Detailed information for compound 175612

Basic information

Technical information
  • TDR Targets ID: 175612
  • Name: 5-(4-bromophenyl)-9-chloro-2,2,4-trimethyl-1, 5-dihydrochromeno[3,4-f]quinoline
  • MW: 466.797 | Formula: C25H21BrClNO
  • H donors: 1 H acceptors: 0 LogP: 6.96 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)C1Oc2ccc(cc2c2c1c1C(=CC(Nc1cc2)(C)C)C)Cl
  • InChi: 1S/C25H21BrClNO/c1-14-13-25(2,3)28-20-10-9-18-19-12-17(27)8-11-21(19)29-24(23(18)22(14)20)15-4-6-16(26)7-5-15/h4-13,24,28H,1-3H3
  • InChiKey: NXOAZERTYTUOOS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-bromophenyl)-9-chloro-2,2,4-trimethyl-1,5-dihydro[1]benzopyrano[3,4-f]quinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0051 0.0304 0.0304
Brugia malayi Animal haem peroxidase family protein 0.0085 0.0555 0.0555
Plasmodium vivax hypothetical protein 0.0086 0.0568 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.1144 0.8526 0.8437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.3299 0.2895
Schistosoma mansoni hypothetical protein 0.0086 0.0568 0.0568
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0568 0.0766
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0086 0.0568 0.0568
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0568 0.0568
Echinococcus multilocularis GPCR, family 2 0.0012 0.0011 0.0011
Trichomonas vaginalis set domain proteins, putative 0.0087 0.0572 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.7937 0.7813
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0086 0.0568 0.0568
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0634 0.4686 0.4366
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0568 0.0568
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0086 0.0568 0.0568
Giardia lamblia GTOR 0.134 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.5362 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Loa Loa (eye worm) hypothetical protein 0.0167 0.1174 0.1174
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0253 0.1825 0.1332
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0568 0.0568
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.1825 0.1825
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.5362 0.5082
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0568 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0253 0.1825 0.1825
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0086 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.7937 0.7813
Onchocerca volvulus Dual oxidase homolog 0.0085 0.0555 0.6829
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0253 0.1825 0.1825
Onchocerca volvulus 0.0085 0.0555 0.6829
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0449 0.3299 0.3299
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0058 0.0355 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.5882 0.5634
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.036 0.2623 0.2178
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0568 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0568 0.0568
Loa Loa (eye worm) animal heme peroxidase 0.0085 0.0555 0.0555
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0449 0.3299 0.3299
Brugia malayi FAT domain containing protein 0.0196 0.1392 0.1392
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0568 1
Echinococcus multilocularis tyrosine protein kinase shark 0.008 0.0522 0.0522
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0568 0.0766
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0011 0.0011
Echinococcus granulosus GPCR family 2 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0273 0.1972 0.1972
Schistosoma mansoni beta-catenin 0.012 0.0818 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.087 0.6463 0.625
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.134 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1825 0.1332
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0449 0.3299 0.2895
Echinococcus multilocularis 0.0086 0.0568 0.0568
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0568 0.0568
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.134 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0282 0.2042 0.2042
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.134 1 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Mycobacterium tuberculosis Conserved hypothetical protein 0.0086 0.0568 0.5
Schistosoma mansoni tyrosine kinase 0.008 0.0522 0.0522
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0086 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0568 0.0568
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.134 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0086 0.0568 0.0568
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0086 0.0568 0.0568
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0253 0.1825 0.1825
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0449 0.3299 0.3299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.5942 0.5698
Leishmania major phosphatidylinositol 3-kinase, putative 0.0449 0.3299 0.2895
Echinococcus granulosus tyrosine protein kinase shark 0.008 0.0522 0.0522
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.3299 0.2895
Entamoeba histolytica hypothetical protein 0.0253 0.1825 0.1332
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0449 0.3299 0.2895
Loa Loa (eye worm) animal heme peroxidase 0.0085 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.7937 0.7813
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0253 0.1825 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0449 0.3299 0.3299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.3299 0.2895
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0196 0.1392 0.1392
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0086 0.0568 0.5
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0449 0.3299 0.2895
Onchocerca volvulus 0.0086 0.0568 0.6996
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0018 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.7937 0.7813
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Onchocerca volvulus 0.0018 0.0051 0.0625
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Echinococcus multilocularis serine protein kinase ATM 0.0253 0.1825 0.1825
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0568 0.0568
Onchocerca volvulus 0.0087 0.0572 0.7038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0085 0.0555 0.0555
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0253 0.1825 0.1825
Brugia malayi Blistered cuticle protein 3 0.0085 0.0555 0.0555
Onchocerca volvulus 0.0051 0.0304 0.3738
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0011 0.0011
Toxoplasma gondii target of rapamycin (TOR), putative 0.0997 0.7416 1
Brugia malayi hypothetical protein 0.0087 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.134 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0086 0.0568 0.0568
Echinococcus granulosus peroxidasin 0.0085 0.0555 0.0555
Echinococcus multilocularis beta catenin 0.012 0.0818 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.5362 0.5082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1825 0.1332
Loa Loa (eye worm) HMP-2 protein 0.012 0.0818 0.0818
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0086 0.0568 0.0568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0211 0.0211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0722 0.5353 0.5074
Loa Loa (eye worm) animal heme peroxidase 0.0085 0.0555 0.0555
Schistosoma mansoni tyrosine kinase 0.0078 0.0508 0.0508
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0051 0.0304 0.0304
Onchocerca volvulus Peroxidasin homolog 0.0085 0.0555 0.6829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0793 0.5882 0.5634
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Loa Loa (eye worm) phosphatidylinositol kinase 0.0086 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0087 0.057 0.057
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1067 0.7945 0.7822
Schistosoma mansoni hypothetical protein 0.0196 0.1392 0.1392
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0086 0.0568 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0568 0.0766
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0196 0.1392 0.1392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.5942 0.5698
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0253 0.1825 0.1825
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0568 0.0568
Echinococcus multilocularis survival motor neuron protein 1 0.0087 0.057 0.057
Brugia malayi Animal haem peroxidase family protein 0.0085 0.0555 0.0555
Onchocerca volvulus Chorion peroxidase homolog 0.0085 0.0555 0.6829
Schistosoma mansoni hypothetical protein 0.0212 0.1512 0.1512
Trichomonas vaginalis conserved hypothetical protein 0.0282 0.2042 0.1563
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0058 0.0355 0.0355
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.134 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.134 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.134 1 1
Onchocerca volvulus 0.0051 0.0301 0.3705
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Mycobacterium leprae conserved hypothetical protein 0.0086 0.0568 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0086 0.0568 0.0568
Brugia malayi hypothetical protein 0.0085 0.0555 0.0555
Loa Loa (eye worm) blistered cuticle protein 3 0.0085 0.0555 0.0555
Onchocerca volvulus 0.0085 0.0555 0.6829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Brugia malayi Pre-SET motif family protein 0.0076 0.0492 0.0492
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0253 0.1825 0.1332
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0899 0.6681 0.6481
Onchocerca volvulus 0.0085 0.0555 0.6829
Echinococcus granulosus pangolin 0.0058 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0196 0.1392 0.1392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1067 0.7945 0.7822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0722 0.5353 0.5074
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0801 0.5942 0.5698
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0086 0.0568 0.0568
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0086 0.0568 0.0568
Toxoplasma gondii FATC domain-containing protein 0.0253 0.1825 0.246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0568 0.0568
Loa Loa (eye worm) phosphatidylinositol 3 0.0449 0.3299 0.3299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0568 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.134 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0568 0.0766
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0086 0.0568 0.0568
Schistosoma mansoni peroxidasin 0.0085 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Schistosoma mansoni survival motor neuron protein 0.0018 0.0051 0.0051
Echinococcus granulosus survival motor neuron protein 1 0.0087 0.057 0.057
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.1174 0.0642
Onchocerca volvulus Cirhin homolog 0.0119 0.0812 1
Onchocerca volvulus Peroxidasin homolog 0.0085 0.0555 0.6829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0253 0.1825 0.1332
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0282 0.2042 0.2754
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.134 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1067 0.7945 0.7822
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0011 0.0011
Schistosoma mansoni pangolin 0.0058 0.0355 0.0355
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0211 0.0211
Echinococcus granulosus hypothetical protein 0.027 0.1946 0.1946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.3299 0.2895
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0086 0.0568 1
Trichomonas vaginalis conserved hypothetical protein 0.0196 0.1392 0.0873
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0557 0.4105 0.375
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0568 0.0568
Brugia malayi Animal haem peroxidase family protein 0.0085 0.0555 0.0555
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0211 0.0211
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0086 0.0568 0.0568
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.134 1 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0568 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0086 0.0568 0.0568
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0086 0.0568 0.0766
Onchocerca volvulus 0.0086 0.0568 0.6996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0449 0.3299 0.2895
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0011 0.0011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.134 1 1
Schistosoma mansoni hypothetical protein 0.0012 0.0011 0.0011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0167 0.1174 0.0642
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0086 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0211 0.0211
Onchocerca volvulus Peroxidase homolog 0.0085 0.0555 0.6829
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0086 0.0568 0.0568
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0011 0.0011
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.012 0.0818 0.0818
Echinococcus multilocularis peroxidasin 0.0085 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0086 0.0568 0.0568
Brugia malayi HMG box family protein 0.0058 0.0355 0.0355
Loa Loa (eye worm) HMG box family protein 0.0058 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0253 0.1825 0.1825
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0086 0.0568 0.0568
Echinococcus granulosus beta catenin 0.012 0.0818 0.0818
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0253 0.1825 0.1332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0997 0.7416 0.7261
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0086 0.0568 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0076 0.0492 0.0492
Echinococcus granulosus serine protein kinase ATM 0.0253 0.1825 0.1825
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0449 0.3299 0.2895
Entamoeba histolytica protein kinase rad3, putative 0.0253 0.1825 0.1332
Schistosoma mansoni peroxidasin 0.0085 0.0555 0.0555
Onchocerca volvulus Peroxidase homolog 0.0085 0.0555 0.6829
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0449 0.3299 0.2895
Echinococcus multilocularis protein pangolin J 0.0058 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.1066 0.7937 0.7813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.5362 0.5082
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.1174 0.0642
Loa Loa (eye worm) animal heme peroxidase 0.0085 0.0555 0.0555
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0086 0.0568 0.0568
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.134 1 1
Brugia malayi Peroxidasin 0.0085 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0722 0.5353 0.5074

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.2 nM Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. ChEMBL. 9464361
EC50 (functional) = 5.2 nM Agonistic activity was measured for modulation of hPR-B (human progesterone receptor) in cotransfected CV-1 cells. ChEMBL. 9464361
Efficacy (functional) = 60 % Compound was Dawley rats expressed as response to MPA at 1 mg/mouse ChEMBL. 9464361
Efficacy (functional) = 83 % Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. ChEMBL. 9464361
Efficacy (functional) = 83 % Agonistic activity of the compound towards hPR-B (human progesterone receptor) in terms of efficacy expressed as percent relative to progesterone 100%. ChEMBL. 9464361
Ki (binding) = 0.59 nM The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. ChEMBL. 9464361
Ki (binding) = 0.59 nM The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells. ChEMBL. 9464361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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