Detailed information for compound 1752761

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 604.778 | Formula: C30H40N2O7S2
  • H donors: 1 H acceptors: 5 LogP: 5.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H](N1C[C@H](C)[C@@H](Oc2c(S1(=O)=O)ccc(c2)C#CCC1CCCC1)CN(S(=O)(=O)c1ccccc1OC)C)C
  • InChi: 1S/C30H40N2O7S2/c1-22-19-32(23(2)21-33)41(36,37)30-17-16-25(13-9-12-24-10-5-6-11-24)18-27(30)39-28(22)20-31(3)40(34,35)29-15-8-7-14-26(29)38-4/h7-8,14-18,22-24,28,33H,5-6,10-12,19-21H2,1-4H3/t22-,23-,28-/m0/s1
  • InChiKey: LUSCQGWIOGZNHP-LXWOLXCRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0121 0.0194 0.0194
Onchocerca volvulus 0.0267 0.0503 0.7845
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.006 0.0063 0.0063
Loa Loa (eye worm) casein kinase II 0.0097 0.0142 0.0142
Brugia malayi jmjC domain containing protein 0.0108 0.0164 0.0164
Echinococcus multilocularis tyrosine kinase 0.0044 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0208 0.0378 0.0378
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0208 0.0378 0.0378
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0022 0.0022
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0332 0.0642 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0055 0.0055
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0053 0.0053
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0097 0.0142 0.0991
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0044 0.0028 0.0231
Onchocerca volvulus 0.0044 0.0028 0.0443
Brugia malayi Pre-SET motif family protein 0.0234 0.0434 0.0434
Brugia malayi beta-lactamase 0.0041 0.0022 0.0022
Echinococcus multilocularis tyrosine protein kinase Abl 0.0073 0.0092 0.0092
Brugia malayi Pax transcription factor protein 2 0.0291 0.0554 0.0554
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0332 0.0642 0.5123
Schistosoma mansoni tyrosine kinase 0.0196 0.0353 0.0353
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0053 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0356 0.0693 0.0693
Schistosoma mansoni tyrosine kinase 0.0073 0.0092 0.0092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0178 0.0315 0.0315
Echinococcus granulosus c src tyrosine kinase 0.0073 0.0092 0.0092
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0023 0.0023
Echinococcus granulosus tyrosine kinase 0.0044 0.0028 0.0028
Echinococcus granulosus raf serine:threonine protein kinase 0.0262 0.0494 0.0494
Schistosoma mansoni hypothetical protein 0.0041 0.0023 0.0023
Echinococcus multilocularis epidermal growth factor receptor 0.0196 0.0353 0.0353
Echinococcus granulosus insulin receptor 0.0121 0.0194 0.0194
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0035 0.0009 0.0072
Schistosoma mansoni tyrosine kinase 0.0183 0.0325 0.0325
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0063 0.0063
Brugia malayi Variant SH3 domain containing protein 0.006 0.0063 0.0063
Echinococcus multilocularis NCK adaptor protein 0.006 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0053 0.0053
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0039 0.0019 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0007 0.0014
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0332 0.0642 0.5123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Entamoeba histolytica protein kinase, putative 0.0035 0.0009 0.0072
Plasmodium vivax unspecified product 0.0609 0.1232 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Brugia malayi Pre-SET motif family protein 0.0034 0.0007 0.0007
Echinococcus granulosus epidermal growth factor receptor 0.0356 0.0693 0.0693
Schistosoma mansoni tyrosine kinase 0.0183 0.0325 0.0325
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0332 0.0642 0.5123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0004 0.0004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0022 0.0022
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0073 0.0092 0.0092
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0063 0.0063
Toxoplasma gondii CMGC kinase, CK2 family 0.0609 0.1232 1
Echinococcus granulosus tyrosine kinase 0.0178 0.0315 0.0315
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0073 0.0092 0.0092
Giardia lamblia Casein kinase II beta chain 0.0332 0.0642 0.5188
Loa Loa (eye worm) hypothetical protein 0.006 0.0063 0.0063
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0242 0.0242
Brugia malayi Casein kinase II, alpha chain 0.0609 0.1232 0.1232
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0138 0.0229 0.0229
Entamoeba histolytica protein kinase domain containing protein 0.0609 0.1232 1
Brugia malayi beta-lactamase family protein 0.0041 0.0022 0.0022
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Echinococcus granulosus tyrosine protein kinase Blk 0.0178 0.0315 0.0315
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0063 0.0063
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0097 0.0142 0.1149
Echinococcus granulosus N chimaerin 0.0039 0.0019 0.0019
Echinococcus granulosus tyrosine protein kinase HCK 0.0148 0.025 0.025
Schistosoma mansoni tyrosine kinase 0.0183 0.0325 0.0325
Toxoplasma gondii ck2 beta subunit 0.0332 0.0642 0.5188
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0005 0.0005
Onchocerca volvulus Huntingtin homolog 0.0138 0.0229 0.357
Mycobacterium ulcerans beta-lactamase 0.0041 0.0022 0.5
Schistosoma mansoni protein kinase 0.0609 0.1232 0.1232
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0609 0.1232 1
Schistosoma mansoni tyrosine kinase 0.0121 0.0194 0.0194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0053 0.0053
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Echinococcus multilocularis casein kinase ii subunit alpha 0.0609 0.1232 0.1232
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Mycobacterium ulcerans lipase LipD 0.0041 0.0022 0.5
Schistosoma mansoni casein kinase II beta subunit 0.0332 0.0642 0.0642
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0044 0.0028 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Giardia lamblia Casein kinase II beta chain 0.0097 0.0142 0.1112
Plasmodium falciparum casein kinase 2, alpha subunit 0.0609 0.1232 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.006 0.0063 0.0063
Brugia malayi Sex muscle abnormal protein 5 0.006 0.0063 0.0063
Onchocerca volvulus 0.0044 0.0028 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0053 0.0053
Loa Loa (eye worm) TK protein kinase 0.0178 0.0315 0.0315
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Brugia malayi RhoGAP domain containing protein 0.0039 0.0019 0.0019
Plasmodium vivax SET domain protein, putative 0.0034 0.0007 0.0014
Loa Loa (eye worm) TK/ABL protein kinase 0.0044 0.0028 0.0028
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0117 0.0117
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0022 0.5
Onchocerca volvulus 0.0044 0.0028 0.0443
Mycobacterium leprae Probable lipase LipE 0.0041 0.0022 0.5
Schistosoma mansoni vav2 0.0039 0.0019 0.0019
Echinococcus multilocularis tyrosine protein kinase Srms 0.0178 0.0315 0.0315
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0063 0.0063
Schistosoma mansoni tyrosine kinase 0.0208 0.0378 0.0378
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Loa Loa (eye worm) SRC-1 0.0208 0.0378 0.0378
Loa Loa (eye worm) beta-lactamase 0.0041 0.0022 0.0022
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0332 0.0642 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0073 0.0092 0.0092
Echinococcus granulosus tyrosine protein kinase Src42A 0.0208 0.0378 0.0378
Echinococcus multilocularis tyrosine protein kinase Blk 0.0178 0.0315 0.0315
Echinococcus granulosus tyrosine protein kinase Lyn 0.0212 0.0387 0.0387
Brugia malayi protein-tyrosine kinase 0.0178 0.0315 0.0315
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0044 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0007
Echinococcus multilocularis raf serine:threonine protein kinase 0.0262 0.0494 0.0494
Echinococcus granulosus growth factor receptor bound protein 2 0.006 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0033 0.0005 0.0005
Echinococcus multilocularis N chimaerin 0.0039 0.0019 0.0019
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Brugia malayi SH2 domain containing protein 0.0044 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0053 0.0053
Brugia malayi hypothetical protein 0.0138 0.0229 0.0229
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Brugia malayi SH2 domain containing protein 0.0044 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0262 0.0494 0.0494
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0154 0.0263 0.0263
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.002 0.002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0165 0.0287 0.0287
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0097 0.0142 0.0991
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.002 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.002 0.002
Brugia malayi Variant SH3 domain containing protein 0.006 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0138 0.0229 0.0229
Brugia malayi MH2 domain containing protein 0.0144 0.0242 0.0242
Schistosoma mansoni tyrosine kinase 0.0044 0.0028 0.0028
Brugia malayi Bromodomain containing protein 0.0033 0.0005 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Leishmania major casein kinase II, putative 0.0609 0.1232 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Brugia malayi hypothetical protein 0.0044 0.0028 0.0028
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.002 0.002
Onchocerca volvulus 0.0044 0.0028 0.0443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0022 0.0022
Giardia lamblia Kinase, CMGC CK2 0.0609 0.1232 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Loa Loa (eye worm) hyaluronidase 0.4728 1 1
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0019 0.0019
Onchocerca volvulus 0.0041 0.0022 0.0336
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0332 0.0642 0.5208
Schistosoma mansoni tyrosine kinase 0.0196 0.0353 0.0353
Loa Loa (eye worm) raf kinase 0.0249 0.0465 0.0465
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0208 0.0378 0.0378
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Echinococcus granulosus tyrosine protein kinase Srms 0.0044 0.0028 0.0028
Echinococcus multilocularis growth factor receptor bound protein 2 0.006 0.0063 0.0063
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Brugia malayi Protein kinase domain containing protein 0.0044 0.0028 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0053 0.0053
Schistosoma mansoni tyrosine kinase 0.0044 0.0028 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Echinococcus multilocularis casein kinase ii subunit beta 0.0332 0.0642 0.0642
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.0554 0.0554
Echinococcus granulosus peregrin 0.0033 0.0005 0.0005
Brugia malayi Protein kinase domain containing protein 0.0044 0.0028 0.0028
Brugia malayi Furin-like cysteine rich region family protein 0.0356 0.0693 0.0693
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Onchocerca volvulus 0.0041 0.0022 0.0336
Brugia malayi Protein kinase domain containing protein 0.0121 0.0194 0.0194
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0196 0.0353 0.0353
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0005 0.0005
Echinococcus multilocularis 0.0107 0.0162 0.0162
Echinococcus granulosus NCK adaptor protein 0.006 0.0063 0.0063
Brugia malayi jmjC domain containing protein 0.004 0.002 0.002
Loa Loa (eye worm) TK/INSR protein kinase 0.0121 0.0194 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Plasmodium vivax casein kinase II beta chain, putative 0.0332 0.0642 0.5188
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Toxoplasma gondii ABC1 family protein 0.0041 0.0022 0.0134
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0121 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.006 0.0063 0.0063
Onchocerca volvulus 0.0291 0.0554 0.8633
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0242 0.0242
Onchocerca volvulus 0.0041 0.0022 0.0336
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0063 0.0063
Onchocerca volvulus Alhambra homolog 0.0033 0.0005 0.008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0108 0.0164 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0053 0.0053
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Trichomonas vaginalis set domain proteins, putative 0.0267 0.0503 0.398
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0007 0.0007
Loa Loa (eye worm) TK protein kinase 0.0148 0.025 0.025
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0033 0.0033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.0434 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0208 0.0378 0.0378
Echinococcus granulosus tyrosine protein kinase Src64B 0.0208 0.0378 0.0378
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0208 0.0378 0.0378
Onchocerca volvulus 0.0044 0.0028 0.0443
Onchocerca volvulus 0.0034 0.0007 0.0106
Echinococcus granulosus epidermal growth factor receptor 0.0196 0.0353 0.0353
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0165 0.0287 0.0287
Schistosoma mansoni growth factor receptor-bound protein 0.006 0.0063 0.0063
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0208 0.0378 0.0378
Onchocerca volvulus 0.0044 0.0028 0.0443
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0332 0.0642 0.5188
Trypanosoma cruzi casein kinase II, putative 0.0609 0.1232 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0487 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0108 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0041 0.0023 0.0023
Brugia malayi Raf kinase 0.0254 0.0475 0.0475
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0208 0.0378 0.0378
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0097 0.0142 0.1149
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Echinococcus multilocularis peregrin 0.0033 0.0005 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0022 0.5
Entamoeba histolytica casein kinase, putative 0.0609 0.1232 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0053 0.0053
Schistosoma mansoni nck2/grb4 0.006 0.0063 0.0063
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0178 0.0315 0.0315
Echinococcus multilocularis c src tyrosine kinase 0.0073 0.0092 0.0092
Echinococcus multilocularis tyrosine protein kinase HCK 0.0148 0.025 0.025
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0039 0.0019 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0044 0.0028 0.0028
Onchocerca volvulus 0.0034 0.0007 0.0114
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0022 0.0134
Mycobacterium ulcerans hypothetical protein 0.0041 0.0022 0.5
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0039 0.0019 0.0019
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Brugia malayi PHD-finger family protein 0.0033 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.0041 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Echinococcus granulosus bifunctional protein NCOAT 0.4728 1 1
Loa Loa (eye worm) Csnk2b protein 0.0332 0.0642 0.0642
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0022 0.5
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.4728 1 1
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0609 0.1232 0.1232
Brugia malayi casein kinase II, putaitve 0.0097 0.0142 0.0142
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0039 0.0019 0.0019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0007 0.0007
Onchocerca volvulus Huntingtin homolog 0.0138 0.0229 0.357
Brugia malayi Protein kinase domain containing protein 0.0044 0.0028 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0027 0.0027
Schistosoma mansoni tyrosine kinase 0.0208 0.0378 0.0378
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Brugia malayi Protein kinase domain containing protein 0.0044 0.0028 0.0028
Schistosoma mansoni Hyaluronidase 0.4728 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Echinococcus granulosus casein kinase ii subunit beta 0.0332 0.0642 0.0642
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0208 0.0378 0.0378
Echinococcus multilocularis bifunctional protein NCOAT 0.4728 1 1
Plasmodium vivax casein kinase II beta chain, putative 0.0332 0.0642 0.5188
Echinococcus granulosus casein kinase ii subunit alpha 0.0609 0.1232 0.1232
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0332 0.0642 0.5208
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Loa Loa (eye worm) TK/EGFR protein kinase 0.0356 0.0693 0.0693
Echinococcus multilocularis epidermal growth factor receptor 0.0356 0.0693 0.0693
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0073 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0005
Echinococcus multilocularis tyrosine protein kinase shark 0.0044 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0208 0.0378 0.0378
Schistosoma mansoni adapter molecule crk 0.006 0.0063 0.0063
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0022 0.0022
Brugia malayi Protein kinase domain containing protein 0.0044 0.0028 0.0028
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0332 0.0642 0.5208
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0022 0.0022
Brugia malayi SRC-1 0.0208 0.0378 0.0378
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.002 0.002
Echinococcus granulosus tyrosine protein kinase shark 0.0044 0.0028 0.0028
Echinococcus multilocularis insulin receptor 0.0121 0.0194 0.0194
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0039 0.0019 0.0019
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.2008 0.4211 0.4211
Brugia malayi Csnk2b protein 0.0332 0.0642 0.0642
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0332 0.0642 0.5123
Entamoeba histolytica protein kinase, putative 0.0148 0.025 0.2032
Brugia malayi Tyrosine-protein kinase abl-1 0.0073 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Trichomonas vaginalis casein kinase II beta chain, putative 0.0097 0.0142 0.0991
Echinococcus granulosus tyrosine protein kinase ABL1 0.0044 0.0028 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0609 0.1232 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0007 0.0007
Plasmodium falciparum casein kinase II beta chain 0.0332 0.0642 0.5188
Loa Loa (eye worm) TK/FER protein kinase 0.0044 0.0028 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0332 0.0642 0.5123
Trypanosoma brucei Casein kinase II 0.0609 0.1232 1
Schistosoma mansoni tyrosine kinase 0.0121 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0041 0.0022 0.0022
Plasmodium falciparum casein kinase II beta chain 0.0332 0.0642 0.5188

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 6.16 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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