TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.771 | Formula: C13H21ClF3N3O5
H donors: 3 H acceptors: 4 LogP: 1.5 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: [O-]C(=O)C(F)(F)F.COC(=O)[C@@H](NC(=O)C)CCCCNC(=[NH2+])CCl
InChi: 1S/C11H20ClN3O3.C2HF3O2/c1-8(16)15-9(11(17)18-2)5-3-4-6-14-10(13)7-12;3-2(4,5)1(6)7/h9H,3-7H2,1-2H3,(H2,13,14)(H,15,16);(H,6,7)/t9-;/m0./s1
InChiKey: GAFUSLDSMURZLF-FVGYRXGTSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.0008	0.0027	0.0017
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0817	0.0817
Schistosoma mansoni	cpg binding protein	0.0028	0.0737	0.0737
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0463	0.0789
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1037	0.8634
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.1199	0.2074
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0008	0.0027	0.0027
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0036	0.1013	0.175
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.0008	0.0027	0.0017
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0028	0.0708	0.6798
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.1199	1
Brugia malayi	TAR-binding protein	0.0067	0.2056	0.2063
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.1037	0.1295
Loa Loa (eye worm)	hepatopoietin HPO2	0.0174	0.5741	0.5737
Brugia malayi	Erv1 / Alr family protein	0.0028	0.0708	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0025	0.061	0.06
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0007	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0071	0.2213	1
Brugia malayi	beta-lactamase family protein	0.0037	0.1037	0.1035
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0036	0.1013	0.175
Brugia malayi	hypothetical protein	0.0016	0.0307	0.0299
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1037	0.1295
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.0008	0.0027	0.0017
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.1037	0.1295
Schistosoma mansoni	hypothetical protein	0.0071	0.2213	0.2213
Toxoplasma gondii	Erv1 / Alr family protein	0.0028	0.0708	0.1217
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.061	0.1046
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0463	0.0463
Leishmania major	hypothetical protein, conserved	0.0037	0.1037	0.1791
Schistosoma mansoni	ran	0.0021	0.0463	0.0463
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0817	0.0814
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0036	0.1013	0.1266
Echinococcus granulosus	sulfhydryl oxidase 1	0.0028	0.0708	0.0708
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.1199	0.1199
Echinococcus multilocularis	cpg binding protein	0.003	0.0793	0.0793
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0008	0.0027	0.0027
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0036	0.1013	0.1004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0183	0.6055	0.6055
Schistosoma mansoni	hypothetical protein	0.0031	0.0817	0.0817
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.0008	0.0027	0.0017
Mycobacterium ulcerans	beta-lactamase	0.0037	0.1037	1
Trypanosoma brucei	quiescin sulfhydryl oxidase	0.0028	0.0708	0.1217
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0036	0.1013	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0017
Schistosoma mansoni	cpg binding protein	0.003	0.0793	0.0793
Brugia malayi	beta-lactamase family protein	0.0037	0.1037	0.1035
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0138	0.4524	0.4524
Onchocerca volvulus		0.0037	0.1037	1
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.1037	0.5
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0008	0.0027	0.0027
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0716	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0097	0.3109	0.3102
Schistosoma mansoni	importin beta-1	0.0028	0.0716	0.0716
Echinococcus granulosus	neutral sphingomyelinase	0.0007	0.001	0.001
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0737	0.0733
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.6055	0.6055
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0036	0.1013	0.4554
Brugia malayi	Augmenter of liver regeneration	0.0174	0.5741	0.578
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0183	0.6055	0.6055
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0007	0.001	0.001
Schistosoma mansoni	synaptojanin	0.0007	0.001	0.001
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.1037	0.1295
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0174	0.5741	1
Mycobacterium leprae	Probable lipase LipE	0.0037	0.1037	0.5
Schistosoma mansoni	hypothetical protein	0.0067	0.2048	0.2048
Schistosoma mansoni	GTP-binding protein alpha subunit	0.0008	0.0027	0.0027
Trypanosoma cruzi	quiescin sulfhydryl oxidase, putative	0.0028	0.0708	0.1217
Brugia malayi	Importin beta-1 subunit	0.0028	0.0716	0.0712
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0183	0.6055	0.6055
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.0008	0.0027	0.0017
Mycobacterium ulcerans	hypothetical protein	0.0037	0.1037	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0716	0.1231
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0028	0.0708	0.6798
Plasmodium falciparum	importin beta, putative	0.0028	0.0716	0.1231
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.061	0.1046
Echinococcus granulosus	tar DNA binding protein	0.0067	0.2056	0.2056
Schistosoma mansoni	cript-related	0.0007	0.001	0.001
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0008	0.0027	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0716	0.0707
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.2056	0.2056
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1037	0.1295
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.1037	0.1037
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0008	0.0027	0.0027
Loa Loa (eye worm)	RNA binding protein	0.0067	0.2056	0.2048
Trichomonas vaginalis	esterase, putative	0.0037	0.1037	0.8634
Onchocerca volvulus		0.0028	0.0737	0.7078
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0817	0.0817
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.1037	1
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0007	0.001	0.001
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0716	0.1231
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0535	0.4411
Loa Loa (eye worm)	G protein alpha subunit 3	0.0008	0.0027	0.0017
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0008	0.0027	0.0027
Schistosoma mansoni	ran	0.0021	0.0463	0.0463
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0008	0.0027	0.0027
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.0008	0.0027	0.0027
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.1037	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.0008	0.0027	0.0017
Echinococcus granulosus	cpg binding protein	0.003	0.0793	0.0793
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0817	0.0808
Entamoeba histolytica	hypothetical protein	0.0071	0.2213	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0463	0.0789
Toxoplasma gondii	Erv1 / Alr family protein	0.0174	0.5741	1
Loa Loa (eye worm)	Erv1/Alr family protein	0.0028	0.0708	0.0698
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0716	0.0716
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0535	0.4411
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.061	0.1046
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0036	0.1013	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.2213	0.2213
Schistosoma mansoni	hypothetical protein	0.0175	0.5781	0.5781
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.0008	0.0027	0.0017
Schistosoma mansoni	hypothetical protein	0.0175	0.5781	0.5781
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.061	0.1046
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0036	0.1013	0.175
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.006	0.006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.6055	0.6055
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.2213	0.2213
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0174	0.5741	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.2048	0.2055
Trichomonas vaginalis	ran, putative	0.0021	0.0463	0.3806
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0008	0.0027	0.0141
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0008	0.0027	0.0017
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0463	0.0463
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0007	0.001	0.001
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0174	0.5741	1
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.0008	0.0027	0.0027
Echinococcus granulosus	muscleblind protein	0.0295	0.9925	0.9925
Schistosoma mansoni	hypothetical protein	0.0031	0.0817	0.0817
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0817	0.0817
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.0008	0.0027	0.0027
Loa Loa (eye worm)	quiescin Q6	0.0028	0.0708	0.0698
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0008	0.0027	0.0141
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1037	0.8634
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0036	0.1013	0.1013
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0535	0.0915
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.2056	0.2048
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0007	0.001	0.001
Schistosoma mansoni	ap endonuclease	0.0036	0.1013	0.1013
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.061	0.1046
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0463	0.0456
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.006	0.006
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.1079	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1836	0.1836
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0056	0.0046
Echinococcus granulosus	GPCR family 2	0.0031	0.0817	0.0817
Mycobacterium ulcerans	lipase LipD	0.0037	0.1037	1
Trichomonas vaginalis	GTP-binding protein (q) alpha-11 subunit, gna11, putative	0.0008	0.0027	0.0141
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.1037	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.1037	0.1295
Loa Loa (eye worm)	beta-lactamase	0.0037	0.1037	0.1027
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.1037	0.1035
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0463	0.0789
Echinococcus multilocularis	sulfhydryl oxidase 1	0.0028	0.0708	0.0708
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.1199	1
Schistosoma mansoni	synaptojanin	0.0007	0.001	0.001
Brugia malayi	RNA, U transporter 1	0.0079	0.2485	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0017
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0142	0.4661	0.4661
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0008	0.0027	0.0027
Schistosoma mansoni	quiescin q6-related sulfhydryl oxidase	0.0028	0.0708	0.0708
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0036	0.1013	0.175
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.1734	0.3007
Trichomonas vaginalis	ap endonuclease, putative	0.0036	0.1013	0.8439
Trichomonas vaginalis	ap endonuclease, putative	0.0036	0.1013	0.8439
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0716	0.0716
Entamoeba histolytica	G protein alpha subunit, putative	0.0008	0.0027	0.0076
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0183	0.6055	0.6055
Toxoplasma gondii	exonuclease III APE	0.0036	0.1013	0.175
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0463	0.0789
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0463	0.0789
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0716	0.1231
Entamoeba histolytica	hypothetical protein	0.0071	0.2213	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.061	0.1046
Echinococcus granulosus	geminin	0.0175	0.5781	0.5781
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.7935	1
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0535	0.4411
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.1199	0.2074
Brugia malayi	RNA binding protein	0.0067	0.2056	0.2063
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0008	0.0027	0.0027
Echinococcus multilocularis	neutral sphingomyelinase	0.0007	0.001	0.001
Toxoplasma gondii	Erv1 / Alr family protein	0.0174	0.5741	1
Onchocerca volvulus		0.0008	0.0027	0.0164
Onchocerca volvulus		0.0037	0.1037	1
Schistosoma mansoni	ap endonuclease	0.0036	0.1013	0.1013
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0008	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0017
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.0008	0.0027	0.0027
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.3109	0.3125
Schistosoma mansoni	neutral sphingomyelinase	0.0007	0.001	0.001
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.1037	0.1295
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1037	0.1037
Schistosoma mansoni	hypothetical protein	0.0031	0.0817	0.0817
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.1037	0.1295
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1037	0.8634
Echinococcus granulosus	synaptojanin 1	0.0007	0.001	0.001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.1037	0.8634
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0708	0.0698
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.2056	0.2063
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0535	0.0915
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1037	0.1791
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.1079	0.1864
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0174	0.5741	0.5741
Schistosoma mansoni	hypothetical protein	0.0031	0.0817	0.0817
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0036	0.1013	0.175
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.1037	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0139	0.0139
Onchocerca volvulus		0.0037	0.1037	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0535	0.238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Echinococcus multilocularis	synaptojanin 1	0.0007	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1037	0.1027
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.1037	0.1027
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.0008	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0708	0.0698
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0008	0.0027	0.0027
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.0008	0.0027	0.0017
Echinococcus granulosus	traf and tnf receptor associated protein	0.0007	0.001	0.001
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0036	0.1013	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.061	0.1046
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0817	0.0817
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.1199	0.2074
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0007	0.001	0.001
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0139	0.0139
Brugia malayi	acetyltransferase, GNAT family protein	0.0142	0.4661	0.4691
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9925	0.9925
Brugia malayi	hypothetical protein	0.0071	0.2213	0.2222
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.1037	0.1037
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0174	0.5741	0.5741
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0142	0.4661	0.4661
Echinococcus multilocularis	muscleblind protein	0.0295	0.9925	0.9925
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.2213	0.2213
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0817	0.0817
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0174	0.5741	1
Brugia malayi	hypothetical protein	0.0025	0.061	0.0604
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.0008	0.0027	0.0017
Brugia malayi	Muscleblind-like protein	0.0295	0.9925	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0183	0.6055	0.6051
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.0008	0.0027	0.0027
Echinococcus multilocularis	muscleblind protein 1	0.0295	0.9925	0.9925
Brugia malayi	G-protein alpha subunit	0.0008	0.0027	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.2056	0.2056
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0183	0.6055	0.6097
Schistosoma mansoni	cpg binding protein	0.003	0.0793	0.0793
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0036	0.1013	0.9389
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.0008	0.0027	0.0017
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0007	0.001	0.001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0183	0.6055	0.6055
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.1037	0.1791
Onchocerca volvulus		0.0008	0.0027	0.0164
Echinococcus multilocularis	expressed protein	0.0008	0.0027	0.0027
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.0008	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0011	0.0139	0.0139
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0708	0.1217
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.0008	0.0027	0.0027
Leishmania major	hypothetical protein, conserved	0.0025	0.061	0.1046
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.1037	0.8634
Onchocerca volvulus	Sulfhydryl oxidase homolog	0.0028	0.0708	0.6798
Toxoplasma gondii	ABC1 family protein	0.0037	0.1037	0.1791
Schistosoma mansoni	hypothetical protein	0.0007	0.001	0.001
Schistosoma mansoni	carbon catabolite repressor protein	0.0007	0.001	0.001
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0463	0.0453
Trichomonas vaginalis	GTP-binding protein alpha subunit, gna, putative	0.0008	0.0027	0.0141
Brugia malayi	hypothetical protein	0.0008	0.0027	0.0017
Trichomonas vaginalis	GTP-binding protein (z) alpha subunit, gnaz, putative	0.0008	0.0027	0.0141
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.0008	0.0027	0.0017
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.0008	0.0027	0.0027
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.1079	0.485
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.1037	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0817	0.0808
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0017
Brugia malayi	quiescin Q6	0.0028	0.0708	0.0704
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0007	0.001	0.001
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.0008	0.0027	0.0027
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0174	0.5741	1
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0463	0.4234
Echinococcus multilocularis	geminin	0.0175	0.5781	0.5781
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0817	0.0814
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.0008	0.0027	0.0017
Entamoeba histolytica	hypothetical protein	0.0071	0.2213	1
Trypanosoma cruzi	quiescin sulfhydryl oxidase, putative	0.0028	0.0708	0.1217
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.2056	0.2048
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.2056	0.2056
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0007	0.001	0.001
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.3109	0.3125
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0174	0.5741	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0036	0.1013	0.1012
Leishmania major	GTP-binding protein, putative	0.0021	0.0463	0.0789
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.3109	0.3102
Loa Loa (eye worm)	hypothetical protein	0.0067	0.2048	0.204
Trichomonas vaginalis	GTP-binding protein (O) alpha subunit, gnao, putative	0.0008	0.0027	0.0141
Onchocerca volvulus		0.0008	0.0027	0.0164
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0036	0.1013	0.175
Trichomonas vaginalis	G protein (olf) alpha subunit, gnal, putative	0.0008	0.0027	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0295	0.9925	0.9925
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.006	0.005
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.2056	0.2056
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.2056	0.2056
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.2056	0.2056
Brugia malayi	beta-lactamase	0.0037	0.1037	0.1035
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.0008	0.0027	0.0027
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0463	0.0789
Loa Loa (eye worm)	acetyltransferase	0.0142	0.4661	0.4656
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.0008	0.0027	0.0027
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.1037	0.1295
Echinococcus granulosus	expressed protein	0.0008	0.0027	0.0027
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0737	0.0727
Leishmania major	hypothetical protein, conserved	0.0174	0.5741	1
Schistosoma mansoni	nocturnin	0.0007	0.001	0.001
Entamoeba histolytica	Ran family GTPase	0.0021	0.0463	0.2054
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.1037	0.1295
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0028	0.0708	0.1217

Activities

Activity type	Activity value	Assay description	Source	Reference
Ratio (binding)	= 50 /M/min	Ratio of Kinact to Ki for human PAD4 using BAEE as substrate after 30 mins	ChEMBL.	24900657
Ratio (binding)	= 62 /M/min	Ratio of Kinact to Ki for human PAD1 using BAEE as substrate after 30 mins	ChEMBL.	24900657
Ratio (binding)	= 120 /M/min	Ratio of Kinact to Ki for mouse PAD2 using BAEE as substrate after 30 mins	ChEMBL.	24900657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2323293

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1727844