Detailed information for compound 1685075

Basic information

Technical information
  • TDR Targets ID: 1685075
  • Name: (2R,3R,4S)-2-[[[(1R)-2-methoxy-1-phenylethyl] amino]methyl]pyrrolidine-3,4-diol
  • MW: 266.336 | Formula: C14H22N2O3
  • H donors: 4 H acceptors: 2 LogP: -0.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC[C@@H](c1ccccc1)NC[C@H]1NC[C@@H]([C@@H]1O)O
  • InChi: 1S/C14H22N2O3/c1-19-9-12(10-5-3-2-4-6-10)15-7-11-14(18)13(17)8-16-11/h2-6,11-18H,7-9H2,1H3/t11-,12+,13+,14-/m1/s1
  • InChiKey: LBDZNBLTXQQPGI-ZOBORPQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S)-2-[[[(1R)-2-methoxy-1-phenyl-ethyl]amino]methyl]pyrrolidine-3,4-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mannosidase, alpha, class 1B, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Schistosoma japonicum ko:K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC3.2.1.113], putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Echinococcus multilocularis transfer RNA-Trp Get druggable targets OG5_126925 All targets in OG5_126925
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide Get druggable targets OG5_126925 All targets in OG5_126925
Schistosoma japonicum Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative Get druggable targets OG5_126925 All targets in OG5_126925
Schistosoma japonicum Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126925 All targets in OG5_126925
Loa Loa (eye worm) mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 Get druggable targets OG5_126925 All targets in OG5_126925
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126925 All targets in OG5_126925
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative Get druggable targets OG5_126925 All targets in OG5_126925
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide Get druggable targets OG5_126925 All targets in OG5_126925
Candida albicans alpha mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
Candida albicans alpha mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase Get druggable targets OG5_126925 All targets in OG5_126925
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0036 0.0047 0.0027
Leishmania major trypanothione reductase 0.0042 0.0071 0.2704
Loa Loa (eye worm) hypothetical protein 0.0045 0.0083 0.0083
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0009 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Schistosoma mansoni survival motor neuron protein 0.0053 0.0116 0.0995
Loa Loa (eye worm) hypothetical protein 0.0082 0.0233 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.004 0.002
Loa Loa (eye worm) glutathione reductase 0.0042 0.0071 0.0071
Brugia malayi intermediate filament protein 0.0031 0.003 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.004 0.002
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0059 0.0588
Schistosoma mansoni phd/f-box containing protein 0.0036 0.005 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.004 0.004
Echinococcus multilocularis transfer RNA-Trp 0.0057 0.0132 0.1104
Onchocerca volvulus 0.0053 0.0116 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.004 0.002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.004 0.0388
Plasmodium vivax glutathione reductase, putative 0.0042 0.0071 0.2704
Onchocerca volvulus Huntingtin homolog 0.0142 0.0475 0.0447
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.005 0.0399
Plasmodium falciparum thioredoxin reductase 0.0042 0.0071 0.2704
Loa Loa (eye worm) mannosidase 0.0057 0.0132 0.0132
Brugia malayi ecdysteroid receptor 0.0034 0.004 0.002
Echinococcus granulosus phd:f box containing protein 0.0036 0.005 0.0493
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.003 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.004 0.0011
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0009 0.0046
Brugia malayi Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 0.0057 0.0132 0.0113
Toxoplasma gondii thioredoxin reductase 0.0042 0.0071 0.0604
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0009 0.0057
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi nuclear receptor NHR-88 0.0034 0.004 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0126 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.004 0.0313
Loa Loa (eye worm) hypothetical protein 0.0055 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0049 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0109 0.0343 0.0343
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0418
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0132
Brugia malayi Thioredoxin reductase 0.0042 0.0071 0.0051
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0071 0.2704
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0338
Mycobacterium tuberculosis Probable dehydrogenase 0.0095 0.0284 0.0859
Loa Loa (eye worm) runx1 0.0315 0.117 0.117
Echinococcus granulosus GPCR family 2 0.0035 0.0043 0.0418
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0136 0.0452 0.3843
Loa Loa (eye worm) hypothetical protein 0.0049 0.0103 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.005 0.0399
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0182 0.153
Trypanosoma brucei trypanothione reductase 0.0042 0.0071 0.2704
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.004 0.0342
Echinococcus multilocularis lysine specific demethylase 5A 0.0136 0.0452 0.3843
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0204 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.004 0.002
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.004 0.002
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.005 0.0427
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0126 1
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.0946 1
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.005 0.0493
Echinococcus granulosus lamin dm0 0.0031 0.003 0.0276
Echinococcus multilocularis Protein lozenge 0.0315 0.117 1
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Echinococcus multilocularis GPCR, family 2 0.0035 0.0043 0.0338
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Loa Loa (eye worm) hypothetical protein 0.0057 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.003 0.003
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.004 0.002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.004 0.0342
Echinococcus granulosus mannosyl oligosaccharide 12 alpha mannosidase 0.0057 0.0132 0.1366
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.004 0.0342
Echinococcus multilocularis musashi 0.0031 0.003 0.0223
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.066 0.2556 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0073 0.0594
Schistosoma mansoni hypothetical protein 0.0035 0.0043 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.004 0.002
Brugia malayi Bromodomain containing protein 0.0044 0.0082 0.0063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0461 0.3938
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0126 1
Brugia malayi hypothetical protein 0.0055 0.0126 0.0106
Schistosoma mansoni lamin 0.0031 0.003 0.0252
Schistosoma mansoni hypothetical protein 0.0053 0.0116 0.0995
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.039 0.1286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0071 0.0719
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.004 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0043 0.0023
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Brugia malayi jmjC domain containing protein 0.0136 0.0452 0.0433
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.004 0.0313
Loa Loa (eye worm) thioredoxin reductase 0.0042 0.0071 0.0071
Echinococcus granulosus endoplasmic reticulum mannosyl oligosaccharide 0.0057 0.0132 0.1366
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0095 0.0284 0.0859
Onchocerca volvulus 0.0034 0.004 0.0011
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0343 0.0324
Brugia malayi jmjC domain containing protein 0.0139 0.0461 0.0442
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.005 0.0493
Mycobacterium tuberculosis Probable reductase 0.0095 0.0284 0.0859
Echinococcus multilocularis lamin dm0 0.0031 0.003 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.004 0.0388
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0042 0.0071 0.2704
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0095 0.0284 0.0859
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0095 0.0284 0.0859
Loa Loa (eye worm) hypothetical protein 0.0259 0.0946 0.0946
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.004 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.2514 1 1
Loa Loa (eye worm) hypothetical protein 0.2514 1 1
Leishmania major hypothetical protein, conserved 0.0055 0.0126 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0132 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.004 0.002
Echinococcus multilocularis lamin 0.0031 0.003 0.0223
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi nuclear hormone receptor 0.0034 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0142 0.0475 0.0475
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.004 0.002
Loa Loa (eye worm) hypothetical protein 0.0142 0.0475 0.0475
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.005 0.0399
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0452 0.3862
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0116 0.0097
Schistosoma mansoni nuclear hormone receptor 0.0034 0.004 0.0342
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0043 0.0043
Echinococcus granulosus lysine specific demethylase 5A 0.0139 0.0461 0.4852
Schistosoma mansoni intermediate filament proteins 0.0031 0.003 0.0252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0139 0.0461 0.3938
Loa Loa (eye worm) hypothetical protein 0.0047 0.0094 0.0094
Echinococcus granulosus lamin 0.0031 0.003 0.0276
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0327 0.0187
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.004 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0327 0.103
Loa Loa (eye worm) hypothetical protein 0.0035 0.0043 0.0043
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0095 0.0284 0.0859
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.004 0.0388
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0327 0.103
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0073 0.0735
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0043 0.0023
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.066 0.2556 1
Plasmodium falciparum glutathione reductase 0.0042 0.0071 0.2704
Loa Loa (eye worm) hypothetical protein 0.0075 0.0204 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0343 0.0324
Echinococcus granulosus intermediate filament protein 0.0031 0.003 0.0276
Schistosoma mansoni bromodomain containing protein 0.0073 0.0199 0.1698
Brugia malayi jmjC domain containing protein 0.0036 0.005 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.004 0.0388
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0126 1
Brugia malayi hypothetical protein 0.0259 0.0946 0.0928
Schistosoma mansoni mannosyl-oligosaccharide alpha-12-mannosidase 0.0057 0.0132 0.113
Schistosoma mansoni thyroid hormone receptor 0.0034 0.004 0.0342
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0182 0.1894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.004 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.004 0.0313
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.004 0.0388
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.004 0.0313
Schistosoma mansoni jumonji domain containing protein 0.0036 0.005 0.0427
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.004 0.0313
Treponema pallidum licC protein (licC) 0.0121 0.039 0.5
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.004 0.0388
Schistosoma mansoni lozenge 0.0315 0.117 1
Echinococcus granulosus FTZ F1 alpha 0.0034 0.004 0.0388
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.066 0.2556 1
Schistosoma mansoni hypothetical protein 0.0075 0.0204 0.1745
Brugia malayi steroid hormone receptor 0.0034 0.004 0.002
Brugia malayi glutathione reductase 0.0042 0.0071 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.004 0.0313
Schistosoma mansoni protein phosphatase 2C 0.0036 0.005 0.0427
Brugia malayi Bromodomain containing protein 0.0087 0.0253 0.0234
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0027
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.004 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.005 0.005
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0121 0.039 1
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0126 1
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0343 0.0343
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0059 0.0475
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0043 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.004 0.004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.004 0.0313
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0126 1
Schistosoma mansoni lamin 0.0031 0.003 0.0252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.004 0.0313
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.066 0.2556 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0136 0.0452 0.4758
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.004 0.002
Onchocerca volvulus 0.2514 1 1
Echinococcus multilocularis mannosyl oligosaccharide 1,2 alpha mannosidase 0.0057 0.0132 0.1104
Echinococcus multilocularis phd:f box containing protein 0.0036 0.005 0.0399
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.004 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.004 0.0342
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.004 0.0388
Schistosoma mansoni thyroid hormone receptor 0.0034 0.004 0.0342
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.004 0.002
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0126 0.2235
Trichomonas vaginalis endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative 0.0057 0.0132 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.004 0.0342
Echinococcus multilocularis endoplasmic reticulum mannosyl oligosaccharide 0.0057 0.0132 0.1104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.004 0.0342
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.005 0.0493
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.004 0.0313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0043 0.0338
Loa Loa (eye worm) jmjC domain-containing protein 0.0139 0.0461 0.0461
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.0946 0.8078
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0327 0.103
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0071 0.0581
Onchocerca volvulus Huntingtin homolog 0.0142 0.0475 0.0447
Loa Loa (eye worm) hypothetical protein 0.0036 0.005 0.005
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.004 0.0011
Schistosoma mansoni hypothetical protein 0.0025 0.0004 0.003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0121 0.039 0.1286
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.004 0.0342
Trichomonas vaginalis mannosyl-oligosaccharide alpha-1,2-mannosidase, putative 0.0057 0.0132 0.5
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.005 0.0427
Schistosoma mansoni coup transcription factor 0.0034 0.004 0.0342
Brugia malayi hypothetical protein 0.0142 0.0475 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.004 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.004 0.0342
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.004 0.0342
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.004 0.0388
Loa Loa (eye worm) intermediate filament protein 0.0031 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.004 0.002

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 12.14 uM Inhibition of human ER alpha mannosidase 1 ChEMBL. 23151473
Ki (binding) = 35.98 uM Inhibition of human golgi alpha mannosidase 2 ChEMBL. 23151473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.