Detailed information for compound 1730374

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 351.868 | Formula: C19H26ClNO3
  • H donors: 1 H acceptors: 1 LogP: 6.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCNc1ccc2c(c1)c(=O)oc(c2Cl)OC
  • InChi: 1S/C19H26ClNO3/c1-3-4-5-6-7-8-9-12-21-14-10-11-15-16(13-14)18(22)24-19(23-2)17(15)20/h10-11,13,21H,3-9,12H2,1-2H3
  • InChiKey: XPEIUDIGZCMDKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Smad1 0.0041 0.0045 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0035 0.1175
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0123 0.0212 0.021
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0061 0.0059
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0084 0.1032
Onchocerca volvulus 0.0071 0.0105 0.0809
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0393 0.4306
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0084 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0035 0.1175
Echinococcus multilocularis ubiquitin specific protease 41 0.0049 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0027 0.0469
Mycobacterium tuberculosis Probable reductase 0.0212 0.0393 0.4306
Schistosoma mansoni tar DNA-binding protein 0.0063 0.009 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0053 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0066 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0105 0.0103
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0105 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0004
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.058 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.009 0.0088
Loa Loa (eye worm) RNA binding protein 0.0063 0.009 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0049 0.084
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0054 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0105 0.1403
Toxoplasma gondii hypothetical protein 0.0123 0.0212 1
Brugia malayi RNA binding protein 0.0063 0.009 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0017 0.0268
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0092 0.1179
Loa Loa (eye worm) hypothetical protein 0.0123 0.0212 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0061 0.2469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0051
Entamoeba histolytica hypothetical protein 0.0073 0.011 0.4403
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0254 0.4109
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.011 0.0108
Loa Loa (eye worm) hypothetical protein 0.0123 0.0212 0.0442
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0123 0.0212 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.003 0.0162
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.058 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.0441 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Leishmania major cathepsin L-like protease 0.0064 0.0092 0.1179
Giardia lamblia DINP protein human, muc B family 0.004 0.0043 0.479
Mycobacterium tuberculosis Conserved protein 0.0071 0.0105 0.0915
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0049 0.0389
Echinococcus multilocularis dna polymerase kappa 0.006 0.0084 0.0082
Brugia malayi Sphingomyelin synthase-related 1 0.0123 0.0212 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0105 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Schistosoma mansoni tar DNA-binding protein 0.0063 0.009 0.0088
Brugia malayi Thioredoxin reductase 0.0093 0.0151 0.0313
Brugia malayi MH2 domain containing protein 0.0604 0.1186 0.2491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Brugia malayi polk-prov protein 0.0037 0.0037 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0049 0.0061 0.0609
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.001 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.2364 0.4755 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0045 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0084 0.1032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0061 0.2469
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0151 0.2232
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.003 0.0059
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0212 0.3341
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.011 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.058 1
Echinococcus granulosus dna polymerase kappa 0.006 0.0084 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.009 0.0185
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0043 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Brugia malayi hypothetical protein 0.03 0.0571 0.1197
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0084 0.2193
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0084 0.1453
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0247 0.0463 0.0461
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0212 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0054 0.1315
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0254 0.4109
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0105 0.0915
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0105 0.4658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.2114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0027 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0393 0.4306
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0212 0.0442
Leishmania major cathepsin L-like protease 0.0064 0.0092 0.1179
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0212 0.3654
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0054 0.0109
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0049 0.0061 1
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.058 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0022 0.0383
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0212 1
Brugia malayi TAR-binding protein 0.0063 0.009 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0241
Entamoeba histolytica hypothetical protein 0.0073 0.011 0.4403
Schistosoma mansoni smad 0.0041 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Schistosoma mansoni thyroid hormone receptor 0.0267 0.0503 0.0501
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0105 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.2114
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0105 0.2981
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0105 0.1807
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0105 0.0915
Trichomonas vaginalis esterase, putative 0.0071 0.0105 0.4658
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0151 0.0313
Echinococcus granulosus tumor protein p63 0.4416 0.8918 0.8917
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Trypanosoma brucei unspecified product 0.0054 0.0071 0.122
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0054 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0212 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0045 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0037 0.0644
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0105 0.4658
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0604
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.003 0.0059
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0049 0.0061 0.2469
Brugia malayi MH2 domain containing protein 0.0041 0.0045 0.0091
Echinococcus granulosus Smad4 0.0041 0.0045 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0035 0.1175
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.003 0.0028
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.0441 0.4873
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0212 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0505
Mycobacterium ulcerans lipase LipD 0.0071 0.0105 0.2981
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.011 0.0108
Echinococcus multilocularis dna polymerase eta 0.0034 0.003 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0022 0.0383
Brugia malayi MH1 domain containing protein 0.0041 0.0045 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0049 0.0389
Entamoeba histolytica hypothetical protein 0.0123 0.0212 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0043 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0035 0.1175
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0054 0.0927
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0061 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.0876 1
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.009 0.0185
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0049 0.0061 0.0059
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0064 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Echinococcus multilocularis tar DNA binding protein 0.0063 0.009 0.0088
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0212 0.3341
Treponema pallidum NADH oxidase 0.0032 0.0027 0.5
Leishmania major cathepsin L-like protease 0.0064 0.0092 0.1179
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0254 0.4386
Echinococcus granulosus tar DNA binding protein 0.0063 0.009 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0151 0.0149
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0287 0.3068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.004 0.1443
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0053 0.0107
Loa Loa (eye worm) hypothetical protein 0.0123 0.0212 0.0442
Mycobacterium tuberculosis Conserved protein 0.0071 0.0105 0.0915
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0105 0.2981
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0212 1
Schistosoma mansoni hypothetical protein 0.0035 0.0033 0.0031
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0081 0.0974
Echinococcus multilocularis tumor protein p63 0.4416 0.8918 0.8917
Loa Loa (eye worm) transcription factor SMAD2 0.0604 0.1186 0.2491
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.003 0.0515
Onchocerca volvulus 0.0071 0.0105 0.0809
Plasmodium vivax sphingomyelin synthase 2, putative 0.0123 0.0212 1
Trypanosoma brucei trypanothione reductase 0.0093 0.0151 0.2597
Entamoeba histolytica hypothetical membrane-spanning protein 0.0123 0.0212 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0045 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0393 0.4306
Onchocerca volvulus 0.0071 0.0105 0.0809
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0061 0.105
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0105 0.4658
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0123 0.0212 0.0442
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.003 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0027 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0004
Echinococcus multilocularis smad 0.0041 0.0045 0.0043
Entamoeba histolytica hypothetical protein 0.0123 0.0212 1
Plasmodium falciparum thioredoxin reductase 0.0093 0.0151 0.668
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0043 0.0747
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0212 0.3341
Entamoeba histolytica hypothetical protein 0.0073 0.011 0.4403
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0054 0.048
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0105 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0017 0.0268
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0027 0.079
Plasmodium vivax glutathione reductase, putative 0.0093 0.0151 0.668
Leishmania major DNA polymerase eta, putative 0.0034 0.003 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0084 0.3635
Brugia malayi hypothetical protein 0.0073 0.011 0.0227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0053 0.0051
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0247 0.0463 0.0461
Trypanosoma brucei inositol phosphorylceramide synthase 0.0123 0.0212 0.3654
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0027 0.0025
Echinococcus granulosus smad 0.0041 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0012
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0027 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Brugia malayi beta-lactamase family protein 0.0071 0.0105 0.0216
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0027 0.0025
Schistosoma mansoni hypothetical protein 0.0247 0.0463 0.0461
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0105 0.0915
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0027 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.003 0.0028
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0035 0.0604
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.003 0.0059
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0053 0.0051
Toxoplasma gondii ABC1 family protein 0.0071 0.0105 0.42
Schistosoma mansoni thyroid hormone receptor 0.0267 0.0503 0.0501
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0005 0.0091
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0061 0.0609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0053 0.0051
Trichomonas vaginalis hypothetical protein 0.0123 0.0212 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0105 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0054 0.048
Schistosoma mansoni smad1 5 8 and 0.0041 0.0045 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0105 0.0915
Brugia malayi beta-lactamase 0.0071 0.0105 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0022 0.0383
Onchocerca volvulus 0.0646 0.1273 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0604 0.1186 0.2491
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0092 0.1179
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0212 0.3654
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0045 0.0043
Entamoeba histolytica hypothetical protein 0.0123 0.0212 1
Leishmania major hypothetical protein, conserved 0.0071 0.0105 0.1403
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0045 0.0043
Trypanosoma brucei unspecified product 0.0023 0.0009 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0054 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0092 0.1179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0033 0.0065
Leishmania major DNA polymerase kappa, putative 0.004 0.0043 0.0292
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0027 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0066 0.0134
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0037 0.0037 0.0074
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0054 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0105 0.4658
Brugia malayi glutathione reductase 0.0093 0.0151 0.0313
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0027 0.0469
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0123 0.0212 0.0442
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0068 0.0733
Entamoeba histolytica hypothetical protein 0.0123 0.0212 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0049 0.0061 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0105 0.0915
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0027 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0084 0.3635
Schistosoma mansoni Smad4 0.0041 0.0045 0.0043
Loa Loa (eye worm) beta-lactamase 0.0071 0.0105 0.0216
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0393 0.4306
Loa Loa (eye worm) hypothetical protein 0.0123 0.0212 0.0442
Loa Loa (eye worm) hypothetical protein 0.0071 0.0105 0.0216
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0084 0.1453
Brugia malayi MH1 domain containing protein 0.0023 0.0008 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0105 0.4658
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0027 0.0469
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0151 0.0149
Brugia malayi MH1 domain containing protein 0.0041 0.0045 0.0091
Plasmodium falciparum glutathione reductase 0.0093 0.0151 0.668
Schistosoma mansoni smad1 5 8 and 0.0041 0.0045 0.0043
Echinococcus granulosus ubiquitin specific protease 41 0.0049 0.0061 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0092 0.1179
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0105 0.0915
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0105 0.1403
Loa Loa (eye worm) TAR-binding protein 0.0063 0.009 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0053 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0066 0.0134
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0151 0.668
Loa Loa (eye worm) hypothetical protein 0.0123 0.0212 0.0442
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0035 0.0141
Mycobacterium ulcerans hypothetical protein 0.0161 0.0287 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.0441 0.4873
Loa Loa (eye worm) hypothetical protein 0.0051 0.0066 0.0134
Schistosoma mansoni hypothetical protein 0.0073 0.011 0.0108
Entamoeba histolytica hypothetical protein 0.0073 0.011 0.4403
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0049 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0646 0.1273 0.2673
Toxoplasma gondii hypothetical protein 0.0049 0.0062 0.1856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.003 0.0939
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.001 0.0017
Mycobacterium ulcerans hypothetical protein 0.0071 0.0105 0.2981
Schistosoma mansoni tar DNA-binding protein 0.0063 0.009 0.0088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0151 0.1455
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.0071 0.122
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Brugia malayi MH1 domain containing protein 0.0023 0.0008 0.0012
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0054 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0035 0.1175
Leishmania major trypanothione reductase 0.0093 0.0151 0.2232
Toxoplasma gondii thioredoxin reductase 0.0093 0.0151 0.668
Brugia malayi beta-lactamase family protein 0.0071 0.0105 0.0216
Echinococcus multilocularis thyroid hormone receptor alpha 0.0267 0.0503 0.0501
Loa Loa (eye worm) nuclear factor I 0.0023 0.0008 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0033 0.0065
Schistosoma mansoni smad1 5 8 and 0.0041 0.0045 0.0043
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0084 0.1032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0045 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0045 0.0091
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.003 0.0047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0061 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0084 0.1453
Loa Loa (eye worm) Smad1 0.0041 0.0045 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0105 0.42
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0092 0.1593
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0393 0.4306
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0105 0.0103
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0393 0.8569
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0084 0.2193
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0212 1
Echinococcus multilocularis Smad4 0.0041 0.0045 0.0043
Mycobacterium ulcerans beta-lactamase 0.0071 0.0105 0.2981
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0049 0.0389
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0054 0.1315
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0037 0.0644
Echinococcus granulosus dna polymerase eta 0.0034 0.003 0.0028
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0123 0.0212 0.3654
Loa Loa (eye worm) hypothetical protein 0.0034 0.003 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0054 0.2114
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0105 0.0915
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0054 0.048
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0049 0.0061 0.0124
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0049 0.0061 0.0059
Plasmodium vivax sphingomyelin synthase 1, putative 0.0123 0.0212 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0053 0.0051
Schistosoma mansoni spingomyelin synthetase-related 0.0123 0.0212 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0212 1
Onchocerca volvulus 0.03 0.0571 0.4476
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.2364 0.4755 1
Echinococcus granulosus sphingomyelin synthase protein 1 0.0123 0.0212 0.021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.003 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0049 0.0061 0.0609
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0054 0.0927
Entamoeba histolytica hypothetical protein 0.0123 0.0212 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0017 0.0268
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0027 0.0025
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0212 1
Loa Loa (eye worm) glutathione reductase 0.0093 0.0151 0.0313
Giardia lamblia GTOR 0.0045 0.0054 0.7887
Schistosoma mansoni tar DNA-binding protein 0.0063 0.009 0.0088
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0049 0.0061 0.1705
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.0441 0.4873
Trypanosoma brucei unspecified product 0.0023 0.0009 0.015
Loa Loa (eye worm) hypothetical protein 0.03 0.0571 0.1197
Schistosoma mansoni cellular tumor antigen P53 0.0646 0.1273 0.1271
Schistosoma mansoni DNA polymerase eta 0.0034 0.003 0.0028
Brugia malayi MH2 domain containing protein 0.0041 0.0045 0.0091

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) > 50 % Inhibition of gamma-secretase-mediated betaAPP K670N/M671L mutant cleavage in HEK293 cells assessed as inhibition of amyloid beta40/42 production at 10 to 30 uM after 8 hrs by chemiluminescence assay relative to control ChEMBL. 23294826

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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