Detailed information for compound 1665605

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 357.467 | Formula: C20H23NO3S
  • H donors: 2 H acceptors: 3 LogP: 3.67 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC[C@H]([C@H](c1ccccc1)C)C(=O)N[C@H](C(=O)O)Cc1ccccc1
  • InChi: 1S/C20H23NO3S/c1-14(16-10-6-3-7-11-16)17(13-25)19(22)21-18(20(23)24)12-15-8-4-2-5-9-15/h2-11,14,17-18,25H,12-13H2,1H3,(H,21,22)(H,23,24)/t14-,17+,18-/m0/s1
  • InChiKey: AQSAVWDCKRXSBP-QGTPRVQTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Starlite/ChEMBL References
Homo sapiens membrane metallo-endopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) angiotensin-converting enzyme family protein Get druggable targets OG5_131988 All targets in OG5_131988
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0749 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Trypanosoma brucei C-14 sterol reductase, putative 0.0098 0.1105 0.5896
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0183 0.0222
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0115 0.1335 0.4272
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Loa Loa (eye worm) peptidase family M13 containing protein 0.0169 0.2067 0.1969
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.179 1
Schistosoma mansoni neprilysin 0.006 0.0576 0.1456
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Loa Loa (eye worm) hypothetical protein 0.0113 0.1307 0.12
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0169 0.2067 0.1969
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Onchocerca volvulus 0.0101 0.1139 0.5951
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.006 0.0576 0.1456
Loa Loa (eye worm) hypothetical protein 0.0033 0.0212 0.0092
Echinococcus multilocularis lamin b receptor 0.0098 0.1105 0.3565
Trypanosoma cruzi C-14 sterol reductase, putative 0.0098 0.1105 0.5896
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0072 0.0739 0.5
Loa Loa (eye worm) hypothetical protein 0.0228 0.2881 0.2793
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.0183 0.0062
Brugia malayi Cation transporter family protein 0.0031 0.0183 0.0062
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0183 0.0062
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.0183 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0366 0.0886
Trypanosoma brucei ornithine decarboxylase 0.0045 0.038 0.1548
Trypanosoma cruzi Emopamil binding protein, putative 0.0148 0.179 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0366 0.0886
Loa Loa (eye worm) hypothetical protein 0.0058 0.056 0.0444
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.0183 0.0062
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0115 0.1335 0.4272
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Onchocerca volvulus 0.0058 0.056 0.2349
Leishmania major sterol C-24 reductase, putative 0.0051 0.046 0.2027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0366 0.0679
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0058 0.056 0.1399
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0366 0.0679
Echinococcus granulosus geminin 0.0164 0.2 0.681
Schistosoma mansoni endothelin-converting enzyme-related 0.0056 0.0521 0.1255
Schistosoma mansoni hypothetical protein 0.0164 0.2 0.6737
Echinococcus granulosus nAChR subunit 0.0031 0.0183 0.0222
Leishmania major C-14 sterol reductase, putative 0.0098 0.1105 0.5896
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0183 0.0062
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0115 0.1335 0.4272
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0056 0.0521 0.1255
Onchocerca volvulus 0.0148 0.179 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0169 0.2067 0.1969
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2992 0.2905
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0056 0.0521 0.1255
Leishmania major hypothetical protein, conserved 0.0148 0.179 1
Onchocerca volvulus 0.0113 0.1307 0.6995
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0228 0.2881 1
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0072 0.0739 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.042 0.0302
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0228 0.2881 0.2793
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0045 0.038 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0366 0.0248
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Loa Loa (eye worm) hypothetical protein 0.0087 0.0945 0.0833
Toxoplasma gondii peptidase family M13 protein 0.0228 0.2881 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2992 0.2905
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0228 0.2881 0.2793
Echinococcus multilocularis nAChR subunit 0.0031 0.0183 0.0222
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0366 0.0248
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Schistosoma mansoni hypothetical protein 0.0033 0.0212 0.0108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0366 0.0679
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0169 0.2067 0.1969
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0183 0.0222
Onchocerca volvulus 0.0101 0.1139 0.5951
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.046 0.2027
Brugia malayi Peptidase family M13 containing protein 0.0228 0.2881 0.2793
Schistosoma mansoni hypothetical protein 0.0164 0.2 0.6737
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Loa Loa (eye worm) LGC-31 protein 0.0031 0.0183 0.0062
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0056 0.0521 0.1255
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) solute carrier family 6 member 4 0.0058 0.056 0.0444
Onchocerca volvulus 0.0101 0.1139 0.5951
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0183 0.0062
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.179 1
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0045 0.038 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0212 0.0092
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.0183 0.0222
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0183 0.0222
Loa Loa (eye worm) hypothetical protein 0.0169 0.2067 0.1969
Loa Loa (eye worm) hypothetical protein 0.0058 0.056 0.0444
Loa Loa (eye worm) hypothetical protein 0.0101 0.1139 0.103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0058 0.056 0.0444
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0366 0.0886
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0183 0.0222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0366 0.0886
Leishmania major ornithine decarboxylase, putative 0.0045 0.038 0.1548
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Echinococcus granulosus endothelin converting enzyme 1 0.0228 0.2881 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.0183 0.0062
Mycobacterium leprae probable zinc metalloprotease 0.0228 0.2881 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0051 0.046 0.0342
Schistosoma mansoni neprilysin-2 (M13 family) 0.0115 0.1335 0.4272
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.0183 0.0222
Schistosoma mansoni sodium/chloride dependent transporter 0.0058 0.056 0.1399
Giardia lamblia Ornithine decarboxylase 0.0045 0.038 0.5
Loa Loa (eye worm) zinc metallopeptidase 4 0.0056 0.0521 0.0405
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0228 0.2881 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0056 0.0521 0.1255
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) serotonin transporter b 0.0058 0.056 0.0444
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.0183 0.0062
Trypanosoma cruzi C-14 sterol reductase, putative 0.0098 0.1105 0.5896
Trypanosoma cruzi Emopamil binding protein, putative 0.0148 0.179 1
Trichomonas vaginalis ornithine decarboxylase, putative 0.0045 0.038 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.042 0.0302
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0169 0.2067 0.1969
Mycobacterium ulcerans zinc metalloprotease 0.0228 0.2881 1
Trypanosoma cruzi sterol C-24 reductase, putative 0.0051 0.046 0.2027
Loa Loa (eye worm) norepinephrine transporter 0.0058 0.056 0.0444
Schistosoma mansoni Lamin B receptor (ERG24) 0.0098 0.1105 0.3419
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.0183 0.0062
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.0183 0.0062
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.0183 0.0062
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.0183 0.0062
Trichomonas vaginalis ornithine decarboxylase, putative 0.0045 0.038 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0183 0.0222
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0183 0.0222
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.0183 0.0062
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0045 0.038 0.0261
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0183 0.0222
Echinococcus multilocularis serotonin transporter 0.0058 0.056 0.159
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0056 0.0521 0.1255
Trypanosoma brucei Emopamil binding protein, putative 0.0148 0.179 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0183 0.0222
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0228 0.2881 0.2793
Brugia malayi Cation transporter family protein 0.0101 0.1139 0.103
Entamoeba histolytica ornithine decarboxylase, putative 0.0045 0.038 0.5
Echinococcus multilocularis geminin 0.0164 0.2 0.681
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.0183 0.0222
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0045 0.038 0.0261
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0183 0.0062
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0183 0.0222
Echinococcus granulosus lamin b receptor 0.0098 0.1105 0.3565
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0183 0.0222
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0045 0.038 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.0183 0.0222
Echinococcus granulosus serotonin transporter 0.0058 0.056 0.159
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0148 0.179 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0183 0.0222
Brugia malayi Cation transporter family protein 0.0031 0.0183 0.0062
Loa Loa (eye worm) hypothetical protein 0.0101 0.1139 0.103
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.1139 0.3545
Schistosoma mansoni hypothetical protein 0.006 0.0576 0.1456
Echinococcus multilocularis endothelin converting enzyme 1 0.0228 0.2881 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.042 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.042 0.0302
Loa Loa (eye worm) hypothetical protein 0.0173 0.2121 0.2024
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.0183 0.0222
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0183 0.0062
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.1139 0.3545
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.0183 0.0222
Brugia malayi peptidase family M13 containing protein 0.0056 0.0521 0.0405
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0183 0.0062
Onchocerca volvulus 0.0045 0.038 0.1225
Loa Loa (eye worm) hypothetical protein 0.0058 0.056 0.0444
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0115 0.1335 0.4272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0183 0.0062
Treponema pallidum sodium- and chloride- dependent transporter 0.0058 0.056 0.5
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.0183 0.0062

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.6 nM In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney ChEMBL. 8164250
Ki (binding) = 1.9 nM Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung ChEMBL. 8164250
Ki (binding) = 3.1 nM In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney ChEMBL. 8164250
Ki (binding) = 3.2 nM In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidney ChEMBL. 8164250
Ki (binding) = 15 nM Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung ChEMBL. 8164250
Ki (binding) = 26 nM Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lung ChEMBL. 8164250

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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