Detailed information for compound 1743890

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.366 | Formula: C14H25N3O4
  • H donors: 4 H acceptors: 4 LogP: -1.3 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C[C@@H](C(=O)NCC(C)C)NC(=O)[C@@H]1N[C@H]1C(=O)O)C
  • InChi: 1S/C14H25N3O4/c1-7(2)5-9(12(18)15-6-8(3)4)16-13(19)10-11(17-10)14(20)21/h7-11,17H,5-6H2,1-4H3,(H,15,18)(H,16,19)(H,20,21)/t9-,10+,11+/m0/s1
  • InChiKey: MJBIERWHRWYNJZ-HBNTYKKESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0252 0.0981
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0077 0.0112 0.0121
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.012 0.5
Schistosoma mansoni neuropeptide receptor 0.0077 0.0114 0.0271
Echinococcus granulosus poly ADP ribose polymerase 1 0.0295 0.0682 0.259
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0077 0.0114 0.0429
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.012 0.14
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Echinococcus multilocularis somatostatin receptor 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0362 0.0857 0.3338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi RNA binding protein 0.0069 0.0093 0.0361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Schistosoma mansoni opsin-like receptor 0.0077 0.0114 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0107 0.0049
Schistosoma mansoni adenoreceptor 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Echinococcus multilocularis neuropeptide receptor A26 0.1042 0.2628 0.296
Brugia malayi putative neuropeptide receptor 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.005
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0053 0.0205
Onchocerca volvulus 0.0077 0.0114 0.0395
Brugia malayi G protein-coupled receptor F59B2.13 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Schistosoma mansoni myosin xvIII 0.0077 0.0114 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0166 0.0456
Onchocerca volvulus 0.0362 0.0857 0.3304
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0107 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0112 0.1309
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1018 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Echinococcus granulosus fmrfamide receptor 0.0077 0.0114 0.0429
Schistosoma mansoni amine GPCR 0.1129 0.2855 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1018 0.2567 1
Mycobacterium tuberculosis Probable reductase 0.0077 0.0112 0.0121
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0362 0.0857 0.3338
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.012 0.0134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0112 0.0265
Schistosoma mansoni hypothetical protein 0.0084 0.0132 0.0335
Loa Loa (eye worm) hypothetical protein 0.0225 0.0498 0.194
Leishmania major hypothetical protein, conserved 0.0039 0.0013 0.0151
Schistosoma mansoni hypothetical protein 0.0077 0.0114 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0362 0.0857 0.3338
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0077 0.0114 0.0444
Echinococcus multilocularis g protein coupled receptor 0.0077 0.0114 0.0127
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0362 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.014 0.0545
Mycobacterium ulcerans dehydrogenase 0.0273 0.0623 0.0568
Echinococcus granulosus neuropeptide FF receptor 2 0.0077 0.0114 0.0429
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0121 0.0227 0.0254
Echinococcus multilocularis neuropeptide s receptor 0.1042 0.2628 0.296
Onchocerca volvulus 0.0054 0.0053 0.0155
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Onchocerca volvulus 0.0077 0.0114 0.0395
Onchocerca volvulus 0.1018 0.2567 1
Schistosoma mansoni inositol monophosphatase 0.008 0.012 0.0293
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus Protein patched homolog 1 0.0087 0.014 0.0528
Schistosoma mansoni histamine h1 receptor 0.0077 0.0114 0.0271
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0273 0.0623 0.2427
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Entamoeba histolytica acyl-coA synthetase, putative 0.0075 0.0107 0.1153
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0077 0.0114 0.0271
Mycobacterium tuberculosis Probable oxidoreductase 0.0085 0.0134 0.0145
Onchocerca volvulus 0.0054 0.0053 0.0157
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0182 0.0709
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0112 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.0114 0.0271
Echinococcus granulosus poly (ADP ribose) polymerase 0.0046 0.0032 0.0117
Schistosoma mansoni neuropeptide receptor 0.0077 0.0114 0.0271
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.012 0.0032
Brugia malayi neuropeptide F receptor 0.0077 0.0114 0.0444
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0295 0.0682 1
Echinococcus granulosus tm gpcr rhodopsin 0.0077 0.0114 0.0429
Schistosoma mansoni opsin-like receptor 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0077 0.0114 0.0395
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0077 0.0112 0.0121
Schistosoma mansoni opsin-like receptor 0.0077 0.0114 0.0271
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0273 0.0623 0.2078
Brugia malayi hypothetical protein 0.0235 0.0526 0.2047
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus inositol monophosphatase 1 0.008 0.012 0.0452
Schistosoma mansoni amine oxidase 0.0273 0.0623 0.2078
Echinococcus multilocularis ring and YY1 binding protein 0.0362 0.0857 0.0964
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Echinococcus granulosus neuropeptide Y receptor 0.0077 0.0114 0.0429
Onchocerca volvulus 0.0077 0.0114 0.0395
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0362 0.0857 1
Onchocerca volvulus 0.0077 0.0114 0.0395
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0093 0.0361
Brugia malayi Blistered cuticle protein 3 0.0054 0.0053 0.0205
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0273 0.0623 0.2427
Brugia malayi beta-lactamase family protein 0.0077 0.0112 0.0437
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0077 0.0114 0.0127
Schistosoma mansoni RNA binding protein 0.0362 0.0857 0.2908
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0162 0.0335 0.3911
Brugia malayi brahma associated protein 60 kDa 0.1018 0.2567 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Echinococcus granulosus neuropeptide s receptor 0.1042 0.2628 1
Echinococcus granulosus sex peptide receptor 0.0077 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0235 0.0526 0.2047
Loa Loa (eye worm) hypothetical protein 0.0075 0.0107 0.0416
Loa Loa (eye worm) G-protein coupled receptor 0.0077 0.0114 0.0444
Schistosoma mansoni peroxidasin 0.0054 0.0053 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0077 0.0114 0.0127
Echinococcus multilocularis expressed conserved protein 0.0191 0.041 0.0461
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0053 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0107 0.1247
Echinococcus granulosus hypothetical protein 0.0077 0.0114 0.0429
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0112 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0048 0.0038 0.0096
Echinococcus multilocularis serotonin receptor 0.0077 0.0114 0.0127
Echinococcus multilocularis fmrfamide receptor 0.0077 0.0114 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0162 0.0335 0.3911
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Brugia malayi SWIB/MDM2 domain containing protein 0.1018 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Trypanosoma brucei DNA repair protein, putative 0.0039 0.0013 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0038 0.0146
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1018 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Trypanosoma cruzi UDP-galactopyranose mutase 0.0273 0.0623 0.727
Echinococcus granulosus dro:myosuppressin receptor 0.0077 0.0114 0.0429
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0107 0.0416
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0053 0.0155
Brugia malayi SWIRM domain containing protein 0.0273 0.0623 0.2427
Echinococcus multilocularis fmrfamide receptor 0.0077 0.0114 0.0127
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0362 0.0857 0.3338
Schistosoma mansoni hypothetical protein 0.0084 0.0132 0.0335
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0053 0.0205
Schistosoma mansoni amine GPCR 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0077 0.0114 0.0444
Leishmania major hypothetical protein, conserved 0.0362 0.0857 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0362 0.0857 0.3338
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0362 0.0857 0.3338
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.005 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0166 0.0456
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0058 0.0225
Loa Loa (eye worm) hypothetical protein 0.0071 0.0097 0.0377
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0526 0.1996
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0362 0.0857 1
Onchocerca volvulus 0.0077 0.0114 0.0395
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0362 0.0857 0.0964
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Leishmania major hypothetical protein, conserved 0.0362 0.0857 1
Echinococcus multilocularis neuropeptides capa receptor 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0225
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.0301 0.0934
Brugia malayi WGR domain containing protein 0.0295 0.0682 0.2655
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0489 0.1188 0.1279
Brugia malayi Melatonin receptor type 1A 0.0077 0.0114 0.0444
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0362 0.0857 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.0301 0.114
Loa Loa (eye worm) hypothetical protein 0.0362 0.0857 0.3338
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi G-protein coupled receptor 0.0077 0.0114 0.0444
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0107 0.0049
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0252 0.0981
Brugia malayi CHE-14 protein 0.0087 0.014 0.0545
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0053 0.0205
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.012 0.14
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi Dopamine receptor protein 1 0.0077 0.0114 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.014 0.0114
Trypanosoma cruzi DNA repair protein, putative 0.0039 0.0013 0.0151
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0077 0.0114 0.0127
Brugia malayi brahma associated protein 60 kDa 0.1018 0.2567 1
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0053 0.0205
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0107 0.1153
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0273 0.0623 0.2427
Echinococcus granulosus tm gpcr rhodopsin 0.0077 0.0114 0.0429
Leishmania major hypothetical protein, conserved 0.0362 0.0857 1
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Mycobacterium tuberculosis Conserved protein 0.0077 0.0112 0.0121
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi beta-lactamase 0.0077 0.0112 0.0437
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Chlamydia trachomatis DNA topoisomerase I 0.1018 0.2567 1
Schistosoma mansoni hypothetical protein 0.0084 0.0132 0.0335
Onchocerca volvulus 0.0077 0.0112 0.0388
Echinococcus granulosus biogenic amine 5HT receptor 0.0077 0.0114 0.0429
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Schistosoma mansoni neuropeptide receptor 0.0077 0.0114 0.0271
Echinococcus multilocularis neuropeptide receptor 0.0077 0.0114 0.0127
Trypanosoma brucei poly(adp-ribose) polymerase 0.0162 0.0335 0.3911
Onchocerca volvulus 0.0077 0.0114 0.0395
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Onchocerca volvulus 0.0077 0.0112 0.0388
Mycobacterium ulcerans oxidoreductase 0.0273 0.0623 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0362 0.0857 1
Loa Loa (eye worm) neuropeptide F receptor 0.0077 0.0114 0.0444
Schistosoma mansoni poly [ADP-ribose] polymerase 0.014 0.0278 0.0854
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0053 0.0155
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0362 0.0857 0.3338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis Niemann Pick C1 protein 0.0203 0.0443 0.0497
Echinococcus granulosus Niemann Pick C1 protein 0.0203 0.0443 0.168
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0112 0.0121
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.012 0.14
Loa Loa (eye worm) hypothetical protein 0.0075 0.0107 0.0416
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0162 0.0335 0.0376
Echinococcus multilocularis sex peptide receptor 0.0077 0.0114 0.0127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0203 0.0443 0.1724
Echinococcus multilocularis neuropeptide Y receptor 0.0077 0.0114 0.0127
Schistosoma mansoni biogenic amine (5HT) receptor 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0362 0.0857 0.3304
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0075 0.0107 0.0115
Onchocerca volvulus 0.0075 0.0107 0.0368
Loa Loa (eye worm) inositol-1 0.008 0.012 0.0467
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0077 0.0114 0.0444
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0075 0.0107 0.0049
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0058 0.0225
Echinococcus granulosus somatostatin receptor 0.0077 0.0114 0.0429
Schistosoma mansoni biogenic amine (5HT) receptor 0.0077 0.0114 0.0271
Loa Loa (eye worm) G-protein coupled receptor 0.0077 0.0114 0.0444
Schistosoma mansoni neuropeptide F-like receptor 0.0077 0.0114 0.0271
Mycobacterium ulcerans hypothetical protein 0.0077 0.0112 0.0055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0077 0.0114 0.0271
Schistosoma mansoni lipoxygenase 0.0121 0.0227 0.0671
Schistosoma mansoni patched 1 0.0087 0.014 0.0364
Mycobacterium ulcerans lipase LipD 0.0077 0.0112 0.0055
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0273 0.0623 0.2078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0182 0.0709
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0166 0.0647
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3439 0.8876 1
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0116 0.0216 0.084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0166 0.0186
Mycobacterium tuberculosis Conserved protein 0.0077 0.0112 0.0121
Echinococcus granulosus g protein coupled receptor 0.0077 0.0114 0.0429
Onchocerca volvulus 0.0077 0.0114 0.0395
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0112 0.0121
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi Dopamine receptor 0.0077 0.0114 0.0444
Schistosoma mansoni biogenic amine receptor 0.0077 0.0114 0.0271
Brugia malayi hypothetical protein 0.0054 0.0053 0.0205
Schistosoma mansoni growth hormone secretagogue receptor 0.0077 0.0114 0.0271
Brugia malayi TAR-binding protein 0.0069 0.0093 0.0361
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0166 0.0647
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0162 0.0335 0.1056
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0107 0.1247
Leishmania major DNA repair protein, putative 0.0039 0.0013 0.0151
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0362 0.0857 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0077 0.0112 0.0121
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0077 0.0114 0.0271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Schistosoma mansoni hypothetical protein 0.0077 0.0114 0.0271
Echinococcus granulosus poly adp ribose polymerase 2 0.0162 0.0335 0.1271
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus poly (ADP ribose) polymerase 0.0046 0.0032 0.0117
Schistosoma mansoni hypothetical protein 0.0077 0.0114 0.0271
Echinococcus granulosus neuropeptide receptor A26 0.1042 0.2628 1
Brugia malayi MH2 domain containing protein 0.013 0.0252 0.0981
Trypanosoma cruzi WLM domain containing protein, putative 0.0362 0.0857 1
Schistosoma mansoni hypothetical protein 0.0071 0.0097 0.021
Entamoeba histolytica hypothetical protein 0.0149 0.0301 0.4137
Mycobacterium leprae Probable lipase LipE 0.0077 0.0112 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0093 0.0195
Brugia malayi hypothetical protein 0.0149 0.0301 0.1172
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0362 0.0857 0.3257
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0225
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.0301 0.0338
Echinococcus multilocularis SWI:SNF matrix associated 0.1018 0.2567 0.2891
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0295 0.0682 0.2286
Brugia malayi neuropeptide F receptor 0.0077 0.0114 0.0444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0075 0.0107 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Echinococcus multilocularis tumor protein p63 0.0369 0.0873 0.0983
Echinococcus multilocularis Niemann Pick C1 protein 0.0291 0.067 0.0754
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Schistosoma mansoni lipoxygenase 0.0084 0.0132 0.0336
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.0451 0.1467
Brugia malayi putative neuropeptide receptor NPR1 0.0077 0.0114 0.0444
Onchocerca volvulus Peroxidase homolog 0.0054 0.0053 0.0155
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0225
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0362 0.0857 0.3338
Schistosoma mansoni amine GPCR 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0077 0.0114 0.0395
Echinococcus granulosus g-protein coupled receptor 0.0077 0.0114 0.0429
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0093 0.0195
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0273 0.0623 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0075 0.0107 0.0164
Brugia malayi beta-lactamase family protein 0.0077 0.0112 0.0437
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis microtubule associated protein 2 0.0612 0.1508 0.1698
Onchocerca volvulus 0.0077 0.0112 0.0388
Echinococcus granulosus WGR domain containing protein 0.0092 0.0151 0.0572
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1018 0.2567 1
Echinococcus multilocularis orexin receptor type 2 0.0077 0.0114 0.0127
Echinococcus granulosus poly (ADP ribose) polymerase 0.0046 0.0032 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0093 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0362 0.0857 1
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus zinc finger protein Ran binding 0.0362 0.0857 0.3257
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0077 0.0114 0.0444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.005 0.0054
Brugia malayi Inositol-1 0.008 0.012 0.0467
Onchocerca volvulus 0.0054 0.0053 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0112 0.0265
Echinococcus granulosus peroxidasin 0.0054 0.0053 0.0197
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0077 0.0114 0.0127
Onchocerca volvulus 0.0077 0.0114 0.0395
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0053 0.0205
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0077 0.0114 0.0429
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0107 0.0416
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1018 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0058 0.0225
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0077 0.0114 0.0127
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0112 0.0437
Echinococcus multilocularis neuropeptide FF receptor 2 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus g protein coupled receptor 0.0077 0.0114 0.0429
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Leishmania major 4-coumarate:coa ligase-like protein 0.0075 0.0107 0.1247
Echinococcus granulosus neuropeptide receptor 0.0077 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0362 0.0857 0.0964
Echinococcus multilocularis zinc finger protein Ran binding 0.0362 0.0857 0.0964
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus neuropeptide receptor 0.0077 0.0114 0.0429
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0053 0.0205
Echinococcus multilocularis allatostatin A receptor 0.0077 0.0114 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0053 0.0055
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0077 0.0112 0.0121
Echinococcus multilocularis protein patched 0.0087 0.014 0.0156
Brugia malayi follicle stimulating hormone receptor 0.0077 0.0114 0.0444
Brugia malayi Peroxidasin 0.0054 0.0053 0.0206
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0077 0.0114 0.0444
Echinococcus granulosus neuropeptide Y receptor 0.0077 0.0114 0.0429
Brugia malayi Serotonin receptor 0.0077 0.0114 0.0444
Echinococcus multilocularis g protein coupled receptor 0.0077 0.0114 0.0127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0077 0.0114 0.0429
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0039 0.0013 0.0151
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0085 0.0134 0.0688
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0166 0.0456
Echinococcus granulosus muscleblind protein 0.0165 0.0344 0.1303
Mycobacterium ulcerans monoamine oxidase 0.0273 0.0623 0.0568
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0068 0.0089 0.0099
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0077 0.0114 0.0127
Loa Loa (eye worm) melatonin receptor type 1A 0.0077 0.0114 0.0444
Echinococcus granulosus tm gpcr rhodopsin 0.0077 0.0114 0.0429
Echinococcus granulosus Zinc finger RanBP2 type 0.0362 0.0857 0.3257
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0362 0.0857 1
Schistosoma mansoni hypothetical protein 0.1018 0.2567 0.8978
Brugia malayi Muscleblind-like protein 0.0165 0.0344 0.1338
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0053 0.0157
Echinococcus granulosus 7tm_1 domain containing protein 0.0077 0.0114 0.0429
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0077 0.0114 0.0444
Onchocerca volvulus 0.0362 0.0857 0.3304
Leishmania major hypothetical protein, conserved 0.0362 0.0857 1
Brugia malayi AKH receptor 0.0077 0.0114 0.0444
Brugia malayi Niemann-Pick C1 protein precursor 0.0203 0.0443 0.1724
Entamoeba histolytica hypothetical protein 0.0149 0.0301 0.4137
Echinococcus multilocularis muscleblind protein 0.0165 0.0344 0.0386
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0107 0.0416
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0075 0.0107 0.0049
Echinococcus granulosus Niemann Pick C1 protein 0.0291 0.067 0.2546
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.012 0.0467
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0085 0.0134 0.0145
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0093 0.0195
Chlamydia trachomatis SWIB complex protein 0.1018 0.2567 1
Schistosoma mansoni microtubule-associated protein tau 0.0612 0.1508 0.522
Echinococcus granulosus alpha 1A adrenergic receptor 0.0077 0.0114 0.0429
Brugia malayi G-protein coupled receptor 0.0077 0.0114 0.0444
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0107 0.0191 0.0745
Loa Loa (eye worm) hypothetical protein 0.0362 0.0857 0.3338
Trichomonas vaginalis conserved hypothetical protein 0.1018 0.2567 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0273 0.0623 0.2427
Echinococcus granulosus poly (ADP ribose) polymerase 0.0092 0.0151 0.0572
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0077 0.0114 0.0429
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0077 0.0114 0.0444
Trypanosoma brucei hypothetical protein, conserved 0.0362 0.0857 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.014 0.0156
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0273 0.0623 0.0568
Onchocerca volvulus 0.0362 0.0857 0.3304
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0077 0.0114 0.0444
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0093 0.0103
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0295 0.0682 0.0767
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0077 0.0114 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0112 0.0121
Brugia malayi Serotonin receptor 0.0077 0.0114 0.0444
Schistosoma mansoni fusion 0.0362 0.0857 0.2908
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Mycobacterium tuberculosis Conserved hypothetical protein 0.0273 0.0623 0.0671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Echinococcus multilocularis G-protein coupled receptor, putative 0.0077 0.0114 0.0127
Onchocerca volvulus 0.0077 0.0114 0.0395
Echinococcus granulosus G protein coupled receptor 139 0.0077 0.0114 0.0429
Toxoplasma gondii ABC1 family protein 0.0077 0.0112 0.0437
Mycobacterium tuberculosis Conserved protein 0.0077 0.0112 0.0121
Loa Loa (eye worm) hypothetical protein 0.0362 0.0857 0.3338
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0077 0.0114 0.0395
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Onchocerca volvulus 0.0077 0.0114 0.0395
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.014 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0112 0.1309
Onchocerca volvulus 0.0077 0.0114 0.0395
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0075 0.0107 0.0049
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0165 0.0344 0.1338
Brugia malayi larval opioid receptor 0.0077 0.0114 0.0444
Echinococcus granulosus lysine specific histone demethylase 1A 0.0273 0.0623 0.2366
Schistosoma mansoni amine GPCR 0.0077 0.0114 0.0271
Echinococcus granulosus peptide allatostatin:somatostatin 0.0077 0.0114 0.0429
Schistosoma mansoni neuropeptide f receptor 76f 0.0077 0.0114 0.0271
Echinococcus multilocularis dro:myosuppressin receptor 0.0077 0.0114 0.0127
Echinococcus multilocularis serotonin receptor 0.0077 0.0114 0.0127
Schistosoma mansoni TRABID protein (C64 family) 0.0362 0.0857 0.2908
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0077 0.0114 0.0429
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0077 0.0114 0.0127
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0053 0.0205
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0273 0.0623 0.0701
Loa Loa (eye worm) brahma associated protein 0.1018 0.2567 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0053 0.0205
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.012 0.0063
Loa Loa (eye worm) hypothetical protein 0.0077 0.0112 0.0437
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.005 0.0054
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0077 0.0114 0.0444
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0077 0.0114 0.0271
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Mycobacterium ulcerans beta-lactamase 0.0077 0.0112 0.0055
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0058 0.0062
Echinococcus multilocularis SWI:SNF matrix associated 0.1018 0.2567 0.2891
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0526 0.0591
Trypanosoma cruzi UDP-galactopyranose mutase 0.0273 0.0623 0.727
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0112 0.0055
Echinococcus granulosus neuropeptides capa receptor 0.0077 0.0114 0.0429
Plasmodium falciparum protoporphyrinogen oxidase 0.0273 0.0623 0.2427
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0207
Trypanosoma cruzi WLM domain containing protein, putative 0.0362 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0093 0.0195
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus granulosus biogenic amine 5HT receptor 0.0077 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0112 0.0121
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Schistosoma mansoni amine oxidase 0.0273 0.0623 0.2078
Brugia malayi Tachykinin-like peptides receptor 99D 0.0077 0.0114 0.0444
Schistosoma mansoni peroxidasin 0.0054 0.0053 0.0055
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0077 0.0114 0.0271
Echinococcus multilocularis neuropeptide receptor 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis neuropeptide Y receptor 0.0077 0.0114 0.0127
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.012 0.1354
Loa Loa (eye worm) neuropeptide F receptor 0.0077 0.0114 0.0444
Echinococcus granulosus 7TM GPCR rhodopsin 0.0077 0.0114 0.0429
Echinococcus granulosus orexin receptor type 2 0.0077 0.0114 0.0429
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1018 0.2567 0.2891
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0121 0.0227 0.0858
Echinococcus granulosus neuropeptides capa receptor 0.0077 0.0114 0.0429
Entamoeba histolytica acyl-CoA synthetase, putative 0.0075 0.0107 0.1153
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.3598 0.929 1
Schistosoma mansoni hypothetical protein 0.0362 0.0857 0.2908
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0107 0.0049
Schistosoma mansoni neuropeptide F-like receptor 0.0077 0.0114 0.0271
Leishmania major UDP-galactopyranose mutase 0.0273 0.0623 0.727
Loa Loa (eye worm) beta-lactamase 0.0077 0.0112 0.0437
Brugia malayi YY1-associated factor 2 0.0362 0.0857 0.3338
Onchocerca volvulus 0.0273 0.0623 0.2388
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0039 0.0013 0.0151
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0103 0.0182 0.0709
Onchocerca volvulus 0.0077 0.0114 0.0395
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0077 0.0114 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0112 0.0437
Onchocerca volvulus Neuropeptide F receptor homolog 0.0077 0.0114 0.0395
Brugia malayi G protein-coupled receptor 0.0077 0.0114 0.0444
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0112 0.1309
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0362 0.0857 0.3304
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Plasmodium vivax hypothetical protein, conserved 0.0273 0.0623 0.2427
Schistosoma mansoni alpha-1 adrenergic receptor 0.0077 0.0114 0.0271
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0077 0.0114 0.0444
Schistosoma mansoni hypothetical protein 0.1018 0.2567 0.8978
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0112 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0273 0.0623 0.2427
Loa Loa (eye worm) hypothetical protein 0.0075 0.0107 0.0416
Echinococcus multilocularis g-protein coupled receptor 0.0077 0.0114 0.0127
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0273 0.0623 0.2427
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0077 0.0114 0.0127
Mycobacterium ulcerans hypothetical protein 0.0075 0.0107 0.0049
Onchocerca volvulus 0.0077 0.0114 0.0395
Echinococcus multilocularis peroxidasin 0.0054 0.0053 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0166 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0112 0.0422
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0077 0.0114 0.0127
Brugia malayi hypothetical protein 0.0273 0.0623 0.2427
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0326 0.0763 0.2973
Schistosoma mansoni hypothetical protein 0.0077 0.0114 0.0271
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.387 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.014 0.0545
Toxoplasma gondii histone lysine-specific demethylase 0.0273 0.0623 0.2427
Mycobacterium tuberculosis Possible oxidoreductase 0.0273 0.0623 0.0671
Brugia malayi Dopamine receptor protein 2 0.0077 0.0114 0.0444
Echinococcus granulosus lysine specific histone demethylase 1A 0.0273 0.0623 0.2366
Onchocerca volvulus Peroxidase homolog 0.0054 0.0053 0.0155
Echinococcus granulosus tachykinin peptides receptor 99D 0.0077 0.0114 0.0429
Brugia malayi amine oxidase, flavin-containing family protein 0.0273 0.0623 0.2427
Echinococcus granulosus tumor protein p63 0.0369 0.0873 0.3319
Mycobacterium ulcerans acyl-CoA synthetase 0.0075 0.0107 0.0049
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0112 0.0265
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0077 0.0114 0.0271
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0077 0.0114 0.0429
Schistosoma mansoni hypothetical protein 0.1018 0.2567 0.8978
Echinococcus multilocularis G protein coupled receptor 139 0.0077 0.0114 0.0127
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.012 0.14
Echinococcus granulosus tar DNA binding protein 0.0069 0.0093 0.0348
Loa Loa (eye worm) hypothetical protein 0.0162 0.0335 0.1305
Trypanosoma brucei hypothetical protein, conserved 0.0362 0.0857 1
Echinococcus granulosus microtubule associated protein 2 0.0612 0.1508 0.5737
Trypanosoma cruzi hypothetical protein, conserved 0.0362 0.0857 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0093 0.0195
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0098 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0077 0.0112 0.0264
Brugia malayi hypothetical protein 0.0077 0.0114 0.0444
Schistosoma mansoni brg-1 associated factor 0.1018 0.2567 0.8978
Brugia malayi ORL1-like opioid receptor 0.0077 0.0114 0.0444
Echinococcus granulosus ring and YY1 binding protein 0.0362 0.0857 0.3257
Toxoplasma gondii ran binding protein 0.0362 0.0857 0.3338
Brugia malayi WGR domain containing protein 0.0162 0.0335 0.1305
Schistosoma mansoni inositol monophosphatase 0.008 0.012 0.0293
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0053 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.005 0.0054
Plasmodium vivax hypothetical protein, conserved 0.1018 0.2567 1
Echinococcus granulosus SWI:SNF matrix associated 0.1018 0.2567 0.9767
Entamoeba histolytica hypothetical protein 0.0149 0.0301 0.4137
Echinococcus granulosus rhodopsin orphan GPCR 0.0077 0.0114 0.0429
Schistosoma mansoni biogenic amine receptor 0.0077 0.0114 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271
Echinococcus multilocularis protoporphyrinogen oxidase 0.0273 0.0623 0.0701
Schistosoma mansoni zinc finger protein 0.0362 0.0857 0.2908
Leishmania major hypothetical protein, conserved 0.0077 0.0112 0.1309
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0344 0.0386
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Onchocerca volvulus 0.0077 0.0114 0.0395
Loa Loa (eye worm) hypothetical protein 0.0165 0.0344 0.1338
Echinococcus multilocularis SWI:SNF matrix associated 0.1018 0.2567 0.2891
Loa Loa (eye worm) TYRA-2 protein 0.0077 0.0114 0.0444
Echinococcus granulosus serotonin receptor 0.0077 0.0114 0.0429
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1018 0.2567 0.9767
Schistosoma mansoni biogenic amine receptor 0.0077 0.0114 0.0271
Onchocerca volvulus 0.0054 0.0053 0.0155
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0077 0.0114 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0166 0.0628
Echinococcus multilocularis g protein coupled receptor 0.0077 0.0114 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0166 0.0628
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.012 0.0032
Echinococcus granulosus g protein coupled receptor 0.0077 0.0114 0.0429
Echinococcus granulosus expressed conserved protein 0.0191 0.041 0.1558
Brugia malayi GnHR receptor homolog 0.0077 0.0114 0.0444
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0362 0.0857 1
Schistosoma mansoni amine GPCR 0.0077 0.0114 0.0271
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0097 0.0377
Loa Loa (eye worm) hypothetical protein 0.0077 0.0114 0.0444
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0112 0.0125
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0203 0.0443 0.6321
Brugia malayi RE15519p 0.0077 0.0114 0.0444
Schistosoma mansoni hypothetical protein 0.0149 0.0301 0.0934
Echinococcus multilocularis neuropeptides capa receptor 0.0077 0.0114 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0077 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Leishmania major hypothetical protein, conserved 0.0362 0.0857 1
Echinococcus multilocularis 0.0273 0.0623 0.0701
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0093 0.0361
Schistosoma mansoni neuropeptide receptor 0.0077 0.0114 0.0271
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0112 0.0121
Echinococcus granulosus allatostatin A receptor 0.0077 0.0114 0.0429
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0077 0.0114 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0182 0.0709
Loa Loa (eye worm) RNA binding protein 0.0069 0.0093 0.0361
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.012 0.0032
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0077 0.0114 0.0395
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0112 0.0437
Brugia malayi sulfakinin receptor protein 0.0077 0.0114 0.0444
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0077 0.0114 0.0127
Echinococcus multilocularis protein dispatched 1 0.01 0.0172 0.0193
Loa Loa (eye worm) hypothetical protein 0.0273 0.0623 0.2427
Loa Loa (eye worm) hypothetical protein 0.0054 0.0053 0.0205
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0085 0.0134 0.0145
Mycobacterium tuberculosis Probable dehydrogenase 0.0077 0.0112 0.0121
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1018 0.2567 1
Entamoeba histolytica hypothetical protein 0.0149 0.0301 0.4137
Chlamydia trachomatis protoporphyrinogen oxidase 0.0273 0.0623 0.2252
Schistosoma mansoni hypothetical protein 0.0084 0.0132 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0077 0.0114 0.0271

Activities

Activity type Activity value Assay description Source Reference
K inact/Ki (binding) = 14400 M-1 s-1 Second order rate constant of the compound for the inactivation of papain at pH 6.5 was reported ChEMBL. 7636871
K inact/Ki (binding) = 720000 M-1 s-1 Second order rate constant of the compound for the inactivation of papain at pH 4 was reported ChEMBL. 7636871

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.