TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 216.236 | Formula: C12H12N2O2
H donors: 2 H acceptors: 2 LogP: 1.35 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc(CCc2ccccc2)n[nH]c1=O
InChi: 1S/C12H12N2O2/c15-11-8-10(13-14-12(11)16)7-6-9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,13,15)(H,14,16)
InChiKey: LQVOQKJUHJKVFE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	D-amino acid oxidase	Starlite/ChEMBL	References
Rattus norvegicus	D-amino-acid oxidase	Starlite/ChEMBL	References
Homo sapiens	D-amino-acid oxidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	D-amino acid oxidase	Get druggable targets OG5_127583	All targets in OG5_127583
Schistosoma japonicum	ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative	Get druggable targets OG5_127583	All targets in OG5_127583
Mycobacterium ulcerans	D-amino acid oxidase Aao	Get druggable targets OG5_127583	All targets in OG5_127583
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	Get druggable targets OG5_127583	All targets in OG5_127583
Candida albicans	putative d-amino acid oxidase	Get druggable targets OG5_127583	All targets in OG5_127583
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127583	All targets in OG5_127583
Schistosoma mansoni	d-amino acid oxidase	Get druggable targets OG5_127583	All targets in OG5_127583
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	Get druggable targets OG5_127583	All targets in OG5_127583
Candida albicans	putative d-amino acid oxidase	Get druggable targets OG5_127583	All targets in OG5_127583
Candida albicans	D-amino acid oxidase	Get druggable targets OG5_127583	All targets in OG5_127583

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium ulcerans	D-amino acid oxidase Aao	D-amino acid oxidase	345 aa	381 aa	23.4 %
Candida albicans	similar to putative d-amino acid oxidase	D-amino-acid oxidase	346 aa	388 aa	22.2 %
Mycobacterium ulcerans	D-amino acid oxidase Aao	D-amino-acid oxidase	346 aa	382 aa	24.1 %
Mycobacterium ulcerans	D-amino acid oxidase Aao	D-amino-acid oxidase	347 aa	378 aa	24.6 %
Onchocerca volvulus	Unconventional prefoldin RPB5 interactor 1 homolog	D-amino-acid oxidase	346 aa	350 aa	31.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0049	0.0414	0.0343
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0049	0.0414	0.1636
Schistosoma mansoni	tyrosine kinase	0.0155	0.2314	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Echinococcus granulosus	Sterile alpha motif type	0.0034	0.0152	0.0095
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Plasmodium vivax	cysteine repeat modular protein 3, putative	0.0041	0.0271	0.0947
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.006	0.0612	0.0745
Trypanosoma brucei	heat shock protein 90, putative	0.0146	0.2153	1
Schistosoma mansoni	DNA topoisomerase II	0.003	0.0074	0.0032
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0049	0.0414	0.0376
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0049	0.0414	0.0343
Echinococcus multilocularis	liprin alpha 2	0.0034	0.0152	0.0095
Plasmodium vivax	heat shock protein 86, putative	0.0146	0.2153	1
Plasmodium falciparum	conserved protein, unknown function	0.0041	0.0271	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0257	0.4133	0.5014
Brugia malayi	Hsp90 protein	0.006	0.0612	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Entamoeba histolytica	hypothetical protein	0.0041	0.0271	0.0947
Echinococcus granulosus	roundabout 2	0.0031	0.0096	0.0027
Trypanosoma cruzi	hypothetical protein	0.0034	0.0152	0.0371
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0049	0.0414	0.1636
Brugia malayi	coiled-coil like protein 1	0.0034	0.0152	0.0189
Entamoeba histolytica	hypothetical protein, conserved	0.0041	0.0271	0.0947
Echinococcus granulosus	endonuclease reverse transcriptase	0.0041	0.0271	0.0243
Echinococcus multilocularis	epidermal growth factor receptor	0.0257	0.4133	0.5014
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0584	1	1
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.0034	0.0152	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Schistosoma mansoni	tyrosine kinase	0.0155	0.2314	0.2281
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0034	0.0152	0.0095
Onchocerca volvulus	Tankyrase homolog	0.0034	0.0152	0.0107
Loa Loa (eye worm)	AIDA-1b	0.0034	0.0152	0.0152
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Trypanosoma brucei	Heat shock protein 83, putative	0.0146	0.2153	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0086	0.1083	0.4855
Trypanosoma brucei	heat shock protein 90, putative	0.0146	0.2153	1
Schistosoma mansoni	heat shock protein	0.006	0.0612	0.0572
Onchocerca volvulus		0.0034	0.0152	0.0107
Onchocerca volvulus		0.0034	0.0152	0.0107
Trypanosoma cruzi	heat shock protein 85, putative	0.0146	0.2153	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0473	0.7999	0.7999
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0049	0.0414	0.0343
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0034	0.0152	0.0189
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0049	0.0414	0.0374
Echinococcus multilocularis	insulin receptor	0.0155	0.2314	0.2766
Toxoplasma gondii	GCC2 and GCC3 domain-containing protein	0.0041	0.0271	0.0947
Schistosoma mansoni	fad oxidoreductase	0.0049	0.0414	0.0374
Loa Loa (eye worm)	TK/INSR protein kinase	0.0155	0.2314	0.2314
Trichomonas vaginalis	cgi-62, putative	0.0034	0.0152	0.0371
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0034	0.0152	0.0095
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0049	0.0414	1
Echinococcus multilocularis	histone acetyltransferase myst3	0.0034	0.0152	0.0095
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Brugia malayi	RE18450p	0.0049	0.0414	0.0518
Echinococcus granulosus	histone acetyltransferase myst3	0.0034	0.0152	0.0095
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0171	0.2605	0.3127
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.003	0.0074	0.0093
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0034	0.0152	0.011
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0049	0.0414	0.0343
Plasmodium falciparum	cysteine repeat modular protein 3	0.0041	0.0271	0.0947
Plasmodium vivax	cysteine repeat modular protein 2, putative	0.0041	0.0271	0.0947
Plasmodium vivax	heat shock protein, putative	0.006	0.0612	0.2588
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0034	0.0152	0.0095
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Plasmodium falciparum	heat shock protein 90, putative	0.006	0.0612	0.2588
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0049	0.0414	0.1636
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0146	0.2153	1
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0034	0.0152	0.0095
Schistosoma mansoni	NAD dehydrogenase	0.0049	0.0414	0.0374
Echinococcus multilocularis	heat shock protein 90	0.0116	0.1621	0.1911
Echinococcus multilocularis	endonuclease reverse transcriptase	0.0041	0.0271	0.0243
Trypanosoma brucei	heat shock protein 84, putative	0.006	0.0612	0.2588
Trichomonas vaginalis	heat shock protein, putative	0.006	0.0612	0.2588
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0271	0.0271
Onchocerca volvulus		0.0034	0.0152	0.0107
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0049	0.0414	0.1636
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0041	0.0271	0.0947
Schistosoma mansoni	Protein aveugle	0.0034	0.0152	0.011
Loa Loa (eye worm)	TK/EPH protein kinase	0.056	0.9566	0.9566
Schistosoma mansoni	tyrosine kinase	0.0248	0.3985	0.3959
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0152	0.0371
Schistosoma mansoni	cell adhesion molecule	0.0029	0.0054	0.0012
Entamoeba histolytica	heat shock protein 90, putative	0.0146	0.2153	1
Loa Loa (eye worm)	tnks protein	0.0034	0.0152	0.0152
Echinococcus multilocularis	endoplasmin	0.0116	0.1621	0.1911
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0116	0.1621	1
Trypanosoma cruzi	Kinesin-13 5, putative	0.0034	0.0152	0.0371
Schistosoma mansoni	heat shock protein	0.0146	0.2153	0.2119
Onchocerca volvulus		0.0433	0.7293	1
Onchocerca volvulus		0.0041	0.0271	0.0273
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0482	0.8169	1
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0049	0.0414	0.0518
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Trichomonas vaginalis	heat shock protein, putative	0.0116	0.1621	0.7443
Schistosoma mansoni	tyrosine kinase	0.0473	0.7999	0.7991
Echinococcus granulosus	liprin alpha 2	0.0034	0.0152	0.0095
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0049	0.0414	0.042
Echinococcus multilocularis	Sterile alpha motif SAM	0.0034	0.0152	0.0095
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Plasmodium falciparum	endoplasmin, putative	0.0089	0.1144	0.5145
Echinococcus multilocularis	polyhomeotic protein 2	0.0034	0.0152	0.0095
Schistosoma mansoni	fad oxidoreductase	0.0049	0.0414	0.0374
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0116	0.1621	0.7443
Brugia malayi	cask-interacting protein 2	0.0034	0.0152	0.0189
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Echinococcus granulosus	heat shock protein 90	0.0116	0.1621	0.1911
Schistosoma mansoni	pyruvate dehydrogenase	0.003	0.0074	0.0032
Trypanosoma cruzi	heat shock protein 85, putative	0.0146	0.2153	1
Trichomonas vaginalis	heat shock protein, putative	0.0089	0.1144	0.5145
Toxoplasma gondii	heat shock protein 90, putative	0.0146	0.2153	1
Schistosoma mansoni	DNAj-like protein	0.0034	0.0152	0.011
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0034	0.0152	0.0095
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Echinococcus multilocularis	heat shock protein	0.0146	0.2153	0.2568
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Onchocerca volvulus		0.0034	0.0152	0.0107
Echinococcus granulosus	epidermal growth factor receptor	0.0257	0.4133	0.5014
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0034	0.0152	0.0371
Giardia lamblia	Grp94/Hsp90	0.0116	0.1621	0.7443
Brugia malayi	Endoplasmin precursor	0.0146	0.2153	0.2691
Plasmodium falciparum	cysteine repeat modular protein 4	0.0041	0.0271	0.0947
Onchocerca volvulus		0.0137	0.1998	0.2664
Brugia malayi	GCC2 and GCC3 family protein	0.0041	0.0271	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Echinococcus granulosus	ephrin type A receptor 4 A	0.0482	0.8169	1
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0049	0.0414	0.1636
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0271	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Echinococcus multilocularis		0.0145	0.2129	0.2538
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.0414
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0049	0.0414	0.0471
Schistosoma mansoni	hypothetical protein	0.0034	0.0152	0.011
Echinococcus granulosus	Sterile alpha motif SAM	0.0034	0.0152	0.0095
Loa Loa (eye worm)	heat shock protein 90	0.0146	0.2153	0.2153
Schistosoma mansoni	tyrosine kinase	0.0248	0.3985	0.3959
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0116	0.1621	0.1911
Echinococcus multilocularis	polycomb protein SCMH1	0.0034	0.0152	0.0095
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0171	0.2605	0.3127
Trypanosoma cruzi	Heat shock protein 83, putative	0.0146	0.2153	1
Toxoplasma gondii	hypothetical protein	0.0041	0.0271	0.0947
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0049	0.0414	0.1636
Brugia malayi	Sphingomyelin synthase-related 1	0.0034	0.0152	0.0189
Brugia malayi	hypothetical protein	0.0034	0.0152	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.0414
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.003	0.0074	0.0093
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0049	0.0414	0.1636
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Onchocerca volvulus		0.0034	0.0152	0.0107
Brugia malayi	GCC2 and GCC3 family protein	0.0041	0.0271	0.0339
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Brugia malayi	Liprin-alpha 2	0.0034	0.0152	0.0189
Echinococcus granulosus	heat shock protein	0.0146	0.2153	0.2568
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Toxoplasma gondii	kringle domain-containing protein	0.0041	0.0271	0.0947
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0116	0.1621	0.1708
Schistosoma mansoni	tyrosine kinase	0.0257	0.4133	0.4108
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0158	0.2365	0.2365
Entamoeba histolytica	hypothetical protein	0.0041	0.0271	0.0947
Entamoeba histolytica	heat shock protein 90, putative	0.0146	0.2153	1
Entamoeba histolytica	90 kDa heat shock protein, putative	0.006	0.0612	0.2588
Trichomonas vaginalis	heat shock protein, putative	0.0146	0.2153	1
Leishmania major	heat shock protein, putative	0.006	0.0612	0.2588
Toxoplasma gondii	hypothetical protein	0.0049	0.0414	0.1636
Brugia malayi	AIDA-1b	0.0034	0.0152	0.0189
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0146	0.2153	1
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0049	0.0414	0.0414
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0152	0.011
Trichomonas vaginalis	endoplasmin, putative	0.0089	0.1144	0.5145
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0049	0.0414	0.1636
Brugia malayi	GCC2 and GCC3 family protein	0.0041	0.0271	0.0339
Schistosoma mansoni	sex comb on midleg homolog	0.0034	0.0152	0.011
Echinococcus multilocularis	heat shock protein 90	0.0146	0.2153	0.2568
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0049	0.0414	0.1636
Schistosoma mansoni	endoplasmin	0.0146	0.2153	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0433	0.7293	0.7293
Echinococcus granulosus	polyhomeotic protein 2	0.0034	0.0152	0.0095
Trichomonas vaginalis	heat shock protein, putative	0.0116	0.1621	0.7443
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0049	0.0414	0.042
Brugia malayi	ephrin receptor 1 precursor	0.0212	0.3343	0.4179
Echinococcus granulosus	pdz domain containing protein	0.0034	0.0152	0.0095
Brugia malayi	Protein kinase domain containing protein	0.0155	0.2314	0.2892
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0271	0.0947
Echinococcus granulosus	endoplasmin	0.0116	0.1621	0.1911
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0049	0.0414	0.0343
Loa Loa (eye worm)	hypothetical protein	0.022	0.3487	0.3487
Schistosoma mansoni	ephrin receptor	0.0441	0.7441	0.743
Toxoplasma gondii	heat shock protein 75, putative	0.006	0.0612	0.2588
Onchocerca volvulus		0.0034	0.0152	0.0107
Echinococcus granulosus	liprin alpha 2	0.0034	0.0152	0.0095
Echinococcus granulosus	polycomb protein SCMH1	0.0034	0.0152	0.0095
Toxoplasma gondii	heat shock protein HSP90	0.0146	0.2153	1
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Schistosoma mansoni	d-amino acid oxidase	0.0584	1	1
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0116	0.1621	0.7443
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0146	0.2153	1
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Onchocerca volvulus		0.0041	0.0271	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Treponema pallidum	heat shock protein 90	0.0116	0.1621	1
Trichomonas vaginalis	heat shock protein, putative	0.0116	0.1621	0.7443
Loa Loa (eye worm)	endoplasmin	0.0146	0.2153	0.2153
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0536	0.9128	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0116	0.1621	0.7443
Mycobacterium ulcerans	heat shock protein 90	0.0116	0.1621	0.1558
Schistosoma mansoni	polyhomeotic	0.0034	0.0152	0.011
Plasmodium vivax	heat shock protein 90, putative	0.006	0.0612	0.2588
Schistosoma mansoni	endoplasmin	0.0146	0.2153	0.2119
Onchocerca volvulus		0.0034	0.0152	0.0107
Trypanosoma cruzi	heat shock protein 85, putative	0.0116	0.1621	0.7443
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0049	0.0414	0.1636
Echinococcus granulosus	insulin receptor	0.0155	0.2314	0.2766
Leishmania major	heat shock protein 83-1	0.0146	0.2153	1
Giardia lamblia	Kinesin-13	0.0034	0.0152	0.0371
Plasmodium vivax	protein kinase, putative	0.0042	0.03	0.1084
Plasmodium falciparum	heat shock protein 90, putative	0.006	0.0612	0.2588
Brugia malayi	cDNA sequence BC016226	0.0049	0.0414	0.0518
Giardia lamblia	CEGP1 protein	0.0041	0.0271	0.0947
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0049	0.0414	0.1636
Echinococcus multilocularis	liprin alpha 2	0.0034	0.0152	0.0095
Entamoeba histolytica	cysteine-rich surface protein, putative	0.0041	0.0271	0.0947
Toxoplasma gondii	Hsp90 domain-containing protein	0.006	0.0612	0.2588
Schistosoma mansoni	Protein aveugle	0.0034	0.0152	0.011
Schistosoma mansoni	hypothetical protein	0.0034	0.0152	0.011
Echinococcus multilocularis	epidermal growth factor receptor	0.0473	0.7999	0.979
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0414	0.0414
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0158	0.2365	0.2957
Trypanosoma cruzi	Kinesin-13 5, putative	0.0034	0.0152	0.0371
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0584	1	1
Schistosoma mansoni	spingomyelin synthetase-related	0.0034	0.0152	0.011
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0049	0.0414	0.1636
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0049	0.0414	0.0343
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0049	0.0414	0.1636
Plasmodium falciparum	heat shock protein 90	0.0146	0.2153	1
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0049	0.0414	0.042
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0152	0.0152
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0049	0.0414	0.1636
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0049	0.0414	0.042
Brugia malayi	Probable DNA topoisomerase II	0.003	0.0074	0.0093
Echinococcus multilocularis	pdz domain containing protein	0.0034	0.0152	0.0095
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0049	0.0414	0.1636
Schistosoma mansoni	heat shock protein	0.0146	0.2153	0.2119
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0271	0.0947
Echinococcus granulosus	epidermal growth factor receptor	0.0473	0.7999	0.979
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0034	0.0152	0.0095
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0034	0.0152	0.011
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.006	0.0612	0.0664
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0049	0.0414	0.0374
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0049	0.0414	0.1636
Brugia malayi	GCC2 and GCC3 family protein	0.0041	0.0271	0.0339
Onchocerca volvulus	Putative fad oxidoreductase	0.0049	0.0414	0.0471
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0049	0.0414	0.1636
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0271	0.0271
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0049	0.0414	0.1636
Echinococcus multilocularis	roundabout 2	0.0031	0.0096	0.0027
Brugia malayi	Furin-like cysteine rich region family protein	0.0473	0.7999	1
Plasmodium falciparum	cysteine repeat modular protein 1	0.0041	0.0271	0.0947
Trypanosoma brucei	heat shock protein, putative	0.0146	0.2153	1
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.006	0.0612	0.0664
Schistosoma mansoni	tyrosine kinase	0.0257	0.4133	0.4108
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0116	0.1621	0.1558
Brugia malayi	heat shock protein 90	0.0146	0.2153	0.2691
Loa Loa (eye worm)	hypothetical protein	0.003	0.0074	0.0074
Giardia lamblia	Hypothetical protein	0.0041	0.0271	0.0947
Entamoeba histolytica	protein kinase, putative	0.0041	0.0271	0.0947
Plasmodium falciparum	cysteine repeat modular protein 2	0.0041	0.0271	0.0947
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0271	0.0271
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0049	0.0414	0.1636
Schistosoma mansoni	hypothetical protein	0.0041	0.0271	0.023
Schistosoma mansoni	phd finger protein	0.0034	0.0152	0.011
Brugia malayi	hypothetical protein	0.0034	0.0152	0.0189
Brugia malayi	bicaudal-C	0.0034	0.0152	0.0189
Onchocerca volvulus	Tyrosine kinase homolog	0.0148	0.2188	0.2928
Leishmania major	hypothetical protein, conserved	0.0049	0.0414	0.1636
Brugia malayi	kinase, mitochondrial precursor	0.003	0.0074	0.0093
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0034	0.0152	0.0152
Brugia malayi	Shank2E	0.0034	0.0152	0.0189
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0034	0.0152	0.0371
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0049	0.0414	0.0471
Echinococcus granulosus	heat shock protein 90	0.0146	0.2153	0.2568
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0049	0.0414	0.0518
Plasmodium vivax	endoplasmin, putative	0.0146	0.2153	1
Loa Loa (eye worm)	TOPoisomerase family member	0.003	0.0074	0.0074
Loa Loa (eye worm)	heat shock protein 75	0.006	0.0612	0.0612
Leishmania major	hypothetical protein, conserved	0.0049	0.0414	0.1636
Loa Loa (eye worm)	hypothetical protein	0.003	0.0074	0.0074
Echinococcus multilocularis	Sterile alpha motif type	0.0034	0.0152	0.0095
Trypanosoma cruzi	heat shock protein, putative	0.006	0.0612	0.2588
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0034	0.0152	0.0371
Schistosoma mansoni	tyrosine kinase	0.0248	0.3985	0.3959
Loa Loa (eye worm)	hypothetical protein	0.003	0.0074	0.0074

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 nM	Inhibition of human full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis	ChEMBL.	23566269
IC50 (binding)	= 3.3 nM	Inhibition of mouse full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis	ChEMBL.	23566269
IC50 (binding)	= 3.8 nM	Inhibition of human recombinant DAAO after 30 mins by plate reader analysis	ChEMBL.	23566269
IC50 (binding)	= 4.6 nM	Inhibition of rat full length DAAO overexpressed in HEK293 cells after 30 mins by plate reader analysis	ChEMBL.	23566269
IC50 (binding)	= 10 nM	In Vitro DAAO Enzyme Assay	BINDINGDB.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2338786

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1733838