.4595
Echinococcus granulosus peroxisome assembly protein 26 0.0259 0.1151 1
Trypanosoma brucei beta tubulin 0.0139 0.0529 0.199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0603 1
Schistosoma mansoni hypothetical protein 0.0043 0.0026 0.0225
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0139 0.0529 0.1252
Giardia lamblia Beta tubulin 0.0139 0.0529 0.1661
Trichomonas vaginalis tubulin beta chain, putative 0.0259 0.1151 1
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Brugia malayi Tubulin beta chain 0.0061 0.0119 0.0164
Trypanosoma cruzi tubulin delta chain 0.0061 0.0119 0.0394
Echinococcus multilocularis Tubulin alpha 1 chain 0.0259 0.1151 0.2724
Schistosoma mansoni patched 1 0.0044 0.0034 0.0297
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0061 0.0119 0.5
Brugia malayi RNA binding protein 0.0066 0.0147 0.0203
Schistosoma mansoni tubulin subunit beta 0.0139 0.0529 0.4595
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0513 0.1213
Giardia lamblia Gamma tubulin 0.0139 0.0529 0.1661
Echinococcus multilocularis tubulin epsilon chain 0.0139 0.0529 0.1252
Trypanosoma brucei alpha tubulin 0.0259 0.1151 0.4409
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1322 0.5072
Loa Loa (eye worm) tubulin beta-1 chain 0.0139 0.0529 0.443
Echinococcus granulosus tubulin alpha 0.0139 0.0529 0.4595
Trichomonas vaginalis tubulin beta chain, putative 0.0139 0.0529 0.443
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Plasmodium falciparum tubulin epsilon chain, putative 0.0139 0.0529 0.1661
Trichomonas vaginalis tubulin gamma chain, putative 0.0061 0.0119 0.0756
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0147 0.1008
Echinococcus granulosus tubulin subunit beta 0.0139 0.0529 0.4595
Trypanosoma cruzi epsilon tubulin, putative 0.0139 0.0529 0.199
Trypanosoma cruzi tubulin gamma chain 0.0139 0.0529 0.199
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Trypanosoma brucei tubulin gamma chain 0.0139 0.0529 0.199
Trypanosoma brucei beta tubulin 0.0139 0.0529 0.199
Giardia lamblia Alpha-tubulin 0.0259 0.1151 0.4179
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Echinococcus multilocularis hypothetical protein 0.0259 0.1151 0.2724
Entamoeba histolytica tubulin gamma chain 0.0139 0.0529 0.4595
Brugia malayi tubulin alpha chain - mouse 0.0259 0.1151 0.1595
Trypanosoma cruzi zeta tubulin, putative 0.0061 0.0119 0.0394
Echinococcus granulosus tubulin gamma 1 chain 0.0139 0.0529 0.4595
Echinococcus granulosus tubulin alpha chain 0.0259 0.1151 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.0214 0.1611
Leishmania major alpha tubulin 0.0259 0.1151 0.4179
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0292 0.1322 0.5072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0138 0.0522 0.1634
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.1275
Leishmania major beta tubulin 0.0139 0.0529 0.1661
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0034 0.0297
Echinococcus granulosus tubulin alpha chain 0.0259 0.1151 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 360 nM Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay ChEMBL. 22727370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22727370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.