TDR Targets

Basic information

Technical information

TDR Targets ID: 169446
Name: (2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-amino-3-sulf anylpropyl]amino]-3-methylpentoxy]-3-phenylpr opanoyl]amino]-4-methylsulfonylbutanoic acid
MW: 517.702 | Formula: C23H39N3O6S2
H donors: 4 H acceptors: 5 LogP: -0.76 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: CCC([C@H](NC[C@H](CS)N)CO[C@H](C(=O)N[C@H](C(=O)O)CCS(=O)(=O)C)Cc1ccccc1)C
InChi: 1S/C23H39N3O6S2/c1-4-16(2)20(25-13-18(24)15-33)14-32-21(12-17-8-6-5-7-9-17)22(27)26-19(23(28)29)10-11-34(3,30)31/h5-9,16,18-21,25,33H,4,10-15,24H2,1-3H3,(H,26,27)(H,28,29)/t16?,18-,19+,20-,21+/m1/s1
InChiKey: SIEXHGZWGJLLAC-QQFYDIPVSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-amino-3-sulfanyl-propyl]amino]-3-methyl-pentoxy]-3-phenyl-propanoyl]amino]-4-methylsulfonyl-butanoic acid
(2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-amino-3-mercaptopropyl]amino]-3-methylpentoxy]-1-oxo-3-phenylpropyl]amino]-4-methylsulfonylbutanoic acid
(2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-azanyl-3-sulfanyl-propyl]amino]-3-methyl-pentoxy]-3-phenyl-propanoyl]amino]-4-methylsulfonyl-butanoic acid
(2S)-2-[[(2S)-2-[(2S)-2-[[(2R)-2-amino-3-mercapto-propyl]amino]-3-methyl-pentoxy]-3-phenyl-propanoyl]amino]-4-mesyl-butyric acid
L 739750

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Protein farnesyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0219	0.0741
Schistosoma mansoni	single-minded	0.0048	0.0346	0.0996
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0719	0.2428
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0376	0.6873
Giardia lamblia	Prenyltransferase	0.0067	0.0546	1
Onchocerca volvulus		0.0347	0.3471	0.5447
Loa Loa (eye worm)	blistered cuticle protein 3	0.0078	0.0658	0.0955
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0816	0.2758
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0719	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0327	0.3257	0.4731
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0067	0.0546	0.6152
Schistosoma mansoni	patched 1	0.0049	0.0355	0.1024
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0067	0.0546	0.0794
Onchocerca volvulus	Peroxidase homolog	0.0078	0.0658	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Brugia malayi	Hemopexin family protein	0.0347	0.3471	0.5042
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0018	0.0034	0.005
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0067	0.0546	0.1574
Schistosoma mansoni	hypothetical protein	0.0047	0.0337	0.0971
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0122	0.0352
Brugia malayi	hypothetical protein	0.0078	0.0658	0.0955
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0376	0.6873
Brugia malayi	Matrixin family protein	0.0245	0.2402	0.3489
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0018	0.0034	0.0631
Trypanosoma brucei	trypanothione reductase	0.0037	0.0227	0.256
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0018	0.0034	0.0561
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0546	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0105	0.0152
Brugia malayi	Niemann-Pick C1 protein precursor	0.0114	0.1036	0.1505
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0219	0.0741
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.0615	1
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0227	0.033
Loa Loa (eye worm)	hypothetical protein	0.006	0.047	0.0683
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0067	0.0546	0.0794
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0719	0.2428
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.0355	0.0355
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0105	0.1708
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0122	0.0177
Echinococcus granulosus	lamin	0.0027	0.0122	0.0122
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0308	0.0447
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0105	0.0152
Schistosoma mansoni	peroxidasin	0.0078	0.0658	0.1895
Brugia malayi	Animal haem peroxidase family protein	0.0078	0.0658	0.0955
Schistosoma mansoni	lamin	0.0027	0.0122	0.0352
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0067	0.0546	1
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0543	0.5518	0.8659
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2402	0.3489
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Echinococcus multilocularis	musashi	0.0027	0.0122	0.0122
Brugia malayi	Blistered cuticle protein 3	0.0078	0.0658	0.0955
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0025	0.0105	0.0302
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0018	0.0034	0.0333
Onchocerca volvulus	Chorion peroxidase homolog	0.0078	0.0658	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0245	0.2402	0.3489
Onchocerca volvulus		0.0025	0.0105	0.0165
Loa Loa (eye worm)	matrix metalloproteinase	0.0245	0.2402	0.3489
Loa Loa (eye worm)	hypothetical protein	0.0298	0.296	0.4299
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0376	0.1269
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0279	0.0805
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0116	0.1054	0.3037
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0034	0.005
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0376	0.3626
Plasmodium falciparum	acyl-CoA synthetase	0.0038	0.0241	0.4414
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0067	0.0546	0.0546
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0018	0.0034	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.005
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0215	0.0728
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0227	0.4162
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0018	0.0034	0.0034
Onchocerca volvulus		0.0051	0.0376	0.0589
Echinococcus granulosus	single minded 2	0.0036	0.0215	0.0215
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0284	0.5192
Brugia malayi	Animal haem peroxidase family protein	0.0078	0.0658	0.0955
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0227	0.033
Onchocerca volvulus		0.0036	0.0215	0.0338
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0018	0.0034	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0241	0.035
Schistosoma mansoni	peroxidasin	0.0078	0.0658	0.1895
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0105	0.0105
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.2284	0.2284
Echinococcus multilocularis	geminin	0.0165	0.1562	0.1562
Onchocerca volvulus		0.0078	0.0658	0.1032
Onchocerca volvulus	Matrilysin homolog	0.0245	0.2402	0.3769
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0342	0.0496
Brugia malayi	Peroxidasin	0.0078	0.0658	0.0955
Entamoeba histolytica	hypothetical protein	0.0042	0.0279	0.2698
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0067	0.0546	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0051	0.0376	0.3626
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0149	0.1397	0.203
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0376	0.0546
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0284	0.0284
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0247	0.2385
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0308	0.0886
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0025	0.0105	0.0105
Mycobacterium ulcerans	hypothetical protein	0.0051	0.0376	0.1269
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0038	0.0241	0.0815
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0025	0.0105	0.0105
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0105	0.1708
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0025	0.0105	0.0302
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0284	0.5192
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0018	0.0034	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0308	0.0886
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0284	0.5192
Echinococcus multilocularis	Niemann Pick C1 protein	0.0114	0.1036	0.1036
Toxoplasma gondii	hypothetical protein	0.0025	0.0105	0.1921
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1182
Onchocerca volvulus	Dual oxidase homolog	0.0078	0.0658	0.1032
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0346	0.0996
Loa Loa (eye worm)	matrixin family protein	0.0543	0.5518	0.8015
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0018	0.0034	0.0034
Brugia malayi	Matrixin family protein	0.0245	0.2402	0.3489
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0105	0.0105
Brugia malayi	hypothetical protein	0.0234	0.2284	0.3317
Brugia malayi	glutathione reductase	0.0037	0.0227	0.033
Brugia malayi	Animal haem peroxidase family protein	0.0078	0.0658	0.0955
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0298	0.296	0.4299
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0018	0.0034	0.0333
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0018	0.0034	0.0631
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0018	0.0034	0.0099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0308	0.0886
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0546	1
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0025	0.0105	0.1013
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0719	0.2428
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0034	0.005
Entamoeba histolytica	hypothetical protein	0.0042	0.0279	0.2698
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Brugia malayi	hypothetical protein	0.0161	0.1528	0.2219
Loa Loa (eye worm)	animal heme peroxidase	0.0078	0.0658	0.0955
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0067	0.0546	0.5275
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.0615	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0114	0.1036	0.1036
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0025	0.0105	0.0105
Brugia malayi	Matrixin family protein	0.0245	0.2402	0.3489
Leishmania major	trypanothione reductase	0.0037	0.0227	0.4162
Onchocerca volvulus	Peroxidasin homolog	0.0078	0.0658	0.1032
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0034	0.005
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0327	0.3257	0.9382
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0247	0.4522
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0122	0.0177
Schistosoma mansoni	hypothetical protein	0.0165	0.1562	0.4499
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0308	0.0308
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0105	0.0152
Loa Loa (eye worm)	acetyltransferase	0.0143	0.1339	0.1946
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0018	0.0034	0.0388
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0376	0.1269
Schistosoma mansoni	hypothetical protein	0.0047	0.0337	0.0971
Schistosoma mansoni	hypothetical protein	0.0047	0.0337	0.0971
Plasmodium vivax	geranylgeranyltransferase, putative	0.0018	0.0034	0.0631
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0247	0.4153
Echinococcus multilocularis	protein patched	0.0049	0.0355	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Echinococcus multilocularis	peroxidasin	0.0078	0.0658	0.0658
Schistosoma mansoni	lamin	0.0027	0.0122	0.0352
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.0546	1
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0025	0.0105	0.1921
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0105	0.1182
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0025	0.0105	0.1921
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0227	0.4162
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0342	0.0984
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0284	0.5192
Mycobacterium ulcerans	hydrolase	0.0298	0.296	1
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0018	0.0034	0.0034
Echinococcus granulosus	intermediate filament protein	0.0027	0.0122	0.0122
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0215	0.0313
Schistosoma mansoni	hypothetical protein	0.0048	0.0342	0.0984
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.0355	0.0355
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0105	0.1377
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0025	0.0105	0.0105
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0067	0.0546	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0025	0.0105	0.1921
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0067	0.0546	1
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0227	0.4162
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0051	0.0376	0.1269
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0816	0.2758
Brugia malayi	intermediate filament protein	0.0027	0.0122	0.0177
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0376	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0376	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0376	0.0546
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0018	0.0034	0.0099
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.0546	0.889
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0105	0.1377
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0233	0.0233
Leishmania major	4-coumarate:coa ligase-like protein	0.0051	0.0376	0.6873
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Onchocerca volvulus		0.0245	0.2402	0.3769
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0973	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0816	0.2758
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0051	0.0376	0.1269
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0308	0.0308
Leishmania major	geranylgeranyltransferase, putative	0.0018	0.0034	0.0631
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.1339	0.3858
Onchocerca volvulus	Peroxidase homolog	0.0078	0.0658	0.1032
Brugia malayi	Matrixin family protein	0.0674	0.6884	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0279	0.2698
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0114	0.1036	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0241	0.035
Plasmodium falciparum	glutathione reductase	0.0037	0.0227	0.4162
Schistosoma mansoni	hypothetical protein	0.01	0.0888	0.2559
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1528	0.2219
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0308	0.0308
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0105	0.1708
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0284	0.5192
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0034	0.0561
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.0546	0.889
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.1339	0.1339
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0227	0.4162
Onchocerca volvulus		0.0027	0.0122	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0227	0.37
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0094	0.0827	0.2382
Entamoeba histolytica	hypothetical protein	0.0042	0.0279	0.2698
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Leishmania major	lanosterol synthase, putative	0.0056	0.0424	0.7761
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0067	0.0546	1
Trypanosoma brucei	RNA helicase, putative	0.01	0.0888	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0122	0.0122
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0074	0.0615	0.2077
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0051	0.0376	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0241	0.035
Brugia malayi	hypoxia-induced factor 1	0.0149	0.1397	0.203
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0376	0.1269
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.094	0.9661	0.9661
Schistosoma mansoni	hypothetical protein	0.0047	0.0337	0.0971
Echinococcus multilocularis	Niemann Pick C1 protein	0.0163	0.1547	0.1547
Mycobacterium ulcerans	acyl-CoA synthetase	0.0051	0.0376	0.1269
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1921
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0233	0.0233
Loa Loa (eye worm)	matrixin family protein	0.0674	0.6884	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0355	0.6505
Echinococcus granulosus	expressed conserved protein	0.0107	0.0964	0.0964
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0051	0.0376	0.3626
Schistosoma mansoni	hypothetical protein	0.0347	0.3471	1
Brugia malayi	Animal haem peroxidase family protein	0.0078	0.0658	0.0955
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1036	0.1505
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0355	0.0516
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0018	0.0034	0.0631
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0067	0.0546	1
Loa Loa (eye worm)	animal heme peroxidase	0.0078	0.0658	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0376	0.0546
Brugia malayi	Matrixin family protein	0.0245	0.2402	0.3489
Loa Loa (eye worm)	hypothetical protein	0.0234	0.2284	0.3317
Schistosoma mansoni	hypothetical protein	0.0042	0.0279	0.0805
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0816	0.2758
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0719	0.2428
Loa Loa (eye worm)	animal heme peroxidase	0.0078	0.0658	0.0955
Loa Loa (eye worm)	animal heme peroxidase	0.0078	0.0658	0.0955
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0219	0.0741
Echinococcus granulosus	geminin	0.0165	0.1562	0.1562
Plasmodium vivax	acyl-CoA synthetase, putative	0.0038	0.0241	0.4414
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0376	0.0546
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0279	0.0279
Brugia malayi	Thioredoxin reductase	0.0037	0.0227	0.033
Onchocerca volvulus	Peroxidasin homolog	0.0078	0.0658	0.1032
Onchocerca volvulus		0.0027	0.0122	0.0192
Echinococcus multilocularis	lamin	0.0027	0.0122	0.0122
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0067	0.0546	0.0546
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0105	0.0152
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.1339	0.1946
Brugia malayi	hypothetical protein	0.0042	0.0279	0.0406
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0298	0.296	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0038	0.0241	0.5
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0018	0.0034	0.0631
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.0355	0.0355
Echinococcus granulosus	peroxidasin	0.0078	0.0658	0.0658
Trypanosoma brucei	lanosterol synthase	0.0074	0.0615	0.692
Echinococcus multilocularis	expressed conserved protein	0.0107	0.0964	0.0964
Schistosoma mansoni	hypothetical protein	0.0165	0.1562	0.4499
Brugia malayi	PAS domain containing protein	0.0048	0.0346	0.0502
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0049	0.0356	0.6512
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0227	0.0768
Leishmania major	farnesyltransferase beta subunit	0.0067	0.0546	1
Echinococcus multilocularis	protein dispatched 1	0.0056	0.0428	0.0428
Brugia malayi	CHE-14 protein	0.0049	0.0355	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Brugia malayi	AMP-binding enzyme family protein	0.0051	0.0376	0.0546
Onchocerca volvulus		0.0078	0.0658	0.1032
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1013
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.0355	0.0516
Echinococcus granulosus	lamin dm0	0.0027	0.0122	0.0122
Onchocerca volvulus		0.0048	0.0342	0.0536
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0051	0.0376	0.1269
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0105	0.1182
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.1297	0.1297
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0279	0.0279
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0308	0.0308
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0376	0.1269
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0122	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0241	0.035
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0018	0.0034	0.0631
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0719	0.2428
Onchocerca volvulus	Matrilysin homolog	0.0625	0.6373	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0051	0.0376	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0241	0.035
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0105	0.1182
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1708
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0018	0.0034	0.0631
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0038	0.0241	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0122	0.0177
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0105	0.1708
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0036	0.0219	0.0741
Onchocerca volvulus		0.0078	0.0658	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Mycobacterium leprae	PROBABLE HYDROLASE	0.0298	0.296	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0308	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0719	0.2428
Echinococcus granulosus	Niemann Pick C1 protein	0.0163	0.1547	0.1547
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0658	0.0955
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.2284	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0117	0.017
Brugia malayi	Animal haem peroxidase family protein	0.0078	0.0658	0.0955
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0034	0.0561
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0105	0.0152

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 240 nM	Activity against bovine Farnesyltransferase	ChEMBL.	9301658
IC50 (binding)	= 240 nM	Activity against bovine Farnesyltransferase	ChEMBL.	9301658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10256036

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 169446