TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.459 | Formula: C24H25NO5
H donors: 0 H acceptors: 2 LogP: 4.21 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1=CN(C=C(C1c1ccccc1)C(=O)OCC)c1ccccc1OC
InChi: 1S/C24H25NO5/c1-4-29-23(26)18-15-25(20-13-9-10-14-21(20)28-3)16-19(24(27)30-5-2)22(18)17-11-7-6-8-12-17/h6-16,22H,4-5H2,1-3H3
InChiKey: JZHZKBADPQPVAS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0029	0.0155	0.1803
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0171	0.0294
Brugia malayi	major facilitator superfamily protein	0.0029	0.0155	0.0266
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.072	0.3249
Loa Loa (eye worm)	MH2 domain-containing protein	0.0233	0.2492	0.4275
Trypanosoma cruzi	hexose transporter	0.0065	0.0562	0.6781
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.003	0.0165	0.0282
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus granulosus	General substrate transporter	0.0179	0.188	0.2544
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Brugia malayi	Bromodomain containing protein	0.003	0.0165	0.0282
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.0287	0.1263
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0165	0.001
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0338	0.3694	0.3595
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0935	0.1603
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0657	0.7944
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0954	0.1291
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0419	0.1862
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0171	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0353	0.0606
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1599
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0266
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0017	0.0008	0.0011
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0088	0.0825	0.1414
Brugia malayi	Phospholipase A2 family protein	0.0523	0.583	1
Echinococcus granulosus	tumor protein p63	0.0659	0.7388	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0913	0.1565
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0155	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0088	0.0825	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0657	0.7944
Brugia malayi	MH2 domain containing protein	0.0233	0.2492	0.4275
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0657	0.0985
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trypanosoma brucei	DNA polymerase eta, putative	0.0018	0.0021	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0619	0.2764
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0072	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0553	0.0827
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0353	0.0606
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.2911
Schistosoma mansoni	hypothetical protein	0.0037	0.0246	0.1109
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.0538	0.6483
Leishmania major	glucose transporter, lmgt1	0.0065	0.0562	0.6731
Plasmodium vivax	hexose transporter	0.0209	0.2217	0.2094
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Trypanosoma cruzi	DNA polymerase eta, putative	0.0018	0.0021	0.0151
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0155	0.0665
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.2911
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0419	0.1862
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0657	0.7913
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0088	0.0825	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0772
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0538	0.2425
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.2217	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0155	0.4044
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0562	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0538	0.0922
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0825	0.3696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0552	0.0947
Giardia lamblia	Hexose transporter	0.0029	0.0155	0.1674
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0155	0.0667
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0165	0.0237
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0238	0.0322
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trichomonas vaginalis	DNA polymerase eta, putative	0.0018	0.0021	0.0056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0224	0.2649
Loa Loa (eye worm)	sugar transporter	0.0029	0.0155	0.0266
Onchocerca volvulus	Phospholipase A2 homolog	0.0095	0.0913	0.1335
Loa Loa (eye worm)	hypothetical protein	0.0523	0.583	1
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0155	0.0223
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0562	0.6731
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0155	0.0223
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0171	0.0294
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0562	0.2506
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0562	0.6781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0619	0.2764
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Echinococcus multilocularis	serine protein kinase ATM	0.0017	0.0008	0.0011
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Schistosoma mansoni	glucose transport protein	0.0209	0.2217	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0088	0.0825	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0029	0.0155	0.1803
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0018	0.0021	0.0056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1596
Brugia malayi	Sugar transporter family protein	0.0209	0.2217	0.3803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0155	0.0667
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.07
Trypanosoma brucei	DNA polymerase IV, putative	0.0018	0.0021	0.0151
Entamoeba histolytica	protein kinase, putative	0.0064	0.0552	0.6666
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0488	0.5877
Brugia malayi	hypothetical protein	0.0037	0.0246	0.0422
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0657	0.7944
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0155	0.0665
Trypanosoma brucei	DNA polymerase IV, putative	0.0018	0.0021	0.0151
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0065	0.0567	0.0848
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0772
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0155	0.534
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0353	0.0478
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0053	0.043	0.5165
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0926	0.1588
Leishmania major	glucose transporter, lmgt2	0.0065	0.0562	0.6731
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0246	0.0333
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0155	0.0665
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0018	0.0021	0.0028
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0562	0.2506
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0825	0.3696
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0657	0.7913
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0353	0.4138
Echinococcus granulosus	serine protein kinase ATM	0.0017	0.0008	0.0011
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.021
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Schistosoma mansoni	hypothetical protein	0.003	0.0165	0.0743
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0552	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Plasmodium falciparum	phd finger protein, putative	0.003	0.0165	0.001
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0353	0.4227
Brugia malayi	jmjC domain containing protein	0.0099	0.0954	0.1636
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0017	0.0008	0.0037
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0088	0.0825	0.372
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0238	0.0408
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0488	0.5877
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0165	0.0223
Echinococcus granulosus	dna polymerase eta	0.0018	0.0021	0.0028
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0353	0.1593
Schistosoma mansoni	protein kinase	0.0064	0.0552	0.2492
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0171	0.0232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Echinococcus granulosus	peregrin	0.003	0.0165	0.0223
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0772
Schistosoma mansoni	hypothetical protein	0.0031	0.0171	0.0772
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0088	0.0825	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0353	0.0478
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0171	0.0232
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.0538	0.0922
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0029	0.0155	0.0267
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0538	0.0728
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0273	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0581	0.0997
Schistosoma mansoni	protein kinase	0.0064	0.0552	0.2492
Leishmania major	protein kinase, putative	0.0064	0.0552	0.6614
Onchocerca volvulus		0.0096	0.0926	0.1358
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.2217	0.3353
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0029	0.0155	0.021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0088	0.0825	0.3696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Giardia lamblia	GTOR	0.0088	0.0825	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0029	0.0155	0.021
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0562	0.6781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0553	0.0827
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trypanosoma cruzi	cysteine peptidase, putative	0.0058	0.0488	0.5877
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0562	0.2506
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0072	0.1547
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0018	0.0021	0.0028
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0155	0.1799
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0155	0.1799
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0029	0.0155	0.1803
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0023	0.0039
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0553	0.0404
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0553	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0552	0.6666
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0155	0.021
Echinococcus multilocularis	dna polymerase eta	0.0018	0.0021	0.0028
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0171	0.0294
Trypanosoma cruzi	major cysteine proteinase, putative	0.0046	0.0345	0.412
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0562	0.6781
Echinococcus granulosus	dna polymerase kappa	0.0018	0.0021	0.0028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0677	0.303
Echinococcus granulosus	GPCR family 2	0.0031	0.0171	0.0232
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0552	0.2464
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0155	0.0667
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0171	0.0232
Schistosoma mansoni	cellular tumor antigen P53	0.0096	0.0926	0.4176
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.0507	0.0686
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0353	0.0524
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0353	0.1593
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0155	0.0665
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0562	0.6781
Trypanosoma brucei	DNA polymerase IV, putative	0.0018	0.0021	0.0151
Brugia malayi	PHD-finger family protein	0.003	0.0165	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0562	0.2506
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0017	0.0008	0.0011
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0018	0.0021	0.0093
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1599
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0041	0.0294	0.35
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0552	0.0748
Entamoeba histolytica	protein kinase, putative	0.0064	0.0552	0.6666
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0538	0.2425
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.2911
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Loa Loa (eye worm)	sugar transporter	0.0209	0.2217	0.3803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0619	0.2764
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0155	0.021
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Schistosoma mansoni	hypothetical protein	0.0209	0.2217	1
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0353	0.0201
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0155	0.0223
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Mycobacterium ulcerans	sugar transporter	0.0029	0.0155	0.4044
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0113	0.0194
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0353	0.4227
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0553	0.0404
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.0538	0.643
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.021
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0018	0.0021	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0353	0.1562
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0553	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0553	0.0404
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.0538	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0155	0.534
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0338	0.3694	0.5596
Leishmania major	cathepsin L-like protease	0.0058	0.0488	0.5814
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0657	0.051
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Plasmodium falciparum	protein kinase 7	0.059	0.6596	0.6542
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0562	0.6781
Onchocerca volvulus	Alhambra homolog	0.003	0.0165	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus multilocularis	tumor protein p63	0.0659	0.7388	1
Schistosoma mansoni	hypothetical protein	0.0066	0.0581	0.2622
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0935	0.1603
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.003	0.0098
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0018	0.0021	0.0151
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0552	0.0947
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0171	0.0232
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0419	0.1862
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0165	0.0743
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0155	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0619	0.2764
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0155	0.1799
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0155	0.0665
Giardia lamblia	Sugar-proton symporter	0.0029	0.0155	0.1674
Toxoplasma gondii	protein kinase, putative	0.059	0.6596	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0353	0.0201
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0935	0.1603
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0088	0.0825	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0553	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0171	0.0294
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.007	0.0619	0.7487
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Leishmania major	cathepsin L-like protease	0.0058	0.0488	0.5814
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Brugia malayi	major facilitator superfamily protein	0.0029	0.0155	0.0266
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0165	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0619	0.2764
Plasmodium falciparum	hexose transporter	0.0209	0.2217	0.2094
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.07
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0088	0.0825	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0954	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0935	0.1603
Schistosoma mansoni	protein kinase	0.0064	0.0552	0.2492
Brugia malayi	ImpB/MucB/SamB family protein	0.0018	0.0021	0.0035
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0552	0.0947
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0553	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0155	0.0667
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0562	0.6781
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.07
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0165	0.0282
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus multilocularis	General substrate transporter	0.0179	0.188	0.2544
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0534	0.0916
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0155	0.07
Entamoeba histolytica	hypothetical protein	0.0047	0.0353	0.4227
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0538	0.0728
Loa Loa (eye worm)	phosphatidylinositol 3	0.0088	0.0825	0.1414
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.2217	0.3001
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0029	0.0155	0.1678
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1599
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0353	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0353	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0886	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0029	0.0155	0.1678
Loa Loa (eye worm)	transcription factor SMAD2	0.0233	0.2492	0.4275
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0238	0.1072
Brugia malayi	jmjC domain containing protein	0.0037	0.0238	0.0408
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0018	0.0021	0.0093
Leishmania major	glucose transporter, lmgt3	0.0065	0.0562	0.6731
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0008	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0552	0.2492
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0155	0.0665
Echinococcus multilocularis	peregrin	0.003	0.0165	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0008	0.0014
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0155	0.0223
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0238	0.0322
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0353	0.4138
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0036	0.0236	0.279
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0165	0.0237
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0155	0.1799
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0266
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0338	0.3694	0.3595
Echinococcus multilocularis	dna polymerase kappa	0.0018	0.0021	0.0028
Brugia malayi	Cam kinase protein 1	0.0064	0.0552	0.0947
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.07
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0008	0.0014
Onchocerca volvulus	Phospholipase A2 homolog	0.0523	0.583	1
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.03	0.0407
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.0538	0.2397
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0538	0.0922
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0155	0.021
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1599
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0273	1
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0266
Schistosoma mansoni	glucose transporter	0.0029	0.0155	0.07
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0029	0.0155	0.0701
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0353	0.3046
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0246	0.0333
Trypanosoma cruzi	cruzipain precursor, putative	0.0058	0.0488	0.5877
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0155	0.1799
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.021
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2217	0.3001
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.007	0.0619	0.7448
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0562	0.6781
Loa Loa (eye worm)	phosphatidylinositol 3	0.0029	0.0155	0.0267
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0238	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0088	0.0825	0.1116
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.0538	0.0922
Trypanosoma cruzi	target of rapamycin kinase 3	0.007	0.0619	0.7487
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0266
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0088	0.0361
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0361	0.1596
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0562	0.2506
Schistosoma mansoni	glucose transport protein	0.0209	0.2217	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0552	0.0748
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0018	0.003	0.0033
Trypanosoma brucei	unspecified product	0.0018	0.0021	0.0151
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Schistosoma mansoni	glucose transport protein	0.0209	0.2217	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0353	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0412	0.0707
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0562	0.6781
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0266
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0581	0.0997
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.0507	0.0686
Leishmania major	cathepsin L-like protease	0.0058	0.0488	0.5814
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0246	0.1109
Giardia lamblia	PHD finger protein 15	0.003	0.0165	0.1792
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0029	0.0155	0.1803
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0553	0.0404
Brugia malayi	ImpB/MucB/SamB family protein	0.0018	0.0021	0.0035
Brugia malayi	Sugar transporter family protein	0.0029	0.0155	0.0266
Brugia malayi	Sugar transporter family protein	0.0029	0.0155	0.0266
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0017	0.0008	0.0037
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0155	0.021
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.2911
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0155	0.0665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0567	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0403	0.069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0057	0.0471	0.2097
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0553	0.0404
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0088	0.0825	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0155	0.0667
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0413	0.1835
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0155	0.1674
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0155	0.4044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0493	0.2196
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0088	0.0825	0.1116
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0088	0.0825	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0018	0.0021	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.0413	0.1835
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0058	0.0488	0.5877
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.03	0.0407
Schistosoma mansoni	DNA polymerase eta	0.0018	0.0021	0.0093
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0553	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0035
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0657	0.051
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0562	0.2506
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0562	0.6781
Leishmania major	hypothetical protein, conserved	0.0029	0.0155	0.1674
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0155	0.4044

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 29.94 %	Inhibition of recombinant His-tagged PDE4B (unknown origin) expressed in Sf9 cells using cAMP as substrate at 30 uM incubated for 15 mins prior to substrate addition measured after 1 hr by luminescence-based assay	ChEMBL.	23380174

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2337711

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1731714