Detailed information for compound 1705354

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 395.445 | Formula: C18H20F3N5S
  • H donors: 1 H acceptors: 2 LogP: 3.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(nc(c1)C)NC(=S)N1CCN(CC1)c1ncccc1C(F)(F)F
  • InChi: 1S/C18H20F3N5S/c1-12-10-13(2)23-15(11-12)24-17(27)26-8-6-25(7-9-26)16-14(18(19,20)21)4-3-5-22-16/h3-5,10-11H,6-9H2,1-2H3,(H,23,24,27)
  • InChiKey: KVKZHHDRJAZSNA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone deacetylase hda2 0.012 0.1686 0.2524
Brugia malayi histone deacetylase 3 (HD3) 0.0223 0.3581 0.352
Plasmodium vivax histone deacetylase, putative 0.0086 0.1049 0.2598
Schistosoma mansoni serine/threonine protein kinase 0.005 0.04 0.0484
Trichomonas vaginalis CMGC family protein kinase 0.005 0.04 0.0699
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0244 0.0174
Echinococcus granulosus RUN 0.0039 0.0185 0.009
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0185 0.009
Brugia malayi histone deacetylase 11 0.0086 0.1049 0.0964
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4927 1
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Brugia malayi hypothetical protein 0.0039 0.0185 0.0091
Onchocerca volvulus 0.01 0.1321 0.1158
Loa Loa (eye worm) histone deacetylase 7A 0.0114 0.1572 0.1572
Loa Loa (eye worm) hypothetical protein 0.0086 0.1049 0.1049
Echinococcus granulosus beta galactosidase 0.0091 0.115 0.1628
Echinococcus multilocularis histone deacetylase 6 0.0114 0.1572 0.2301
Echinococcus granulosus histone deacetylase 7 0.0114 0.1572 0.2301
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0306 0.0282
Echinococcus multilocularis histone deacetylase 6 0.012 0.1686 0.2483
Onchocerca volvulus 0.0047 0.0348 0.0166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0306 0.0282
Trypanosoma cruzi histone deacetylase 1, putative 0.0223 0.3581 0.7175
Brugia malayi hypothetical protein 0.0039 0.0185 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.4927 1
Onchocerca volvulus Galectin homolog 0.0573 1 1
Mycobacterium ulcerans hypothetical protein 0.0156 0.2348 0.3505
Leishmania major histone deacetylase, putative 0.0114 0.1572 0.296
Brugia malayi hypothetical protein 0.0035 0.0129 0.0035
Plasmodium vivax histone deacetylase 2, putative 0.0114 0.1572 0.4125
Echinococcus multilocularis histone deacetylase 8 0.0086 0.1049 0.1468
Entamoeba histolytica hypothetical protein 0.0097 0.1252 0.2011
Echinococcus multilocularis RUN 0.0039 0.0185 0.009
Schistosoma mansoni histone deacetylase 0.0223 0.3581 0.5529
Loa Loa (eye worm) hypothetical protein 0.0034 0.0094 0.0094
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.04 0.0502
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.04 0.0502
Echinococcus multilocularis histone deacetylase 3 0.0223 0.3581 0.5504
Leishmania major histone deacetylase, putative 0.0223 0.3581 0.7175
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0129 0.0055
Schistosoma mansoni histone deacetylase 1 2 3 0.0086 0.1049 0.1514
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0055
Trypanosoma brucei histone deacetylase 4 0.0114 0.1572 0.296
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0185 0.009
Echinococcus granulosus histone deacetylase 0.0114 0.1572 0.2301
Echinococcus multilocularis beta galactosidase 0.0091 0.115 0.1628
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Schistosoma mansoni hypothetical protein 0.0047 0.0348 0.0402
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0377 0.64 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1715 0.1715
Schistosoma mansoni alpha-l-fucosidase 0.0377 0.64 1
Brugia malayi galectin 0.0422 0.7218 0.7191
Plasmodium vivax histone deacetylase 1, putative 0.0223 0.3581 1
Schistosoma mansoni ap endonuclease 0.0037 0.0161 0.0105
Plasmodium falciparum histone deacetylase 1 0.0223 0.3581 1
Loa Loa (eye worm) histone deacetylase 3 0.0223 0.3581 0.3581
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0223 0.3581 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.3581 0.3581
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.038 0.038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.2348 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0161 0.0051
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0185 0.009
Trypanosoma cruzi histone deacetylase, putative 0.0114 0.1572 0.296
Schistosoma mansoni rab6-interacting 0.0039 0.0185 0.0144
Toxoplasma gondii hypothetical protein 0.0048 0.0357 0.0572
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0161 0.5
Loa Loa (eye worm) histone deacetylase 0.0114 0.1572 0.1572
Echinococcus granulosus mitogen activated protein kinase 0.005 0.04 0.0432
Schistosoma mansoni galectin 0.0122 0.1715 0.257
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0111 0.1524 0.2225
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0185 0.0185
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.1252 0.2011
Schistosoma mansoni histone deacetylase 0.0223 0.3581 0.5529
Entamoeba histolytica histone deacetylase, putative 0.0223 0.3581 0.618
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.04 0.0432
Loa Loa (eye worm) hypothetical protein 0.0122 0.1715 0.1715
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0111 0.1524 0.1444
Trypanosoma brucei histone deacetylase 3 0.0114 0.1572 0.296
Leishmania major histone deacetylase, putative 0.0223 0.3581 0.7175
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.04 0.0502
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.04 0.0699
Schistosoma mansoni hypothetical protein 0.0061 0.0599 0.08
Toxoplasma gondii histone deacetylase HDAC4 0.0086 0.1049 0.2598
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.2057 0.3978
Brugia malayi Doublecortin family protein 0.0039 0.0185 0.0091
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0122 0.1715 0.1715
Brugia malayi galectin 0.0122 0.1715 0.1636
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0461 0.0529
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1321 0.1901
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2057 0.3978
Giardia lamblia Histone deacetylase 0.0223 0.3581 0.6158
Loa Loa (eye worm) hypothetical protein 0.0573 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0161 0.0067
Onchocerca volvulus Histone deacetylase 10 homolog 0.0086 0.1049 0.0881
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0169 0.2584 0.3915
Plasmodium falciparum histone deacetylase 2 0.0114 0.1572 0.4125
Toxoplasma gondii histone deacetylase HDAC3 0.0223 0.3581 1
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0122 0.1715 0.1715
Schistosoma mansoni ap endonuclease 0.0037 0.0161 0.0105
Loa Loa (eye worm) histone deacetylase 11 0.0086 0.1049 0.1049
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0223 0.3581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0335
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0461 0.0529
Trypanosoma cruzi histone deacetylase, putative 0.0114 0.1572 0.296
Brugia malayi Alpha-L-fucosidase family protein 0.0377 0.64 0.6366
Loa Loa (eye worm) histone deacetylase 1 0.0223 0.3581 0.3581
Trypanosoma brucei histone deacetylase, putative 0.0114 0.1572 0.296
Echinococcus multilocularis histone deacetylase 6 0.0114 0.1572 0.2301
Loa Loa (eye worm) MBCTL1 0.0054 0.0461 0.0461
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0161 0.0051
Brugia malayi MAP kinase sur-1 0.005 0.04 0.0308
Toxoplasma gondii histone deacetylase HDAC5 0.0086 0.1049 0.2598
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0161 0.0161
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.04 0.0502
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.04 0.0502
Trypanosoma cruzi histone deacetylase 1, putative 0.0223 0.3581 0.7175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.038 0.0288
Loa Loa (eye worm) hypothetical protein 0.0039 0.0185 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0306 0.0282
Loa Loa (eye worm) galectin 0.0422 0.7218 0.7218
Schistosoma mansoni histone deacetylase hda2 0.0086 0.1049 0.1514
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.034 0.5715 1
Brugia malayi Histone deacetylase family protein 0.0114 0.1572 0.1491
Echinococcus granulosus histone deacetylase 8 0.0086 0.1049 0.1468
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.3745 0.5765
Loa Loa (eye worm) hypothetical protein 0.0039 0.0185 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.005 0.04 0.0699
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0244 0.0174
Toxoplasma gondii histone deacetylase HDAC2 0.0223 0.3581 1
Schistosoma mansoni lipoxygenase 0.01 0.1311 0.1929
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.4927 1
Echinococcus multilocularis histone deacetylase 1 0.0223 0.3581 0.5504
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0161 0.0057
Loa Loa (eye worm) hypothetical protein 0.0111 0.1524 0.1524
Schistosoma mansoni histone deacetylase 4 5 0.0114 0.1572 0.2343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0335
Trichomonas vaginalis CMGC family protein kinase 0.005 0.04 0.0699
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.038 0.0288
Echinococcus granulosus histone deacetylase 3 0.0223 0.3581 0.5504
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0461 0.0581
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0306 0.0213
Plasmodium vivax histone deacetylase, putative 0.0114 0.1572 0.4125
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Trypanosoma cruzi histone deacetylase, putative 0.0086 0.1049 0.1864
Toxoplasma gondii histone deacetylase HDAC1 0.0114 0.1572 0.4125
Brugia malayi Galactoside-binding lectin family protein 0.0122 0.1715 0.1636
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.4927 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0306 0.0335
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.04 0.0432
Trypanosoma cruzi histone deacetylase, putative 0.0114 0.1572 0.296
Brugia malayi Histone deacetylase 1 0.0223 0.3581 0.352
Giardia lamblia DNA repair protein RAD52 0.034 0.5715 1
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0185 0.009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0244 0.0174
Echinococcus multilocularis histone deacetylase 0.0114 0.1572 0.2301
Onchocerca volvulus Galectin homolog 0.0122 0.1715 0.1559
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1321 0.1901
Loa Loa (eye worm) galactoside-binding lectin family protein 0.0122 0.1715 0.1715
Trypanosoma brucei histone deacetylase 2 0.0086 0.1049 0.1864
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0412 0.0526
Loa Loa (eye worm) hypothetical protein 0.0049 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.0232 0.3745 0.3745
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.2515 0.6882
Echinococcus granulosus histone deacetylase 6 0.0114 0.1572 0.2301
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0185 0.009
Schistosoma mansoni polycystin 1-related 0.0039 0.0185 0.0144
Schistosoma mansoni beta-galactosidase 0.0091 0.115 0.1674
Loa Loa (eye worm) hypothetical protein 0.0275 0.4524 0.4524
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0223 0.3581 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1321 0.1945
Brugia malayi histone deacetylase 1 (HD1) 0.0223 0.3581 0.352
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0169 0.2584 0.3915
Echinococcus granulosus Galectin carbohydrate recognition domain 0.0122 0.1715 0.2529
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0185 0.009
Loa Loa (eye worm) hypothetical protein 0.0091 0.115 0.115
Brugia malayi Galactoside-binding lectin family protein 0.0122 0.1715 0.1636
Brugia malayi Galactoside-binding lectin family protein 0.0122 0.1715 0.1636
Giardia lamblia Kinase, CMGC MAPK 0.005 0.04 0.043
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1321 0.1238
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.04 0.04
Schistosoma mansoni histone deacetylase 4 5 0.0114 0.1572 0.2343
Schistosoma mansoni survival motor neuron protein 0.0047 0.0348 0.0402
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0185 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.2057 0.3978
Loa Loa (eye worm) alpha-L-fucosidase 0.0377 0.64 0.64
Trichomonas vaginalis CMGC family protein kinase 0.005 0.04 0.0699
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0161 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0101 0.1325 0.1951
Echinococcus multilocularis histone deacetylase 7 0.0114 0.1572 0.2301
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.04 0.0502
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0377 0.64 1
Brugia malayi hypothetical protein 0.0232 0.3745 0.3685
Schistosoma mansoni lipoxygenase 0.0169 0.2584 0.3948
Trypanosoma brucei histone deacetylase 1 0.0223 0.3581 0.7175
Echinococcus multilocularis Galectin, carbohydrate recognition domain 0.0122 0.1715 0.2529
Plasmodium falciparum histone deacetylase, putative 0.0114 0.1572 0.4125
Echinococcus granulosus histone deacetylase 1 0.0223 0.3581 0.5504
Trichomonas vaginalis histone deacetylase, putative 0.0223 0.3581 1
Schistosoma mansoni rab6-interacting 0.0039 0.0185 0.0144
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.04 0.0502
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0185 0.0071
Mycobacterium ulcerans alpha-L-fucosidase 0.0377 0.64 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0244 0.0174
Leishmania major histone deacetylase, putative 0.0114 0.1572 0.296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0306 0.0282
Schistosoma mansoni hypothetical protein 0.0039 0.0185 0.0144
Trypanosoma cruzi histone deacetylase, putative 0.0086 0.1049 0.1864
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.3745 0.5765
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0111 0.1524 0.2225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0306 0.0306
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.2515 0.6882
Echinococcus granulosus histone deacetylase 6 0.0114 0.1572 0.2301
Schistosoma mansoni loxhd1 0.0039 0.0185 0.0144
Echinococcus granulosus histone deacetylase 6 0.012 0.1686 0.2483
Loa Loa (eye worm) galectin 0.0122 0.1715 0.1715
Brugia malayi Histone deacetylase family protein 0.0114 0.1572 0.1491
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.04 0.0432
Loa Loa (eye worm) hypothetical protein 0.01 0.1321 0.1321
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0348 0.0256
Trypanosoma brucei protein kinase, putative 0.005 0.04 0.0502

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. Gel-Based Assay for Inhibitos of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase): Chemistry Optimization Follow up. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.5227 uM PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Counterscreen Against HSD17b4. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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