Detailed information for compound 175228

Basic information

Technical information
  • TDR Targets ID: 175228
  • Name: N,N-dibutylcyclohexanamine
  • MW: 211.387 | Formula: C14H29N
  • H donors: 0 H acceptors: 0 LogP: 4.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C1CCCCC1)CCCC
  • InChi: 1S/C14H29N/c1-3-5-12-15(13-6-4-2)14-10-8-7-9-11-14/h14H,3-13H2,1-2H3
  • InChiKey: HTDCNKTXDLRMHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dibutyl(cyclohexyl)amine
  • dibutyl-cyclohexyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0017 0.0018
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0013 0.0002 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.0042 0.0257
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.4879 0.384 0.384
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0398 0.0306 0.0306
Schistosoma mansoni cellular tumor antigen P53 0.004 0.0024 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0007 0.0045
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Giardia lamblia Hypothetical protein 0.0398 0.0306 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0005 0.0005
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0022 0.0009 0.0088
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1429 0.1119 0.2914
Mycobacterium ulcerans two component regulator - sensor kinase 0.0271 0.0206 0.2006
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0063 0.0042 0.0042
Leishmania major hypothetical protein, conserved 0.0271 0.0206 0.0537
Onchocerca volvulus Huntingtin homolog 0.0099 0.007 0.3406
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0007 0.0007
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2419 0.19 0.19
Loa Loa (eye worm) hypothetical protein 1.1261 0.8873 0.9161
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0271 0.0206 0.0206
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.1782
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0398 0.0306 0.0796
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0271 0.0206 0.1827
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0398 0.0306 0.0306
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Onchocerca volvulus 0.0024 0.0011 0.0542
Mycobacterium leprae Probable two-component sensor kinase 0.0271 0.0206 0.2474
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0005 0.0014
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.1429 0.1119 0.1119
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0011 0.0089
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.1302 0.1019 1
Trypanosoma brucei heat shock protein 90, putative 0.0271 0.0206 0.0537
Brugia malayi Latrophilin receptor protein 2 0.0045 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0005 0.0005
Schistosoma mansoni endoplasmin 0.0271 0.0206 0.0537
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0271 0.0206 1
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Leishmania major DNA topoisomerase ii 0.0271 0.0206 0.0537
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0005 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0063 0.0042 0.0411
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0398 0.0306 0.0796
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0005 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0271 0.0206 0.254
Loa Loa (eye worm) hypothetical protein 0.0398 0.0306 0.0316
Mycobacterium ulcerans hypothetical protein 0.0024 0.0011 0.0089
Trichomonas vaginalis heat shock protein, putative 0.0271 0.0206 0.1827
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.3782
Brugia malayi Probable ClpP-like protease 0.0063 0.0042 0.0042
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0271 0.0206 0.1979
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0142 0.0104 0.0104
Loa Loa (eye worm) TATA binding protein associated factor 0.0013 0.0002 0.0002
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.4879 0.384 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0398 0.0306 0.0306
Echinococcus multilocularis chromobox protein 1 0.0056 0.0036 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0011 0.0011
Toxoplasma gondii exonuclease III APE 0.0019 0.0007 0.0033
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0271 0.0206 0.2474
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0011 0.0199
Echinococcus granulosus heat shock protein 0.0271 0.0206 0.0206
Trypanosoma cruzi heat shock protein 85, putative 0.0271 0.0206 0.0537
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0002 0.0002
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0036 0.0308
Trichomonas vaginalis endoplasmin, putative 0.0271 0.0206 0.1827
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0017 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0017 0.0133
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0028
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0271 0.0206 0.1979
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0063 0.0042 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0018 0.0048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0005 0.0005
Trypanosoma brucei DNA topoisomerase ii 0.0271 0.0206 0.0537
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.3782
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0398 0.0306 0.2719
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.0017 0.0005 0.0005
Onchocerca volvulus 0.0036 0.0021 0.1006
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0398 0.0306 0.0796
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.0022 0.0009 0.0046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0007 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0271 0.0206 0.0537
Giardia lamblia hypothetical protein 0.0398 0.0306 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.1746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0127 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0271 0.0206 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0005 0.0005
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0398 0.0306 0.3782
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.4879 0.384 0.384
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0021 0.0183
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.4879 0.384 0.384
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0398 0.0306 0.0796
Plasmodium falciparum heat shock protein 90 0.0271 0.0206 0.254
Toxoplasma gondii hypothetical protein 0.1031 0.0805 0.5183
Schistosoma mansoni coup transcription factor 0.0017 0.0005 0.0014
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0013 0.0002 0.0006
Onchocerca volvulus 0.0192 0.0143 0.6946
Trichomonas vaginalis conserved hypothetical protein 0.0398 0.0306 0.2719
Onchocerca volvulus 0.0013 0.0002 0.0104
Mycobacterium tuberculosis Probable two component sensor kinase 0.0271 0.0206 0.1979
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0011
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.2719
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0005 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.0025 0.0189
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0127 0.0092 0.0092
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.1429 0.1119 0.2914
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.0391
Chlamydia trachomatis DNA gyrase subunit B 0.0271 0.0206 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0398 0.0306 0.0306
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0005 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0005 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0271 0.0206 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0005 0.0005
Onchocerca volvulus 0.0124 0.009 0.4343
Mycobacterium ulcerans putative regulatory protein 0.1031 0.0805 0.7895
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0271 0.0206 0.2006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.001 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0089
Brugia malayi TATA binding protein associated factor 0.0013 0.0002 0.0002
Trichomonas vaginalis receptor histidine kinase, putative 0.0271 0.0206 0.1827
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus multilocularis heat shock protein 90 0.0271 0.0206 0.0206
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0007 0.0007
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Mycobacterium leprae conserved hypothetical protein 0.1031 0.0805 1
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0021 0.0054
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0271 0.0206 0.1979
Leishmania major cAMP-specific phosphodiesterase, putative 0.0398 0.0306 0.0796
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0005 0.0005
Schistosoma mansoni pyruvate dehydrogenase 0.4879 0.384 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0271 0.0206 0.1827
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0271 0.0206 0.2006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.001 0.0068
Echinococcus multilocularis heat shock protein 0.0271 0.0206 0.0206
Onchocerca volvulus 0.004 0.0024 0.1145
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1429 0.1119 0.2914
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0005 0.0014
Plasmodium falciparum phosphodiesterase delta, putative 0.0398 0.0306 0.3782
Trichomonas vaginalis receptor histidine kinase, putative 0.0271 0.0206 0.1827
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0005 0.0005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.1429 0.1119 0.1119
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0398 0.0306 0.3782
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Plasmodium falciparum phosphodiesterase gamma, putative 0.0398 0.0306 0.3782
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0036 0.0021 0.0054
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0271 0.0206 1
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Plasmodium falciparum DNA topoisomerase 2 0.0271 0.0206 0.254
Brugia malayi Heterochromatin protein 1 0.0056 0.0036 0.0036
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0036 0.0021 0.0054
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0271 0.0206 0.2006
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0271 0.0206 0.2006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0011 0.0024
Loa Loa (eye worm) transcription factor SMAD2 0.0112 0.0081 0.0083
Trypanosoma brucei Heat shock protein 83, putative 0.0271 0.0206 0.0537
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0002 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Loa Loa (eye worm) hypothetical protein 0.1429 0.1119 0.1155
Loa Loa (eye worm) hypothetical protein 0.0111 0.0079 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0012
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0002 0.0002
Toxoplasma gondii DNA topoisomerase 2, putative 0.0271 0.0206 0.1317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0011 0.0029
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0271 0.0206 0.1979
Trichomonas vaginalis DNA topoisomerase II, putative 0.0271 0.0206 0.1827
Trypanosoma brucei heat shock protein 90, putative 0.0271 0.0206 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.1031 0.0805 0.7191
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0002 0.0006
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.0796
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.3782
Mycobacterium tuberculosis Conserved protein 0.0271 0.0206 0.1979
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0011 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Loa Loa (eye worm) peptidase family M1 containing protein 0.01 0.0071 0.0073
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0398 0.0306 0.0316
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0021 0.0021
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0142 0.0104 0.0108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0045 0.0028 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.0179 0.0184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0045 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0005 0.0005
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0271 0.0206 0.1979
Trypanosoma brucei hypothetical protein, conserved 0.0398 0.0306 0.0796
Schistosoma mansoni hypothetical protein 0.0045 0.0028 0.0072
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.0042 0.0257
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0398 0.0306 0.0796
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0005 0.0005
Plasmodium vivax heat shock protein 86, putative 0.0271 0.0206 0.254
Onchocerca volvulus 0.0017 0.0005 0.0258
Plasmodium falciparum GAF domain-related protein, putative 0.1031 0.0805 1
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.0025 0.0025
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Entamoeba histolytica DNA topoisomerase II, putative 0.0271 0.0206 1
Echinococcus granulosus chromobox protein 1 0.0056 0.0036 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0019 0.015
Trypanosoma cruzi DNA topoisomerase II, putative 0.0271 0.0206 0.0537
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0021 0.0054
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0271 0.0206 0.1317
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0011 0.0199
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.3782
Loa Loa (eye worm) hypothetical protein 0.0184 0.0138 0.0142
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Echinococcus multilocularis tumor protein p63 0.0273 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0045 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 1.2291 0.9686 1
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0271 0.0206 0.254
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0271 0.0206 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0271 0.0206 0.254
Schistosoma mansoni chromobox protein 0.0056 0.0036 0.0095
Loa Loa (eye worm) endoplasmin 0.0271 0.0206 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0005 0.0005
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0398 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.0072
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0029
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0022 0.0009 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.1031 0.0805 0.7191
Echinococcus granulosus tumor protein p63 0.0273 0.0208 0.0208
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0021 0.0054
Brugia malayi kinase, mitochondrial precursor 0.4879 0.384 0.384
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Echinococcus granulosus heat shock protein 90 0.0271 0.0206 0.0206
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0005 0.0005
Brugia malayi chromobox protein homolog 3 0.0032 0.0017 0.0017
Mycobacterium ulcerans putative regulatory protein 0.1031 0.0805 0.7895
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1429 0.1119 0.1119
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0006 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0005 0.0005
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Trichomonas vaginalis sensor histidine kinase, putative 0.0271 0.0206 0.1827
Plasmodium falciparum DNA gyrase subunit B 0.0271 0.0206 0.254
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0398 0.0306 0.0796
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0005 0.0014
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0005 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0029
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0398 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Schistosoma mansoni pyruvate dehydrogenase 0.4608 0.3626 0.9443
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0005 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0398 0.0306 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0005 0.0005
Schistosoma mansoni heat shock protein 0.0271 0.0206 0.0537
Loa Loa (eye worm) TOPoisomerase family member 0.0271 0.0206 0.0213
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0127 0.0092 0.024
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0398 0.0306 0.0306
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0271 0.0206 0.0213
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0021 0.068
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1429 0.1119 0.2914
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0005 0.0005
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0013 0.0002 0.0006
Brugia malayi hypothetical protein 0.0013 0.0002 0.0002
Mycobacterium tuberculosis Possible two component sensor kinase 0.0271 0.0206 0.1979
Toxoplasma gondii heat shock protein 90, putative 0.0271 0.0206 0.1317
Trypanosoma brucei aminopeptidase, putative 0.0013 0.0002 0.0006
Schistosoma mansoni peptidase Clp (S14 family) 0.0063 0.0042 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0012 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0005 0.0005
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.1977 0.1551 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0005 0.0005
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0021 0.0054
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0007 0.0016
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Brugia malayi Peptidase family M1 containing protein 0.0124 0.009 0.009
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0271 0.0206 0.1979
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0028 0.0028
Brugia malayi Peptidase family M1 containing protein 0.0013 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.001 0.001
Trypanosoma brucei cAMP-specific phosphodiesterase 0.1429 0.1119 0.2914
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0028 0.0028
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.1302 0.1019 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Trypanosoma cruzi heat shock protein 85, putative 0.0271 0.0206 0.0537
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0006 0.0052
Brugia malayi follicle stimulating hormone receptor 0.0237 0.0179 0.0179
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0013 0.0002 0.0002
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0271 0.0206 0.0537
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0089
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0007 0.0019
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0271 0.0206 1
Brugia malayi Pre-SET motif family protein 0.0168 0.0125 0.0125
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0005 0.0005
Leishmania major mitochondrial DNA topoisomerase II 0.0271 0.0206 0.0537
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0271 0.0206 0.1979
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0005 0.0014
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.0796
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Entamoeba histolytica heat shock protein 90, putative 0.0271 0.0206 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0271 0.0206 0.2006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0007 0.0019
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0013 0.0002 0.0002
Brugia malayi heat shock protein 90 0.0271 0.0206 0.0206
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0398 0.0306 0.0306
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.1706 0.1337 0.3482
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0005 0.0014
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0271 0.0206 0.0537
Brugia malayi nuclear receptor NHR-88 0.0017 0.0005 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0032 0.0017 0.0823
Schistosoma mansoni heat shock protein 0.0271 0.0206 0.0537
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0007 0.0007
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0271 0.0206 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0011 0.0011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Brugia malayi hypothetical protein 0.0099 0.007 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0011 0.0011
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.0025 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.1429 0.1119 1
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0005
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0045 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0007 0.0045
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1429 0.1119 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0021 0.0167
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.1302 0.1019 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0398 0.0306 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0398 0.0306 0.0796
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0398 0.0306 0.0796
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0398 0.0306 0.0796
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.0042 0.0496
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0022 0.0009 0.0102
Schistosoma mansoni ap endonuclease 0.0019 0.0007 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0127 0.0092 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0005 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0127 0.0092 0.024
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0271 0.0206 0.1827
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.3782
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Plasmodium vivax DNA topoisomerase II, putative 0.0271 0.0206 0.254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0127 0.0092 0.0092
Plasmodium vivax phosphodiesterase gamma, putative 0.0398 0.0306 0.3782
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Toxoplasma gondii hypothetical protein 0.1031 0.0805 0.5183
Mycobacterium leprae Probable two component sensor kinase MprB 0.0271 0.0206 0.2474
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0271 0.0206 0.2006
Trypanosoma cruzi heat shock protein 90, putative 0.0271 0.0206 0.0537
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.0025 0.0195
Chlamydia trachomatis DNA gyrase subunit B 0.0271 0.0206 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0271 0.0206 0.0206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0011 0.0029
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0398 0.0306 0.0796
Brugia malayi MH2 domain containing protein 0.0112 0.0081 0.0081
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0021 0.0054
Echinococcus granulosus leukotriene A 4 hydrolase 0.0013 0.0002 0.0002
Toxoplasma gondii GAF domain-containing protein 0.1031 0.0805 0.5183
Trypanosoma cruzi DNA topoisomerase II, putative 0.0271 0.0206 0.0537
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0011 0.0199
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0007 0.0063
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0271 0.0206 0.1979
Loa Loa (eye worm) hypothetical protein 0.0097 0.0069 0.0071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Trypanosoma cruzi Heat shock protein 83, putative 0.0271 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0063 0.0042 0.0043
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.1706 0.1337 0.3482
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0142 0.0104 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0142 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0005 0.0005
Mycobacterium ulcerans putative regultory protein 0.0271 0.0206 0.2006
Trypanosoma cruzi Aminopeptidase M1, putative 0.0036 0.0021 0.0054
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.0138 0.6673
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0127 0.0092 0.0092
Echinococcus multilocularis GPCR, family 2 0.0045 0.0028 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0011 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0011 0.0055
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0021 0.0021
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0398 0.0306 0.0306
Brugia malayi nuclear hormone receptor 0.0017 0.0005 0.0005
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0398 0.0306 0.0306
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.1782
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0005 0.0258
Echinococcus multilocularis aminopeptidase N 0.0124 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.1031 0.0805 0.7191
Trypanosoma cruzi heat shock protein 85, putative 0.0271 0.0206 0.0537
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0099 0.007 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0127 0.0092 0.0092
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0005 0.0005
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0271 0.0206 0.1317
Brugia malayi SET domain containing protein 0.001 0.0000031299 0.0000031299
Loa Loa (eye worm) PDE1B protein 0.0398 0.0306 0.0316
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0271 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0097 0.0069 0.0069
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0019 0.0915
Brugia malayi N-terminal motif family protein 0.0184 0.0138 0.0138
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0398 0.0306 0.0306
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1429 0.1119 1
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0005 0.0014
Brugia malayi Endoplasmin precursor 0.0271 0.0206 0.0206
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0398 0.0306 0.0306
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0011 0.0089
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Brugia malayi Pre-SET motif family protein 0.0024 0.0011 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0005 0.0258
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 1.2689 1 1
Brugia malayi Probable DNA topoisomerase II 0.0271 0.0206 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0192 0.0143 0.1263
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0127 0.0092 0.0095
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0005 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0005 0.0005
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0271 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.4879 0.384 0.3964
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0011 0.0029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0006 0.0041
Schistosoma mansoni ap endonuclease 0.0019 0.0007 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1031 0.0805 0.7191
Plasmodium vivax SET domain protein, putative 0.0024 0.0011 0.0112
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0021 0.0167
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0007 0.0019
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0045 0.0028 0.0028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Mycobacterium ulcerans DNA gyrase subunit B 0.0271 0.0206 0.2006
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0271 0.0206 0.2474
Giardia lamblia Pms1-like protein 0.0271 0.0206 0.6662
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0271 0.0206 0.2006
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Trichomonas vaginalis conserved hypothetical protein 0.0398 0.0306 0.2719
Toxoplasma gondii heat shock protein HSP90 0.0271 0.0206 0.1317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0011
Onchocerca volvulus 0.0025 0.0012 0.0562
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0007
Schistosoma mansoni DNA topoisomerase II 0.0271 0.0206 0.0537
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Loa Loa (eye worm) heat shock protein 90 0.0271 0.0206 0.0213
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Echinococcus granulosus aminopeptidase N 0.0124 0.009 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0021 0.0054
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.2719
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0271 0.0206 0.1827
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 1.2689 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0005 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0271 0.0206 0.1979
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.2719
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0168 0.0125 0.0129
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.1706 0.1337 0.8618
Loa Loa (eye worm) MH2 domain-containing protein 0.0112 0.0081 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0005 0.0005
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.0496
Schistosoma mansoni pyruvate dehydrogenase 0.4608 0.3626 0.9443
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0011 0.0089
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0011 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0005 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0005 0.0005
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Toxoplasma gondii hypothetical protein 0.1031 0.0805 0.5183
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0398 0.0306 0.2719
Brugia malayi steroid hormone receptor 0.0017 0.0005 0.0005
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1429 0.1119 0.2914
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0005 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0002 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0007 0.0063
Echinococcus granulosus chromobox protein 1 0.0056 0.0036 0.0036
Onchocerca volvulus 0.0033 0.0018 0.0891
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0005 0.0005
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.1706 0.1337 0.3482
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.1429 0.1119 0.2914
Schistosoma mansoni hypothetical protein 0.0045 0.0028 0.0072
Echinococcus granulosus GPCR family 2 0.0045 0.0028 0.0028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0005 0.0014
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0398 0.0306 0.0796
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0006 0.0008
Trypanosoma brucei developmentally regulated phosphoprotein 0.4879 0.384 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0007 0.0019
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0002 0.0006
Schistosoma mansoni endoplasmin 0.0271 0.0206 0.0537
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Plasmodium vivax hypothetical protein, conserved 0.1031 0.0805 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.0391
Leishmania major heat shock protein 83-1 0.0271 0.0206 0.0537
Entamoeba histolytica heat shock protein 90, putative 0.0271 0.0206 1
Trypanosoma cruzi aminopeptidase, putative 0.0013 0.0002 0.0006
Plasmodium vivax endoplasmin, putative 0.0271 0.0206 0.254
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0271 0.0206 1
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0019 0.015
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0398 0.0306 0.0306
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0011 0.0058
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0271 0.0206 0.0206
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0398 0.0306 0.0306
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0042 0.1746
Plasmodium falciparum endoplasmin, putative 0.0271 0.0206 0.254
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0398 0.0306 0.0306
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0398 0.0306 0.2719
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0011 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Schistosoma mansoni chromobox protein 0.0056 0.0036 0.0095
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.4879 0.384 1
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0005 0.0014
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0271 0.0206 0.2006
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0036 0.0308
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0398 0.0306 0.196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0011 0.0011
Onchocerca volvulus Huntingtin homolog 0.0099 0.007 0.3406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0045 0.0028 0.0072
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1429 0.1119 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0013 0.0002 0.0006
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0271 0.0206 1
Trypanosoma cruzi hypothetical protein, conserved 0.0398 0.0306 0.0796
Loa Loa (eye worm) hypothetical protein 0.0087 0.0061 0.0063
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0398 0.0306 0.0306
Loa Loa (eye worm) heterochromatin protein 1 0.0056 0.0036 0.0038
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0271 0.0206 0.0537
Trypanosoma cruzi heat shock protein 90, putative 0.0271 0.0206 0.0537
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0271 0.0206 0.1827
Schistosoma mansoni aminopeptidase A (M01 family) 0.0013 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0398 0.0306 0.0316
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0271 0.0206 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0021 0.0054
Schistosoma mansoni hypothetical protein 0.0097 0.0069 0.0179
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0029
Trypanosoma brucei heat shock protein, putative 0.0271 0.0206 0.0537
Leishmania major hypothetical protein, conserved 0.0398 0.0306 0.0796
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0398 0.0306 0.0796
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1429 0.1119 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0005 0.0005
Giardia lamblia Heat shock protein HSP 90-alpha 0.0271 0.0206 0.6662
Echinococcus multilocularis chromobox protein 1 0.0056 0.0036 0.0036
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0024 0.0011 0.0028
Brugia malayi hypothetical protein 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0271 0.0206 0.0213
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0271 0.0206 0.0537

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 50 % Compound was tested in vivo for anti-filarial activity against A .viteae through oral route of administration at 200 mg/kg for 5 days and sterilization of female worms was observed ChEMBL. 10714488
Reduction (functional) = 0 % Compound was tested in vivo for anti-filarial activity against A .viteae through oral route of administration at 200 mg/kg for 5 days and macrofilaricidal response was observed ChEMBL. 10714488
Reduction (functional) = 93 % Compound was tested in vivo for anti-filarial activity against A .viteae through oral route of administration at 200 mg/kg for 5 days and microfilaricidal response was observed ChEMBL. 10714488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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