TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 757.442 | Formula: C41H59ClN3O6S-
H donors: 5 H acceptors: 5 LogP: 7.88 Rotable bonds: 25
Rule of 5 violations (Lipinski): 2
SMILES: CSCC[C@H](C(=O)O)NC(=O)[C@H](NC(=O)[C@H](C(C)C)NCc1cccc(c1O)OC/C=C(/CC/C=C(/CCC=C(C)C)\C)\C)Cc1ccccc1.[Cl-]
InChi: 1S/C41H59N3O6S.ClH/c1-28(2)14-11-15-30(5)16-12-17-31(6)22-24-50-36-21-13-20-33(38(36)45)27-42-37(29(3)4)40(47)44-35(26-32-18-9-8-10-19-32)39(46)43-34(41(48)49)23-25-51-7;/h8-10,13-14,16,18-22,29,34-35,37,42,45H,11-12,15,17,23-27H2,1-7H3,(H,43,46)(H,44,47)(H,48,49);1H/p-1/b30-16+,31-22+;/t34-,35-,37-;/m0./s1
InChiKey: WOAQVRXUMARCJT-LIUDSTGRSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0206	0.0206
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.1266	0.1691
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0377	0.1377
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0206	0.0275
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0092	0.0865	0.3337
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0092	0.0865	0.0865
Brugia malayi	hypothetical protein	0.0033	0.0157	0.0209
Schistosoma mansoni	lipoxygenase	0.0057	0.0439	0.114
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0493	0.1281
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0206	0.0534
Brugia malayi	TAR-binding protein	0.0125	0.1266	0.1691
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.01	0.0967	0.1292
Giardia lamblia	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.5
Echinococcus granulosus	tar DNA binding protein	0.0125	0.1266	0.3288
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Echinococcus granulosus	muscleblind protein	0.0149	0.1555	0.404
Plasmodium falciparum	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.0143
Leishmania major	guanosine monophosphate reductase	0.0229	0.2524	1
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0216	0.236	1
Trypanosoma brucei	GMP reductase	0.0229	0.2524	1
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0216	0.0562
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0551	0.1432
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0077
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0095	0.0907	0.1211
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0967	0.0967
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0095	0.0907	0.1211
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0229	0.2524	0.9571
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0493	0.124
Echinococcus granulosus	lamin	0.0054	0.0408	0.106
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0077
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0493	0.1281
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Brugia malayi	glutamate dehydrogenase, mitochondrial precursor, putative	0.0023	0.0034	0.0045
Trypanosoma cruzi	GMP reductase	0.0229	0.2524	1
Onchocerca volvulus	Glutamate dehydrogenase, mitochondrial homolog	0.0023	0.0034	0.0039
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0216	0.236	0.9291
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Trichomonas vaginalis	set domain proteins, putative	0.0729	0.8554	1
Toxoplasma gondii	ABC1 family protein	0.0037	0.0206	0.069
Toxoplasma gondii	IMP dehydrogenas	0.0229	0.2524	1
Schistosoma mansoni	Smad4	0.0025	0.0057	0.0149
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.2077
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0077
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0229	0.2524	0.5
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0206	0.0275
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0057	0.0077
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0229	0.2524	0.3372
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0408	0.106
Brugia malayi	glutamate dehydrogenase, mitochondrial precursor, putative	0.0023	0.0034	0.0045
Leishmania major	hypothetical protein, conserved	0.0051	0.0377	0.1377
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0109	0.1071	0.3732
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0059	0.0079
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Plasmodium vivax	glutamate dehydrogenase (NADP+), putative	0.0023	0.0034	0.0143
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0408	0.0545
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0069	0.0585	0.0647
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0377	0.1377
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0551	0.1432
Echinococcus granulosus	histone lysine methyltransferase setb	0.0092	0.0865	0.2247
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0585	0.152
Brugia malayi	MH2 domain containing protein	0.0367	0.4179	0.5582
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0551	0.2077
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0229	0.2524	0.6557
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0216	0.236	1
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Loa Loa (eye worm)	Smad1	0.0025	0.0057	0.0077
Trichomonas vaginalis	esterase, putative	0.0037	0.0206	0.0202
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0408	0.0545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.01	0.0967	0.2512
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0206	0.0202
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0641	0.7486	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.2628	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0493	0.1187
Echinococcus multilocularis	muscleblind protein	0.0149	0.1555	0.1555
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0034	0.0034
Onchocerca volvulus	Putative GMP reductase	0.0095	0.0907	0.106
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0092	0.0865	0.2247
Brugia malayi	RNA binding protein	0.0125	0.1266	0.1691
Brugia malayi	intermediate filament protein	0.0054	0.0408	0.0545
Schistosoma mansoni	hypothetical protein	0.0023	0.0034	0.009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0967	0.2512
Echinococcus granulosus	Glutamate dehydrogenase mitochondrial	0.0023	0.0034	0.0088
Onchocerca volvulus		0.0054	0.0408	0.0477
Echinococcus granulosus	smad	0.0025	0.0057	0.0149
Onchocerca volvulus		0.0037	0.0206	0.024
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.2077
Echinococcus granulosus	intermediate filament protein	0.0054	0.0408	0.106
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.1266	0.1266
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0206	0.069
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0216	0.0216
Schistosoma mansoni	lamin	0.0054	0.0408	0.106
Echinococcus multilocularis	lamin	0.0054	0.0408	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1555	0.2077
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0105	0.0141
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0057	0.0149
Echinococcus granulosus	lamin dm0	0.0054	0.0408	0.106
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0206	0.0871
Brugia malayi	Muscleblind-like protein	0.0149	0.1555	0.2077
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0206	0.0275
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0057	0.0077
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0493	0.1845
Brugia malayi	Pre-SET motif family protein	0.0092	0.0865	0.1155
Trypanosoma cruzi	GMP reductase	0.0229	0.2524	1
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0377	0.1377
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.1266	0.1691
Brugia malayi	Melibiase family protein	0.0069	0.0585	0.0782
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0206	0.0534
Loa Loa (eye worm)	MH2 domain-containing protein	0.0367	0.4179	0.5582
Echinococcus granulosus	geminin	0.0339	0.385	1
Echinococcus granulosus	glutamate dehydrogenase	0.0023	0.0034	0.0088
Onchocerca volvulus	Glutamate dehydrogenase, mitochondrial homolog	0.0023	0.0034	0.0039
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0229	0.2524	0.6557
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0585	0.0782
Plasmodium falciparum	NADP-specific glutamate dehydrogenase	0.0023	0.0034	0.0143
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0069	0.0585	0.152
Echinococcus multilocularis	lamin dm0	0.0054	0.0408	0.0408
Echinococcus multilocularis	musashi	0.0054	0.0408	0.0408
Onchocerca volvulus		0.0037	0.0206	0.024
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0103	0.1	0.1
Echinococcus multilocularis	Glutamate dehydrogenase, mitochondrial	0.0023	0.0034	0.0034
Brugia malayi	Pre-SET motif family protein	0.0641	0.7486	1
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0229	0.2524	1
Echinococcus multilocularis	glutamate dehydrogenase	0.0023	0.0034	0.0034
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0206	0.069
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0103	0.1	0.2596
Brugia malayi	hypothetical protein	0.0051	0.0377	0.0503
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0229	0.2524	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0057	0.0057
Onchocerca volvulus		0.0729	0.8554	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0377	0.0503
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Schistosoma mansoni	hypothetical protein	0.0339	0.385	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.0439	0.0439
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0408	0.0545
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0071	0.0071
Onchocerca volvulus		0.0054	0.0408	0.0477
Loa Loa (eye worm)	RNA binding protein	0.0125	0.1266	0.1691
Brugia malayi	GMP reductase	0.0095	0.0907	0.1211
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0551	0.149
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0229	0.2524	0.2524
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0229	0.2524	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.01	0.0967	0.0967
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0493	0.1281
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1266	0.3288
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.01	0.0967	0.1292
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0057	0.0057
Brugia malayi	beta-lactamase family protein	0.0037	0.0206	0.0275
Echinococcus multilocularis	geminin	0.0339	0.385	0.385
Brugia malayi	Smad1	0.0025	0.0057	0.0077
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.012	0.121	0.4144
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0551	0.0736
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0396	0.0529
Onchocerca volvulus		0.0092	0.0865	0.1011
Plasmodium vivax	SET domain protein, putative	0.0092	0.0865	0.3665
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0493	0.1845
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0109	0.1071	0.3732
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0493	0.0493
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0105	0.0141
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.012	0.121	0.433
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0551	0.0551
Brugia malayi	beta-lactamase	0.0037	0.0206	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0059	0.0079
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0377	0.0738
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0408	0.0545
Onchocerca volvulus		0.0037	0.0206	0.024
Schistosoma mansoni	hypothetical protein	0.0339	0.385	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0103	0.1	0.2596
Loa Loa (eye worm)	GMP reductase	0.0095	0.0907	0.1211
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Toxoplasma gondii	melibiase subfamily protein	0.0103	0.1	0.3878
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0034	0.009
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0092	0.0865	0.0865
Echinococcus multilocularis	smad	0.0025	0.0057	0.0057
Brugia malayi	beta-lactamase family protein	0.0037	0.0206	0.0275
Loa Loa (eye worm)	transcription factor SMAD2	0.0367	0.4179	0.5582
Echinococcus multilocularis	muscleblind protein 1	0.0149	0.1555	0.1555
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0071	0.0095
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0089	0.0824	0.2141
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0149
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0077
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.1266	0.1691
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0071	0.0184
Echinococcus granulosus	Smad4	0.0025	0.0057	0.0149
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0206	0.0534
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0551	0.0736
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0057	0.0149
Schistosoma mansoni	smad	0.0025	0.0057	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1555	0.2077
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0103	0.1	0.1
Schistosoma mansoni	glutamate dehydrogenase	0.0023	0.0034	0.0088
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0057	0.0149
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0377	0.1597
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.01	0.0967	0.2512
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0229	0.2524	0.3372
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0206	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0275
Schistosoma mansoni	lamin	0.0054	0.0408	0.106
Echinococcus multilocularis	Smad4	0.0025	0.0057	0.0057
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0229	0.2524	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0865	0.1155
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0551	0.5
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0229	0.2524	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0206	0.0202
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0092	0.0865	0.2247
Leishmania major	hypothetical protein, conserved	0.0037	0.0206	0.069
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.0439	0.114

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 70 uM	Inhibition of farnesyl transferase	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 271754

Bibliographic References

No literature references available for this target.

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Detailed information for compound 170932