TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 526.626 | Formula: C31H34N4O4
H donors: 3 H acceptors: 4 LogP: 4.29 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCCNC(=O)c1cc2CN([C@H](c2c(n1)c1cccc(c1)c1cc2c(o1)cccc2)CCO)C(=O)NC(C)C
InChi: 1S/C31H34N4O4/c1-4-13-32-30(37)24-16-23-18-35(31(38)33-19(2)3)25(12-14-36)28(23)29(34-24)22-10-7-9-20(15-22)27-17-21-8-5-6-11-26(21)39-27/h5-11,15-17,19,25,36H,4,12-14,18H2,1-3H3,(H,32,37)(H,33,38)/t25-/m0/s1
InChiKey: UKGDNCXUTMVRPA-VWLOTQADSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0026	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Brugia malayi	Serotonin receptor	0.0463	0.4113	0.4235
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Trypanosoma brucei	unspecified product	0.0022	0.0026	0.0898
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0105	0.5312
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0198	0.0274
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.004	0.0198	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0198	0.0975
Onchocerca volvulus		0.004	0.0198	0.0087
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0381	0.0381
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Echinococcus multilocularis	serotonin transporter	0.0238	0.2033	0.2843
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0198	0.0975
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0198	0.0198
Onchocerca volvulus	CoRest homolog	0.1098	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Onchocerca volvulus		0.004	0.0198	0.0087
Schistosoma mansoni	sodium-dependent amino acid transporter	0.004	0.0198	0.0975
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0198	0.0274
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0026	0.5
Treponema pallidum	sodium- and chloride- dependent transporter	0.0238	0.2033	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0381	0.0393
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0105	0.5312
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0105	0.3572
Leishmania major	DNA polymerase eta, putative	0.0051	0.0295	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0198	0.0975
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0198	0.0975
Loa Loa (eye worm)	GATA zinc finger family protein	0.0031	0.0112	0.0112
Toxoplasma gondii	hypothetical protein	0.004	0.0198	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0198	1
Brugia malayi	hypothetical protein	0.004	0.0198	0.0204
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.003	0.0105	0.0105
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0026	0.0898
Schistosoma mansoni	rest corepressor (corest) protein	0.0031	0.0112	0.0551
Leishmania major	hypothetical protein, conserved	0.003	0.0105	0.3572
Schistosoma mansoni	hypothetical protein	0.0041	0.0205	0.1007
Loa Loa (eye worm)	hypothetical protein	0.1067	0.9711	0.9711
Brugia malayi	follicle stimulating hormone receptor	0.0271	0.2332	0.2401
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Echinococcus granulosus	hypothetical protein	0.08	0.7236	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0105	0.5312
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0026	0.0898
Brugia malayi	hypothetical protein	0.003	0.0105	0.0108
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Echinococcus granulosus	SANT DNA binding	0.0031	0.0112	0.0155
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0238	0.2033	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0238	0.2033	1
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.004	0.0198	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0205	0.0205
Echinococcus multilocularis	conserved hypothetical protein	0.079	0.715	1
Leishmania major	DNA polymerase eta, putative	0.0036	0.0155	0.5244
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Plasmodium vivax	hypothetical protein	0.0031	0.0112	0.5652
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0026	0.013
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0036	0.0155	0.7801
Trypanosoma brucei	DNA polymerase eta, putative	0.0051	0.0295	1
Brugia malayi	ELM2 domain containing protein	0.0031	0.0112	0.0115
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0381	0.0393
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0205	0.0211
Brugia malayi	Myb-like DNA-binding domain containing protein	0.1067	0.9711	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.004	0.0198	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2033	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0112	0.0112
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0198	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.004	0.0198	0.0274
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2033	0.2033
Brugia malayi	ImpB/MucB/SamB family protein	0.0051	0.0295	0.0304
Onchocerca volvulus		0.0238	0.2033	0.1942
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.004	0.0198	0.0277
Loa Loa (eye worm)	hypothetical protein	0.006	0.0381	0.0381
Echinococcus multilocularis	metastasis associated protein MTA1	0.0031	0.0112	0.0157
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0026	0.0037
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0105	0.3572
Schistosoma mansoni	metastasis-associated protein 1 (mta1)	0.0031	0.0112	0.0551
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0198	0.0975
Loa Loa (eye worm)	serotonin transporter b	0.0238	0.2033	0.2033
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0026	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.004	0.0198	0.0274
Echinococcus multilocularis	mesoderm induction early response protein 1	0.0031	0.0112	0.0157
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0105	0.3572
Echinococcus granulosus	metastasis associated protein 1 mta1	0.0031	0.0112	0.0155
Loa Loa (eye worm)	norepinephrine transporter	0.0238	0.2033	0.2033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0105	0.5312
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.004	0.0198	0.0975
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0031	0.0112	0.0115
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0026	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0026	0.5
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0198	0.0277
Plasmodium falciparum	amino acid transporter, putative	0.004	0.0198	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0026	0.013
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0198	0.0204
Schistosoma mansoni	DNA polymerase eta	0.0051	0.0295	0.145
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0026	0.5
Schistosoma mansoni	zinc finger protein	0.0031	0.0112	0.0552
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0198	0.0204
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Loa Loa (eye worm)	hypothetical protein	0.004	0.0198	0.0198
Brugia malayi	ELM2 domain containing protein	0.0031	0.0112	0.0115
Trypanosoma cruzi	DNA polymerase eta, putative	0.0051	0.0295	1
Echinococcus granulosus	dna polymerase eta	0.0051	0.0295	0.0407
Echinococcus multilocularis	SANT, DNA binding	0.0031	0.0112	0.0157
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0238	0.2033	0.2033
Echinococcus multilocularis	rest corepressor (corest) protein	0.0031	0.0112	0.0157
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0026	0.0037
Plasmodium vivax	amine transporter, putative	0.004	0.0198	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0238	0.2033	0.2093
Echinococcus multilocularis	zinc finger protein 541	0.0031	0.0112	0.0157
Trypanosoma cruzi	DNA polymerase eta, putative	0.0036	0.0155	0.5244
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.004	0.0198	0.0198
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0026	0.0037
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.004	0.0198	0.0277
Plasmodium falciparum	transporter, putative	0.004	0.0198	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0238	0.2033	0.2033
Echinococcus granulosus	REST corepressor 3	0.0031	0.0112	0.0155
Onchocerca volvulus		0.004	0.0198	0.0087
Echinococcus granulosus	metastasis associated protein MTA1	0.0031	0.0112	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0295	0.0295
Schistosoma mansoni	metastasis-associated protein 1 (mta1)	0.0031	0.0112	0.0551
Brugia malayi	hypothetical protein	0.002	0.0005	0.0005
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0198	0.0975
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0198	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0026	0.0898
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0026	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0026	0.0898
Echinococcus granulosus	zinc finger protein 541	0.0031	0.0112	0.0155
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.004	0.0198	1
Toxoplasma gondii	hypothetical protein	0.004	0.0198	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.004	0.0198	0.0975
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Echinococcus granulosus	mesoderm induction early response protein 1	0.0031	0.0112	0.0155
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.004	0.0198	0.0204
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0026	0.0027
Echinococcus multilocularis	metastasis associated protein 1 (mta1)	0.0031	0.0112	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0112	0.0112
Echinococcus granulosus	serotonin transporter	0.0238	0.2033	0.2809
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0271	0.2332	0.2332
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0112	0.0112
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0026	0.0037
Echinococcus multilocularis	sodium and chloride dependent glycine	0.004	0.0198	0.0277
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.004	0.0198	0.0975
Echinococcus multilocularis	dna polymerase eta	0.0051	0.0295	0.0412
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0026	0.5
Schistosoma mansoni	rest corepressor (corest) protein	0.0031	0.0112	0.0551
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0026	0.0898
Echinococcus granulosus	sodium and chloride dependent glycine	0.004	0.0198	0.0274
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.004	0.0198	0.0204
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.004	0.0198	0.0277

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	4.1095 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2143168

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1704745