TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.47 | Formula: C11H9KN8O2S2
H donors: 3 H acceptors: 7 LogP: 0.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)[N-]c1nc(c(s1)c1csc(n1)C(=O)Nc1nnn[nH]1)C.[K+]
InChi: 1S/C11H10N8O2S2.K/c1-4-7(23-11(12-4)13-5(2)20)6-3-22-9(14-6)8(21)15-10-16-18-19-17-10;/h3H,1-2H3,(H3,12,13,14,15,16,17,18,19,20,21);/q;+1/p-1
InChiKey: LVWQRKFUGWZCGY-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0054	0.0217	0.1058
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0197	0.563
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0197	0.3034
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0077	0.0347	0.0434
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0077	0.0347	0.0434
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0347	0.568
Schistosoma mansoni	hypothetical protein	0.0045	0.016	0.0776
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0026	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0811
Mycobacterium tuberculosis	Probable lipase LipD	0.0077	0.0347	0.0434
Brugia malayi	Inositol-1	0.0038	0.0121	0.0879
Brugia malayi	beta-lactamase family protein	0.0077	0.0347	0.2596
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.017	0.0825
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0037	0.0115	0.055
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0026	0.0363
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0347	0.0434
Brugia malayi	hypothetical protein	0.0243	0.1322	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0121	0.3388
Loa Loa (eye worm)	inositol-1	0.0038	0.0121	0.0688
Echinococcus multilocularis	protein patched	0.0046	0.017	0.0165
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0347	0.0434
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0121	0.3388
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0347	0.1706
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0081	0.0374	0.616
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0198	0.147
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.1322	0.1318
Toxoplasma gondii	ABC1 family protein	0.0077	0.0347	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0468	0.2311
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0039	0.0584
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0039	0.023
Entamoeba histolytica	hypothetical protein	0.0024	0.0039	0.023
Schistosoma mansoni	hypothetical protein	0.0361	0.2009	1
Brugia malayi	beta-lactamase family protein	0.0077	0.0347	0.2596
Trypanosoma brucei	hypothetical protein, conserved	0.0077	0.0347	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0468	0.3517
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0121	0.1676
Loa Loa (eye worm)	cytochrome P450 family protein	0.0057	0.0234	0.1339
Trypanosoma brucei	cytochrome P450, putative	0.0027	0.0057	0.1543
Mycobacterium tuberculosis	Probable esterase LipL	0.0077	0.0347	0.0434
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0094	0.0449	0.7495
Brugia malayi	Cytochrome P450 family protein	0.0057	0.0234	0.1744
Schistosoma mansoni	hypothetical protein	0.0317	0.1752	0.8715
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.004	0.013	0.0624
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0039	0.1001
Brugia malayi	metabotropic glutamate receptor type 2	0.0022	0.0024	0.0149
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.004	0.013	0.1839
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0077	0.0346	0.0342
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.004	0.013	0.095
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0197	0.0961
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0057	0.09
Brugia malayi	RNA, U transporter 1	0.0084	0.0392	0.2939
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0108	0.0532	0.896
Echinococcus granulosus	snurportin 1	0.0317	0.1752	0.8715
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0209	0.0204
Entamoeba histolytica	hypothetical protein	0.0077	0.0346	0.5674
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0077	0.0346	0.1704
Schistosoma mansoni	hypothetical protein	0.0077	0.0346	0.1704
Schistosoma mansoni	metabotropic glutamate receptor	0.0037	0.0115	0.055
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0121	0.1977
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0057	0.0232	1
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0057	0.04
Entamoeba histolytica	hypothetical protein	0.0077	0.0346	0.5674
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0532	0.3036
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.0347	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0347	0.568
Mycobacterium ulcerans	TetR family transcriptional regulator	0.1364	0.7882	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0077	0.0347	0.2596
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0197	0.3034
Echinococcus granulosus	Niemann Pick C1 protein	0.0155	0.0804	0.3987
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0468	0.2311
Loa Loa (eye worm)	hypothetical protein	0.0046	0.017	0.0971
Trypanosoma brucei	protein kinase, putative	0.0051	0.0197	0.563
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0103	0.059
Mycobacterium tuberculosis	Probable lipase LipE	0.0077	0.0347	0.0434
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0121	0.1676
Mycobacterium tuberculosis	Probable hydrolase	0.0077	0.0347	0.0434
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.0591	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.005	0.0192	0.0937
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0044	0.0157	0.1156
Schistosoma mansoni	hypothetical protein	0.0045	0.016	0.0776
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0347	0.568
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0347	0.5837
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Onchocerca volvulus		0.0077	0.0347	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0197	0.3286
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0052	0.0205	0.3175
Schistosoma mansoni	hypothetical protein	0.0045	0.016	0.0776
Brugia malayi	beta-lactamase	0.0077	0.0347	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0072	0.0067
Loa Loa (eye worm)	beta-lactamase	0.0077	0.0347	0.1979
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0347	0.568
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0197	0.0961
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0468	0.2311
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.057	0.9637
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.1752	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0026	0.0621
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0468	0.2672
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.0532	0.0527
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0097	0.0117
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0027	0.0057	0.0067
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0542	0.2679
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.1364	0.7882	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0103	0.0749
Echinococcus multilocularis	snurportin 1	0.0317	0.1752	0.1748
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0197	0.3286
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0347	0.1706
Brugia malayi	CHE-14 protein	0.0046	0.017	0.1256
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.017	0.0825
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0347	0.5837
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0039	0.023
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0118	0.0591	0.4448
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0231	0.132
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0109	0.0624
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.004	0.013	0.2135
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Mycobacterium ulcerans	transcriptional regulator	0.1364	0.7882	1
Loa Loa (eye worm)	CYP4Cod1	0.0027	0.0057	0.0328
Onchocerca volvulus		0.0077	0.0347	1
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0121	0.0578
Trypanosoma cruzi	cytochrome P450, putative	0.0027	0.0057	0.09
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0028	0.006	0.1654
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0347	0.0342
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0468	0.0464
Echinococcus multilocularis	geminin	0.0361	0.2009	0.2005
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.017	0.0971
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.004	0.013	0.1839
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0197	0.563
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0118	0.0591	1
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.0508	0.3821
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0077	0.0347	0.0434
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0072	0.1961
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0222	0.12	0.5966
Schistosoma mansoni	transcription factor LCR-F1	0.0077	0.0346	0.1704
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0197	0.3034
Loa Loa (eye worm)	cytochrome P450	0.0018	0.0005	0.0027
Brugia malayi	MAP kinase sur-1	0.0051	0.0197	0.1462
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.004	0.013	0.3658
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0121	0.1676
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0118	0.0591	1
Mycobacterium leprae	conserved hypothetical protein	0.0077	0.0347	0.0434
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0097	0.0117
Loa Loa (eye worm)	phosphatidylinositol 3	0.0198	0.1059	0.6046
Mycobacterium ulcerans	esterase/lipase LipP	0.0077	0.0347	0.0434
Mycobacterium ulcerans	hypothetical protein	0.0077	0.0347	0.0434
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0121	0.1676
Schistosoma mansoni	metabotropic glutamate receptor	0.0022	0.0024	0.0098
Schistosoma mansoni	hypothetical protein	0.0035	0.0103	0.0492
Echinococcus granulosus	beta LACTamase domain containing family member	0.0077	0.0347	0.1706
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0197	0.3034
Echinococcus multilocularis	Niemann Pick C1 protein	0.0155	0.0804	0.0799
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0077	0.0347	0.2596
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0077	0.0347	0.0434
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.0532	0.263
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0109	0.1785
Schistosoma mansoni	survival motor neuron protein	0.005	0.0189	0.0917
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0198	0.147
Mycobacterium ulcerans	lipase LipD	0.0077	0.0347	0.0434
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0057	0.0328
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0026	0.0621
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0077	0.0347	0.1979
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0198	0.1132
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0054	0.0217	0.0212
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0121	0.1977
Schistosoma mansoni	hypothetical protein	0.0361	0.2009	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0121	0.0578
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0197	0.563
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0197	0.563
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0197	0.8301
Loa Loa (eye worm)	hypothetical protein	0.003	0.0072	0.041
Schistosoma mansoni	patched 1	0.0046	0.017	0.0825
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.1364	0.7882	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0468	0.2311
Leishmania major	cytochrome p450-like protein	0.0027	0.0057	0.1543
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.1364	0.7882	1
Echinococcus granulosus	importin subunit beta 1	0.003	0.0072	0.0335
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0057	0.0328
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0489	0.2764	0.3502
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0468	0.2311
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0121	0.3388
Schistosoma mansoni	importin beta-1	0.003	0.0072	0.0335
Echinococcus multilocularis	expressed conserved protein	0.0102	0.0493	0.0489
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0057	0.04
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0198	0.1132
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0026	0.0021
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0121	0.0147
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0121	0.0578
Plasmodium falciparum	importin beta, putative	0.003	0.0072	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0121	0.5
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0077	0.0347	0.1706
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0217	0.1238
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0072	0.1961
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.017	0.2553
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0197	0.3286
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0077	0.0347	0.0342
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0222	0.12	0.5966
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0197	0.0961
Mycobacterium leprae	Probable lipase LipE	0.0077	0.0347	0.0434
Brugia malayi	Niemann-Pick C1 protein precursor	0.0108	0.0532	0.4002
Echinococcus granulosus	geminin	0.0361	0.2009	1
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.1322	0.6572
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0081	0.0374	0.616
Brugia malayi	hypothetical protein	0.0077	0.0346	0.2594
Onchocerca volvulus		0.0077	0.0347	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0189	0.1396
Entamoeba histolytica	hypothetical protein	0.0094	0.0449	0.7495
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0197	0.0193
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0118	0.0591	1
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0037	0.0115	0.011
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0468	0.0464
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.004	0.013	0.1839
Leishmania major	hypothetical protein, conserved	0.0077	0.0347	1
Loa Loa (eye worm)	glutamate receptor	0.0044	0.0157	0.0896
Entamoeba histolytica	hypothetical protein	0.0077	0.0346	0.5674
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0026	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0118	0.0591	1
Schistosoma mansoni	ran	0.0022	0.0026	0.0106
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0197	0.3286
Trichomonas vaginalis	esterase, putative	0.0077	0.0347	0.568
Echinococcus granulosus	expressed conserved protein	0.0102	0.0493	0.2438
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0118	0.0591	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0121	0.0116
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0026	0.0161
Plasmodium vivax	importin-beta 2, putative	0.003	0.0072	0.1429
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.004	0.013	0.1839
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0222	0.12	0.1196
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0197	0.0193
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0347	0.568
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0197	0.1126
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0347	0.0434
Schistosoma mansoni	hypothetical protein	0.005	0.0189	0.0917
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0072	0.1961
Leishmania major	GTP-binding protein, putative	0.0022	0.0026	0.0621
Schistosoma mansoni	ran	0.0022	0.0026	0.0106
Entamoeba histolytica	hypothetical protein	0.0077	0.0346	0.5674
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.004	0.013	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0347	0.1979
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0026	0.0148
Schistosoma mansoni	hypothetical protein	0.0045	0.016	0.0776
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0039	0.023
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.017	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0243	0.1322	0.7547
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.004	0.0133	0.0971
Mycobacterium ulcerans	beta-lactamase	0.0077	0.0347	0.0434
Brugia malayi	Importin beta-1 subunit	0.003	0.0072	0.0509

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.013 uM	Inhibition of PI3Kdelta	ChEMBL.	22924688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2216873

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1696864