Detailed information for compound 169248

Basic information

Technical information
  • TDR Targets ID: 169248
  • Name: 1-[2-(3,4-dichlorophenyl)ethyl]-3-isoquinolin -5-ylurea
  • MW: 360.237 | Formula: C18H15Cl2N3O
  • H donors: 2 H acceptors: 2 LogP: 4.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1ccnc2)NCCc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C18H15Cl2N3O/c19-15-5-4-12(10-16(15)20)6-9-22-18(24)23-17-3-1-2-13-11-21-8-7-14(13)17/h1-5,7-8,10-11H,6,9H2,(H2,22,23,24)
  • InChiKey: DYLGBLIADBFOMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(3,4-dichlorophenyl)ethyl]-3-(5-isoquinolyl)urea
  • 1-[2-(3,4-dichlorophenyl)ethyl]-3-isoquinolin-5-yl-urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calpain (C02 family) 0.0022 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0377 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0642
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Plasmodium falciparum serine repeat antigen 3 0.002 0.0123 0.1434
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0152 0.0152
Onchocerca volvulus 0.0027 0.0229 0.069
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0053
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0108 0.1258
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0037
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0123 0.1434
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0123 0.0123
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0239 0.0721
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0123 0.0371
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0235
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0859 0.1905
Echinococcus multilocularis calpain A 0.006 0.0719 0.0719
Onchocerca volvulus 0.0041 0.044 0.1324
Entamoeba histolytica cysteine proteinase 2 0.004 0.0422 0.2944
Schistosoma mansoni intermediate filament proteins 0.0027 0.0229 0.0229
Brugia malayi Pre-SET motif family protein 0.0207 0.2899 0.6979
Brugia malayi cathepsin L-like precursor 0.0049 0.0561 0.1352
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0152 0.0642
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0203 0.1485
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.2526
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0123 0.1434
Plasmodium vivax vivapain-3 0.004 0.0422 0.4907
Echinococcus granulosus chromobox protein 1 0.0069 0.0859 0.0859
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.044 0.044
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0272 0.0272
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0642
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0123 0.1434
Leishmania major cathepsin L-like protease 0.0116 0.1553 1
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1434 0.1434
Loa Loa (eye worm) cysteine protease 0.0069 0.086 0.1909
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0239 0.0721
Schistosoma mansoni chromobox protein 0.0069 0.0859 0.0859
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0123 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0123 0.0371
Loa Loa (eye worm) hypothetical protein 0.0315 0.4506 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Echinococcus multilocularis cysteine protease 0.0069 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0069 0.086 0.1909
Loa Loa (eye worm) hypothetical protein 0.003 0.0272 0.0603
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0196 0.0196
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0024 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Brugia malayi 6-phosphofructokinase 0.0108 0.1434 0.3452
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0451 0.1358
Loa Loa (eye worm) hypothetical protein 0.0017 0.0083 0.0184
Echinococcus multilocularis hypothetical protein 0.0022 0.0152 0.0152
Echinococcus granulosus calpain A 0.006 0.0719 0.0719
Entamoeba histolytica calpain large subunit domain III containing protein 0.0015 0.0056 0.0389
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.086 0.086
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0265 0.1932
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0045 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.029
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0123 0.0297
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.000000000053517 0.000000000053517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0561 0.169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0123 0.0123
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0422 0.0422
Schistosoma mansoni hypothetical protein 0.0036 0.0362 0.0362
Brugia malayi Cathepsin L-like precursor 0.0049 0.0561 0.1352
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.086 0.086
Brugia malayi hypothetical protein 0.0025 0.0203 0.049
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.006 0.0719 0.0719
Onchocerca volvulus 0.0069 0.086 0.2589
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.086 0.6
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0123 0.0371
Echinococcus granulosus lamin 0.0027 0.0229 0.0229
Echinococcus multilocularis calpain 5 0.0022 0.0152 0.0152
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0203 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Entamoeba histolytica cysteine proteinase 1, putative 0.004 0.0422 0.2944
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.4153 0.4153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.0784
Onchocerca volvulus 0.003 0.0283 0.0852
Leishmania major cathepsin L-like protease 0.0069 0.086 0.5371
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1434 0.1434
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0069 0.086 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0123 0.0297
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0235
Plasmodium vivax calpain, putative 0.0022 0.0152 0.1767
Echinococcus granulosus calpain 0.0022 0.0152 0.0152
Giardia lamblia Cathepsin B precursor 0.0104 0.137 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.000000000053517 0.000000000053517
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0123 0.1434
Echinococcus granulosus Chromo domain 0.0011 0.000000000053517 0.000000000053517
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Plasmodium vivax unspecified product 0.002 0.0131 0.1519
Schistosoma mansoni cathepsin s 0.002 0.0131 0.0131
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0203 0.0451
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0235
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000037331
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0123 0.1434
Loa Loa (eye worm) calpain 0.0022 0.0152 0.0337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0377 0.0836
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1434 0.3363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0272
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0256 0.0256
Plasmodium falciparum serine repeat antigen 6 0.002 0.0123 0.1434
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0123 0.0123
Loa Loa (eye worm) ctsf protein 0.0069 0.086 0.1909
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0131 0.0315
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0422 0.1016
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0146 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0371
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0377 0.0377
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.2526
Brugia malayi hypothetical protein 0.0036 0.0362 0.0872
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0229 0.0509
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0123 0.1434
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0123 0.1434
Echinococcus multilocularis cathepsin L cysteine protease 0.0069 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0036 0.036 0.0799
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0152 0.0642
Plasmodium vivax SET domain protein, putative 0.003 0.0272 0.316
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0642
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0265 0.1932
Giardia lamblia Cathepsin B precursor 0.0104 0.137 1
Entamoeba histolytica hypothetical protein 0.0011 0.000000000053517 0.00000000037331
Loa Loa (eye worm) calpain family protein 1 0.0042 0.0456 0.1013
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.2526
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1434 0.92
Giardia lamblia Cathepsin B precursor 0.0104 0.137 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0096 0.1255 0.2926
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1434 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.006 0.0719 0.0719
Plasmodium vivax vivapain-1 0.004 0.0422 0.4907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0422 0.127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0362 0.0362
Entamoeba histolytica hypothetical protein 0.0036 0.0362 0.2526
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0146 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0422 0.127
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.002 0.0131 0.0315
Onchocerca volvulus Cathepsin F homolog 0.0069 0.086 0.2589
Onchocerca volvulus 0.0069 0.086 0.2589
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0123 0.0123
Echinococcus multilocularis cathepsin b 0.0291 0.4153 0.4153
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0123 0.0901
Schistosoma mansoni cathepsin F (C01 family) 0.0069 0.086 0.086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0422 0.2944
Echinococcus multilocularis microtubule associated protein 2 0.0685 1 1
Brugia malayi CHD4 protein 0.0011 0.000000000053517 0.00000000012885
Brugia malayi calpain 7 0.0022 0.0152 0.0366
Schistosoma mansoni microtubule-associated protein tau 0.0685 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0377 0.0377
Onchocerca volvulus 0.0049 0.0561 0.169
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0123 0.0123
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0045 0.0108
Plasmodium falciparum serine repeat antigen 2 0.002 0.0123 0.1434
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.0784
Echinococcus granulosus chromobox protein 1 0.0069 0.0859 0.0859
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0152 0.0152
Entamoeba histolytica cysteine protease, putative 0.0069 0.086 0.6
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0362 0.0362
Echinococcus granulosus cathepsin l1 0.0069 0.086 0.086
Brugia malayi hypothetical protein 0.0121 0.1626 0.3914
Onchocerca volvulus 0.0069 0.086 0.2589
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000053517 0.000000000053517
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1553 0.3655
Entamoeba histolytica protein kinase, putative 0.0015 0.0056 0.0389
Echinococcus granulosus calpain A 0.0022 0.0152 0.0152
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Loa Loa (eye worm) hypothetical protein 0.0057 0.068 0.1509
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Echinococcus granulosus cathepsin L 0.002 0.0123 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Entamoeba histolytica cysteine proteinase, putative 0.0049 0.0561 0.3917
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Brugia malayi Pre-SET motif family protein 0.003 0.0272 0.0654
Loa Loa (eye worm) RecQ helicase 0.0021 0.0146 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0123 0.0371
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0422 0.0894
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0265 0.0797
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0407 0.1226
Schistosoma mansoni cathepsin F (C01 family) 0.0049 0.0561 0.0561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0123 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Echinococcus multilocularis chromobox protein 1 0.0069 0.0859 0.0859
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0024 0.0024
Loa Loa (eye worm) calpain 5 0.0015 0.0056 0.0124
Entamoeba histolytica cysteine proteinase, putative 0.0069 0.086 0.6
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0377 0.0377
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0152 0.0235
Brugia malayi chromobox protein homolog 3 0.0039 0.0407 0.0981
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0123 0.1434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0272
Onchocerca volvulus 0.0069 0.086 0.2589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0422 0.2446
Echinococcus granulosus cathepsin b 0.0291 0.4153 0.4153
Leishmania major cathepsin L-like protease 0.0069 0.086 0.5371
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0265 0.1932
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0235
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0104 0.137 0.3207
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0407 0.1226
Loa Loa (eye worm) hypothetical protein 0.0049 0.0561 0.1246
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0203 0.2364
Brugia malayi calpain family protein 1 0.0057 0.068 0.1638
Echinococcus multilocularis calpain family protein 1, d 0.0042 0.0456 0.0456
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0291 0.4153 0.4153
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0131 0.029
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0719 0.0719
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0203 0.2364
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0229 0.0509
Plasmodium falciparum serine repeat antigen 1 0.002 0.0123 0.1434
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0377 0.2629
Entamoeba histolytica hypothetical protein 0.002 0.0123 0.0861
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0123 0.0274
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1434 0.4315
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0377 0.0377
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0407 0.1226
Echinococcus granulosus bloom syndrome protein 0.0021 0.0146 0.0146
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.000000000053517 0.00000000011876
Loa Loa (eye worm) cathepsin B 0.0104 0.137 0.304
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0265 0.1134
Echinococcus granulosus cathepsin b 0.0291 0.4153 0.4153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0642
Toxoplasma gondii cathepsin CPC1 0.002 0.0123 0.0901
Plasmodium vivax vivapain-2 0.0069 0.086 1
Leishmania major hypothetical protein, conserved 0.0025 0.0203 0.0986
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0123 0.0297
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0203 0.2364
Plasmodium vivax unspecified product 0.002 0.0123 0.1434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0123 0.1434
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0123 0.0297
Loa Loa (eye worm) hypothetical protein 0.0039 0.0407 0.0904
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0123 0.1434
Trypanosoma cruzi cysteine proteinase, putative 0.004 0.0422 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1553 0.3655
Echinococcus granulosus cathepsin L cysteine proteinase 0.0069 0.086 0.086
Onchocerca volvulus 0.002 0.0123 0.0371
Plasmodium vivax unspecified product 0.004 0.0422 0.4907
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0069 0.086 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0066 0.0817 0.1857
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0377 0.0377
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0235
Brugia malayi cathepsin L precursor 0.002 0.0123 0.0297
Onchocerca volvulus 0.0011 0.000000048316 0.00000014543
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0146 0.0146
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.008 0.008
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0123 0.1434
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0422 0.2944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Echinococcus multilocularis cathepsin L 0.004 0.0422 0.0422
Brugia malayi 6-phosphofructokinase 0.0108 0.1434 0.3452
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0265 0.1846
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1434 0.3181
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0123 0.0371
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0131 0.0183
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0104 0.137 0.8773
Leishmania major cathepsin L-like protease 0.0116 0.1553 1
Trypanosoma cruzi cysteine peptidase, putative 0.004 0.0422 0.0894
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Trichomonas vaginalis set domain proteins, putative 0.0235 0.3322 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1434 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0272 0.0272
Leishmania major cathepsin L-like protease 0.0069 0.086 0.5371
Brugia malayi Cathepsin L-like cysteine proteinase 0.0049 0.0561 0.1352
Trypanosoma cruzi cruzipain precursor, putative 0.0116 0.1553 0.3655
Echinococcus granulosus intermediate filament protein 0.0027 0.0229 0.0229
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0123 0.0861
Onchocerca volvulus Cathepsin L homolog 0.002 0.0123 0.0371
Onchocerca volvulus Cathepsin L homolog 0.0069 0.086 0.2589
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0377 0.0907
Schistosoma mansoni lamin 0.0027 0.0229 0.0229
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.4153 0.4153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0493
Schistosoma mansoni lamin 0.0027 0.0229 0.0229
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.000000000053517 0.00000000012885
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0451 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1434 0.92
Echinococcus granulosus cathepsin l cysteine peptidase 0.0069 0.086 0.086
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0123 0.0371
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Brugia malayi calpain family protein 1 0.0057 0.068 0.1638
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0272 0.1985
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Brugia malayi intermediate filament protein 0.0027 0.0229 0.0552
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0123 0.1434
Schistosoma mansoni cathepsin C 0.002 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0377 0.0377
Brugia malayi hypothetical protein 0.0016 0.0072 0.0173
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0451 0.1358
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0265 0.5
Leishmania major cathepsin L-like protease 0.0069 0.086 0.5371
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0152 0.0642
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0291 0.4153 1
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Leishmania major cysteine peptidase A (CPA) 0.0069 0.086 0.5371
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0123 0.0371
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0045 0.0518
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0123 0.1434
Brugia malayi Cathepsin L-like precursor 0.0049 0.0561 0.1352
Echinococcus multilocularis calpain 0.0022 0.0152 0.0152
Plasmodium falciparum serine repeat antigen 4 0.002 0.0123 0.1434
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0265 0.3077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0123 0.0371
Echinococcus multilocularis cysteine protease 0.0069 0.086 0.086
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0152 0.0642
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0362 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0123 0.0371
Plasmodium falciparum serine repeat antigen 7 0.002 0.0123 0.1434
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0146 0.0441
Trypanosoma cruzi cysteine peptidase, putative 0.0116 0.1553 0.3655
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1434 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0123 0.0297
Trypanosoma cruzi cysteine protease, putative 0.004 0.0422 0.0894
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Loa Loa (eye worm) hypothetical protein 0.002 0.0131 0.029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Echinococcus granulosus lamin dm0 0.0027 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0377 0.1134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Plasmodium falciparum serine repeat antigen 5 0.002 0.0123 0.1434
Loa Loa (eye worm) hypothetical protein 0.0069 0.086 0.1909
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0291 0.4153 0.4153
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0235
Loa Loa (eye worm) hypothetical protein 0.0011 0.000000000053517 0.00000000011876
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0235
Echinococcus multilocularis lamin 0.0027 0.0229 0.0229
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0272 0.0272
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0123 0.0123
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0422 0.2944
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0104 0.137 0.8773
Brugia malayi Cathepsin L-like precursor 0.002 0.0131 0.0315
Echinococcus multilocularis cathepsin L 0.002 0.0123 0.0123
Plasmodium falciparum cysteine proteinase falcipain 1 0.004 0.0422 0.4907
Echinococcus multilocularis musashi 0.0027 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0203 0.036
Brugia malayi phosphofructokinase 0.0108 0.1434 0.3452
Onchocerca volvulus 0.0069 0.086 0.2589
Plasmodium vivax hypothetical protein, conserved 0.0011 0.000000000053517 0.00000000062216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0377 0.2144
Trypanosoma brucei antigen, putative 0.0022 0.0152 0.0642
Toxoplasma gondii cathepsin CPL 0.0069 0.086 0.628
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0422 0.0422
Plasmodium vivax vivapain-2 0.0069 0.086 1
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0265 0.5
Echinococcus multilocularis chromobox protein 1 0.0069 0.0859 0.0859
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Leishmania major cathepsin L-like protease 0.0116 0.1553 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0049 0.0561 0.169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0229 0.0509
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.000000000053517 0.000000000053517
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0377 0.2144
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1434 0.1434
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1434 0.4315
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.004 0.0422 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0152 0.0642
Echinococcus granulosus calpain 5 0.0022 0.0152 0.0152
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0042 0.0307
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.068 0.068
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0123 0.1434
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Plasmodium falciparum serine repeat antigen 9 0.002 0.0123 0.1434
Leishmania major cathepsin L-like protease 0.0069 0.086 0.5371
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1434 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Loa Loa (eye worm) hypothetical protein 0.0049 0.0561 0.1246
Echinococcus granulosus Chromobox protein 3 0.0011 0.000000048316 0.000000048316
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0265 0.3077
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.000000000053517 0.00000000062216
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1434 0.4315
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0104 0.137 0.4123
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0123 0.0371
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0123 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0123 0.0371
Echinococcus granulosus cathepsin l1 0.0049 0.0561 0.0561
Onchocerca volvulus 0.0069 0.086 0.2589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0123 0.0297
Loa Loa (eye worm) hypothetical protein 0.003 0.0283 0.0628
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Brugia malayi calpain 5 0.0015 0.0056 0.0134
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0719 0.0719
Entamoeba histolytica cysteine protease, putative 0.002 0.0123 0.0861
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.000000000053517 0.000000000053517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0069 0.086 0.2589
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Brugia malayi fibroinase precursor 0.002 0.0123 0.0297
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0123 0.0123
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0229 0.0552
Echinococcus granulosus cathepsin L 0.004 0.0422 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0859 0.2584
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1434 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0123 0.0123
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Toxoplasma gondii cathepsin CPC2 0.002 0.0123 0.0901
Brugia malayi Papain family cysteine protease containing protein 0.0069 0.086 0.2071
Echinococcus multilocularis cathepsin b 0.0291 0.4153 0.4153
Schistosoma mansoni chromobox protein 0.0069 0.0859 0.0859
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Echinococcus multilocularis Chromobox protein 3 0.0011 0.000000048316 0.000000048316
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1434 0.3181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Trypanosoma cruzi cruzipain precursor, putative 0.002 0.0131 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0069 0.086 0.2589
Schistosoma mansoni hypothetical protein 0.0011 0.000000000053517 0.000000000053517
Loa Loa (eye worm) fibroinase 0.0069 0.086 0.1909
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0104 0.137 0.137
Entamoeba histolytica cysteine protease, putative 0.004 0.0422 0.2944
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0203 0.0986
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0265 0.3077
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0377 0.0377
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000037331
Onchocerca volvulus 0.0235 0.3322 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0123 0.0274
Toxoplasma gondii cathepsin B 0.0104 0.137 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0069 0.086 1
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0422 0.1016
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000037331
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.086 0.1963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0069 0.086 0.1909
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1434 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0584 0.1296
Onchocerca volvulus 0.0036 0.036 0.1084
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1434 0.4315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Echinococcus granulosus cysteine protease 0.004 0.0422 0.0422
Brugia malayi SET domain containing protein 0.0012 0.0016 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0265 0.0797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0123 0.0371
Loa Loa (eye worm) hypothetical protein 0.0291 0.4153 0.9217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0123 0.0274
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1434 0.5
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.000000000053517 0.00000000039071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0561 0.1246
Echinococcus multilocularis Chromo domain 0.0011 0.000000000053517 0.000000000053517
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0422 0.0422
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0377 0.2034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0116 0.1553 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.000000000053517 0.000000000053517
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1434 0.1434
Brugia malayi cathepsin B-like cysteine proteinase 0.0291 0.4153 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.000000000053517 0.00000000016109
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0123 0.0297
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.000000000053517 0.00000000012885
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0377 0.1134
Onchocerca volvulus 0.0027 0.0229 0.069
Onchocerca volvulus 0.0069 0.086 0.2589
Brugia malayi Heterochromatin protein 1 0.0069 0.0859 0.2067
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0265 0.3077
Brugia malayi Cathepsin L-like precursor 0.0069 0.086 0.2071
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0859 0.2584
Loa Loa (eye worm) calpain family protein 1 0.0057 0.068 0.1509
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0069 0.086 0.086
Echinococcus multilocularis lamin dm0 0.0027 0.0229 0.0229
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.2899 0.6432
Echinococcus granulosus cathepsin L cysteine protease 0.004 0.0422 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.004 0.0422 0.2446
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0456 0.1013
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0196 0.0196
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1434 0.3181
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0123 0.1434
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.086 0.2589
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0123 0.0861
Plasmodium falciparum serine repeat antigen 8 0.002 0.0123 0.1434
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0422 0.2944
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0069 0.086 0.2589
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0152 0.0235

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
IC50 (functional) = 10 nM Antagonistic activity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane, as inhibition of agonist-induced intracellular [Ca2+] levels. ChEMBL. 15149643
Ki (binding) = 17 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643
Ki (binding) = 17 nM Binding affinity towards human vanilloid receptor subtype 1 expressed in HEK293 cell membrane using [3H]-RTX as radioligand. ChEMBL. 15149643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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