Detailed information for compound 171663

Basic information

Technical information
  • TDR Targets ID: 171663
  • Name: R 71762
  • MW: 442.415 | Formula: C22H20F2N4O4
  • H donors: 1 H acceptors: 4 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FCC1COc2c3n1cc(C(=O)O)c(=O)c3cc(c2N1CCN(CC1)c1ccccn1)F
  • InChi: 1S/C22H20F2N4O4/c23-10-13-12-32-21-18-14(20(29)15(22(30)31)11-28(13)18)9-16(24)19(21)27-7-5-26(6-8-27)17-3-1-2-4-25-17/h1-4,9,11,13H,5-8,10,12H2,(H,30,31)
  • InChiKey: FASWMSDWHLSHQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS007743
  • R-71762
  • (+/-) 9-Fluoro-3-fluoromethyl-2,3-dihydro-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
  • AIDS-007743

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0554 0.0669 0.1923
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.1561
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0016 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0104 0.1472
Plasmodium vivax hypothetical protein, conserved 0.0106 0.0104 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0106 0.0104 0.1561
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0109 0.3704
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0048 1
Brugia malayi beta-lactamase family protein 0.0037 0.0016 0.0139
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0106 0.0104 0.1472
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0312 0.0364 0.1047
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0106 0.0104 0.0289
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0312 0.0364 0.5396
Mycobacterium leprae conserved hypothetical protein 0.0106 0.0104 0.8178
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0554 0.0669 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0016 0.0243
Loa Loa (eye worm) glutathione reductase 0.0048 0.0031 0.0358
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0016 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0348 0.0409 0.6117
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0554 0.0669 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.03
Leishmania major phosphatidylinositol kinase, putative 0.0106 0.0104 0.0289
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0104 0.1472
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0554 0.0669 0.1851
Toxoplasma gondii target of rapamycin (TOR), putative 0.0554 0.0669 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0016 0.0139
Entamoeba histolytica hypothetical protein 0.0036 0.0015 0.0223
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.7945 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0104 0.1472
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0031 0.0358
Mycobacterium tuberculosis Probable reductase 0.011 0.0109 0.3704
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0015 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.2779 0.3478 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0029 0.0328
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0016 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0106 0.0104 0.1561
Leishmania major phosphatidylinositol 3-kinase, putative 0.0554 0.0669 0.1851
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0031 0.0024
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0554 0.0669 0.1851
Trichomonas vaginalis esterase, putative 0.0037 0.0016 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0015 0.0119
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0106 0.0104 0.03
Plasmodium falciparum glutathione reductase 0.0048 0.0031 0.2435
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0104 0.0097
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0104 0.1472
Entamoeba histolytica hypothetical protein 0.0106 0.0104 0.1561
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0104 0.0097
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0554 0.0669 0.1851
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0106 0.0104 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0106 0.0104 0.1561
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1561
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0104 0.3536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.03
Trypanosoma brucei trypanothione reductase 0.0048 0.0031 0.0358
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0106 0.0104 0.1561
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0029 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0106 0.0104 0.1561
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0554 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0669 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0106 0.0104 0.1472
Leishmania major phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.0289
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0312 0.0364 0.0357
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0206 0.023 0.066
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Plasmodium vivax hypothetical protein 0.0106 0.0104 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0104 0.1561
Leishmania major trypanothione reductase 0.0048 0.0031 0.0085
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0104 0.0097
Toxoplasma gondii FATC domain-containing protein 0.0312 0.0364 0.5396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0016 0.0139
Schistosoma mansoni transcription factor btf3 0.0036 0.0015 0.0119
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0048 0.0041
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0031 0.0581
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0029 0.0328
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0106 0.0104 0.03
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0312 0.0364 0.5396
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.0366 0.5418
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0048 0.0619
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0109 0.3704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.0409 0.6076
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0048 0.0619
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0109 0.3704
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0031 0.0024
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0106 0.0104 0.1472
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0124 0.4324
Brugia malayi beta-lactamase 0.0037 0.0016 0.0139
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0106 0.0104 0.1472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0029 0.0328
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0554 0.0669 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0106 0.0104 0.03
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0106 0.0104 0.1472
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0015 0.0809
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0106 0.0104 0.1561
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0106 0.0104 0.0097
Leishmania major hypothetical protein, unknown function 0.0106 0.0104 0.0289
Giardia lamblia GTOR 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0016 0.0139
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0106 0.0104 0.0097
Loa Loa (eye worm) hypothetical protein 0.0106 0.0104 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Schistosoma mansoni hypothetical protein 0.0106 0.0104 0.1472
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0669 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0048 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0106 0.0104 0.1472
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0106 0.0104 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0124 0.4324
Entamoeba histolytica hypothetical protein 0.0312 0.0364 0.5444
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0016 0.0009
Echinococcus multilocularis snurportin 1 0.0313 0.0366 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0106 0.0104 0.1472
Echinococcus multilocularis transcription factor btf3 0.0036 0.0015 0.0008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0124 0.4324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0312 0.0364 0.1047
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0241 0.0275 0.0268
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0106 0.0104 0.03
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0048 0.0619
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0109 0.3704
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.0266 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0106 0.0104 0.1561
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0048 0.0041
Trypanosoma cruzi target of rapamycin kinase 3 0.0554 0.0669 0.1923
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0104 0.1472
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0669 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0031 0.2435
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0312 0.0364 0.0357
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0554 0.0669 0.1851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0206 0.023 0.3434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0029 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0124 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0104 0.1561
Brugia malayi Thioredoxin reductase 0.0048 0.0031 0.0358
Loa Loa (eye worm) hypothetical protein 0.0106 0.0104 0.1472
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0016 0.0047
Echinococcus multilocularis 0.0106 0.0104 0.0097
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0312 0.0364 0.5396
Brugia malayi beta-NAC-like protein 0.0036 0.0015 0.0119
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0106 0.0104 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0015 0.0223
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0554 0.0669 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0106 0.0104 0.0289
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0312 0.0364 0.5396
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.1012 0.1006
Schistosoma mansoni fkbp-rapamycin associated protein 0.0312 0.0364 0.5396
Brugia malayi glutathione reductase 0.0048 0.0031 0.0358
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0312 0.0364 0.5444
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0029 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0554 0.0669 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0048 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Loa Loa (eye worm) beta-lactamase 0.0037 0.0016 0.0139
Schistosoma mansoni hypothetical protein 0.0313 0.0366 0.5418
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0029 0.0328
Toxoplasma gondii thioredoxin reductase 0.0048 0.0031 0.0358
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0106 0.0104 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0104 0.1561
Entamoeba histolytica hypothetical protein 0.0106 0.0104 0.1561
Echinococcus granulosus transcription factor btf3 0.0036 0.0015 0.0008
Echinococcus granulosus serine protein kinase ATM 0.0312 0.0364 0.0357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0139
Leishmania major basic transcription factor 3a, putative 0.0036 0.0015 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0015 0.0223
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0104 0.1472
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0109 0.3704
Echinococcus granulosus snurportin 1 0.0313 0.0366 0.0359
Loa Loa (eye worm) hypothetical protein 0.0206 0.023 0.3364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0029 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.0275 0.4107
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0016 0.0139
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0106 0.0104 1
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0015 0.0043
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0348 0.0409 0.6076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0104 0.1472
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0106 0.0104 0.03
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0554 0.0669 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Brugia malayi FAT domain containing protein 0.0241 0.0275 0.4044
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0554 0.0669 0.0662
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0554 0.0669 0.0662
Echinococcus multilocularis serine protein kinase ATM 0.0312 0.0364 0.0357
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0109 0.8565
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0106 0.0104 0.03
Echinococcus multilocularis Zinc finger, PHD finger 0.0106 0.0104 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1561
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.03
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0048 0.1274
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0106 0.0104 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0669 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0016 0.0243
Loa Loa (eye worm) hypothetical protein 0.0241 0.0275 0.4044
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0554 0.0669 0.0662
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0016 0.0243
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0104 0.1472
Entamoeba histolytica protein kinase rad3, putative 0.0312 0.0364 0.5444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0106 0.0104 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0348 0.0409 0.6117
Leishmania major phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.0289
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0106 0.0104 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0016 0.0243
Onchocerca volvulus 0.0106 0.0104 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0106 0.0104 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0106 0.0104 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.023 0.3434
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0106 0.0104 0.1472
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0015 0.0223
Plasmodium falciparum thioredoxin reductase 0.0048 0.0031 0.2435
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0106 0.0104 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0015 0.0809
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0015 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0348 0.0409 0.6076
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0015 0.0119
Plasmodium vivax glutathione reductase, putative 0.0048 0.0031 0.2435
Entamoeba histolytica hypothetical protein 0.0106 0.0104 0.1561
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0241 0.0275 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0016 0.0946
Leishmania major hypothetical protein, conserved 0.2885 0.3612 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0016 0.0243
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0106 0.0104 0.03
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0016 0.0139
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0554 0.0669 1
Onchocerca volvulus 0.0106 0.0104 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0554 0.0669 0.1923
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0031 0.0088
Brugia malayi RNA, U transporter 1 0.0083 0.0075 0.1032
Loa Loa (eye worm) hypothetical protein 0.0312 0.0364 0.5396
Schistosoma mansoni hypothetical protein 0.0241 0.0275 0.4044
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0106 0.0104 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0106 0.0104 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Entamoeba histolytica hypothetical protein 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0364 0.5444
Brugia malayi beta-lactamase family protein 0.0037 0.0016 0.0139
Leishmania major hypothetical protein, conserved 0.0037 0.0016 0.0045
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0554 0.0669 0.1923
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0048 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0106 0.0104 0.1472
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0106 0.0104 0.0097
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0554 0.0669 1
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0015 0.0119
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0554 0.0669 0.1923
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0106 0.0104 0.1472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0029 0.0022
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0106 0.0104 0.1561
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0106 0.0104 0.1472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0106 0.0104 0.1561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0669 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0106 0.0104 0.1472

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 60 uM Cytotoxicity to HIV-1 IIIB chronically infected Molt-4 cells assayed using tetrazolium based colorimetric assay ChEMBL. 10560726
IC50 (functional) = 1.7 uM Anti-HIV activity against HIV-1 IIIB chronically infected Molt-4 cells ChEMBL. 10560726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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